Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WXY1_LEIDO

TriTrypDb:

LdBPK_231830.1 , LdCL_230025400 , LDHU3_23.2410

Length:

203

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3S7WXY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXY1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	48	50	PF00675	0.395
CLV_PCSK_KEX2_1	48	50	PF00082	0.395
CLV_PCSK_SKI1_1	172	176	PF00082	0.555
DOC_MAPK_gen_1	48	56	PF00069	0.585
DOC_WW_Pin1_4	41	46	PF00397	0.602
DOC_WW_Pin1_4	9	14	PF00397	0.654
LIG_14-3-3_CanoR_1	127	136	PF00244	0.620
LIG_eIF4E_1	109	115	PF01652	0.358
LIG_FHA_1	111	117	PF00498	0.446
LIG_FHA_1	156	162	PF00498	0.327
LIG_FHA_1	95	101	PF00498	0.310
LIG_GBD_Chelix_1	116	124	PF00786	0.501
LIG_LIR_Gen_1	112	120	PF02991	0.358
LIG_LIR_Gen_1	181	191	PF02991	0.343
LIG_LIR_Nem_3	102	107	PF02991	0.387
LIG_LIR_Nem_3	112	118	PF02991	0.207
LIG_LIR_Nem_3	155	160	PF02991	0.279
LIG_LIR_Nem_3	181	186	PF02991	0.355
LIG_LIR_Nem_3	187	191	PF02991	0.314
LIG_Pex14_2	75	79	PF04695	0.358
LIG_Rb_LxCxE_1	131	151	PF01857	0.513
LIG_Rb_LxCxE_1	32	44	PF01857	0.669
LIG_SH2_STAP1	139	143	PF00017	0.456
LIG_SH2_STAT5	109	112	PF00017	0.358
LIG_Sin3_3	79	86	PF02671	0.410
LIG_SUMO_SIM_anti_2	192	198	PF11976	0.279
LIG_SUMO_SIM_anti_2	37	44	PF11976	0.613
LIG_SUMO_SIM_par_1	145	151	PF11976	0.358
LIG_WRC_WIRS_1	180	185	PF05994	0.343
MOD_CDK_SPxxK_3	41	48	PF00069	0.600
MOD_CK1_1	131	137	PF00069	0.643
MOD_CK1_1	155	161	PF00069	0.358
MOD_CK2_1	134	140	PF00069	0.632
MOD_GlcNHglycan	31	34	PF01048	0.539
MOD_GlcNHglycan	64	67	PF01048	0.358
MOD_GSK3_1	127	134	PF00069	0.648
MOD_GSK3_1	148	155	PF00069	0.358
MOD_GSK3_1	178	185	PF00069	0.367
MOD_GSK3_1	37	44	PF00069	0.715
MOD_GSK3_1	58	65	PF00069	0.358
MOD_N-GLC_1	131	136	PF02516	0.448
MOD_NEK2_1	110	115	PF00069	0.343
MOD_NEK2_1	120	125	PF00069	0.561
MOD_NEK2_1	148	153	PF00069	0.518
MOD_NEK2_1	162	167	PF00069	0.402
MOD_NEK2_1	62	67	PF00069	0.358
MOD_NEK2_1	81	86	PF00069	0.431
MOD_NEK2_1	94	99	PF00069	0.375
MOD_NEK2_2	152	157	PF00069	0.279
MOD_PKA_2	128	134	PF00069	0.613
MOD_Plk_1	131	137	PF00069	0.643
MOD_Plk_1	37	43	PF00069	0.614
MOD_Plk_4	110	116	PF00069	0.422
MOD_Plk_4	37	43	PF00069	0.614
MOD_ProDKin_1	41	47	PF00069	0.600
MOD_ProDKin_1	9	15	PF00069	0.656
MOD_SUMO_rev_2	5	11	PF00179	0.600
TRG_ER_diArg_1	126	129	PF00400	0.672
TRG_ER_diArg_1	47	49	PF00400	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I0L5	Leishmania infantum	98%	100%
Q4QAZ5	Leishmania major	83%	100%