Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WY17_LEIDO

TriTrypDb:

LdBPK_240060.1 , LdCL_240005500 , LDHU3_24.0080

Length:

400

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 1
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S7WY17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WY17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.346
CLV_PCSK_KEX2_1	306	308	PF00082	0.465
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.417
CLV_PCSK_PC7_1	302	308	PF00082	0.436
CLV_PCSK_SKI1_1	223	227	PF00082	0.536
CLV_PCSK_SKI1_1	307	311	PF00082	0.439
DOC_CYCLIN_RxL_1	154	165	PF00134	0.358
DOC_CYCLIN_yCln2_LP_2	146	149	PF00134	0.416
DOC_MAPK_gen_1	275	283	PF00069	0.300
DOC_MAPK_gen_1	314	322	PF00069	0.660
DOC_MAPK_MEF2A_6	276	285	PF00069	0.257
DOC_PP2B_LxvP_1	146	149	PF13499	0.416
DOC_USP7_MATH_1	166	170	PF00917	0.426
DOC_USP7_MATH_1	173	177	PF00917	0.340
DOC_USP7_UBL2_3	102	106	PF12436	0.309
DOC_USP7_UBL2_3	306	310	PF12436	0.676
DOC_WW_Pin1_4	1	6	PF00397	0.421
DOC_WW_Pin1_4	358	363	PF00397	0.734
DOC_WW_Pin1_4	62	67	PF00397	0.453
LIG_14-3-3_CanoR_1	157	162	PF00244	0.352
LIG_14-3-3_CanoR_1	174	178	PF00244	0.230
LIG_14-3-3_CanoR_1	321	327	PF00244	0.709
LIG_14-3-3_CanoR_1	368	374	PF00244	0.645
LIG_Actin_WH2_2	53	70	PF00022	0.306
LIG_BRCT_BRCA1_1	15	19	PF00533	0.572
LIG_BRCT_BRCA1_1	159	163	PF00533	0.402
LIG_BRCT_BRCA1_1	24	28	PF00533	0.380
LIG_BRCT_BRCA1_1	3	7	PF00533	0.410
LIG_FHA_1	110	116	PF00498	0.523
LIG_FHA_1	208	214	PF00498	0.368
LIG_FHA_1	48	54	PF00498	0.408
LIG_FHA_2	191	197	PF00498	0.398
LIG_FHA_2	201	207	PF00498	0.463
LIG_LIR_Gen_1	141	149	PF02991	0.557
LIG_LIR_Gen_1	193	202	PF02991	0.242
LIG_LIR_Gen_1	294	303	PF02991	0.499
LIG_LIR_Gen_1	4	15	PF02991	0.466
LIG_LIR_Gen_1	46	57	PF02991	0.365
LIG_LIR_Nem_3	132	136	PF02991	0.434
LIG_LIR_Nem_3	141	146	PF02991	0.550
LIG_LIR_Nem_3	154	159	PF02991	0.336
LIG_LIR_Nem_3	162	167	PF02991	0.367
LIG_LIR_Nem_3	193	197	PF02991	0.354
LIG_LIR_Nem_3	232	236	PF02991	0.389
LIG_LIR_Nem_3	294	298	PF02991	0.666
LIG_LIR_Nem_3	4	10	PF02991	0.464
LIG_LIR_Nem_3	46	52	PF02991	0.371
LIG_PCNA_PIPBox_1	178	187	PF02747	0.298
LIG_PCNA_yPIPBox_3	174	185	PF02747	0.295
LIG_Pex14_1	278	282	PF04695	0.300
LIG_SH2_CRK	164	168	PF00017	0.323
LIG_SH2_CRK	236	240	PF00017	0.454
LIG_SH2_CRK	3	7	PF00017	0.484
LIG_SH2_CRK	336	340	PF00017	0.686
LIG_SH2_CRK	346	350	PF00017	0.703
LIG_SH2_CRK	359	363	PF00017	0.589
LIG_SH2_GRB2like	136	139	PF00017	0.448
LIG_SH2_NCK_1	164	168	PF00017	0.323
LIG_SH2_NCK_1	359	363	PF00017	0.645
LIG_SH2_SRC	334	337	PF00017	0.696
LIG_SH2_STAP1	104	108	PF00017	0.351
LIG_SH2_STAP1	233	237	PF00017	0.376
LIG_SH2_STAP1	386	390	PF00017	0.655
LIG_SH2_STAT3	386	389	PF00017	0.738
LIG_SH2_STAT3	396	399	PF00017	0.603
LIG_SH2_STAT5	104	107	PF00017	0.271
LIG_SH2_STAT5	136	139	PF00017	0.425
LIG_SH2_STAT5	164	167	PF00017	0.382
LIG_SH2_STAT5	247	250	PF00017	0.356
LIG_SH2_STAT5	279	282	PF00017	0.276
LIG_SH2_STAT5	295	298	PF00017	0.518
LIG_SH2_STAT5	390	393	PF00017	0.663
LIG_SH2_STAT5	86	89	PF00017	0.384
