Mitochondrial carrier protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WXX9_LEIDO

TriTrypDb:

LdBPK_231630.1 , LdCL_230023500 , LDHU3_23.2170

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 12
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14
GO:0005743	mitochondrial inner membrane	5	1
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1

Expansion

Sequence features

A0A3S7WXX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXX9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0009987	cellular process	1	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0000095	S-adenosyl-L-methionine transmembrane transporter activity	4	1
GO:0005215	transporter activity	1	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015101	organic cation transmembrane transporter activity	5	1
GO:0022857	transmembrane transporter activity	2	1
GO:1901682	sulfur compound transmembrane transporter activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	179	181	PF00675	0.565
CLV_NRD_NRD_1	49	51	PF00675	0.479
CLV_PCSK_KEX2_1	179	181	PF00082	0.440
CLV_PCSK_KEX2_1	49	51	PF00082	0.479
CLV_PCSK_SKI1_1	144	148	PF00082	0.256
CLV_PCSK_SKI1_1	302	306	PF00082	0.280
CLV_PCSK_SKI1_1	38	42	PF00082	0.542
CLV_PCSK_SKI1_1	382	386	PF00082	0.315
CLV_PCSK_SKI1_1	76	80	PF00082	0.240
DEG_APCC_DBOX_1	117	125	PF00400	0.279
DEG_Nend_Nbox_1	1	3	PF02207	0.691
DOC_CKS1_1	131	136	PF01111	0.222
DOC_CYCLIN_RxL_1	73	83	PF00134	0.258
DOC_CYCLIN_yClb1_LxF_4	142	147	PF00134	0.231
DOC_PP1_RVXF_1	142	148	PF00149	0.231
DOC_PP1_RVXF_1	361	367	PF00149	0.290
DOC_PP2B_LxvP_1	202	205	PF13499	0.315
DOC_PP2B_LxvP_1	239	242	PF13499	0.373
DOC_PP2B_LxvP_1	317	320	PF13499	0.373
DOC_PP4_FxxP_1	147	150	PF00568	0.231
DOC_USP7_MATH_1	216	220	PF00917	0.287
DOC_USP7_MATH_1	283	287	PF00917	0.592
DOC_USP7_MATH_1	395	399	PF00917	0.524
DOC_USP7_MATH_1	65	69	PF00917	0.222
DOC_WW_Pin1_4	110	115	PF00397	0.259
DOC_WW_Pin1_4	130	135	PF00397	0.252
DOC_WW_Pin1_4	22	27	PF00397	0.705
DOC_WW_Pin1_4	6	11	PF00397	0.727
LIG_BRCT_BRCA1_1	157	161	PF00533	0.246
LIG_BRCT_BRCA1_1	190	194	PF00533	0.246
LIG_BRCT_BRCA1_1	305	309	PF00533	0.313
LIG_FHA_1	23	29	PF00498	0.419
LIG_FHA_1	316	322	PF00498	0.313
LIG_FHA_1	324	330	PF00498	0.316
LIG_FHA_2	330	336	PF00498	0.340
LIG_FHA_2	337	343	PF00498	0.295
LIG_LIR_Apic_2	55	61	PF02991	0.489
LIG_LIR_Gen_1	248	259	PF02991	0.337
LIG_LIR_Nem_3	248	254	PF02991	0.312
LIG_LIR_Nem_3	291	296	PF02991	0.468
LIG_LIR_Nem_3	306	312	PF02991	0.258
LIG_PDZ_Class_1	394	399	PF00595	0.474
LIG_SH2_CRK	138	142	PF00017	0.290
LIG_SH2_CRK	251	255	PF00017	0.307
LIG_SH2_GRB2like	58	61	PF00017	0.417
LIG_SH2_NCK_1	251	255	PF00017	0.280
LIG_SH2_NCK_1	58	62	PF00017	0.557
LIG_SH2_SRC	126	129	PF00017	0.277
LIG_SH2_SRC	13	16	PF00017	0.524
LIG_SH2_SRC	58	61	PF00017	0.560
LIG_SH2_STAT3	128	131	PF00017	0.363
LIG_SH2_STAT5	13	16	PF00017	0.524
LIG_SH2_STAT5	148	151	PF00017	0.344
LIG_SH2_STAT5	155	158	PF00017	0.449
LIG_SH2_STAT5	184	187	PF00017	0.396
LIG_SH2_STAT5	374	377	PF00017	0.256
LIG_SH3_3	93	99	PF00018	0.346
LIG_TYR_ITIM	249	254	PF00017	0.269
LIG_TYR_ITIM	257	262	PF00017	0.233
LIG_UBA3_1	78	86	PF00899	0.237
MOD_CK1_1	20	26	PF00069	0.669
MOD_CK1_1	291	297	PF00069	0.483
MOD_CK1_1	315	321	PF00069	0.240
MOD_CK1_1	69	75	PF00069	0.323
