Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WXX2_LEIDO

TriTrypDb:

LdBPK_231810.1 , LdCL_230025200 , LDHU3_23.2380

Length:

852

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WXX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXX2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.634
CLV_C14_Caspase3-7	198	202	PF00656	0.632
CLV_C14_Caspase3-7	585	589	PF00656	0.552
CLV_C14_Caspase3-7	838	842	PF00656	0.504
CLV_NRD_NRD_1	13	15	PF00675	0.569
CLV_NRD_NRD_1	294	296	PF00675	0.469
CLV_NRD_NRD_1	450	452	PF00675	0.653
CLV_NRD_NRD_1	553	555	PF00675	0.611
CLV_NRD_NRD_1	668	670	PF00675	0.404
CLV_NRD_NRD_1	97	99	PF00675	0.514
CLV_PCSK_KEX2_1	12	14	PF00082	0.577
CLV_PCSK_KEX2_1	294	296	PF00082	0.492
CLV_PCSK_KEX2_1	452	454	PF00082	0.696
CLV_PCSK_KEX2_1	553	555	PF00082	0.611
CLV_PCSK_KEX2_1	668	670	PF00082	0.408
CLV_PCSK_KEX2_1	97	99	PF00082	0.514
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.696
CLV_PCSK_SKI1_1	14	18	PF00082	0.527
CLV_PCSK_SKI1_1	186	190	PF00082	0.539
CLV_PCSK_SKI1_1	205	209	PF00082	0.494
CLV_PCSK_SKI1_1	437	441	PF00082	0.584
CLV_PCSK_SKI1_1	554	558	PF00082	0.563
CLV_PCSK_SKI1_1	604	608	PF00082	0.445
CLV_PCSK_SKI1_1	661	665	PF00082	0.343
CLV_PCSK_SKI1_1	702	706	PF00082	0.327
CLV_PCSK_SKI1_1	714	718	PF00082	0.347
CLV_PCSK_SKI1_1	812	816	PF00082	0.332
DEG_APCC_DBOX_1	263	271	PF00400	0.498
DEG_APCC_DBOX_1	713	721	PF00400	0.410
DEG_SCF_FBW7_1	139	145	PF00400	0.556
DEG_SCF_FBW7_2	303	310	PF00400	0.415
DEG_SPOP_SBC_1	211	215	PF00917	0.582
DEG_SPOP_SBC_1	464	468	PF00917	0.551
DEG_SPOP_SBC_1	80	84	PF00917	0.531
DOC_CKS1_1	139	144	PF01111	0.558
DOC_CYCLIN_yCln2_LP_2	184	190	PF00134	0.568
DOC_MAPK_MEF2A_6	18	27	PF00069	0.568
DOC_MAPK_MEF2A_6	259	267	PF00069	0.593
DOC_MAPK_MEF2A_6	318	326	PF00069	0.391
DOC_PP1_RVXF_1	169	176	PF00149	0.403
DOC_PP2B_LxvP_1	324	327	PF13499	0.324
DOC_PP2B_LxvP_1	56	59	PF13499	0.523
DOC_PP4_FxxP_1	216	219	PF00568	0.651
DOC_PP4_FxxP_1	794	797	PF00568	0.358
DOC_SPAK_OSR1_1	295	299	PF12202	0.425
DOC_USP7_MATH_1	161	165	PF00917	0.537
DOC_USP7_MATH_1	190	194	PF00917	0.729
DOC_USP7_MATH_1	269	273	PF00917	0.532
DOC_USP7_MATH_1	41	45	PF00917	0.557
DOC_USP7_MATH_1	459	463	PF00917	0.608
DOC_USP7_MATH_1	48	52	PF00917	0.486
DOC_USP7_MATH_1	537	541	PF00917	0.655
DOC_USP7_MATH_1	556	560	PF00917	0.474
DOC_USP7_MATH_1	57	61	PF00917	0.518
DOC_USP7_MATH_1	580	584	PF00917	0.560
