Membrane-bound acid phosphatase 2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

membrane-bound acid phosphatase 2

Species:

Leishmania donovani

UniProt:

A0A3S7WXU0_LEIDO

TriTrypDb:

LdBPK_231430.1 , LdCL_230021400 , LDHU3_23.1910

Length:

531

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 65

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 35, no: 4
NetGPI	no	yes: 0, no: 39

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	28
GO:0110165	cellular anatomical entity	1	28

Expansion

Sequence features

A0A3S7WXU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXU0

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016311	dephosphorylation	5	5
GO:0044237	cellular metabolic process	2	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0003993	acid phosphatase activity	6	2
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	325	329	PF00656	0.357
CLV_NRD_NRD_1	200	202	PF00675	0.531
CLV_NRD_NRD_1	432	434	PF00675	0.499
CLV_NRD_NRD_1	522	524	PF00675	0.420
CLV_PCSK_KEX2_1	200	202	PF00082	0.499
CLV_PCSK_KEX2_1	431	433	PF00082	0.521
CLV_PCSK_SKI1_1	121	125	PF00082	0.470
CLV_PCSK_SKI1_1	2	6	PF00082	0.596
DEG_APCC_DBOX_1	1	9	PF00400	0.484
DEG_APCC_DBOX_1	230	238	PF00400	0.317
DEG_Nend_UBRbox_1	1	4	PF02207	0.579
DEG_SPOP_SBC_1	461	465	PF00917	0.435
DOC_ANK_TNKS_1	406	413	PF00023	0.248
DOC_CDC14_PxL_1	221	229	PF14671	0.354
DOC_CYCLIN_yCln2_LP_2	15	21	PF00134	0.618
DOC_CYCLIN_yCln2_LP_2	310	313	PF00134	0.202
DOC_MAPK_MEF2A_6	2	9	PF00069	0.533
DOC_MAPK_NFAT4_5	2	10	PF00069	0.312
DOC_PP1_RVXF_1	380	387	PF00149	0.374
DOC_PP2B_LxvP_1	15	18	PF13499	0.592
DOC_PP2B_LxvP_1	310	313	PF13499	0.202
DOC_USP7_MATH_1	278	282	PF00917	0.336
DOC_USP7_MATH_1	390	394	PF00917	0.411
DOC_USP7_MATH_1	422	426	PF00917	0.291
DOC_USP7_MATH_1	43	47	PF00917	0.328
DOC_USP7_MATH_1	461	465	PF00917	0.432
DOC_USP7_MATH_1	484	488	PF00917	0.534
DOC_WW_Pin1_4	340	345	PF00397	0.295
DOC_WW_Pin1_4	359	364	PF00397	0.299
DOC_WW_Pin1_4	471	476	PF00397	0.538
DOC_WW_Pin1_4	522	527	PF00397	0.673
DOC_WW_Pin1_4	53	58	PF00397	0.392
LIG_14-3-3_CanoR_1	105	113	PF00244	0.261
LIG_14-3-3_CanoR_1	200	208	PF00244	0.292
LIG_14-3-3_CanoR_1	297	303	PF00244	0.175
LIG_14-3-3_CanoR_1	337	342	PF00244	0.265
LIG_14-3-3_CanoR_1	79	87	PF00244	0.330
LIG_BRCT_BRCA1_1	524	528	PF00533	0.495
LIG_deltaCOP1_diTrp_1	349	356	PF00928	0.272
LIG_EH1_1	501	509	PF00400	0.341
LIG_FHA_1	105	111	PF00498	0.277
LIG_FHA_1	145	151	PF00498	0.270
LIG_FHA_1	20	26	PF00498	0.374
LIG_FHA_1	315	321	PF00498	0.302
LIG_FHA_1	379	385	PF00498	0.332
LIG_FHA_1	492	498	PF00498	0.236
LIG_FHA_1	499	505	PF00498	0.318
LIG_FHA_1	511	517	PF00498	0.434
LIG_FHA_2	134	140	PF00498	0.285
LIG_FHA_2	205	211	PF00498	0.251
LIG_FHA_2	227	233	PF00498	0.161
LIG_FHA_2	303	309	PF00498	0.283
LIG_GBD_Chelix_1	318	326	PF00786	0.375
LIG_LIR_Gen_1	178	186	PF02991	0.312
LIG_LIR_Gen_1	203	213	PF02991	0.283
LIG_LIR_Gen_1	379	388	PF02991	0.257
LIG_LIR_Gen_1	393	403	PF02991	0.386
LIG_LIR_Gen_1	418	424	PF02991	0.433
LIG_LIR_Gen_1	525	531	PF02991	0.577
LIG_LIR_Nem_3	128	134	PF02991	0.259
LIG_LIR_Nem_3	141	146	PF02991	0.287
LIG_LIR_Nem_3	173	179	PF02991	0.305
LIG_LIR_Nem_3	203	209	PF02991	0.215
LIG_LIR_Nem_3	222	227	PF02991	0.269
LIG_LIR_Nem_3	280	286	PF02991	0.295
LIG_LIR_Nem_3	379	383	PF02991	0.274
LIG_LIR_Nem_3	393	399	PF02991	0.288
LIG_LIR_Nem_3	400	406	PF02991	0.254
LIG_LIR_Nem_3	418	423	PF02991	0.265
LIG_LIR_Nem_3	525	531	PF02991	0.642
LIG_LIR_Nem_3	62	66	PF02991	0.222
LIG_LYPXL_S_1	130	134	PF13949	0.474
