Elongator complex protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acetyltransferase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WXV4_LEIDO

TriTrypDb:

LdBPK_231610.1 , LdCL_230023300 , LDHU3_23.2140

Length:

709

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0005634	nucleus	5	2
GO:0005635	nuclear envelope	4	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	2
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0032991	protein-containing complex	1	2
GO:0033588	elongator holoenzyme complex	3	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:0005819	spindle	5	1

Expansion

Sequence features

A0A3S7WXV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXV4

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	2
GO:0002098	tRNA wobble uridine modification	8	2
GO:0002926	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation	9	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	1
GO:0006396	RNA processing	6	2
GO:0006399	tRNA metabolic process	7	2
GO:0006400	tRNA modification	6	2
GO:0006473	protein acetylation	6	1
GO:0006475	internal protein amino acid acetylation	7	1
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006996	organelle organization	4	1
GO:0008033	tRNA processing	8	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	1
GO:0016070	RNA metabolic process	5	2
GO:0016570	histone modification	5	1
GO:0016573	histone acetylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0018393	internal peptidyl-lysine acetylation	8	1
GO:0018394	peptidyl-lysine acetylation	7	1
GO:0019538	protein metabolic process	3	1
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0036211	protein modification process	4	1
GO:0043007	maintenance of rDNA	6	1
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	1
GO:0043570	maintenance of DNA repeat elements	5	1
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	2
GO:0051276	chromosome organization	5	1
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	23
GO:0003676	nucleic acid binding	3	23
GO:0003723	RNA binding	4	23
GO:0003824	catalytic activity	1	23
GO:0005488	binding	1	23
GO:0016407	acetyltransferase activity	5	23
GO:0016740	transferase activity	2	23
GO:0016746	acyltransferase activity	3	23
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	23
GO:0043167	ion binding	2	23
GO:0043169	cation binding	3	23
GO:0046872	metal ion binding	4	23
GO:0051536	iron-sulfur cluster binding	3	23
GO:0051539	4 iron, 4 sulfur cluster binding	4	23
GO:0051540	metal cluster binding	2	23
GO:0097159	organic cyclic compound binding	2	23
GO:0106261	tRNA uridine(34) acetyltransferase activity	6	12
GO:1901363	heterocyclic compound binding	2	23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.508
CLV_NRD_NRD_1	119	121	PF00675	0.410
CLV_NRD_NRD_1	160	162	PF00675	0.405
CLV_NRD_NRD_1	189	191	PF00675	0.417
CLV_NRD_NRD_1	343	345	PF00675	0.222
CLV_NRD_NRD_1	643	645	PF00675	0.293
CLV_NRD_NRD_1	704	706	PF00675	0.649
CLV_PCSK_KEX2_1	119	121	PF00082	0.405
CLV_PCSK_KEX2_1	13	15	PF00082	0.543
