Ran-interacting Mog1 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ran-binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WY05_LEIDO

TriTrypDb:

LdBPK_231660.1 , LdCL_230023800 , LDHU3_23.2220

Length:

213

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WY05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WY05

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0006606	protein import into nucleus	5	1
GO:0006886	intracellular protein transport	4	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0033365	protein localization to organelle	5	1
GO:0034504	protein localization to nucleus	6	1
GO:0046907	intracellular transport	3	1
GO:0051169	nuclear transport	4	1
GO:0051170	import into nucleus	6	1
GO:0051649	establishment of localization in cell	3	1
GO:0072594	establishment of protein localization to organelle	4	1

Molecular functions
Term	Name	Level	Count
GO:0005085	guanyl-nucleotide exchange factor activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0030234	enzyme regulator activity	2	1
GO:0030695	GTPase regulator activity	4	1
GO:0031267	small GTPase binding	5	1
GO:0051020	GTPase binding	4	1
GO:0060589	nucleoside-triphosphatase regulator activity	3	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1
GO:0140678	molecular function inhibitor activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	53	55	PF00675	0.344
CLV_PCSK_KEX2_1	181	183	PF00082	0.493
CLV_PCSK_KEX2_1	53	55	PF00082	0.207
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.355
CLV_PCSK_SKI1_1	178	182	PF00082	0.465
CLV_Separin_Metazoa	50	54	PF03568	0.407
DEG_APCC_KENBOX_2	138	142	PF00400	0.424
DEG_SCF_FBW7_1	150	157	PF00400	0.487
DOC_CYCLIN_RxL_1	178	188	PF00134	0.494
DOC_MAPK_gen_1	137	145	PF00069	0.405
DOC_MAPK_MEF2A_6	139	147	PF00069	0.392
DOC_PP2B_LxvP_1	207	210	PF13499	0.328
DOC_PP4_FxxP_1	152	155	PF00568	0.405
DOC_USP7_MATH_1	172	176	PF00917	0.311
DOC_USP7_MATH_1	196	200	PF00917	0.320
DOC_WW_Pin1_4	150	155	PF00397	0.469
LIG_14-3-3_CanoR_1	15	19	PF00244	0.435
LIG_14-3-3_CanoR_1	182	190	PF00244	0.348
LIG_14-3-3_CanoR_1	53	61	PF00244	0.408
LIG_BIR_II_1	1	5	PF00653	0.411
LIG_BRCT_BRCA1_1	116	120	PF00533	0.419
LIG_CaM_IQ_9	124	139	PF13499	0.445
LIG_deltaCOP1_diTrp_1	204	208	PF00928	0.302
LIG_EVH1_2	91	95	PF00568	0.356
LIG_FHA_1	122	128	PF00498	0.482
LIG_FHA_1	151	157	PF00498	0.421
LIG_FHA_1	2	8	PF00498	0.407
LIG_FHA_1	85	91	PF00498	0.476
LIG_FHA_2	183	189	PF00498	0.404
LIG_FHA_2	19	25	PF00498	0.414
LIG_FHA_2	37	43	PF00498	0.465
LIG_LIR_Apic_2	168	172	PF02991	0.253
LIG_LIR_Gen_1	117	127	PF02991	0.428
LIG_LIR_Nem_3	117	123	PF02991	0.453
LIG_LIR_Nem_3	142	147	PF02991	0.437
LIG_LIR_Nem_3	204	208	PF02991	0.302
LIG_LIR_Nem_3	26	31	PF02991	0.401
LIG_LIR_Nem_3	93	98	PF02991	0.404
LIG_SH2_CRK	194	198	PF00017	0.214
LIG_SH2_GRB2like	133	136	PF00017	0.405
LIG_SH2_NCK_1	194	198	PF00017	0.214
LIG_SH2_NCK_1	38	42	PF00017	0.445
LIG_SH2_STAP1	194	198	PF00017	0.214
LIG_SH2_STAT5	133	136	PF00017	0.423
LIG_SH2_STAT5	194	197	PF00017	0.210
LIG_SH2_STAT5	38	41	PF00017	0.405
LIG_SH3_3	101	107	PF00018	0.483
LIG_SH3_3	109	115	PF00018	0.356
LIG_SH3_3	161	167	PF00018	0.510
LIG_SUMO_SIM_anti_2	199	204	PF11976	0.363
LIG_SUMO_SIM_par_1	157	165	PF11976	0.415
LIG_SUMO_SIM_par_1	21	27	PF11976	0.447
LIG_TRAF2_1	185	188	PF00917	0.446
LIG_TRAF2_1	210	213	PF00917	0.426
LIG_TRAF2_1	83	86	PF00917	0.390
LIG_TYR_ITIM	192	197	PF00017	0.205
MOD_CK1_1	131	137	PF00069	0.404
MOD_CK1_1	165	171	PF00069	0.470
MOD_CK2_1	182	188	PF00069	0.340
MOD_CK2_1	80	86	PF00069	0.496
MOD_GlcNHglycan	100	103	PF01048	0.231
MOD_GlcNHglycan	92	95	PF01048	0.263
MOD_GSK3_1	14	21	PF00069	0.461
MOD_GSK3_1	150	157	PF00069	0.447
MOD_GSK3_1	192	199	PF00069	0.369
MOD_GSK3_1	36	43	PF00069	0.400
MOD_GSK3_1	80	87	PF00069	0.517
MOD_N-GLC_2	75	77	PF02516	0.204
MOD_NEK2_1	1	6	PF00069	0.366
MOD_NEK2_1	14	19	PF00069	0.350
MOD_NEK2_1	192	197	PF00069	0.405
MOD_NEK2_1	97	102	PF00069	0.417
MOD_PIKK_1	80	86	PF00454	0.513
MOD_PKA_1	53	59	PF00069	0.407
MOD_PKA_2	128	134	PF00069	0.445
MOD_PKA_2	14	20	PF00069	0.396
MOD_PKA_2	53	59	PF00069	0.419
MOD_Plk_2-3	36	42	PF00069	0.428
MOD_Plk_4	165	171	PF00069	0.399
MOD_Plk_4	18	24	PF00069	0.437
MOD_Plk_4	43	49	PF00069	0.445
MOD_ProDKin_1	150	156	PF00069	0.469
TRG_AP2beta_CARGO_1	142	151	PF09066	0.437
TRG_DiLeu_BaEn_1	188	193	PF01217	0.303
TRG_DiLeu_BaEn_2	139	145	PF01217	0.466
TRG_DiLeu_BaEn_2	203	209	PF01217	0.445
TRG_DiLeu_BaEn_4	85	91	PF01217	0.390
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.360
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.385
TRG_ENDOCYTIC_2	194	197	PF00928	0.210
TRG_ENDOCYTIC_2	68	71	PF00928	0.498
TRG_ER_diArg_1	52	54	PF00400	0.407
TRG_NES_CRM1_1	191	204	PF08389	0.316
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBA3	Leptomonas seymouri	65%	100%
A0A0S4JIB8	Bodo saltans	47%	100%
A0A1X0NWS3	Trypanosomatidae	49%	96%
A0A422NXZ5	Trypanosoma rangeli	51%	100%
A3KPP3	Danio rerio	31%	100%
A4HD13	Leishmania braziliensis	86%	100%
A4I0J9	Leishmania infantum	100%	100%
C9ZVC7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AWG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O75002	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
P47123	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	98%
Q32PE2	Bos taurus	30%	100%
Q4QB12	Leishmania major	95%	100%
Q54ML6	Dictyostelium discoideum	31%	100%
Q9HD47	Homo sapiens	31%	100%