LIG_LYPXL_yS_3	131	134	PF13949	0.256
LIG_LYPXL_yS_3	224	227	PF13949	0.378
LIG_NRBOX	4	10	PF00104	0.373
LIG_PCNA_yPIPBox_3	263	271	PF02747	0.236
LIG_PDZ_Class_1	526	531	PF00595	0.523
LIG_Pex14_2	119	123	PF04695	0.343
LIG_Pex14_2	153	157	PF04695	0.307
LIG_Pex14_2	348	352	PF04695	0.386
LIG_SH2_CRK	403	407	PF00017	0.301
LIG_SH2_GRB2like	146	149	PF00017	0.345
LIG_SH2_STAP1	146	150	PF00017	0.334
LIG_SH2_STAP1	97	101	PF00017	0.273
LIG_SH2_STAT3	149	152	PF00017	0.350
LIG_SH2_STAT5	143	146	PF00017	0.333
LIG_SH2_STAT5	149	152	PF00017	0.260
LIG_SH2_STAT5	194	197	PF00017	0.292
LIG_SH2_STAT5	246	249	PF00017	0.282
LIG_SH2_STAT5	396	399	PF00017	0.293
LIG_SH2_STAT5	60	63	PF00017	0.270
LIG_SH3_3	14	20	PF00018	0.348
LIG_SH3_3	164	170	PF00018	0.265
LIG_SH3_3	338	344	PF00018	0.184
LIG_SH3_3	465	471	PF00018	0.525
LIG_SH3_3	84	90	PF00018	0.294
LIG_SH3_5	93	97	PF00018	0.211
LIG_SUMO_SIM_par_1	316	321	PF11976	0.293
LIG_UBA3_1	208	215	PF00899	0.348
LIG_WRC_WIRS_1	499	504	PF05994	0.341
MOD_CK1_1	104	110	PF00069	0.303
MOD_CK1_1	115	121	PF00069	0.317
MOD_CK1_1	196	202	PF00069	0.307
MOD_CK1_1	327	333	PF00069	0.257
MOD_CK1_1	343	349	PF00069	0.362
MOD_CK1_1	487	493	PF00069	0.514
MOD_CK1_1	85	91	PF00069	0.327
MOD_CK2_1	133	139	PF00069	0.327
MOD_CK2_1	343	349	PF00069	0.377
MOD_CK2_1	61	67	PF00069	0.161
MOD_GlcNHglycan	114	117	PF01048	0.455
MOD_GlcNHglycan	260	263	PF01048	0.532
MOD_GlcNHglycan	288	291	PF01048	0.487
MOD_GlcNHglycan	345	348	PF01048	0.577
MOD_GlcNHglycan	363	366	PF01048	0.462
MOD_GlcNHglycan	370	373	PF01048	0.507
MOD_GlcNHglycan	424	427	PF01048	0.534
MOD_GlcNHglycan	486	489	PF01048	0.722
MOD_GlcNHglycan	63	66	PF01048	0.512
MOD_GSK3_1	286	293	PF00069	0.270
MOD_GSK3_1	298	305	PF00069	0.273
MOD_GSK3_1	322	329	PF00069	0.298
MOD_GSK3_1	39	46	PF00069	0.349
MOD_GSK3_1	455	462	PF00069	0.351
MOD_GSK3_1	487	494	PF00069	0.499
MOD_GSK3_1	522	529	PF00069	0.609
MOD_GSK3_1	75	82	PF00069	0.331
MOD_N-GLC_1	125	130	PF02516	0.478
MOD_N-GLC_1	248	253	PF02516	0.470
MOD_N-GLC_1	368	373	PF02516	0.500
MOD_N-GLC_1	47	52	PF02516	0.542
MOD_N-GLC_1	479	484	PF02516	0.592
MOD_N-GLC_2	373	375	PF02516	0.507
MOD_NEK2_1	277	282	PF00069	0.297
MOD_NEK2_1	314	319	PF00069	0.252
MOD_NEK2_1	322	327	PF00069	0.345
MOD_NEK2_1	444	449	PF00069	0.337
MOD_NEK2_1	61	66	PF00069	0.287
MOD_NEK2_1	69	74	PF00069	0.280
MOD_NEK2_1	75	80	PF00069	0.296
MOD_NEK2_2	204	209	PF00069	0.309
MOD_OFUCOSY	434	439	PF10250	0.509
MOD_OFUCOSY	452	459	PF10250	0.610
MOD_PIKK_1	232	238	PF00454	0.282
MOD_PIKK_1	47	53	PF00454	0.318
MOD_PKA_2	104	110	PF00069	0.262
MOD_PKA_2	199	205	PF00069	0.305
MOD_PKA_2	232	238	PF00069	0.306
MOD_PKB_1	431	439	PF00069	0.208
MOD_PKB_1	77	85	PF00069	0.354
MOD_Plk_1	125	131	PF00069	0.320
MOD_Plk_1	291	297	PF00069	0.269
MOD_Plk_1	327	333	PF00069	0.175
MOD_Plk_1	378	384	PF00069	0.285
MOD_Plk_1	47	53	PF00069	0.328
MOD_Plk_1	479	485	PF00069	0.375
MOD_Plk_1	82	88	PF00069	0.286
MOD_Plk_4	115	121	PF00069	0.355
MOD_Plk_4	126	132	PF00069	0.322
MOD_Plk_4	314	320	PF00069	0.270
MOD_Plk_4	82	88	PF00069	0.289
MOD_ProDKin_1	340	346	PF00069	0.295
MOD_ProDKin_1	359	365	PF00069	0.302
MOD_ProDKin_1	471	477	PF00069	0.539
MOD_ProDKin_1	522	528	PF00069	0.675
MOD_ProDKin_1	53	59	PF00069	0.359
TRG_ENDOCYTIC_2	131	134	PF00928	0.302
TRG_ENDOCYTIC_2	156	159	PF00928	0.246
TRG_ENDOCYTIC_2	224	227	PF00928	0.346
TRG_ENDOCYTIC_2	396	399	PF00928	0.299
TRG_ENDOCYTIC_2	403	406	PF00928	0.290
TRG_ER_diArg_1	430	433	PF00400	0.318
TRG_ER_diArg_1	76	79	PF00400	0.308
TRG_NES_CRM1_1	308	321	PF08389	0.259