CLV_PCSK_KEX2_1	343	345	PF00082	0.228
CLV_PCSK_KEX2_1	495	497	PF00082	0.217
CLV_PCSK_KEX2_1	643	645	PF00082	0.300
CLV_PCSK_KEX2_1	704	706	PF00082	0.599
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.584
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.284
CLV_PCSK_SKI1_1	120	124	PF00082	0.400
CLV_PCSK_SKI1_1	624	628	PF00082	0.430
CLV_PCSK_SKI1_1	693	697	PF00082	0.614
DEG_APCC_DBOX_1	474	482	PF00400	0.417
DEG_APCC_DBOX_1	495	503	PF00400	0.417
DOC_MAPK_gen_1	190	201	PF00069	0.416
DOC_MAPK_gen_1	322	330	PF00069	0.379
DOC_MAPK_gen_1	340	350	PF00069	0.423
DOC_MAPK_HePTP_8	188	204	PF00069	0.373
DOC_MAPK_MEF2A_6	322	330	PF00069	0.375
DOC_PIKK_1	97	105	PF02985	0.454
DOC_PP2B_LxvP_1	25	28	PF13499	0.498
DOC_PP4_FxxP_1	205	208	PF00568	0.297
DOC_PP4_FxxP_1	211	214	PF00568	0.384
DOC_USP7_MATH_1	135	139	PF00917	0.486
DOC_USP7_MATH_1	160	164	PF00917	0.372
DOC_USP7_MATH_1	307	311	PF00917	0.432
DOC_USP7_MATH_1	400	404	PF00917	0.430
DOC_USP7_MATH_1	684	688	PF00917	0.617
DOC_WW_Pin1_4	20	25	PF00397	0.534
DOC_WW_Pin1_4	699	704	PF00397	0.663
LIG_14-3-3_CanoR_1	161	169	PF00244	0.398
LIG_14-3-3_CanoR_1	306	312	PF00244	0.443
LIG_14-3-3_CanoR_1	343	349	PF00244	0.446
LIG_14-3-3_CanoR_1	540	548	PF00244	0.242
LIG_AP2alpha_1	535	539	PF02296	0.275
LIG_BIR_II_1	1	5	PF00653	0.780
LIG_EH1_1	459	467	PF00400	0.484
LIG_eIF4E_1	460	466	PF01652	0.451
LIG_EVH1_1	25	29	PF00568	0.501
LIG_FHA_1	430	436	PF00498	0.423
LIG_FHA_1	485	491	PF00498	0.454
LIG_FHA_1	607	613	PF00498	0.334
LIG_FHA_1	632	638	PF00498	0.264
LIG_FHA_1	654	660	PF00498	0.321
LIG_FHA_2	296	302	PF00498	0.427
LIG_FHA_2	314	320	PF00498	0.416
LIG_FHA_2	330	336	PF00498	0.410
LIG_FHA_2	603	609	PF00498	0.298
LIG_LIR_Apic_2	203	208	PF02991	0.263
LIG_LIR_Apic_2	210	214	PF02991	0.341
LIG_LIR_Apic_2	92	96	PF02991	0.509
LIG_LIR_Gen_1	110	118	PF02991	0.535
LIG_LIR_Gen_1	434	445	PF02991	0.417
LIG_LIR_Gen_1	545	555	PF02991	0.301
LIG_LIR_Gen_1	683	692	PF02991	0.440
LIG_LIR_Gen_1	85	93	PF02991	0.487
LIG_LIR_LC3C_4	197	202	PF02991	0.372
LIG_LIR_Nem_3	110	115	PF02991	0.454
LIG_LIR_Nem_3	166	172	PF02991	0.420
LIG_LIR_Nem_3	276	280	PF02991	0.434
LIG_LIR_Nem_3	425	430	PF02991	0.423
LIG_LIR_Nem_3	434	440	PF02991	0.422
LIG_LIR_Nem_3	545	551	PF02991	0.285
LIG_LIR_Nem_3	557	563	PF02991	0.261
LIG_LIR_Nem_3	593	597	PF02991	0.311
LIG_LIR_Nem_3	683	688	PF02991	0.636
LIG_LIR_Nem_3	694	698	PF02991	0.653
LIG_LIR_Nem_3	85	89	PF02991	0.472
LIG_PCNA_yPIPBox_3	174	188	PF02747	0.423
LIG_PDZ_Class_3	704	709	PF00595	0.478
LIG_Pex14_2	241	245	PF04695	0.516
LIG_Pex14_2	411	415	PF04695	0.315
LIG_Pex14_2	535	539	PF04695	0.259
LIG_PTB_Apo_2	454	461	PF02174	0.540
LIG_PTB_Phospho_1	454	460	PF10480	0.540
LIG_SH2_CRK	169	173	PF00017	0.410
LIG_SH2_CRK	594	598	PF00017	0.275
LIG_SH2_CRK	646	650	PF00017	0.317
LIG_SH2_NCK_1	252	256	PF00017	0.429
LIG_SH2_NCK_1	300	304	PF00017	0.430
LIG_SH2_NCK_1	93	97	PF00017	0.423
LIG_SH2_STAP1	284	288	PF00017	0.432
LIG_SH2_STAP1	685	689	PF00017	0.446
LIG_SH2_STAT5	219	222	PF00017	0.417
