Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WXT8_LEIDO

TriTrypDb:

LdBPK_231250.1 , LdCL_230019600 , LDHU3_23.1650

Length:

557

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WXT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXT8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.498
CLV_NRD_NRD_1	204	206	PF00675	0.645
CLV_NRD_NRD_1	332	334	PF00675	0.617
CLV_NRD_NRD_1	356	358	PF00675	0.721
CLV_NRD_NRD_1	406	408	PF00675	0.683
CLV_NRD_NRD_1	481	483	PF00675	0.662
CLV_NRD_NRD_1	498	500	PF00675	0.778
CLV_NRD_NRD_1	545	547	PF00675	0.653
CLV_PCSK_KEX2_1	180	182	PF00082	0.502
CLV_PCSK_KEX2_1	206	208	PF00082	0.717
CLV_PCSK_KEX2_1	302	304	PF00082	0.648
CLV_PCSK_KEX2_1	332	334	PF00082	0.617
CLV_PCSK_KEX2_1	356	358	PF00082	0.721
CLV_PCSK_KEX2_1	406	408	PF00082	0.668
CLV_PCSK_KEX2_1	481	483	PF00082	0.696
CLV_PCSK_KEX2_1	497	499	PF00082	0.609
CLV_PCSK_KEX2_1	515	517	PF00082	0.622
CLV_PCSK_KEX2_1	545	547	PF00082	0.698
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.502
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.692
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.670
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.533
CLV_PCSK_SKI1_1	152	156	PF00082	0.521
CLV_PCSK_SKI1_1	165	169	PF00082	0.561
CLV_PCSK_SKI1_1	198	202	PF00082	0.697
CLV_PCSK_SKI1_1	401	405	PF00082	0.616
CLV_PCSK_SKI1_1	427	431	PF00082	0.802
DEG_APCC_DBOX_1	151	159	PF00400	0.527
DEG_COP1_1	47	56	PF00400	0.525
DEG_SCF_FBW7_2	386	393	PF00400	0.612
DEG_SPOP_SBC_1	259	263	PF00917	0.601
DEG_SPOP_SBC_1	525	529	PF00917	0.586
DOC_CDC14_PxL_1	227	235	PF14671	0.615
DOC_CKS1_1	428	433	PF01111	0.545
DOC_MAPK_gen_1	108	115	PF00069	0.556
DOC_MAPK_MEF2A_6	235	244	PF00069	0.606
DOC_PP4_FxxP_1	501	504	PF00568	0.625
DOC_PP4_FxxP_1	58	61	PF00568	0.572
DOC_USP7_MATH_1	222	226	PF00917	0.579
DOC_USP7_MATH_1	245	249	PF00917	0.696
DOC_USP7_MATH_1	343	347	PF00917	0.638
DOC_USP7_MATH_1	486	490	PF00917	0.789
DOC_USP7_MATH_1	491	495	PF00917	0.583
DOC_USP7_MATH_1	531	535	PF00917	0.604
DOC_USP7_MATH_1	6	10	PF00917	0.607
DOC_WW_Pin1_4	158	163	PF00397	0.623
DOC_WW_Pin1_4	297	302	PF00397	0.646
DOC_WW_Pin1_4	379	384	PF00397	0.631
DOC_WW_Pin1_4	386	391	PF00397	0.594
DOC_WW_Pin1_4	42	47	PF00397	0.678
DOC_WW_Pin1_4	427	432	PF00397	0.614
DOC_WW_Pin1_4	467	472	PF00397	0.621
DOC_WW_Pin1_4	500	505	PF00397	0.688
LIG_14-3-3_CanoR_1	260	265	PF00244	0.611
LIG_14-3-3_CanoR_1	498	504	PF00244	0.770
LIG_Actin_WH2_2	150	167	PF00022	0.467
LIG_BRCT_BRCA1_1	488	492	PF00533	0.745
LIG_deltaCOP1_diTrp_1	442	452	PF00928	0.702
LIG_eIF4E_1	264	270	PF01652	0.630
