Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC palmitoyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WXW1_LEIDO

TriTrypDb:

LdBPK_231710.1 , LdCL_230024200 , LDHU3_23.2270

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7WXW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXW1

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016409	palmitoyltransferase activity	5	7
GO:0016417	S-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	7
GO:0019707	protein-cysteine S-acyltransferase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.450
CLV_NRD_NRD_1	154	156	PF00675	0.356
CLV_NRD_NRD_1	361	363	PF00675	0.583
CLV_NRD_NRD_1	563	565	PF00675	0.605
CLV_NRD_NRD_1	595	597	PF00675	0.441
CLV_PCSK_KEX2_1	130	132	PF00082	0.434
CLV_PCSK_KEX2_1	153	155	PF00082	0.361
CLV_PCSK_KEX2_1	361	363	PF00082	0.583
CLV_PCSK_KEX2_1	563	565	PF00082	0.605
CLV_PCSK_KEX2_1	595	597	PF00082	0.458
CLV_PCSK_SKI1_1	106	110	PF00082	0.358
CLV_PCSK_SKI1_1	154	158	PF00082	0.352
CLV_PCSK_SKI1_1	410	414	PF00082	0.362
CLV_PCSK_SKI1_1	432	436	PF00082	0.335
CLV_PCSK_SKI1_1	599	603	PF00082	0.392
DEG_APCC_DBOX_1	153	161	PF00400	0.527
DEG_APCC_DBOX_1	607	615	PF00400	0.658
DEG_SPOP_SBC_1	287	291	PF00917	0.733
DEG_SPOP_SBC_1	303	307	PF00917	0.654
DEG_SPOP_SBC_1	328	332	PF00917	0.691
DOC_ANK_TNKS_1	577	584	PF00023	0.726
DOC_CDC14_PxL_1	241	249	PF14671	0.641
DOC_CKS1_1	1	6	PF01111	0.631
DOC_CYCLIN_yCln2_LP_2	193	199	PF00134	0.628
DOC_MAPK_gen_1	130	136	PF00069	0.621
DOC_MAPK_gen_1	595	604	PF00069	0.604
DOC_MAPK_MEF2A_6	26	33	PF00069	0.369
DOC_MAPK_MEF2A_6	371	380	PF00069	0.626
DOC_MAPK_RevD_3	140	154	PF00069	0.522
DOC_PP1_RVXF_1	104	110	PF00149	0.557
DOC_PP1_RVXF_1	133	139	PF00149	0.576
DOC_PP2B_LxvP_1	617	620	PF13499	0.675
DOC_PP4_FxxP_1	109	112	PF00568	0.557
DOC_PP4_FxxP_1	206	209	PF00568	0.707
DOC_PP4_FxxP_1	604	607	PF00568	0.610
DOC_USP7_MATH_1	212	216	PF00917	0.713
DOC_USP7_MATH_1	235	239	PF00917	0.727
DOC_USP7_MATH_1	311	315	PF00917	0.689
DOC_USP7_MATH_1	322	326	PF00917	0.687
DOC_USP7_MATH_1	328	332	PF00917	0.656
DOC_USP7_MATH_1	384	388	PF00917	0.561
DOC_USP7_MATH_1	399	403	PF00917	0.521
DOC_USP7_MATH_1	446	450	PF00917	0.337
DOC_USP7_MATH_1	573	577	PF00917	0.677
DOC_USP7_MATH_1	620	624	PF00917	0.712
DOC_USP7_MATH_2	63	69	PF00917	0.433
DOC_WW_Pin1_4	120	125	PF00397	0.622
DOC_WW_Pin1_4	192	197	PF00397	0.707
DOC_WW_Pin1_4	199	204	PF00397	0.711
DOC_WW_Pin1_4	221	226	PF00397	0.750
DOC_WW_Pin1_4	227	232	PF00397	0.706
DOC_WW_Pin1_4	273	278	PF00397	0.651
DOC_WW_Pin1_4	290	295	PF00397	0.740
DOC_WW_Pin1_4	324	329	PF00397	0.746
DOC_WW_Pin1_4	569	574	PF00397	0.677
DOC_WW_Pin1_4	615	620	PF00397	0.658
LIG_14-3-3_CanoR_1	106	112	PF00244	0.557
LIG_14-3-3_CanoR_1	11	16	PF00244	0.612
