Qb-SNARE protein, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WY13_LEIDO

TriTrypDb:

LdBPK_231800.1 , LdCL_230025100 , LDHU3_23.2370

Length:

347

Annotations

LeishMANIAdb annotations

Similar to other Eukaryotic vesicle-associated V-SNARE proteins, especially VTI1.. Localization: Vesicular (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 18
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	15
GO:0016020	membrane	2	20
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	20
GO:0005794	Golgi apparatus	5	5
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0010008	endosome membrane	5	2
GO:0012506	vesicle membrane	4	2
GO:0012507	ER to Golgi transport vesicle membrane	6	2
GO:0030658	transport vesicle membrane	5	2
GO:0030659	cytoplasmic vesicle membrane	5	2
GO:0030662	coated vesicle membrane	5	2
GO:0031090	organelle membrane	3	2
GO:0031201	SNARE complex	3	2
GO:0031902	late endosome membrane	6	2
GO:0032991	protein-containing complex	1	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098796	membrane protein complex	2	2

Expansion

Sequence features

A0A3S7WY13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WY13

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	19
GO:0006886	intracellular protein transport	4	15
GO:0008104	protein localization	4	19
GO:0009987	cellular process	1	19
GO:0015031	protein transport	4	19
GO:0016192	vesicle-mediated transport	4	11
GO:0033036	macromolecule localization	2	19
GO:0045184	establishment of protein localization	3	19
GO:0046907	intracellular transport	3	15
GO:0051179	localization	1	19
GO:0051234	establishment of localization	2	19
GO:0051641	cellular localization	2	19
GO:0051649	establishment of localization in cell	3	15
GO:0070727	cellular macromolecule localization	3	19
GO:0071702	organic substance transport	4	19
GO:0071705	nitrogen compound transport	4	19
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	1
GO:0048193	Golgi vesicle transport	5	1
GO:0006906	vesicle fusion	6	2
GO:0006996	organelle organization	4	2
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0048284	organelle fusion	5	2
GO:0061024	membrane organization	4	2
GO:0061025	membrane fusion	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090174	organelle membrane fusion	6	2

