Protein arginine methyltransferase NDUFAF7

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative S-adenosyl-L-methionine-dependent methyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WXU3_LEIDO

TriTrypDb:

LdBPK_231080.1 , LdCL_230017900 , LDHU3_23.1440

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S7WXU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXU3

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0010257	NADH dehydrogenase complex assembly	6	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0032981	mitochondrial respiratory chain complex I assembly	7	1
GO:0033108	mitochondrial respiratory chain complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0008168	methyltransferase activity	4	10
GO:0008170	N-methyltransferase activity	5	10
GO:0008276	protein methyltransferase activity	3	10
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	10
GO:0016273	arginine N-methyltransferase activity	6	10
GO:0016274	protein-arginine N-methyltransferase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016741	transferase activity, transferring one-carbon groups	3	10
GO:0035243	protein-arginine omega-N symmetric methyltransferase activity	5	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	177	179	PF00675	0.369
CLV_NRD_NRD_1	360	362	PF00675	0.328
CLV_NRD_NRD_1	404	406	PF00675	0.355
CLV_PCSK_KEX2_1	177	179	PF00082	0.369
CLV_PCSK_KEX2_1	182	184	PF00082	0.369
CLV_PCSK_KEX2_1	360	362	PF00082	0.328
CLV_PCSK_KEX2_1	404	406	PF00082	0.355
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.325
CLV_PCSK_PC7_1	178	184	PF00082	0.325
CLV_PCSK_SKI1_1	149	153	PF00082	0.253
CLV_PCSK_SKI1_1	182	186	PF00082	0.253
CLV_PCSK_SKI1_1	350	354	PF00082	0.265
CLV_PCSK_SKI1_1	361	365	PF00082	0.289
CLV_PCSK_SKI1_1	394	398	PF00082	0.321
CLV_PCSK_SKI1_1	53	57	PF00082	0.359
DEG_APCC_DBOX_1	148	156	PF00400	0.278
DEG_APCC_DBOX_1	349	357	PF00400	0.277
DOC_CKS1_1	129	134	PF01111	0.253
DOC_CKS1_1	39	44	PF01111	0.503
DOC_CYCLIN_RxL_1	128	139	PF00134	0.277
DOC_MAPK_gen_1	194	201	PF00069	0.254
DOC_MAPK_gen_1	273	282	PF00069	0.369
DOC_PP1_RVXF_1	192	198	PF00149	0.254
DOC_PP1_RVXF_1	345	352	PF00149	0.253
DOC_PP1_RVXF_1	359	366	PF00149	0.302
DOC_PP4_FxxP_1	328	331	PF00568	0.253
DOC_USP7_MATH_1	257	261	PF00917	0.265
DOC_USP7_MATH_1	3	7	PF00917	0.712
DOC_USP7_UBL2_3	394	398	PF12436	0.378
DOC_USP7_UBL2_3	52	56	PF12436	0.499
DOC_WW_Pin1_4	128	133	PF00397	0.253
DOC_WW_Pin1_4	23	28	PF00397	0.650
DOC_WW_Pin1_4	331	336	PF00397	0.253
DOC_WW_Pin1_4	38	43	PF00397	0.462
DOC_WW_Pin1_4	427	432	PF00397	0.306
LIG_14-3-3_CanoR_1	228	235	PF00244	0.253
LIG_14-3-3_CanoR_1	44	48	PF00244	0.603
LIG_Actin_WH2_2	337	352	PF00022	0.253
LIG_BIR_III_2	220	224	PF00653	0.253
LIG_BRCT_BRCA1_1	202	206	PF00533	0.277
LIG_BRCT_BRCA1_1	429	433	PF00533	0.314
LIG_eIF4E_1	157	163	PF01652	0.253
LIG_EVH1_1	438	442	PF00568	0.444
LIG_FHA_1	129	135	PF00498	0.286
LIG_FHA_1	209	215	PF00498	0.226
LIG_FHA_2	105	111	PF00498	0.347
LIG_FHA_2	235	241	PF00498	0.253
LIG_FHA_2	368	374	PF00498	0.318
LIG_Integrin_RGD_1	444	446	PF01839	0.468
LIG_LIR_Apic_2	262	267	PF02991	0.253
LIG_LIR_Gen_1	124	134	PF02991	0.287
LIG_LIR_Gen_1	217	227	PF02991	0.253
LIG_LIR_Gen_1	341	349	PF02991	0.253
LIG_LIR_Gen_1	430	441	PF02991	0.398
LIG_LIR_Nem_3	217	222	PF02991	0.253
LIG_LIR_Nem_3	248	254	PF02991	0.253
LIG_LIR_Nem_3	341	346	PF02991	0.253
LIG_LIR_Nem_3	414	419	PF02991	0.307
