Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WXT9_LEIDO

TriTrypDb:

LdBPK_231480.1 , LdCL_230021900 , LDHU3_23.1980

Length:

716

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WXT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXT9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.722
CLV_C14_Caspase3-7	401	405	PF00656	0.587
CLV_C14_Caspase3-7	591	595	PF00656	0.542
CLV_MEL_PAP_1	193	199	PF00089	0.417
CLV_NRD_NRD_1	244	246	PF00675	0.428
CLV_NRD_NRD_1	311	313	PF00675	0.492
CLV_NRD_NRD_1	316	318	PF00675	0.542
CLV_NRD_NRD_1	361	363	PF00675	0.380
CLV_NRD_NRD_1	372	374	PF00675	0.429
CLV_NRD_NRD_1	468	470	PF00675	0.487
CLV_NRD_NRD_1	478	480	PF00675	0.529
CLV_NRD_NRD_1	634	636	PF00675	0.525
CLV_NRD_NRD_1	644	646	PF00675	0.428
CLV_NRD_NRD_1	651	653	PF00675	0.382
CLV_NRD_NRD_1	666	668	PF00675	0.486
CLV_NRD_NRD_1	689	691	PF00675	0.494
CLV_NRD_NRD_1	695	697	PF00675	0.515
CLV_NRD_NRD_1	94	96	PF00675	0.510
CLV_PCSK_FUR_1	370	374	PF00082	0.547
CLV_PCSK_KEX2_1	244	246	PF00082	0.467
CLV_PCSK_KEX2_1	316	318	PF00082	0.593
CLV_PCSK_KEX2_1	361	363	PF00082	0.398
CLV_PCSK_KEX2_1	372	374	PF00082	0.497
CLV_PCSK_KEX2_1	468	470	PF00082	0.489
CLV_PCSK_KEX2_1	478	480	PF00082	0.521
CLV_PCSK_KEX2_1	633	635	PF00082	0.543
CLV_PCSK_KEX2_1	644	646	PF00082	0.433
CLV_PCSK_KEX2_1	664	666	PF00082	0.356
CLV_PCSK_KEX2_1	688	690	PF00082	0.510
CLV_PCSK_KEX2_1	94	96	PF00082	0.510
CLV_PCSK_PC1ET2_1	664	666	PF00082	0.510
CLV_PCSK_PC1ET2_1	688	690	PF00082	0.510
CLV_PCSK_PC7_1	312	318	PF00082	0.563
CLV_PCSK_PC7_1	90	96	PF00082	0.580
CLV_PCSK_SKI1_1	105	109	PF00082	0.515
CLV_PCSK_SKI1_1	228	232	PF00082	0.546
CLV_PCSK_SKI1_1	239	243	PF00082	0.351
CLV_PCSK_SKI1_1	494	498	PF00082	0.595
CLV_PCSK_SKI1_1	52	56	PF00082	0.461
CLV_PCSK_SKI1_1	59	63	PF00082	0.503
CLV_PCSK_SKI1_1	613	617	PF00082	0.456
DEG_APCC_DBOX_1	195	203	PF00400	0.532
DEG_Nend_Nbox_1	1	3	PF02207	0.486
DEG_SPOP_SBC_1	109	113	PF00917	0.642
DOC_CYCLIN_yCln2_LP_2	304	310	PF00134	0.489
DOC_MAPK_MEF2A_6	188	197	PF00069	0.439
DOC_MAPK_MEF2A_6	334	342	PF00069	0.451
DOC_MAPK_MEF2A_6	4	12	PF00069	0.367
DOC_PP1_SILK_1	308	313	PF00149	0.493
DOC_PP2B_LxvP_1	304	307	PF13499	0.616
DOC_PP4_FxxP_1	581	584	PF00568	0.505
DOC_USP7_MATH_1	110	114	PF00917	0.697
DOC_USP7_MATH_1	152	156	PF00917	0.795
DOC_USP7_MATH_1	529	533	PF00917	0.619
DOC_USP7_MATH_1	557	561	PF00917	0.722
DOC_USP7_UBL2_3	660	664	PF12436	0.465
DOC_WW_Pin1_4	112	117	PF00397	0.566
DOC_WW_Pin1_4	131	136	PF00397	0.783
DOC_WW_Pin1_4	269	274	PF00397	0.600
DOC_WW_Pin1_4	297	302	PF00397	0.565
DOC_WW_Pin1_4	408	413	PF00397	0.571
DOC_WW_Pin1_4	494	499	PF00397	0.521
DOC_WW_Pin1_4	513	518	PF00397	0.591
LIG_14-3-3_CanoR_1	150	158	PF00244	0.632