Molecular functions
Term	Name	Level	Count
GO:0005484	SNAP receptor activity	3	6
GO:0030674	protein-macromolecule adaptor activity	2	6
GO:0060090	molecular adaptor activity	1	6
GO:0000149	SNARE binding	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	271	275	PF00656	0.552
CLV_C14_Caspase3-7	76	80	PF00656	0.623
CLV_NRD_NRD_1	12	14	PF00675	0.341
CLV_NRD_NRD_1	188	190	PF00675	0.530
CLV_NRD_NRD_1	275	277	PF00675	0.245
CLV_NRD_NRD_1	96	98	PF00675	0.329
CLV_PCSK_KEX2_1	12	14	PF00082	0.341
CLV_PCSK_KEX2_1	188	190	PF00082	0.500
CLV_PCSK_KEX2_1	26	28	PF00082	0.362
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.367
CLV_PCSK_SKI1_1	290	294	PF00082	0.356
DEG_APCC_DBOX_1	156	164	PF00400	0.519
DEG_APCC_DBOX_1	39	47	PF00400	0.545
DOC_CDC14_PxL_1	46	54	PF14671	0.523
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.535
DOC_MAPK_gen_1	12	20	PF00069	0.540
DOC_MAPK_JIP1_4	40	46	PF00069	0.544
DOC_PP4_MxPP_1	1	4	PF00568	0.562
DOC_USP7_MATH_1	172	176	PF00917	0.627
DOC_USP7_MATH_1	247	251	PF00917	0.464
DOC_USP7_MATH_1	330	334	PF00917	0.555
DOC_USP7_MATH_1	34	38	PF00917	0.560
DOC_USP7_MATH_1	4	8	PF00917	0.560
DOC_USP7_UBL2_3	284	288	PF12436	0.657
DOC_WW_Pin1_4	30	35	PF00397	0.569
LIG_14-3-3_CanoR_1	146	153	PF00244	0.541
LIG_14-3-3_CanoR_1	252	261	PF00244	0.473
LIG_Actin_WH2_2	77	94	PF00022	0.561
LIG_BIR_III_4	225	229	PF00653	0.438
LIG_BRCT_BRCA1_1	301	305	PF00533	0.207
LIG_FHA_1	119	125	PF00498	0.496
LIG_FHA_1	238	244	PF00498	0.516
LIG_FHA_1	263	269	PF00498	0.506
LIG_FHA_1	292	298	PF00498	0.414
LIG_FHA_2	146	152	PF00498	0.521
LIG_FHA_2	160	166	PF00498	0.414
LIG_FHA_2	81	87	PF00498	0.617
LIG_LIR_Gen_1	302	313	PF02991	0.362
LIG_LIR_Nem_3	302	308	PF02991	0.362
LIG_LIR_Nem_3	67	73	PF02991	0.571
LIG_SH2_CRK	102	106	PF00017	0.499
LIG_SH2_PTP2	309	312	PF00017	0.463
LIG_SH2_STAP1	73	77	PF00017	0.548
LIG_SH2_STAT5	309	312	PF00017	0.430
LIG_SH3_3	11	17	PF00018	0.535
LIG_SH3_3	44	50	PF00018	0.525
LIG_SUMO_SIM_anti_2	178	185	PF11976	0.596
LIG_SUMO_SIM_anti_2	294	300	PF11976	0.464
LIG_SUMO_SIM_anti_2	42	48	PF11976	0.539
LIG_SUMO_SIM_par_1	263	271	PF11976	0.497
LIG_SUMO_SIM_par_1	296	302	PF11976	0.402
LIG_TRAF2_1	162	165	PF00917	0.543
LIG_TRAF2_1	72	75	PF00917	0.568
LIG_UBA3_1	182	190	PF00899	0.728
LIG_UBA3_1	278	284	PF00899	0.464
MOD_CK1_1	30	36	PF00069	0.569
MOD_CK1_1	320	326	PF00069	0.457
MOD_CK1_1	339	345	PF00069	0.498
MOD_CK1_1	42	48	PF00069	0.530
MOD_CK2_1	145	151	PF00069	0.501
MOD_CK2_1	159	165	PF00069	0.416
MOD_GlcNHglycan	173	177	PF01048	0.409
MOD_GlcNHglycan	225	229	PF01048	0.319
MOD_GlcNHglycan	279	282	PF01048	0.264
MOD_GlcNHglycan	59	62	PF01048	0.411
MOD_GSK3_1	105	112	PF00069	0.484
MOD_GSK3_1	155	162	PF00069	0.516
MOD_GSK3_1	30	37	PF00069	0.560
MOD_GSK3_1	316	323	PF00069	0.498
MOD_GSK3_1	330	337	PF00069	0.524
MOD_N-GLC_1	237	242	PF02516	0.269
MOD_N-GLC_1	317	322	PF02516	0.731
MOD_NEK2_1	217	222	PF00069	0.578
MOD_NEK2_1	291	296	PF00069	0.366
MOD_NEK2_2	247	252	PF00069	0.585
MOD_NEK2_2	4	9	PF00069	0.560
MOD_NEK2_2	65	70	PF00069	0.473
MOD_NEK2_2	80	85	PF00069	0.516
MOD_PKA_1	188	194	PF00069	0.666
MOD_PKA_2	145	151	PF00069	0.523
MOD_PKA_2	188	194	PF00069	0.759
MOD_PKA_2	316	322	PF00069	0.403
MOD_PKA_2	39	45	PF00069	0.545
MOD_PKA_2	91	97	PF00069	0.477
MOD_Plk_1	262	268	PF00069	0.520
MOD_Plk_4	119	125	PF00069	0.540
MOD_Plk_4	299	305	PF00069	0.448
MOD_Plk_4	336	342	PF00069	0.507
MOD_Plk_4	34	40	PF00069	0.627
MOD_Plk_4	42	48	PF00069	0.611
MOD_Plk_4	65	71	PF00069	0.551
MOD_ProDKin_1	30	36	PF00069	0.567
MOD_SUMO_rev_2	94	100	PF00179	0.438
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.495
TRG_ENDOCYTIC_2	309	312	PF00928	0.403
TRG_ER_diArg_1	11	13	PF00400	0.547
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.284
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.264
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G6	Leptomonas seymouri	72%	100%
A0A0N1HXG1	Leptomonas seymouri	31%	100%
A0A1X0NWY4	Trypanosomatidae	30%	100%
A0A1X0NY79	Trypanosomatidae	52%	100%
A0A3Q8IEP1	Leishmania donovani	36%	100%
A0A3S5IRB0	Trypanosoma rangeli	50%	100%
A0A422NJV1	Trypanosoma rangeli	34%	100%
A4HD24	Leishmania braziliensis	37%	99%
A4HD25	Leishmania braziliensis	84%	100%
A4I0L1	Leishmania infantum	38%	98%
A4I0L2	Leishmania infantum	100%	100%
C9ZVI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AWH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	98%
E9AWH3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QAZ8	Leishmania major	90%	97%
Q4QAZ9	Leishmania major	39%	98%
V5ARB2	Trypanosoma cruzi	51%	100%
V5BFR7	Trypanosoma cruzi	34%	100%