LIG_SH3_2	63	68	PF14604	0.336
LIG_SH3_3	57	63	PF00018	0.490
LIG_SUMO_SIM_par_1	111	116	PF11976	0.379
LIG_SUMO_SIM_par_1	78	83	PF11976	0.383
LIG_TYR_ITIM	192	197	PF00017	0.347
LIG_TYR_ITSM	160	167	PF00017	0.309
LIG_WRC_WIRS_1	181	186	PF05994	0.345
MOD_CDC14_SPxK_1	65	68	PF00782	0.331
MOD_CDK_SPxK_1	62	68	PF00069	0.338
MOD_CK1_1	109	115	PF00069	0.356
MOD_CK1_1	139	145	PF00069	0.448
MOD_CK1_1	151	157	PF00069	0.465
MOD_CK1_1	176	182	PF00069	0.417
MOD_CK1_1	207	213	PF00069	0.424
MOD_CK1_1	361	367	PF00069	0.686
MOD_CK1_1	92	98	PF00069	0.393
MOD_Cter_Amidation	304	307	PF01082	0.380
MOD_GlcNHglycan	108	111	PF01048	0.692
MOD_GlcNHglycan	115	118	PF01048	0.619
MOD_GlcNHglycan	303	306	PF01048	0.350
MOD_GlcNHglycan	322	325	PF01048	0.389
MOD_GSK3_1	102	109	PF00069	0.442
MOD_GSK3_1	113	120	PF00069	0.409
MOD_GSK3_1	134	141	PF00069	0.432
MOD_GSK3_1	147	154	PF00069	0.384
MOD_GSK3_1	162	169	PF00069	0.259
MOD_GSK3_1	173	180	PF00069	0.313
MOD_GSK3_1	200	207	PF00069	0.386
MOD_GSK3_1	262	269	PF00069	0.462
MOD_GSK3_1	301	308	PF00069	0.534
MOD_GSK3_1	43	50	PF00069	0.368
MOD_GSK3_1	62	69	PF00069	0.502
MOD_GSK3_1	80	87	PF00069	0.315
MOD_N-GLC_1	100	105	PF02516	0.570
MOD_N-GLC_1	134	139	PF02516	0.620
MOD_N-GLC_1	151	156	PF02516	0.540
MOD_N-GLC_1	157	162	PF02516	0.516
MOD_N-GLC_1	266	271	PF02516	0.655
MOD_N-GLC_1	35	40	PF02516	0.576
MOD_N-GLC_2	138	140	PF02516	0.647
MOD_NEK2_1	113	118	PF00069	0.410
MOD_NEK2_1	119	124	PF00069	0.372
MOD_NEK2_1	13	18	PF00069	0.550
MOD_NEK2_1	159	164	PF00069	0.292
MOD_NEK2_1	177	182	PF00069	0.265
MOD_NEK2_1	197	202	PF00069	0.426
MOD_NEK2_1	291	296	PF00069	0.457
MOD_NEK2_1	43	48	PF00069	0.425
MOD_NEK2_1	52	57	PF00069	0.362
MOD_NEK2_2	305	310	PF00069	0.531
MOD_PIKK_1	166	172	PF00454	0.429
MOD_PIKK_1	197	203	PF00454	0.408
MOD_PKA_2	173	179	PF00069	0.403
MOD_PKA_2	301	307	PF00069	0.596
MOD_PKA_2	320	326	PF00069	0.565
MOD_PKA_2	367	373	PF00069	0.682
MOD_Plk_1	100	106	PF00069	0.316
MOD_Plk_1	151	157	PF00069	0.417
MOD_Plk_1	22	28	PF00069	0.448
MOD_Plk_1	223	229	PF00069	0.395
MOD_Plk_1	35	41	PF00069	0.353
MOD_Plk_4	129	135	PF00069	0.439
MOD_Plk_4	159	165	PF00069	0.304
MOD_Plk_4	180	186	PF00069	0.370
MOD_Plk_4	204	210	PF00069	0.409
MOD_Plk_4	226	232	PF00069	0.364
MOD_Plk_4	235	241	PF00069	0.318
MOD_Plk_4	80	86	PF00069	0.355
MOD_ProDKin_1	1	7	PF00069	0.418
MOD_ProDKin_1	358	364	PF00069	0.733
MOD_ProDKin_1	62	68	PF00069	0.457
TRG_ENDOCYTIC_2	164	167	PF00928	0.317
TRG_ENDOCYTIC_2	194	197	PF00928	0.354
TRG_ENDOCYTIC_2	236	239	PF00928	0.407
TRG_ENDOCYTIC_2	279	282	PF00928	0.280
TRG_ENDOCYTIC_2	295	298	PF00928	0.535
TRG_ENDOCYTIC_2	3	6	PF00928	0.485
TRG_ENDOCYTIC_2	346	349	PF00928	0.690

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0L6	Leptomonas seymouri	46%	95%
A0A3R7P473	Trypanosoma rangeli	30%	100%
A4HD64	Leishmania braziliensis	62%	99%
A4I0M9	Leishmania infantum	99%	100%
D0A6X7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AWJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QAX4	Leishmania major	90%	100%
V5C0T3	Trypanosoma cruzi	27%	100%