LIG_FHA_1	222	228	PF00498	0.644
LIG_FHA_1	428	434	PF00498	0.609
LIG_FHA_1	520	526	PF00498	0.559
LIG_FHA_2	164	170	PF00498	0.541
LIG_FHA_2	364	370	PF00498	0.697
LIG_FHA_2	387	393	PF00498	0.607
LIG_FHA_2	433	439	PF00498	0.611
LIG_FHA_2	47	53	PF00498	0.622
LIG_FHA_2	533	539	PF00498	0.662
LIG_IBAR_NPY_1	419	421	PF08397	0.616
LIG_LIR_Apic_2	418	424	PF02991	0.530
LIG_LIR_Apic_2	55	61	PF02991	0.569
LIG_LIR_Gen_1	172	182	PF02991	0.451
LIG_LIR_Nem_3	172	177	PF02991	0.480
LIG_LIR_Nem_3	261	267	PF02991	0.614
LIG_LIR_Nem_3	311	315	PF02991	0.608
LIG_LIR_Nem_3	66	72	PF02991	0.598
LIG_LYPXL_yS_3	239	242	PF13949	0.589
LIG_SH2_CRK	174	178	PF00017	0.502
LIG_SH2_CRK	264	268	PF00017	0.750
LIG_SH2_CRK	421	425	PF00017	0.538
LIG_SH2_CRK	69	73	PF00017	0.547
LIG_SH2_NCK_1	421	425	PF00017	0.538
LIG_SH2_STAP1	293	297	PF00017	0.664
LIG_SH2_STAP1	325	329	PF00017	0.557
LIG_SH2_STAP1	437	441	PF00017	0.596
LIG_SH2_STAP1	73	77	PF00017	0.594
LIG_SH2_STAP1	89	93	PF00017	0.487
LIG_SH2_STAT3	77	80	PF00017	0.534
LIG_SH2_STAT5	174	177	PF00017	0.458
LIG_SH3_1	235	241	PF00018	0.627
LIG_SH3_1	482	488	PF00018	0.673
LIG_SH3_3	235	241	PF00018	0.627
LIG_SH3_3	369	375	PF00018	0.586
LIG_SH3_3	380	386	PF00018	0.615
LIG_SH3_3	422	428	PF00018	0.627
LIG_SH3_3	482	488	PF00018	0.716
LIG_SH3_3	58	64	PF00018	0.652
LIG_SH3_4	189	196	PF00018	0.520
LIG_SUMO_SIM_par_1	156	161	PF11976	0.518
LIG_SUMO_SIM_par_1	240	246	PF11976	0.596
LIG_SUMO_SIM_par_1	267	274	PF11976	0.631
LIG_TRAF2_1	24	27	PF00917	0.625
LIG_TRAF2_1	390	393	PF00917	0.670
LIG_TYR_ITSM	170	177	PF00017	0.457
LIG_TYR_ITSM	260	267	PF00017	0.615
LIG_UBA3_1	124	130	PF00899	0.424
MOD_CDC14_SPxK_1	300	303	PF00782	0.620
MOD_CDK_SPK_2	297	302	PF00069	0.625
MOD_CDK_SPxK_1	297	303	PF00069	0.622
MOD_CDK_SPxxK_3	158	165	PF00069	0.528
MOD_CK1_1	163	169	PF00069	0.447
MOD_CK1_1	274	280	PF00069	0.650
MOD_CK1_1	470	476	PF00069	0.645
MOD_CK1_1	503	509	PF00069	0.642
MOD_CK2_1	163	169	PF00069	0.566
MOD_CK2_1	21	27	PF00069	0.587
MOD_CK2_1	240	246	PF00069	0.562
MOD_CK2_1	363	369	PF00069	0.696
MOD_CK2_1	386	392	PF00069	0.620
MOD_CK2_1	432	438	PF00069	0.740
MOD_CK2_1	499	505	PF00069	0.541
MOD_CK2_1	532	538	PF00069	0.794
MOD_CK2_1	6	12	PF00069	0.594
MOD_Cter_Amidation	479	482	PF01082	0.638
MOD_DYRK1A_RPxSP_1	427	431	PF00069	0.543
MOD_GlcNHglycan	118	121	PF01048	0.504
MOD_GlcNHglycan	282	287	PF01048	0.605
MOD_GlcNHglycan	315	318	PF01048	0.555
MOD_GlcNHglycan	345	348	PF01048	0.773
MOD_GlcNHglycan	350	353	PF01048	0.802
MOD_GlcNHglycan	372	375	PF01048	0.792
MOD_GlcNHglycan	438	442	PF01048	0.714
MOD_GlcNHglycan	493	496	PF01048	0.623
MOD_GlcNHglycan	505	508	PF01048	0.690