DOC_USP7_MATH_1	587	591	PF00917	0.537
DOC_USP7_MATH_1	766	770	PF00917	0.399
DOC_USP7_MATH_1	80	84	PF00917	0.597
DOC_WW_Pin1_4	138	143	PF00397	0.681
DOC_WW_Pin1_4	215	220	PF00397	0.820
DOC_WW_Pin1_4	227	232	PF00397	0.586
DOC_WW_Pin1_4	303	308	PF00397	0.447
DOC_WW_Pin1_4	363	368	PF00397	0.651
DOC_WW_Pin1_4	491	496	PF00397	0.643
DOC_WW_Pin1_4	554	559	PF00397	0.630
DOC_WW_Pin1_4	680	685	PF00397	0.406
DOC_WW_Pin1_4	76	81	PF00397	0.608
DOC_WW_Pin1_4	841	846	PF00397	0.415
LIG_14-3-3_CanoR_1	174	184	PF00244	0.519
LIG_14-3-3_CanoR_1	461	465	PF00244	0.556
LIG_14-3-3_CanoR_1	746	751	PF00244	0.380
LIG_14-3-3_CanoR_1	812	817	PF00244	0.329
LIG_APCC_ABBA_1	325	330	PF00400	0.420
LIG_APCC_ABBAyCdc20_2	437	443	PF00400	0.665
LIG_BIR_III_4	426	430	PF00653	0.647
LIG_BIR_III_4	832	836	PF00653	0.436
LIG_BRCT_BRCA1_1	192	196	PF00533	0.546
LIG_BRCT_BRCA1_1	270	274	PF00533	0.377
LIG_BRCT_BRCA1_2	270	276	PF00533	0.401
LIG_eIF4E_1	605	611	PF01652	0.368
LIG_FHA_1	20	26	PF00498	0.576
LIG_FHA_1	363	369	PF00498	0.665
LIG_FHA_1	388	394	PF00498	0.497
LIG_FHA_1	507	513	PF00498	0.613
LIG_FHA_1	727	733	PF00498	0.343
LIG_FHA_1	76	82	PF00498	0.636
LIG_FHA_1	777	783	PF00498	0.410
LIG_FHA_1	813	819	PF00498	0.331
LIG_FHA_1	91	97	PF00498	0.454
LIG_FHA_2	143	149	PF00498	0.690
LIG_FHA_2	196	202	PF00498	0.721
LIG_FHA_2	3	9	PF00498	0.593
LIG_FHA_2	406	412	PF00498	0.618
LIG_FHA_2	41	47	PF00498	0.477
LIG_FHA_2	486	492	PF00498	0.643
LIG_FHA_2	555	561	PF00498	0.616
LIG_FHA_2	747	753	PF00498	0.363
LIG_LIR_Apic_2	213	219	PF02991	0.694
LIG_LIR_Gen_1	394	405	PF02991	0.462
LIG_LIR_LC3C_4	430	435	PF02991	0.564
LIG_LIR_Nem_3	394	400	PF02991	0.438
LIG_LIR_Nem_3	60	65	PF02991	0.476
LIG_LIR_Nem_3	699	704	PF02991	0.368
LIG_LIR_Nem_3	817	823	PF02991	0.537
LIG_MYND_1	566	570	PF01753	0.610
LIG_PCNA_yPIPBox_3	276	289	PF02747	0.440
LIG_PDZ_Class_3	847	852	PF00595	0.480
LIG_SH2_CRK	62	66	PF00017	0.485
LIG_SH2_NCK_1	522	526	PF00017	0.609
LIG_SH2_PTP2	656	659	PF00017	0.340
LIG_SH2_STAP1	522	526	PF00017	0.609
LIG_SH2_STAT3	111	114	PF00017	0.475
LIG_SH2_STAT3	290	293	PF00017	0.537
LIG_SH2_STAT5	111	114	PF00017	0.475
LIG_SH2_STAT5	605	608	PF00017	0.381
LIG_SH2_STAT5	633	636	PF00017	0.367
LIG_SH2_STAT5	647	650	PF00017	0.271
LIG_SH2_STAT5	656	659	PF00017	0.340
LIG_SH2_STAT5	820	823	PF00017	0.344
LIG_SH3_1	237	243	PF00018	0.627
LIG_SH3_3	225	231	PF00018	0.601
LIG_SH3_3	237	243	PF00018	0.586