LIG_14-3-3_CanoR_1	196	200	PF00244	0.531
LIG_14-3-3_CanoR_1	228	234	PF00244	0.461
LIG_14-3-3_CanoR_1	332	338	PF00244	0.478
LIG_14-3-3_CanoR_1	701	709	PF00244	0.678
LIG_Actin_WH2_2	204	220	PF00022	0.388
LIG_Actin_WH2_2	608	623	PF00022	0.567
LIG_APCC_ABBA_1	74	79	PF00400	0.570
LIG_BRCT_BRCA1_1	577	581	PF00533	0.552
LIG_CtBP_PxDLS_1	78	82	PF00389	0.526
LIG_deltaCOP1_diTrp_1	26	33	PF00928	0.281
LIG_FHA_1	12	18	PF00498	0.281
LIG_FHA_1	158	164	PF00498	0.557
LIG_FHA_1	221	227	PF00498	0.450
LIG_FHA_1	298	304	PF00498	0.651
LIG_FHA_1	347	353	PF00498	0.401
LIG_FHA_1	387	393	PF00498	0.413
LIG_FHA_1	413	419	PF00498	0.467
LIG_FHA_1	442	448	PF00498	0.433
LIG_FHA_2	189	195	PF00498	0.511
LIG_FHA_2	497	503	PF00498	0.600
LIG_FHA_2	556	562	PF00498	0.730
LIG_FHA_2	66	72	PF00498	0.470
LIG_IRF3_LxIS_1	11	18	PF10401	0.274
LIG_LIR_Apic_2	578	584	PF02991	0.505
LIG_LIR_Gen_1	432	441	PF02991	0.404
LIG_LIR_Gen_1	46	54	PF02991	0.385
LIG_LIR_Nem_3	26	30	PF02991	0.281
LIG_LIR_Nem_3	432	437	PF02991	0.410
LIG_LIR_Nem_3	46	51	PF02991	0.251
LIG_NRBOX	690	696	PF00104	0.501
LIG_Pex14_2	367	371	PF04695	0.392
LIG_SH2_CRK	13	17	PF00017	0.281
LIG_SH2_PTP2	48	51	PF00017	0.377
LIG_SH2_STAP1	13	17	PF00017	0.281
LIG_SH2_STAP1	363	367	PF00017	0.401
LIG_SH2_STAP1	642	646	PF00017	0.531
LIG_SH2_STAT3	363	366	PF00017	0.438
LIG_SH2_STAT5	13	16	PF00017	0.281
LIG_SH2_STAT5	210	213	PF00017	0.470
LIG_SH2_STAT5	248	251	PF00017	0.422
LIG_SH2_STAT5	391	394	PF00017	0.579
LIG_SH2_STAT5	48	51	PF00017	0.377
LIG_SH2_STAT5	648	651	PF00017	0.565
LIG_SH3_2	414	419	PF14604	0.543
LIG_SH3_3	114	120	PF00018	0.621
LIG_SH3_3	318	324	PF00018	0.609
LIG_SH3_3	411	417	PF00018	0.606
LIG_SH3_3	523	529	PF00018	0.746
LIG_SUMO_SIM_anti_2	339	345	PF11976	0.481
LIG_SUMO_SIM_par_1	13	19	PF11976	0.274
LIG_SUMO_SIM_par_1	339	345	PF11976	0.571
LIG_TYR_ITIM	11	16	PF00017	0.281
LIG_UBA3_1	340	346	PF00899	0.514
MOD_CDK_SPxxK_3	412	419	PF00069	0.476
MOD_CK1_1	118	124	PF00069	0.705
MOD_CK1_1	144	150	PF00069	0.691
MOD_CK1_1	154	160	PF00069	0.762
MOD_CK1_1	234	240	PF00069	0.474
MOD_CK1_1	266	272	PF00069	0.755
MOD_CK1_1	492	498	PF00069	0.492
MOD_CK1_1	531	537	PF00069	0.706
MOD_CK2_1	188	194	PF00069	0.585
MOD_CK2_1	333	339	PF00069	0.464
MOD_CK2_1	496	502	PF00069	0.622
MOD_CK2_1	555	561	PF00069	0.694
MOD_CK2_1	65	71	PF00069	0.498
MOD_GlcNHglycan	117	120	PF01048	0.734
MOD_GlcNHglycan	135	138	PF01048	0.517
MOD_GlcNHglycan	143	146	PF01048	0.684
MOD_GlcNHglycan	154	157	PF01048	0.741
MOD_GlcNHglycan	233	236	PF01048	0.447
MOD_GlcNHglycan	393	396	PF01048	0.610
MOD_GlcNHglycan	491	494	PF01048	0.489
MOD_GlcNHglycan	534	537	PF01048	0.699
MOD_GlcNHglycan	577	580	PF01048	0.626
MOD_GlcNHglycan	704	707	PF01048	0.565
MOD_GSK3_1	108	115	PF00069	0.579