MOD_GlcNHglycan	516	519	PF01048	0.647
MOD_GlcNHglycan	8	11	PF01048	0.698
MOD_GSK3_1	156	163	PF00069	0.456
MOD_GSK3_1	169	176	PF00069	0.377
MOD_GSK3_1	222	229	PF00069	0.528
MOD_GSK3_1	247	254	PF00069	0.593
MOD_GSK3_1	282	289	PF00069	0.706
MOD_GSK3_1	293	300	PF00069	0.573
MOD_GSK3_1	377	384	PF00069	0.775
MOD_GSK3_1	42	49	PF00069	0.588
MOD_GSK3_1	466	473	PF00069	0.770
MOD_GSK3_1	486	493	PF00069	0.661
MOD_GSK3_1	499	506	PF00069	0.665
MOD_GSK3_1	514	521	PF00069	0.602
MOD_GSK3_1	532	539	PF00069	0.724
MOD_N-GLC_1	370	375	PF02516	0.805
MOD_NEK2_1	271	276	PF00069	0.676
MOD_NEK2_1	304	309	PF00069	0.699
MOD_NEK2_1	350	355	PF00069	0.694
MOD_NEK2_1	370	375	PF00069	0.650
MOD_NEK2_1	519	524	PF00069	0.521
MOD_NEK2_2	173	178	PF00069	0.500
MOD_NEK2_2	293	298	PF00069	0.536
MOD_PIKK_1	350	356	PF00454	0.783
MOD_PIKK_1	394	400	PF00454	0.680
MOD_PIKK_1	526	532	PF00454	0.611
MOD_PKA_1	206	212	PF00069	0.687
MOD_PKA_2	206	212	PF00069	0.754
MOD_PKA_2	259	265	PF00069	0.611
MOD_PKA_2	304	310	PF00069	0.557
MOD_PKA_2	343	349	PF00069	0.763
MOD_PKA_2	532	538	PF00069	0.792
MOD_PKB_1	303	311	PF00069	0.555
MOD_PKB_1	497	505	PF00069	0.712
MOD_Plk_1	271	277	PF00069	0.680
MOD_Plk_4	169	175	PF00069	0.584
MOD_Plk_4	251	257	PF00069	0.656
MOD_ProDKin_1	158	164	PF00069	0.619
MOD_ProDKin_1	297	303	PF00069	0.644
MOD_ProDKin_1	379	385	PF00069	0.630
MOD_ProDKin_1	386	392	PF00069	0.590
MOD_ProDKin_1	42	48	PF00069	0.684
MOD_ProDKin_1	427	433	PF00069	0.616
MOD_ProDKin_1	467	473	PF00069	0.623
MOD_ProDKin_1	500	506	PF00069	0.687
TRG_DiLeu_BaEn_1	149	154	PF01217	0.510
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.647
TRG_DiLeu_BaLyEn_6	318	323	PF01217	0.563
TRG_DiLeu_LyEn_5	149	154	PF01217	0.463
TRG_ENDOCYTIC_2	174	177	PF00928	0.505
TRG_ENDOCYTIC_2	239	242	PF00928	0.589
TRG_ENDOCYTIC_2	264	267	PF00928	0.630
TRG_ENDOCYTIC_2	554	557	PF00928	0.651
TRG_ENDOCYTIC_2	69	72	PF00928	0.626
TRG_ER_diArg_1	136	139	PF00400	0.536
TRG_ER_diArg_1	141	144	PF00400	0.540
TRG_ER_diArg_1	205	208	PF00400	0.672
TRG_ER_diArg_1	331	333	PF00400	0.604
TRG_ER_diArg_1	481	483	PF00400	0.701
TRG_ER_diArg_1	496	499	PF00400	0.628
TRG_ER_diArg_1	544	546	PF00400	0.625
TRG_NLS_MonoExtN_4	301	306	PF00514	0.626
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	455	460	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I063	Leptomonas seymouri	48%	100%
A0A422NP96	Trypanosoma rangeli	29%	100%
A4HCX4	Leishmania braziliensis	67%	99%
A4I0F7	Leishmania infantum	99%	100%
E9AWC0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QB52	Leishmania major	91%	100%
V5AZA1	Trypanosoma cruzi	30%	100%