LIG_SH3_3	409	415	PF00018	0.532
LIG_SH3_3	512	518	PF00018	0.592
LIG_SH3_3	527	533	PF00018	0.552
LIG_SH3_3	564	570	PF00018	0.614
LIG_SH3_3	737	743	PF00018	0.510
LIG_SH3_3	801	807	PF00018	0.405
LIG_SUMO_SIM_anti_2	376	384	PF11976	0.571
LIG_SUMO_SIM_anti_2	815	820	PF11976	0.340
LIG_SUMO_SIM_par_1	702	707	PF11976	0.325
LIG_SUMO_SIM_par_1	731	736	PF11976	0.364
LIG_TRAF2_1	392	395	PF00917	0.482
LIG_TYR_ITIM	818	823	PF00017	0.337
LIG_WW_3	218	222	PF00397	0.575
LIG_WW_3	658	662	PF00397	0.334
MOD_CDC14_SPxK_1	218	221	PF00782	0.569
MOD_CDC14_SPxK_1	683	686	PF00782	0.419
MOD_CDK_SPxK_1	215	221	PF00069	0.573
MOD_CDK_SPxK_1	680	686	PF00069	0.414
MOD_CDK_SPxxK_3	227	234	PF00069	0.579
MOD_CDK_SPxxK_3	491	498	PF00069	0.644
MOD_CDK_SPxxK_3	841	848	PF00069	0.406
MOD_CK1_1	138	144	PF00069	0.592
MOD_CK1_1	152	158	PF00069	0.576
MOD_CK1_1	197	203	PF00069	0.638
MOD_CK1_1	215	221	PF00069	0.656
MOD_CK1_1	226	232	PF00069	0.657
MOD_CK1_1	416	422	PF00069	0.649
MOD_CK1_1	463	469	PF00069	0.611
MOD_CK1_1	493	499	PF00069	0.647
MOD_CK1_1	552	558	PF00069	0.611
MOD_CK1_1	582	588	PF00069	0.507
MOD_CK1_1	625	631	PF00069	0.442
MOD_CK1_1	75	81	PF00069	0.614
MOD_CK1_1	786	792	PF00069	0.553
MOD_CK1_1	84	90	PF00069	0.585
MOD_CK2_1	405	411	PF00069	0.683
MOD_CK2_1	467	473	PF00069	0.665
MOD_CK2_1	475	481	PF00069	0.526
MOD_CK2_1	746	752	PF00069	0.374
MOD_Cter_Amidation	10	13	PF01082	0.567
MOD_DYRK1A_RPxSP_1	554	558	PF00069	0.619
MOD_GlcNHglycan	192	195	PF01048	0.622
MOD_GlcNHglycan	225	228	PF01048	0.786
MOD_GlcNHglycan	271	274	PF01048	0.509
MOD_GlcNHglycan	436	440	PF01048	0.684
MOD_GlcNHglycan	455	458	PF01048	0.509
MOD_GlcNHglycan	467	470	PF01048	0.573
MOD_GlcNHglycan	554	557	PF01048	0.581
MOD_GlcNHglycan	582	585	PF01048	0.700
MOD_GlcNHglycan	588	592	PF01048	0.541
MOD_GlcNHglycan	59	62	PF01048	0.652
MOD_GlcNHglycan	624	627	PF01048	0.441
MOD_GlcNHglycan	776	779	PF01048	0.380
MOD_GlcNHglycan	784	788	PF01048	0.418
MOD_GlcNHglycan	86	89	PF01048	0.656
MOD_GSK3_1	134	141	PF00069	0.675
MOD_GSK3_1	149	156	PF00069	0.636
MOD_GSK3_1	19	26	PF00069	0.567
MOD_GSK3_1	190	197	PF00069	0.650
MOD_GSK3_1	210	217	PF00069	0.793
MOD_GSK3_1	223	230	PF00069	0.619
MOD_GSK3_1	358	365	PF00069	0.629
MOD_GSK3_1	413	420	PF00069	0.656
MOD_GSK3_1	459	466	PF00069	0.606
MOD_GSK3_1	475	482	PF00069	0.649
MOD_GSK3_1	48	55	PF00069	0.548
MOD_GSK3_1	490	497	PF00069	0.538
MOD_GSK3_1	502	509	PF00069	0.585