MOD_GSK3_1	11	18	PF00069	0.305
MOD_GSK3_1	144	151	PF00069	0.697
MOD_GSK3_1	178	185	PF00069	0.582
MOD_GSK3_1	229	236	PF00069	0.494
MOD_GSK3_1	342	349	PF00069	0.501
MOD_GSK3_1	387	394	PF00069	0.537
MOD_GSK3_1	408	415	PF00069	0.715
MOD_GSK3_1	492	499	PF00069	0.589
MOD_GSK3_1	527	534	PF00069	0.625
MOD_LATS_1	162	168	PF00433	0.514
MOD_LATS_1	344	350	PF00433	0.445
MOD_N-GLC_1	170	175	PF02516	0.568
MOD_N-GLC_1	263	268	PF02516	0.633
MOD_N-GLC_1	574	579	PF02516	0.609
MOD_NEK2_1	11	16	PF00069	0.281
MOD_NEK2_1	342	347	PF00069	0.508
MOD_NEK2_1	537	542	PF00069	0.740
MOD_NEK2_1	574	579	PF00069	0.543
MOD_NEK2_1	592	597	PF00069	0.549
MOD_NEK2_1	646	651	PF00069	0.562
MOD_PIKK_1	170	176	PF00454	0.591
MOD_PIKK_1	220	226	PF00454	0.424
MOD_PIKK_1	529	535	PF00454	0.584
MOD_PIKK_1	537	543	PF00454	0.760
MOD_PKA_2	195	201	PF00069	0.607
MOD_PKA_2	333	339	PF00069	0.483
MOD_PKA_2	427	433	PF00069	0.479
MOD_Plk_1	170	176	PF00069	0.566
MOD_Plk_1	287	293	PF00069	0.545
MOD_Plk_4	11	17	PF00069	0.303
MOD_Plk_4	355	361	PF00069	0.385
MOD_Plk_4	376	382	PF00069	0.385
MOD_Plk_4	387	393	PF00069	0.438
MOD_Plk_4	44	50	PF00069	0.384
MOD_ProDKin_1	112	118	PF00069	0.569
MOD_ProDKin_1	131	137	PF00069	0.783
MOD_ProDKin_1	269	275	PF00069	0.602
MOD_ProDKin_1	297	303	PF00069	0.557
MOD_ProDKin_1	408	414	PF00069	0.565
MOD_ProDKin_1	494	500	PF00069	0.529
MOD_ProDKin_1	513	519	PF00069	0.591
MOD_SUMO_rev_2	465	473	PF00179	0.534
TRG_DiLeu_BaEn_1	337	342	PF01217	0.549
TRG_DiLeu_BaEn_1	7	12	PF01217	0.281
TRG_ENDOCYTIC_2	13	16	PF00928	0.281
TRG_ENDOCYTIC_2	30	33	PF00928	0.281
TRG_ENDOCYTIC_2	434	437	PF00928	0.442
TRG_ENDOCYTIC_2	48	51	PF00928	0.377
TRG_ER_diArg_1	332	335	PF00400	0.558
TRG_ER_diArg_1	360	362	PF00400	0.381
TRG_ER_diArg_1	371	373	PF00400	0.397
TRG_ER_diArg_1	467	469	PF00400	0.495
TRG_ER_diArg_1	477	479	PF00400	0.427
TRG_ER_diArg_1	57	60	PF00400	0.473
TRG_ER_diArg_1	633	635	PF00400	0.553
TRG_ER_diArg_1	644	646	PF00400	0.452
TRG_ER_diArg_1	665	667	PF00400	0.563
TRG_ER_diArg_1	689	691	PF00400	0.508
TRG_NES_CRM1_1	254	267	PF08389	0.475
TRG_NES_CRM1_1	64	80	PF08389	0.551
TRG_NLS_Bipartite_1	652	668	PF00514	0.680
TRG_NLS_MonoCore_2	663	668	PF00514	0.514
TRG_NLS_MonoExtN_4	686	692	PF00514	0.474
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	689	693	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJP3	Leptomonas seymouri	66%	92%
A0A1X0NWS4	Trypanosomatidae	48%	78%
A0A3S5IS90	Trypanosoma rangeli	51%	95%
A4HCZ5	Leishmania braziliensis	85%	100%
A4I0I0	Leishmania infantum	100%	100%
C9ZVA6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	91%
E9AWE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%
Q4QB30	Leishmania major	96%	100%
V5BJA5	Trypanosoma cruzi	51%	100%