LeishMANIAdb
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Uncharacterized_protein_family_UPF0546/EamA-like_ transporter_family_putative/Pfam:PF10639/Pfam:PF00892

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized_protein_family_UPF0546/EamA-like_ transporter_family_putative/Pfam:PF10639/Pfam:PF00892
Gene product:
Uncharacterised protein family UPF0546, putative
Species:
Leishmania donovani
UniProt:
A0A3S7WXT4_LEIDO
TriTrypDb:
LdBPK_231420.1 , LdCL_230021300 , LDHU3_23.1900
Length:
121

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A0A3S7WXT4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXT4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 41 43 PF00675 0.276
CLV_PCSK_KEX2_1 41 43 PF00082 0.276
CLV_PCSK_SKI1_1 44 48 PF00082 0.252
DEG_Nend_Nbox_1 1 3 PF02207 0.511
DOC_CYCLIN_RxL_1 41 48 PF00134 0.445
DOC_CYCLIN_yClb1_LxF_4 75 81 PF00134 0.254
LIG_14-3-3_CanoR_1 97 107 PF00244 0.434
LIG_Actin_WH2_2 50 66 PF00022 0.279
LIG_BRCT_BRCA1_1 55 59 PF00533 0.254
LIG_BRCT_BRCA1_1 76 80 PF00533 0.254
LIG_DCNL_PONY_1 1 4 PF03556 0.547
LIG_EH1_1 79 87 PF00400 0.314
LIG_FHA_1 13 19 PF00498 0.426
LIG_FHA_1 46 52 PF00498 0.282
LIG_NRBOX 6 12 PF00104 0.507
LIG_RPA_C_Fungi 94 106 PF08784 0.346
LIG_SH2_STAP1 116 120 PF00017 0.428
LIG_SH2_STAT5 45 48 PF00017 0.287
LIG_SH3_3 11 17 PF00018 0.410
LIG_SH3_3 37 43 PF00018 0.280
LIG_SUMO_SIM_anti_2 3 8 PF11976 0.280
LIG_SUMO_SIM_anti_2 87 93 PF11976 0.346
LIG_SUMO_SIM_par_1 105 111 PF11976 0.314
MOD_CK1_1 28 34 PF00069 0.286
MOD_CK1_1 69 75 PF00069 0.377
MOD_CK2_1 59 65 PF00069 0.339
MOD_GlcNHglycan 118 121 PF01048 0.529
MOD_GlcNHglycan 28 31 PF01048 0.281
MOD_GlcNHglycan 53 56 PF01048 0.342
MOD_GSK3_1 108 115 PF00069 0.370
MOD_GSK3_1 76 83 PF00069 0.265
MOD_N-GLC_1 51 56 PF02516 0.314
MOD_NEK2_1 108 113 PF00069 0.337
MOD_NEK2_1 26 31 PF00069 0.383
MOD_NEK2_1 53 58 PF00069 0.254
MOD_NEK2_1 59 64 PF00069 0.254
MOD_NEK2_1 80 85 PF00069 0.268
MOD_PIKK_1 45 51 PF00454 0.245
MOD_PKA_2 98 104 PF00069 0.290
MOD_Plk_1 66 72 PF00069 0.339
MOD_Plk_4 53 59 PF00069 0.324
MOD_Plk_4 69 75 PF00069 0.290
MOD_Plk_4 76 82 PF00069 0.253
MOD_Plk_4 84 90 PF00069 0.196
TRG_DiLeu_BaLyEn_6 14 19 PF01217 0.254
TRG_ER_diArg_1 40 42 PF00400 0.339
TRG_ER_diArg_1 96 99 PF00400 0.280

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4IWN9 Bodo saltans 61% 100%
A0A1X0NYC0 Trypanosomatidae 66% 96%
A0A422N7S4 Trypanosoma rangeli 62% 99%
A0NGI1 Anopheles gambiae 33% 86%
A4HCY9 Leishmania braziliensis 88% 100%
A4I0H4 Leishmania infantum 100% 100%
A7YW81 Bos taurus 30% 86%
C9ZV99 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 100%
Q4QB36 Leishmania major 96% 100%
Q54ZG7 Dictyostelium discoideum 40% 95%
Q8R1E7 Mus musculus 30% 86%
Q8WY98 Homo sapiens 30% 74%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS