WD domain, G-beta repeat family protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD40/YVTN repeat-like-containing protein

Species:

Leishmania donovani

UniProt:

A0A3S7WY01_LEIDO

TriTrypDb:

LdBPK_240120.1 , LdCL_240006100 , LDHU3_24.0140

Length:

555

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, Guanine nucleotide-binding beta subunit-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005840	ribosome	5	1
GO:0032991	protein-containing complex	1	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S7WY01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WY01

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.403
CLV_C14_Caspase3-7	71	75	PF00656	0.530
CLV_NRD_NRD_1	130	132	PF00675	0.426
CLV_NRD_NRD_1	151	153	PF00675	0.570
CLV_NRD_NRD_1	239	241	PF00675	0.508
CLV_NRD_NRD_1	328	330	PF00675	0.637
CLV_PCSK_KEX2_1	130	132	PF00082	0.440
CLV_PCSK_KEX2_1	151	153	PF00082	0.496
CLV_PCSK_KEX2_1	239	241	PF00082	0.508
CLV_PCSK_KEX2_1	452	454	PF00082	0.408
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.512
CLV_PCSK_SKI1_1	152	156	PF00082	0.517
CLV_PCSK_SKI1_1	233	237	PF00082	0.632
CLV_PCSK_SKI1_1	351	355	PF00082	0.465
DEG_APCC_DBOX_1	150	158	PF00400	0.546
DEG_Nend_UBRbox_1	1	4	PF02207	0.479
DEG_SPOP_SBC_1	264	268	PF00917	0.392
DEG_SPOP_SBC_1	505	509	PF00917	0.595
DOC_CYCLIN_RxL_1	149	159	PF00134	0.503
DOC_CYCLIN_yCln2_LP_2	66	72	PF00134	0.486
DOC_MAPK_DCC_7	312	322	PF00069	0.501
DOC_MAPK_gen_1	151	157	PF00069	0.523
DOC_MAPK_MEF2A_6	2	9	PF00069	0.447
DOC_PP2B_LxvP_1	543	546	PF13499	0.539
DOC_USP7_MATH_1	506	510	PF00917	0.590
DOC_USP7_UBL2_3	47	51	PF12436	0.559
DOC_WW_Pin1_4	227	232	PF00397	0.551
DOC_WW_Pin1_4	313	318	PF00397	0.518
DOC_WW_Pin1_4	461	466	PF00397	0.628
LIG_14-3-3_CanoR_1	239	248	PF00244	0.538
LIG_14-3-3_CanoR_1	290	298	PF00244	0.374
LIG_14-3-3_CanoR_1	301	306	PF00244	0.399
LIG_14-3-3_CanoR_1	34	42	PF00244	0.487
LIG_14-3-3_CanoR_1	65	69	PF00244	0.492
LIG_APCC_ABBA_1	96	101	PF00400	0.506
LIG_BRCT_BRCA1_1	80	84	PF00533	0.438
LIG_Clathr_ClatBox_1	373	377	PF01394	0.532
LIG_FHA_1	195	201	PF00498	0.462
LIG_FHA_1	2	8	PF00498	0.557
LIG_FHA_1	302	308	PF00498	0.473
LIG_FHA_1	37	43	PF00498	0.480
LIG_FHA_1	387	393	PF00498	0.541
LIG_FHA_1	430	436	PF00498	0.462
LIG_FHA_1	445	451	PF00498	0.269
LIG_FHA_1	538	544	PF00498	0.432
LIG_FHA_2	148	154	PF00498	0.420
LIG_FHA_2	21	27	PF00498	0.598
LIG_FHA_2	337	343	PF00498	0.513
LIG_FHA_2	437	443	PF00498	0.497
LIG_GBD_Chelix_1	58	66	PF00786	0.495
LIG_LIR_Gen_1	186	196	PF02991	0.552
LIG_LIR_Gen_1	518	528	PF02991	0.427
LIG_LIR_Nem_3	186	192	PF02991	0.543
LIG_LIR_Nem_3	246	250	PF02991	0.542
LIG_LIR_Nem_3	275	279	PF02991	0.468
LIG_LIR_Nem_3	457	462	PF02991	0.585
LIG_LIR_Nem_3	518	523	PF02991	0.429
LIG_PDZ_Class_2	550	555	PF00595	0.568
LIG_REV1ctd_RIR_1	82	91	PF16727	0.461
LIG_SH2_CRK	520	524	PF00017	0.371
LIG_SH2_CRK	55	59	PF00017	0.521
LIG_SH2_GRB2like	313	316	PF00017	0.517
LIG_SH2_STAP1	142	146	PF00017	0.377
LIG_SH2_STAP1	218	222	PF00017	0.412
LIG_SH2_STAP1	292	296	PF00017	0.374
LIG_SH2_STAP1	55	59	PF00017	0.547
LIG_SH2_STAT5	222	225	PF00017	0.422
LIG_SH2_STAT5	254	257	PF00017	0.467
LIG_SH2_STAT5	313	316	PF00017	0.531
LIG_SH2_STAT5	361	364	PF00017	0.376
LIG_SH2_STAT5	385	388	PF00017	0.455
LIG_SH2_STAT5	495	498	PF00017	0.504
LIG_SH3_3	228	234	PF00018	0.607
LIG_SUMO_SIM_anti_2	74	81	PF11976	0.389
LIG_SUMO_SIM_par_1	153	159	PF11976	0.490
LIG_TYR_ITIM	187	192	PF00017	0.537
LIG_WRC_WIRS_1	550	555	PF05994	0.678
MOD_CDC14_SPxK_1	230	233	PF00782	0.662
MOD_CDK_SPxK_1	227	233	PF00069	0.621
MOD_CK1_1	156	162	PF00069	0.505
MOD_CK1_1	266	272	PF00069	0.520
MOD_CK1_1	356	362	PF00069	0.462
MOD_CK1_1	426	432	PF00069	0.547
MOD_CK1_1	436	442	PF00069	0.372
MOD_CK1_1	444	450	PF00069	0.357
MOD_CK1_1	500	506	PF00069	0.548
MOD_CK1_1	508	514	PF00069	0.599
MOD_CK1_1	92	98	PF00069	0.466
MOD_CK2_1	147	153	PF00069	0.419
MOD_CK2_1	20	26	PF00069	0.514
MOD_CK2_1	396	402	PF00069	0.578
MOD_GlcNHglycan	200	203	PF01048	0.473
MOD_GlcNHglycan	355	359	PF01048	0.514
MOD_GlcNHglycan	425	428	PF01048	0.481
MOD_GlcNHglycan	472	475	PF01048	0.417
MOD_GlcNHglycan	515	518	PF01048	0.626
MOD_GlcNHglycan	91	94	PF01048	0.568
MOD_GSK3_1	156	163	PF00069	0.500
MOD_GSK3_1	172	179	PF00069	0.261
MOD_GSK3_1	194	201	PF00069	0.412
MOD_GSK3_1	234	241	PF00069	0.523
MOD_GSK3_1	265	272	PF00069	0.384
MOD_GSK3_1	365	372	PF00069	0.479
MOD_GSK3_1	386	393	PF00069	0.470
MOD_GSK3_1	406	413	PF00069	0.398
MOD_GSK3_1	429	436	PF00069	0.417
MOD_GSK3_1	437	444	PF00069	0.384
MOD_GSK3_1	470	477	PF00069	0.435
MOD_GSK3_1	497	504	PF00069	0.573
MOD_GSK3_1	64	71	PF00069	0.491
MOD_N-GLC_1	169	174	PF02516	0.486
MOD_N-GLC_1	212	217	PF02516	0.549
MOD_N-GLC_1	423	428	PF02516	0.484
MOD_N-GLC_1	497	502	PF02516	0.571
MOD_NEK2_1	1	6	PF00069	0.541
MOD_NEK2_1	132	137	PF00069	0.425
MOD_NEK2_1	20	25	PF00069	0.561
MOD_NEK2_1	212	217	PF00069	0.481
MOD_NEK2_1	238	243	PF00069	0.511
MOD_NEK2_1	296	301	PF00069	0.519
MOD_NEK2_1	346	351	PF00069	0.435
MOD_NEK2_1	353	358	PF00069	0.456
MOD_NEK2_1	404	409	PF00069	0.493
MOD_NEK2_1	476	481	PF00069	0.392
MOD_NEK2_2	234	239	PF00069	0.578
MOD_NEK2_2	441	446	PF00069	0.320
MOD_PIKK_1	379	385	PF00454	0.442
MOD_PKA_1	239	245	PF00069	0.564
MOD_PKA_2	238	244	PF00069	0.443
MOD_PKA_2	311	317	PF00069	0.542
MOD_PKA_2	64	70	PF00069	0.496
MOD_Plk_1	212	218	PF00069	0.489
MOD_Plk_1	37	43	PF00069	0.479
MOD_Plk_1	410	416	PF00069	0.421
MOD_Plk_1	441	447	PF00069	0.486
MOD_Plk_1	501	507	PF00069	0.564
MOD_Plk_2-3	537	543	PF00069	0.398
MOD_Plk_2-3	549	555	PF00069	0.539
MOD_Plk_4	160	166	PF00069	0.516
MOD_Plk_4	212	218	PF00069	0.476
MOD_Plk_4	301	307	PF00069	0.504
MOD_Plk_4	369	375	PF00069	0.420
MOD_Plk_4	37	43	PF00069	0.556
MOD_Plk_4	411	417	PF00069	0.391
MOD_Plk_4	441	447	PF00069	0.423
MOD_Plk_4	527	533	PF00069	0.536
MOD_Plk_4	54	60	PF00069	0.316
MOD_ProDKin_1	227	233	PF00069	0.562
MOD_ProDKin_1	313	319	PF00069	0.512
MOD_ProDKin_1	461	467	PF00069	0.620
MOD_SUMO_rev_2	108	112	PF00179	0.537
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.467
TRG_ENDOCYTIC_2	189	192	PF00928	0.549
TRG_ENDOCYTIC_2	520	523	PF00928	0.373
TRG_ENDOCYTIC_2	55	58	PF00928	0.530
TRG_ER_diArg_1	129	131	PF00400	0.441
TRG_ER_diArg_1	238	240	PF00400	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1S8	Leptomonas seymouri	73%	100%
A0A1X0NIQ5	Trypanosomatidae	48%	99%
A0A3R7NVJ1	Trypanosoma rangeli	47%	99%
A4HD70	Leishmania braziliensis	91%	100%
C9ZSK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	87%
D0A6Y3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	99%
E9AH24	Leishmania infantum	100%	100%
E9AWK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QAW8	Leishmania major	98%	100%
V5C0S8	Trypanosoma cruzi	48%	99%