LIG_SH2_STAT5	230	233	PF00017	0.417
LIG_SH2_STAT5	336	339	PF00017	0.429
LIG_SH2_STAT5	467	470	PF00017	0.414
LIG_SH2_STAT5	489	492	PF00017	0.417
LIG_SH2_STAT5	548	551	PF00017	0.245
LIG_SH3_2	304	309	PF14604	0.484
LIG_SH3_3	21	27	PF00018	0.517
LIG_SH3_3	218	224	PF00018	0.417
LIG_SH3_3	29	35	PF00018	0.451
LIG_SH3_3	301	307	PF00018	0.441
LIG_SH3_3	394	400	PF00018	0.417
LIG_SUMO_SIM_anti_2	197	203	PF11976	0.343
LIG_SUMO_SIM_anti_2	266	272	PF11976	0.417
LIG_SUMO_SIM_par_1	197	203	PF11976	0.343
LIG_SUMO_SIM_par_1	596	601	PF11976	0.259
LIG_TRAF2_1	572	575	PF00917	0.354
LIG_UBA3_1	587	596	PF00899	0.324
LIG_WRC_WIRS_1	685	690	PF05994	0.592
LIG_WRC_WIRS_1	692	697	PF05994	0.543
LIG_WRPW_2	449	452	PF00400	0.259
MOD_CDK_SPK_2	699	704	PF00069	0.445
MOD_CDK_SPxK_1	699	705	PF00069	0.448
MOD_CK1_1	126	132	PF00069	0.463
MOD_CK1_1	163	169	PF00069	0.386
MOD_CK1_1	542	548	PF00069	0.262
MOD_CK1_1	63	69	PF00069	0.705
MOD_CK1_1	667	673	PF00069	0.584
MOD_CK1_1	683	689	PF00069	0.608
MOD_CK1_1	85	91	PF00069	0.490
MOD_CK2_1	135	141	PF00069	0.545
MOD_CK2_1	253	259	PF00069	0.275
MOD_CK2_1	307	313	PF00069	0.250
MOD_CK2_1	335	341	PF00069	0.342
MOD_CK2_1	399	405	PF00069	0.289
MOD_CK2_1	569	575	PF00069	0.303
MOD_CK2_1	602	608	PF00069	0.282
MOD_CK2_1	68	74	PF00069	0.541
MOD_GlcNHglycan	138	141	PF01048	0.527
MOD_GlcNHglycan	196	199	PF01048	0.382
MOD_GlcNHglycan	20	23	PF01048	0.480
MOD_GlcNHglycan	255	258	PF01048	0.275
MOD_GlcNHglycan	301	304	PF01048	0.301
MOD_GlcNHglycan	337	340	PF01048	0.452
MOD_GlcNHglycan	415	418	PF01048	0.505
MOD_GlcNHglycan	43	46	PF01048	0.522
MOD_GlcNHglycan	54	57	PF01048	0.738
MOD_GlcNHglycan	666	669	PF01048	0.581
MOD_GlcNHglycan	681	685	PF01048	0.612
MOD_GSK3_1	156	163	PF00069	0.414
MOD_GSK3_1	295	302	PF00069	0.270
MOD_GSK3_1	344	351	PF00069	0.302
MOD_GSK3_1	431	438	PF00069	0.259
MOD_GSK3_1	529	536	PF00069	0.208
MOD_GSK3_1	569	576	PF00069	0.340
MOD_GSK3_1	598	605	PF00069	0.296
MOD_GSK3_1	60	67	PF00069	0.630
MOD_GSK3_1	680	687	PF00069	0.553
MOD_N-GLC_1	418	423	PF02516	0.405
MOD_NEK2_1	123	128	PF00069	0.424
MOD_NEK2_1	156	161	PF00069	0.473
MOD_NEK2_1	200	205	PF00069	0.310
MOD_NEK2_1	273	278	PF00069	0.259
MOD_NEK2_1	289	294	PF00069	0.365
MOD_NEK2_1	348	353	PF00069	0.283
MOD_NEK2_1	410	415	PF00069	0.449
MOD_NEK2_1	52	57	PF00069	0.703
MOD_NEK2_1	653	658	PF00069	0.337
MOD_NEK2_1	68	73	PF00069	0.455
MOD_NEK2_1	688	693	PF00069	0.583
MOD_NEK2_1	698	703	PF00069	0.646
MOD_NEK2_2	275	280	PF00069	0.259
MOD_PIKK_1	246	252	PF00454	0.275
MOD_PIKK_1	554	560	PF00454	0.401
MOD_PIKK_1	598	604	PF00454	0.387
MOD_PIKK_1	606	612	PF00454	0.178
MOD_PIKK_1	613	619	PF00454	0.234
MOD_PK_1	60	66	PF00069	0.521
MOD_PKA_2	160	166	PF00069	0.398
MOD_PKA_2	253	259	PF00069	0.275
MOD_PKA_2	539	545	PF00069	0.247
MOD_PKA_2	606	612	PF00069	0.448
MOD_Plk_1	313	319	PF00069	0.262
MOD_Plk_1	418	424	PF00069	0.401
MOD_Plk_1	554	560	PF00069	0.324
MOD_Plk_1	653	659	PF00069	0.340
MOD_Plk_1	680	686	PF00069	0.663
MOD_Plk_2-3	313	319	PF00069	0.294
MOD_Plk_4	200	206	PF00069	0.330
MOD_Plk_4	289	295	PF00069	0.269