LIG_14-3-3_CanoR_1	239	247	PF00244	0.643
LIG_14-3-3_CanoR_1	361	370	PF00244	0.647
LIG_14-3-3_CanoR_1	496	502	PF00244	0.521
LIG_14-3-3_CanoR_1	564	573	PF00244	0.714
LIG_14-3-3_CanoR_1	74	78	PF00244	0.368
LIG_BIR_II_1	1	5	PF00653	0.615
LIG_BIR_III_2	351	355	PF00653	0.716
LIG_BRCT_BRCA1_1	386	390	PF00533	0.521
LIG_BRCT_BRCA1_1	448	452	PF00533	0.337
LIG_BRCT_BRCA1_1	508	512	PF00533	0.596
LIG_CSL_BTD_1	470	473	PF09270	0.320
LIG_deltaCOP1_diTrp_1	117	126	PF00928	0.608
LIG_deltaCOP1_diTrp_1	464	471	PF00928	0.320
LIG_FHA_1	1	7	PF00498	0.624
LIG_FHA_1	34	40	PF00498	0.381
LIG_FHA_1	448	454	PF00498	0.316
LIG_FHA_1	57	63	PF00498	0.424
LIG_FHA_1	82	88	PF00498	0.334
LIG_FHA_2	346	352	PF00498	0.744
LIG_Integrin_RGD_1	578	580	PF01839	0.541
LIG_LIR_Gen_1	103	112	PF02991	0.532
LIG_LIR_Gen_1	449	460	PF02991	0.337
LIG_LIR_Nem_3	103	107	PF02991	0.526
LIG_LIR_Nem_3	14	18	PF02991	0.595
LIG_LIR_Nem_3	387	393	PF02991	0.521
LIG_LIR_Nem_3	449	455	PF02991	0.372
LIG_LIR_Nem_3	466	472	PF02991	0.290
LIG_NRBOX	17	23	PF00104	0.554
LIG_Pex14_2	435	439	PF04695	0.369
LIG_Pex14_2	600	604	PF04695	0.565
LIG_PTAP_UEV_1	585	590	PF05743	0.717
LIG_REV1ctd_RIR_1	43	52	PF16727	0.353
LIG_SH2_CRK	25	29	PF00017	0.371
LIG_SH2_CRK	440	444	PF00017	0.358
LIG_SH2_CRK	612	616	PF00017	0.712
LIG_SH2_STAT5	114	117	PF00017	0.569
LIG_SH2_STAT5	122	125	PF00017	0.567
LIG_SH2_STAT5	433	436	PF00017	0.369
LIG_SH2_STAT5	485	488	PF00017	0.391
LIG_SH2_STAT5	75	78	PF00017	0.402
LIG_SH2_STAT5	79	82	PF00017	0.361
LIG_SH3_2	116	121	PF14604	0.605
LIG_SH3_3	113	119	PF00018	0.599
LIG_SH3_3	193	199	PF00018	0.716
LIG_SH3_3	222	228	PF00018	0.774
LIG_SH3_3	340	346	PF00018	0.688
LIG_SH3_3	521	527	PF00018	0.647
LIG_SH3_3	583	589	PF00018	0.746
LIG_SH3_3	613	619	PF00018	0.681
LIG_SH3_CIN85_PxpxPR_1	626	631	PF14604	0.685
LIG_TRAF2_1	159	162	PF00917	0.569
LIG_TRFH_1	612	616	PF08558	0.668
LIG_TYR_ITIM	438	443	PF00017	0.358
LIG_TYR_ITIM	483	488	PF00017	0.337
LIG_WRC_WIRS_1	101	106	PF05994	0.369
MOD_CDK_SPK_2	120	125	PF00069	0.620
MOD_CDK_SPxK_1	273	279	PF00069	0.633
MOD_CDK_SPxK_1	329	335	PF00069	0.692
MOD_CK1_1	2	8	PF00069	0.594
MOD_CK1_1	214	220	PF00069	0.746
MOD_CK1_1	290	296	PF00069	0.737
MOD_CK1_1	313	319	PF00069	0.723
MOD_CK1_1	320	326	PF00069	0.699
MOD_CK1_1	519	525	PF00069	0.623
MOD_CK1_1	529	535	PF00069	0.594
MOD_CK1_1	571	577	PF00069	0.806
MOD_CK1_1	587	593	PF00069	0.683
MOD_CK2_1	292	298	PF00069	0.728
MOD_CK2_1	496	502	PF00069	0.513
MOD_CK2_1	512	518	PF00069	0.532
MOD_Cter_Amidation	593	596	PF01082	0.368
MOD_GlcNHglycan	138	141	PF01048	0.376
MOD_GlcNHglycan	186	189	PF01048	0.565
MOD_GlcNHglycan	271	274	PF01048	0.486
MOD_GlcNHglycan	282	286	PF01048	0.498
MOD_GlcNHglycan	294	297	PF01048	0.473