LIG_LIR_Nem_3	423	429	PF02991	0.302
LIG_MLH1_MIPbox_1	429	433	PF16413	0.314
LIG_MYND_1	331	335	PF01753	0.253
LIG_NRP_CendR_1	444	447	PF00754	0.659
LIG_PTB_Apo_2	213	220	PF02174	0.253
LIG_SH2_CRK	157	161	PF00017	0.253
LIG_SH2_CRK	403	407	PF00017	0.322
LIG_SH2_GRB2like	157	160	PF00017	0.253
LIG_SH2_SRC	264	267	PF00017	0.253
LIG_SH2_STAT5	218	221	PF00017	0.253
LIG_SH2_STAT5	229	232	PF00017	0.253
LIG_SH2_STAT5	264	267	PF00017	0.253
LIG_SH3_2	439	444	PF14604	0.468
LIG_SH3_3	251	257	PF00018	0.253
LIG_SH3_3	434	440	PF00018	0.408
LIG_SH3_3	7	13	PF00018	0.656
LIG_TRFH_1	206	210	PF08558	0.277
LIG_UBA3_1	147	153	PF00899	0.253
LIG_UBA3_1	293	302	PF00899	0.253
LIG_WW_2	439	442	PF00397	0.510
MOD_CDK_SPK_2	128	133	PF00069	0.253
MOD_CDK_SPxK_1	23	29	PF00069	0.626
MOD_CDK_SPxK_1	38	44	PF00069	0.441
MOD_CK1_1	37	43	PF00069	0.499
MOD_CK1_1	5	11	PF00069	0.553
MOD_CK2_1	104	110	PF00069	0.341
MOD_CK2_1	234	240	PF00069	0.253
MOD_CK2_1	331	337	PF00069	0.278
MOD_CK2_1	367	373	PF00069	0.205
MOD_GlcNHglycan	257	260	PF01048	0.253
MOD_GlcNHglycan	261	264	PF01048	0.253
MOD_GlcNHglycan	48	51	PF01048	0.603
MOD_GlcNHglycan	5	8	PF01048	0.736
MOD_GSK3_1	1	8	PF00069	0.702
MOD_GSK3_1	143	150	PF00069	0.369
MOD_GSK3_1	183	190	PF00069	0.271
MOD_GSK3_1	200	207	PF00069	0.243
MOD_GSK3_1	240	247	PF00069	0.347
MOD_GSK3_1	255	262	PF00069	0.178
MOD_GSK3_1	269	276	PF00069	0.253
MOD_GSK3_1	338	345	PF00069	0.253
MOD_GSK3_1	34	41	PF00069	0.487
MOD_N-GLC_1	427	432	PF02516	0.310
MOD_NEK2_1	147	152	PF00069	0.324
MOD_NEK2_1	22	27	PF00069	0.518
MOD_NEK2_1	316	321	PF00069	0.253
MOD_NEK2_1	412	417	PF00069	0.305
MOD_NEK2_2	342	347	PF00069	0.369
MOD_PIKK_1	367	373	PF00454	0.303
MOD_PIKK_1	73	79	PF00454	0.323
MOD_PKA_2	143	149	PF00069	0.253
MOD_PKA_2	227	233	PF00069	0.253
MOD_PKA_2	43	49	PF00069	0.572
MOD_Plk_1	338	344	PF00069	0.265
MOD_Plk_4	143	149	PF00069	0.253
MOD_Plk_4	208	214	PF00069	0.279
MOD_Plk_4	289	295	PF00069	0.386
MOD_ProDKin_1	128	134	PF00069	0.253
MOD_ProDKin_1	23	29	PF00069	0.651
MOD_ProDKin_1	331	337	PF00069	0.253
MOD_ProDKin_1	38	44	PF00069	0.462
MOD_ProDKin_1	427	433	PF00069	0.317
MOD_SUMO_for_1	388	391	PF00179	0.386
MOD_SUMO_rev_2	179	184	PF00179	0.277
MOD_SUMO_rev_2	390	396	PF00179	0.388
MOD_SUMO_rev_2	49	58	PF00179	0.402
TRG_DiLeu_BaEn_2	100	106	PF01217	0.418
TRG_DiLeu_BaEn_2	208	214	PF01217	0.277
TRG_DiLeu_BaLyEn_6	328	333	PF01217	0.253
TRG_ENDOCYTIC_2	403	406	PF00928	0.330
TRG_ENDOCYTIC_2	416	419	PF00928	0.293
TRG_ENDOCYTIC_2	72	75	PF00928	0.320
TRG_ER_diArg_1	403	405	PF00400	0.367
TRG_ER_FFAT_2	100	110	PF00635	0.401
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.278
TRG_Pf-PMV_PEXEL_1	404	408	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBT9	Leptomonas seymouri	87%	91%
A0A1X0NXJ4	Trypanosomatidae	81%	100%
A4HCW1	Leishmania braziliensis	96%	100%
A4I0E1	Leishmania infantum	100%	100%
C9ZV33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	100%
E9AWA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q08BY0	Danio rerio	30%	100%
Q09644	Caenorhabditis elegans	29%	100%
Q2KHV5	Bos taurus	31%	100%
Q4QB74	Leishmania major	98%	100%
Q54S83	Dictyostelium discoideum	35%	92%
Q5BKM6	Xenopus tropicalis	32%	100%
Q5XI79	Rattus norvegicus	33%	100%
Q6GQ37	Xenopus laevis	31%	100%
Q7L592	Homo sapiens	34%	100%
Q9CWG8	Mus musculus	33%	100%
Q9VGR2	Drosophila melanogaster	29%	100%
V5D7M8	Trypanosoma cruzi	81%	100%