MOD_GSK3_1	543	550	PF00069	0.674
MOD_GSK3_1	552	559	PF00069	0.581
MOD_GSK3_1	621	628	PF00069	0.437
MOD_GSK3_1	67	74	PF00069	0.457
MOD_GSK3_1	746	753	PF00069	0.558
MOD_GSK3_1	75	82	PF00069	0.605
MOD_N-GLC_1	547	552	PF02516	0.682
MOD_NEK2_1	105	110	PF00069	0.482
MOD_NEK2_1	23	28	PF00069	0.558
MOD_NEK2_1	268	273	PF00069	0.380
MOD_NEK2_1	417	422	PF00069	0.589
MOD_NEK2_1	485	490	PF00069	0.629
MOD_NEK2_1	52	57	PF00069	0.452
MOD_NEK2_1	549	554	PF00069	0.639
MOD_NEK2_1	597	602	PF00069	0.352
MOD_NEK2_2	460	465	PF00069	0.548
MOD_OFUCOSY	748	754	PF10250	0.434
MOD_PIKK_1	175	181	PF00454	0.511
MOD_PIKK_1	427	433	PF00454	0.643
MOD_PIKK_1	531	537	PF00454	0.621
MOD_PIKK_1	543	549	PF00454	0.565
MOD_PIKK_1	589	595	PF00454	0.536
MOD_PIKK_1	723	729	PF00454	0.353
MOD_PIKK_1	90	96	PF00454	0.567
MOD_PKA_2	114	120	PF00069	0.614
MOD_PKA_2	444	450	PF00069	0.686
MOD_PKA_2	460	466	PF00069	0.603
MOD_PKA_2	499	505	PF00069	0.626
MOD_PKA_2	552	558	PF00069	0.625
MOD_PKB_1	451	459	PF00069	0.610
MOD_Plk_1	435	441	PF00069	0.650
MOD_Plk_1	783	789	PF00069	0.342
MOD_Plk_4	114	120	PF00069	0.560
MOD_Plk_4	19	25	PF00069	0.569
MOD_Plk_4	413	419	PF00069	0.530
MOD_Plk_4	502	508	PF00069	0.602
MOD_ProDKin_1	138	144	PF00069	0.682
MOD_ProDKin_1	215	221	PF00069	0.822
MOD_ProDKin_1	227	233	PF00069	0.586
MOD_ProDKin_1	303	309	PF00069	0.442
MOD_ProDKin_1	363	369	PF00069	0.648
MOD_ProDKin_1	491	497	PF00069	0.642
MOD_ProDKin_1	554	560	PF00069	0.630
MOD_ProDKin_1	680	686	PF00069	0.414
MOD_ProDKin_1	76	82	PF00069	0.608
MOD_ProDKin_1	841	847	PF00069	0.407
TRG_DiLeu_BaEn_1	377	382	PF01217	0.569
TRG_DiLeu_BaEn_1	481	486	PF01217	0.530
TRG_DiLeu_BaEn_4	168	174	PF01217	0.530
TRG_ENDOCYTIC_2	62	65	PF00928	0.485
TRG_ENDOCYTIC_2	633	636	PF00928	0.405
TRG_ENDOCYTIC_2	820	823	PF00928	0.344
TRG_ER_diArg_1	12	14	PF00400	0.577
TRG_ER_diArg_1	263	266	PF00400	0.575
TRG_ER_diArg_1	294	296	PF00400	0.492
TRG_ER_diArg_1	498	501	PF00400	0.628
TRG_ER_diArg_1	96	98	PF00400	0.520
TRG_NES_CRM1_1	100	116	PF08389	0.474
TRG_NLS_MonoExtN_4	449	455	PF00514	0.611
TRG_Pf-PMV_PEXEL_1	171	176	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	205	210	PF00026	0.666

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P625	Leptomonas seymouri	44%	99%
A4HD26	Leishmania braziliensis	71%	98%
A4I0L3	Leishmania infantum	99%	100%
E9AWH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QAZ7	Leishmania major	92%	100%