MOD_GlcNHglycan	320	323	PF01048	0.524
MOD_GlcNHglycan	324	327	PF01048	0.516
MOD_GlcNHglycan	33	36	PF01048	0.369
MOD_GlcNHglycan	479	482	PF01048	0.284
MOD_GlcNHglycan	518	521	PF01048	0.423
MOD_GlcNHglycan	575	578	PF01048	0.535
MOD_GlcNHglycan	586	589	PF01048	0.581
MOD_GSK3_1	184	191	PF00069	0.754
MOD_GSK3_1	235	242	PF00069	0.760
MOD_GSK3_1	269	276	PF00069	0.634
MOD_GSK3_1	277	284	PF00069	0.728
MOD_GSK3_1	286	293	PF00069	0.725
MOD_GSK3_1	294	301	PF00069	0.663
MOD_GSK3_1	302	309	PF00069	0.631
MOD_GSK3_1	310	317	PF00069	0.642
MOD_GSK3_1	318	325	PF00069	0.641
MOD_GSK3_1	447	454	PF00069	0.329
MOD_GSK3_1	502	509	PF00069	0.587
MOD_GSK3_1	512	519	PF00069	0.581
MOD_GSK3_1	565	572	PF00069	0.756
MOD_GSK3_1	65	72	PF00069	0.508
MOD_GSK3_1	73	80	PF00069	0.428
MOD_LATS_1	360	366	PF00433	0.687
MOD_N-GLC_1	447	452	PF02516	0.316
MOD_N-GLC_2	423	425	PF02516	0.320
MOD_NEK2_1	100	105	PF00069	0.476
MOD_NEK2_1	134	139	PF00069	0.656
MOD_NEK2_1	439	444	PF00069	0.389
MOD_NEK2_1	451	456	PF00069	0.275
MOD_NEK2_1	512	517	PF00069	0.626
MOD_NEK2_1	552	557	PF00069	0.595
MOD_NEK2_1	565	570	PF00069	0.677
MOD_NEK2_1	69	74	PF00069	0.418
MOD_NEK2_1	77	82	PF00069	0.367
MOD_NEK2_2	355	360	PF00069	0.710
MOD_NEK2_2	384	389	PF00069	0.574
MOD_PIKK_1	519	525	PF00454	0.646
MOD_PIKK_1	69	75	PF00454	0.421
MOD_PKA_2	334	340	PF00069	0.735
MOD_PKA_2	502	508	PF00069	0.498
MOD_PKA_2	73	79	PF00069	0.367
MOD_Plk_1	249	255	PF00069	0.682
MOD_Plk_1	447	453	PF00069	0.316
MOD_Plk_4	214	220	PF00069	0.794
MOD_Plk_4	447	453	PF00069	0.382
MOD_Plk_4	456	462	PF00069	0.298
MOD_Plk_4	65	71	PF00069	0.421
MOD_ProDKin_1	120	126	PF00069	0.620
MOD_ProDKin_1	192	198	PF00069	0.706
MOD_ProDKin_1	199	205	PF00069	0.713
MOD_ProDKin_1	221	227	PF00069	0.744
MOD_ProDKin_1	273	279	PF00069	0.652
MOD_ProDKin_1	290	296	PF00069	0.740
MOD_ProDKin_1	324	330	PF00069	0.746
MOD_ProDKin_1	569	575	PF00069	0.677
MOD_ProDKin_1	615	621	PF00069	0.663
TRG_DiLeu_BaEn_1	65	70	PF01217	0.422
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.369
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.348
TRG_ENDOCYTIC_2	101	104	PF00928	0.433
TRG_ENDOCYTIC_2	431	434	PF00928	0.536
TRG_ENDOCYTIC_2	440	443	PF00928	0.305
TRG_ENDOCYTIC_2	485	488	PF00928	0.337
TRG_ENDOCYTIC_2	612	615	PF00928	0.676
TRG_ER_diArg_1	10	13	PF00400	0.605
TRG_ER_diArg_1	152	155	PF00400	0.560
TRG_ER_diArg_1	361	363	PF00400	0.778
TRG_ER_diArg_1	563	565	PF00400	0.804
TRG_ER_diArg_1	626	629	PF00400	0.693

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HD17	Leishmania braziliensis	60%	99%
A4I0K3	Leishmania infantum	99%	100%
E9AWG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AWG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QB07	Leishmania major	90%	100%