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y5	Leptomonas seymouri	45%	93%
A0A0N1I756	Leptomonas seymouri	38%	100%
A0A0N1PEH4	Leptomonas seymouri	37%	100%
A0A0S4IRF5	Bodo saltans	23%	79%
A0A0S4IUV8	Bodo saltans	22%	100%
A0A0S4IV77	Bodo saltans	35%	100%
A0A0S4IXN9	Bodo saltans	24%	100%
A0A0S4JEA9	Bodo saltans	27%	100%
A0A0S4JJK3	Bodo saltans	27%	100%
A0A0S4JW09	Bodo saltans	28%	100%
A0A1X0NNY4	Trypanosomatidae	36%	96%
A0A1X0NQL4	Trypanosomatidae	28%	97%
A0A1X0NY34	Trypanosomatidae	25%	100%
A0A1X0P7V5	Trypanosomatidae	45%	100%
A0A3Q8IR23	Leishmania donovani	51%	100%
A0A3R7KSH4	Trypanosoma rangeli	25%	100%
A0A3R7MEN7	Trypanosoma rangeli	43%	100%
A0A3R7MHJ7	Trypanosoma rangeli	28%	100%
A0A3S5H827	Leishmania donovani	39%	100%
A0A3S7X1W4	Leishmania donovani	44%	97%
A4HCZ0	Leishmania braziliensis	85%	100%
A4HGW8	Leishmania braziliensis	43%	100%
A4HPC1	Leishmania braziliensis	39%	100%
A4HPC5	Leishmania braziliensis	50%	100%
A4HQG6	Leishmania braziliensis	35%	100%
A4HQG9	Leishmania braziliensis	35%	100%
A4I0H5	Leishmania infantum	99%	100%
A4I3Z8	Leishmania infantum	44%	100%
A4ICA5	Leishmania infantum	35%	100%
A4ICG3	Leishmania infantum	39%	100%
A4ICG5	Leishmania infantum	51%	100%
B1H1P9	Xenopus laevis	27%	100%
D0A3E0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
D0A947	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A948	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A9J5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AT34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AT36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AWD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B088	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
P11117	Homo sapiens	26%	100%
P20611	Rattus norvegicus	25%	100%
P24638	Mus musculus	26%	100%
Q0P5F0	Bos taurus	27%	100%
Q4Q0A9	Leishmania major	30%	99%
Q4Q1G2	Leishmania major	51%	100%
Q4Q1G4	Leishmania major	38%	100%
Q4Q7Z7	Leishmania major	44%	100%
Q4QB35	Leishmania major	95%	100%
Q4R5N9	Macaca fascicularis	27%	100%
Q5NVF6	Pongo abelii	26%	100%
V5BCI2	Trypanosoma cruzi	26%	100%
V5BK91	Trypanosoma cruzi	41%	100%
V5BL75	Trypanosoma cruzi	27%	100%