Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WXU2_LEIDO

TriTrypDb:

LdBPK_231510.1 , LdCL_230022200 , LDHU3_23.2020

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WXU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXU2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.689
CLV_NRD_NRD_1	188	190	PF00675	0.618
CLV_NRD_NRD_1	239	241	PF00675	0.558
CLV_NRD_NRD_1	252	254	PF00675	0.591
CLV_NRD_NRD_1	48	50	PF00675	0.774
CLV_NRD_NRD_1	94	96	PF00675	0.636
CLV_PCSK_KEX2_1	178	180	PF00082	0.736
CLV_PCSK_KEX2_1	190	192	PF00082	0.688
CLV_PCSK_KEX2_1	239	241	PF00082	0.558
CLV_PCSK_KEX2_1	252	254	PF00082	0.591
CLV_PCSK_KEX2_1	38	40	PF00082	0.765
CLV_PCSK_KEX2_1	93	95	PF00082	0.647
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.688
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.747
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.686
CLV_PCSK_PC7_1	34	40	PF00082	0.717
CLV_PCSK_SKI1_1	158	162	PF00082	0.576
CLV_PCSK_SKI1_1	178	182	PF00082	0.740
CLV_PCSK_SKI1_1	191	195	PF00082	0.767
CLV_PCSK_SKI1_1	97	101	PF00082	0.677
DEG_SPOP_SBC_1	16	20	PF00917	0.775
DEG_SPOP_SBC_1	192	196	PF00917	0.750
DOC_CYCLIN_RxL_1	155	164	PF00134	0.661
DOC_CYCLIN_RxL_1	93	105	PF00134	0.640
DOC_MAPK_gen_1	93	101	PF00069	0.613
DOC_USP7_MATH_1	148	152	PF00917	0.738
DOC_USP7_MATH_1	17	21	PF00917	0.699
DOC_USP7_MATH_1	207	211	PF00917	0.648
DOC_USP7_MATH_1	42	46	PF00917	0.828
DOC_USP7_MATH_1	56	60	PF00917	0.685
DOC_USP7_MATH_1	75	79	PF00917	0.740
DOC_USP7_MATH_1	8	12	PF00917	0.790
DOC_USP7_UBL2_3	93	97	PF12436	0.578
LIG_14-3-3_CanoR_1	12	17	PF00244	0.713
LIG_14-3-3_CanoR_1	158	163	PF00244	0.528
LIG_14-3-3_CanoR_1	178	184	PF00244	0.627
LIG_14-3-3_CanoR_1	49	55	PF00244	0.754
LIG_14-3-3_CanoR_1	94	100	PF00244	0.648
LIG_BRCT_BRCA1_1	103	107	PF00533	0.739
LIG_Clathr_ClatBox_1	159	163	PF01394	0.571
LIG_FHA_1	140	146	PF00498	0.730
LIG_FHA_1	96	102	PF00498	0.616
LIG_FHA_2	119	125	PF00498	0.653
LIG_FHA_2	159	165	PF00498	0.529
LIG_FHA_2	224	230	PF00498	0.616
LIG_FHA_2	85	91	PF00498	0.676
LIG_Pex14_2	107	111	PF04695	0.644
LIG_SH2_STAP1	168	172	PF00017	0.667
LIG_SH2_STAP1	241	245	PF00017	0.655
LIG_SH3_2	213	218	PF14604	0.756
LIG_SH3_2	80	85	PF14604	0.754
LIG_SH3_3	210	216	PF00018	0.757
LIG_SH3_3	77	83	PF00018	0.756
LIG_SUMO_SIM_par_1	158	164	PF11976	0.672
LIG_TRAF2_1	161	164	PF00917	0.547
MOD_CK1_1	149	155	PF00069	0.723
MOD_CK1_1	15	21	PF00069	0.746
MOD_CK1_1	208	214	PF00069	0.825
MOD_CK1_1	22	28	PF00069	0.681
MOD_CK1_1	261	267	PF00069	0.645
MOD_CK1_1	84	90	PF00069	0.694
MOD_CK2_1	118	124	PF00069	0.653
MOD_CK2_1	158	164	PF00069	0.571
MOD_CK2_1	223	229	PF00069	0.634
MOD_CK2_1	23	29	PF00069	0.728
MOD_CK2_1	84	90	PF00069	0.685
MOD_GlcNHglycan	148	151	PF01048	0.640
MOD_GlcNHglycan	197	200	PF01048	0.735
MOD_GlcNHglycan	204	208	PF01048	0.688
MOD_GlcNHglycan	210	213	PF01048	0.700
MOD_GlcNHglycan	42	45	PF01048	0.811
MOD_GlcNHglycan	46	49	PF01048	0.735
MOD_GSK3_1	16	23	PF00069	0.676
MOD_GSK3_1	191	198	PF00069	0.724
MOD_GSK3_1	203	210	PF00069	0.682
MOD_GSK3_1	40	47	PF00069	0.707
MOD_GSK3_1	62	69	PF00069	0.806
MOD_GSK3_1	8	15	PF00069	0.756
MOD_GSK3_1	84	91	PF00069	0.617
MOD_NEK2_1	138	143	PF00069	0.728
MOD_PIKK_1	20	26	PF00454	0.611
MOD_PIKK_1	263	269	PF00454	0.715
MOD_PK_1	12	18	PF00069	0.775
MOD_PKA_1	49	55	PF00069	0.609
MOD_PKA_2	65	71	PF00069	0.697
MOD_PKB_1	189	197	PF00069	0.767
MOD_Plk_4	118	124	PF00069	0.624
MOD_Plk_4	95	101	PF00069	0.612
MOD_SUMO_for_1	37	40	PF00179	0.719
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.665
TRG_ER_diArg_1	177	179	PF00400	0.726
TRG_ER_diArg_1	238	240	PF00400	0.548
TRG_NLS_Bipartite_1	178	193	PF00514	0.721
TRG_Pf-PMV_PEXEL_1	158	163	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W9	Leptomonas seymouri	51%	100%
A4HCZ8	Leishmania braziliensis	71%	100%
A4I0I3	Leishmania infantum	99%	100%
E9AWE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QB27	Leishmania major	91%	100%