MOD_Cter_Amidation	47	50	PF01082	0.487
MOD_GlcNHglycan	190	193	PF01048	0.335
MOD_GlcNHglycan	198	201	PF01048	0.341
MOD_GlcNHglycan	214	217	PF01048	0.343
MOD_GlcNHglycan	218	221	PF01048	0.318
MOD_GlcNHglycan	285	288	PF01048	0.644
MOD_GlcNHglycan	305	308	PF01048	0.288
MOD_GlcNHglycan	309	312	PF01048	0.291
MOD_GSK3_1	106	113	PF00069	0.430
MOD_GSK3_1	151	158	PF00069	0.314
MOD_GSK3_1	16	23	PF00069	0.497
MOD_GSK3_1	2	9	PF00069	0.593
MOD_GSK3_1	212	219	PF00069	0.400
MOD_GSK3_1	303	310	PF00069	0.272
MOD_GSK3_1	61	68	PF00069	0.414
MOD_GSK3_1	70	77	PF00069	0.246
MOD_N-GLC_1	389	394	PF02516	0.491
MOD_NEK2_1	116	121	PF00069	0.384
MOD_NEK2_1	2	7	PF00069	0.596
MOD_NEK2_1	282	287	PF00069	0.634
MOD_NEK2_1	300	305	PF00069	0.246
MOD_NEK2_1	312	317	PF00069	0.293
MOD_NEK2_1	365	370	PF00069	0.310
MOD_NEK2_1	66	71	PF00069	0.307
MOD_NEK2_2	205	210	PF00069	0.280
MOD_NEK2_2	218	223	PF00069	0.280
MOD_NEK2_2	81	86	PF00069	0.309
MOD_OFUCOSY	102	108	PF10250	0.230
MOD_PIKK_1	263	269	PF00454	0.470
MOD_PKA_2	178	184	PF00069	0.542
MOD_Plk_1	61	67	PF00069	0.519
MOD_Plk_4	151	157	PF00069	0.279
MOD_Plk_4	241	247	PF00069	0.260
MOD_Plk_4	249	255	PF00069	0.305
MOD_Plk_4	288	294	PF00069	0.578
MOD_Plk_4	312	318	PF00069	0.358
MOD_Plk_4	53	59	PF00069	0.594
MOD_Plk_4	74	80	PF00069	0.308
MOD_ProDKin_1	110	116	PF00069	0.259
MOD_ProDKin_1	130	136	PF00069	0.252
MOD_ProDKin_1	22	28	PF00069	0.711
MOD_ProDKin_1	6	12	PF00069	0.727
TRG_ENDOCYTIC_2	138	141	PF00928	0.290
TRG_ENDOCYTIC_2	251	254	PF00928	0.285
TRG_ENDOCYTIC_2	259	262	PF00928	0.295
TRG_ENDOCYTIC_2	374	377	PF00928	0.282
TRG_ER_diArg_1	117	120	PF00400	0.279
TRG_ER_diArg_1	324	327	PF00400	0.285
TRG_Pf-PMV_PEXEL_1	122	127	PF00026	0.303
TRG_Pf-PMV_PEXEL_1	226	231	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	382	386	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX21	Leptomonas seymouri	61%	100%
A0A0N1I0W9	Leptomonas seymouri	24%	100%
A0A0S4KJX8	Bodo saltans	26%	100%
A0A1X0NWP7	Trypanosomatidae	44%	79%
A0A1X0P952	Trypanosomatidae	21%	100%
A0A3Q8IFM5	Leishmania donovani	26%	100%
A0A3R7M746	Trypanosoma rangeli	47%	100%
A4HD10	Leishmania braziliensis	74%	100%
A4HHT5	Leishmania braziliensis	21%	100%
A4HJZ1	Leishmania braziliensis	26%	100%
A4I0J6	Leishmania infantum	100%	100%
A4I7H4	Leishmania infantum	26%	100%
A6QR09	Bos taurus	23%	100%
A6ZV78	Saccharomyces cerevisiae (strain YJM789)	25%	100%
C9ZKK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
C9ZVC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AWF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B2D1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
F4HT41	Arabidopsis thaliana	24%	100%
P33303	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P53257	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q03829	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	20%	100%
Q08CI8	Danio rerio	25%	100%
Q4Q5S5	Leishmania major	26%	100%
Q4QB15	Leishmania major	92%	100%
Q54S10	Dictyostelium discoideum	20%	100%
Q55E45	Dictyostelium discoideum	21%	100%
Q5U680	Mus musculus	24%	100%
Q641C8	Xenopus laevis	23%	100%
Q6GLA2	Xenopus tropicalis	23%	100%
Q920G8	Mus musculus	24%	100%
Q94AG6	Arabidopsis thaliana	26%	100%
Q9H1K4	Homo sapiens	24%	100%
V5C243	Trypanosoma cruzi	22%	100%
V5DFJ2	Trypanosoma cruzi	46%	100%