2Fe-2S_iron-sulfur_cluster_binding_domain_contain ing_protein_putative/Pfam:PF13085

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

succinate dehydrogenase and fumarate reductase iron-sulfur protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WXW0_LEIDO

TriTrypDb:

LdBPK_231680.1 , LdCL_230023900 , LDHU3_23.2240

Length:

247

Annotations

Annotations by Jardim et al.

Tricarboxylic acid cycle, succinate dehydrogenase iron-sulfur subunit 2 (SDH2N) Complex II Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	yes	yes: 14

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7WXW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXW0

Function

Biological processes
Term	Name	Level	Count
GO:0006099	tricarboxylic acid cycle	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0009060	aerobic respiration	6	1
GO:0009987	cellular process	1	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0022900	electron transport chain	4	1
GO:0022904	respiratory electron transport chain	5	1
GO:0044237	cellular metabolic process	2	1
GO:0045333	cellular respiration	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0009055	electron transfer activity	3	12
GO:0016491	oxidoreductase activity	2	12
GO:0051536	iron-sulfur cluster binding	3	12
GO:0051540	metal cluster binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.485
CLV_NRD_NRD_1	15	17	PF00675	0.388
CLV_NRD_NRD_1	2	4	PF00675	0.500
CLV_PCSK_KEX2_1	15	17	PF00082	0.399
CLV_PCSK_KEX2_1	188	190	PF00082	0.585
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.417
CLV_PCSK_SKI1_1	128	132	PF00082	0.233
CLV_PCSK_SKI1_1	16	20	PF00082	0.541
CLV_PCSK_SKI1_1	237	241	PF00082	0.393
CLV_PCSK_SKI1_1	30	34	PF00082	0.277
DEG_Nend_Nbox_1	1	3	PF02207	0.536
DOC_MAPK_gen_1	29	35	PF00069	0.332
DOC_MAPK_HePTP_8	65	77	PF00069	0.368
DOC_MAPK_MEF2A_6	54	63	PF00069	0.223
DOC_MAPK_MEF2A_6	68	77	PF00069	0.223
DOC_USP7_MATH_1	243	247	PF00917	0.546
DOC_USP7_MATH_1	76	80	PF00917	0.393
DOC_WW_Pin1_4	166	171	PF00397	0.428
LIG_14-3-3_CanoR_1	157	162	PF00244	0.387
LIG_14-3-3_CanoR_1	16	26	PF00244	0.419
LIG_14-3-3_CanoR_1	78	85	PF00244	0.230
LIG_14-3-3_CanoR_1	8	14	PF00244	0.452
LIG_Clathr_ClatBox_1	35	39	PF01394	0.257
LIG_EH1_1	57	65	PF00400	0.223
LIG_eIF4E_1	58	64	PF01652	0.238
LIG_FHA_1	208	214	PF00498	0.369
LIG_FHA_1	230	236	PF00498	0.455
LIG_LIR_Gen_1	156	165	PF02991	0.426
LIG_LIR_Gen_1	57	66	PF02991	0.225
LIG_LIR_Nem_3	156	161	PF02991	0.373
LIG_LIR_Nem_3	57	61	PF02991	0.225
LIG_RPA_C_Fungi	143	155	PF08784	0.461
LIG_SH2_CRK	134	138	PF00017	0.334
LIG_SH2_CRK	158	162	PF00017	0.337
LIG_SH2_PTP2	136	139	PF00017	0.362
LIG_SH2_SRC	134	137	PF00017	0.351
LIG_SH2_STAT5	136	139	PF00017	0.390
LIG_SH3_3	112	118	PF00018	0.233
LIG_TRAF2_1	179	182	PF00917	0.591
MOD_CK1_1	166	172	PF00069	0.545
MOD_CK2_1	150	156	PF00069	0.404
MOD_CK2_1	166	172	PF00069	0.358
MOD_CK2_1	211	217	PF00069	0.414
MOD_CK2_1	42	48	PF00069	0.369
MOD_CK2_1	77	83	PF00069	0.223
MOD_GlcNHglycan	165	168	PF01048	0.571
MOD_GSK3_1	146	153	PF00069	0.482
MOD_GSK3_1	207	214	PF00069	0.335
MOD_GSK3_1	225	232	PF00069	0.366
MOD_GSK3_1	42	49	PF00069	0.391
MOD_N-GLC_1	207	212	PF02516	0.344
MOD_N-GLC_1	42	47	PF02516	0.384
MOD_NEK2_1	146	151	PF00069	0.415
MOD_NEK2_1	226	231	PF00069	0.468
MOD_NEK2_1	242	247	PF00069	0.328
MOD_NEK2_1	77	82	PF00069	0.223
MOD_OFUCOSY	82	89	PF10250	0.223
MOD_PIKK_1	146	152	PF00454	0.407
MOD_PIKK_1	207	213	PF00454	0.413
MOD_PK_1	157	163	PF00069	0.372
MOD_PKA_1	188	194	PF00069	0.537
MOD_PKA_2	188	194	PF00069	0.547
MOD_PKA_2	77	83	PF00069	0.257
MOD_Plk_1	189	195	PF00069	0.497
MOD_Plk_1	42	48	PF00069	0.384
MOD_Plk_4	150	156	PF00069	0.446
MOD_Plk_4	211	217	PF00069	0.457
MOD_Plk_4	9	15	PF00069	0.560
MOD_ProDKin_1	166	172	PF00069	0.430
TRG_ENDOCYTIC_2	10	13	PF00928	0.617
TRG_ENDOCYTIC_2	134	137	PF00928	0.317
TRG_ENDOCYTIC_2	158	161	PF00928	0.342
TRG_ENDOCYTIC_2	58	61	PF00928	0.238
TRG_ER_diArg_1	14	16	PF00400	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P629	Leptomonas seymouri	81%	100%
A0A0S4IR27	Bodo saltans	55%	96%
A0A1X0NWZ7	Trypanosomatidae	62%	100%
A0A422NXP1	Trypanosoma rangeli	63%	100%
A4HD14	Leishmania braziliensis	91%	100%
A4I0K0	Leishmania infantum	100%	100%
C9ZVC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AWG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QB10	Leishmania major	97%	100%
V5BNQ0	Trypanosoma cruzi	63%	74%