MOD_Plk_4	374	380	PF00069	0.353
MOD_Plk_4	410	416	PF00069	0.426
MOD_Plk_4	485	491	PF00069	0.259
MOD_Plk_4	653	659	PF00069	0.330
MOD_Plk_4	684	690	PF00069	0.588
MOD_Plk_4	691	697	PF00069	0.582
MOD_Plk_4	85	91	PF00069	0.538
MOD_ProDKin_1	20	26	PF00069	0.532
MOD_ProDKin_1	699	705	PF00069	0.667
MOD_SUMO_rev_2	92	102	PF00179	0.509
TRG_DiLeu_BaEn_4	574	580	PF01217	0.238
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.519
TRG_DiLeu_BaLyEn_6	380	385	PF01217	0.259
TRG_ENDOCYTIC_2	169	172	PF00928	0.398
TRG_ENDOCYTIC_2	452	455	PF00928	0.368
TRG_ENDOCYTIC_2	548	551	PF00928	0.238
TRG_ENDOCYTIC_2	560	563	PF00928	0.227
TRG_ENDOCYTIC_2	594	597	PF00928	0.259
TRG_ENDOCYTIC_2	646	649	PF00928	0.264
TRG_ENDOCYTIC_2	685	688	PF00928	0.636
TRG_ER_diArg_1	12	15	PF00400	0.703
TRG_ER_diArg_1	322	325	PF00400	0.262
TRG_ER_diArg_1	342	344	PF00400	0.266
TRG_ER_diArg_1	474	477	PF00400	0.261
TRG_ER_diArg_1	507	510	PF00400	0.409
TRG_ER_diArg_1	563	566	PF00400	0.259
TRG_ER_diArg_1	642	644	PF00400	0.245
TRG_ER_diArg_1	703	705	PF00400	0.613
TRG_ER_FFAT_2	331	341	PF00635	0.238
TRG_NES_CRM1_1	341	354	PF08389	0.275
TRG_NLS_MonoExtC_3	11	16	PF00514	0.519
TRG_NLS_MonoExtC_3	189	194	PF00514	0.419
TRG_NLS_MonoExtN_4	12	17	PF00514	0.518
TRG_NLS_MonoExtN_4	190	195	PF00514	0.421
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.284
TRG_Pf-PMV_PEXEL_1	660	664	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P567	Leptomonas seymouri	86%	100%
A0A0N1PFU7	Leptomonas seymouri	45%	95%
A0A0S4IQT9	Bodo saltans	69%	100%
A0A0S4KPU1	Bodo saltans	46%	100%
A0A1X0NG94	Trypanosomatidae	41%	96%
A0A1X0NX69	Trypanosomatidae	76%	100%
A0A3Q8ICG0	Leishmania donovani	46%	93%
A0A3R7KUY9	Trypanosoma rangeli	77%	100%
A0A422NDG5	Trypanosoma rangeli	42%	95%
A4H8F0	Leishmania braziliensis	45%	93%
A4HD08	Leishmania braziliensis	94%	100%
A4HWS3	Leishmania infantum	46%	93%
A4I0J4	Leishmania infantum	100%	100%
C9ZVC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
C9ZW50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D5VRB9	Methanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME)	36%	100%
E9AQI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	92%
E9AWF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O14023	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q02908	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
Q1ZXC6	Dictyostelium discoideum	33%	100%
Q23651	Caenorhabditis elegans	34%	100%
Q2KJ61	Bos taurus	32%	100%
Q4QB17	Leishmania major	96%	100%
Q4QEZ6	Leishmania major	45%	93%
Q58536	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	36%	100%
Q5HZM6	Xenopus laevis	33%	100%
Q5RIC0	Danio rerio	33%	100%
Q5ZHS1	Gallus gallus	34%	100%
Q60LW7	Caenorhabditis briggsae	35%	100%
Q6NVL5	Xenopus tropicalis	32%	100%
Q7X7L3	Oryza sativa subsp. japonica	35%	100%
Q93ZR1	Arabidopsis thaliana	33%	100%
Q9CZX0	Mus musculus	31%	100%
Q9H9T3	Homo sapiens	32%	100%
Q9VQZ6	Drosophila melanogaster	33%	100%
V5B5L2	Trypanosoma cruzi	43%	100%
V5BNQ5	Trypanosoma cruzi	77%	100%