Sucrose-6-phosphate hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sucrose hydrolase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WXS2_LEIDO

TriTrypDb:

LdBPK_272290.1 , LdCL_230017700 , LDHU3_23.1430

Length:

527

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A0A3S7WXS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXS2

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	20
GO:0008152	metabolic process	1	20
GO:0044238	primary metabolic process	2	20
GO:0071704	organic substance metabolic process	2	20

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	20
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	20
GO:0004564	beta-fructofuranosidase activity	5	18
GO:0016787	hydrolase activity	2	20
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	328	330	PF00675	0.332
CLV_PCSK_KEX2_1	328	330	PF00082	0.332
CLV_PCSK_KEX2_1	440	442	PF00082	0.335
CLV_PCSK_PC1ET2_1	440	442	PF00082	0.335
CLV_PCSK_SKI1_1	211	215	PF00082	0.384
CLV_PCSK_SKI1_1	245	249	PF00082	0.385
CLV_PCSK_SKI1_1	265	269	PF00082	0.195
CLV_PCSK_SKI1_1	328	332	PF00082	0.294
CLV_PCSK_SKI1_1	441	445	PF00082	0.372
DEG_COP1_1	381	390	PF00400	0.332
DEG_Nend_UBRbox_3	1	3	PF02207	0.544
DOC_CDC14_PxL_1	384	392	PF14671	0.325
DOC_CKS1_1	293	298	PF01111	0.209
DOC_CKS1_1	379	384	PF01111	0.390
DOC_MAPK_MEF2A_6	261	268	PF00069	0.323
DOC_MAPK_MEF2A_6	475	482	PF00069	0.274
DOC_MAPK_NFAT4_5	261	269	PF00069	0.253
DOC_PP1_RVXF_1	263	270	PF00149	0.272
DOC_PP2B_LxvP_1	353	356	PF13499	0.339
DOC_PP4_FxxP_1	192	195	PF00568	0.339
DOC_USP7_MATH_1	12	16	PF00917	0.515
DOC_USP7_MATH_1	168	172	PF00917	0.427
DOC_WW_Pin1_4	292	297	PF00397	0.231
DOC_WW_Pin1_4	337	342	PF00397	0.384
DOC_WW_Pin1_4	378	383	PF00397	0.387
LIG_14-3-3_CanoR_1	503	508	PF00244	0.437
LIG_APCC_ABBA_1	469	474	PF00400	0.299
LIG_BRCT_BRCA1_1	490	494	PF00533	0.372
LIG_deltaCOP1_diTrp_1	85	92	PF00928	0.309
LIG_DLG_GKlike_1	357	365	PF00625	0.253
LIG_EH_1	80	84	PF12763	0.322
LIG_FHA_1	212	218	PF00498	0.390
LIG_FHA_1	223	229	PF00498	0.300
LIG_FHA_1	363	369	PF00498	0.318
LIG_FHA_1	387	393	PF00498	0.290
LIG_FHA_1	461	467	PF00498	0.265
LIG_FHA_2	142	148	PF00498	0.272
LIG_FHA_2	403	409	PF00498	0.318
LIG_FHA_2	94	100	PF00498	0.324
LIG_KLC1_Yacidic_2	432	436	PF13176	0.478
LIG_LIR_Gen_1	233	241	PF02991	0.339
LIG_LIR_Nem_3	201	207	PF02991	0.365
LIG_LIR_Nem_3	233	239	PF02991	0.339
LIG_LIR_Nem_3	254	258	PF02991	0.284
LIG_LIR_Nem_3	305	309	PF02991	0.342
LIG_NRBOX	216	222	PF00104	0.384
LIG_Pex14_1	48	52	PF04695	0.376
LIG_Pex14_2	83	87	PF04695	0.269
LIG_PTB_Apo_2	128	135	PF02174	0.297
LIG_PTB_Apo_2	442	449	PF02174	0.335
LIG_PTB_Apo_2	68	75	PF02174	0.272
LIG_PTB_Phospho_1	128	134	PF10480	0.297
LIG_PTB_Phospho_1	442	448	PF10480	0.335
LIG_PTB_Phospho_1	68	74	PF10480	0.272
LIG_SH2_GRB2like	69	72	PF00017	0.272
LIG_SH2_NCK_1	361	365	PF00017	0.272
LIG_SH2_SRC	434	437	PF00017	0.450
LIG_SH2_STAP1	407	411	PF00017	0.332
LIG_SH2_STAT3	162	165	PF00017	0.318
LIG_SH2_STAT3	316	319	PF00017	0.339
LIG_SH2_STAT5	134	137	PF00017	0.339
LIG_SH2_STAT5	189	192	PF00017	0.363
LIG_SH2_STAT5	255	258	PF00017	0.241
LIG_SH2_STAT5	289	292	PF00017	0.384
LIG_SH2_STAT5	434	437	PF00017	0.470
LIG_SH3_2	296	301	PF14604	0.209
LIG_SH3_3	179	185	PF00018	0.339
LIG_SH3_3	293	299	PF00018	0.312
LIG_SUMO_SIM_par_1	388	393	PF11976	0.273
LIG_TRAF2_1	25	28	PF00917	0.385
LIG_WRC_WIRS_1	54	59	PF05994	0.228
LIG_WW_1	186	189	PF00397	0.384
MOD_CK1_1	123	129	PF00069	0.291
MOD_CK1_1	277	283	PF00069	0.208
MOD_CK2_1	141	147	PF00069	0.272
MOD_CK2_1	21	27	PF00069	0.518
MOD_CK2_1	357	363	PF00069	0.253
MOD_CK2_1	402	408	PF00069	0.332
MOD_CK2_1	415	421	PF00069	0.335
MOD_CK2_1	426	432	PF00069	0.335
MOD_CK2_1	473	479	PF00069	0.335
MOD_Cter_Amidation	272	275	PF01082	0.272
MOD_GlcNHglycan	122	125	PF01048	0.328
MOD_GlcNHglycan	14	17	PF01048	0.475
MOD_GlcNHglycan	149	152	PF01048	0.315
MOD_GlcNHglycan	349	352	PF01048	0.408
MOD_GlcNHglycan	4	7	PF01048	0.523
MOD_GlcNHglycan	428	431	PF01048	0.372
MOD_GlcNHglycan	453	456	PF01048	0.335
MOD_GSK3_1	143	150	PF00069	0.247
MOD_GSK3_1	2	9	PF00069	0.549
MOD_GSK3_1	337	344	PF00069	0.334
MOD_GSK3_1	347	354	PF00069	0.347
MOD_GSK3_1	451	458	PF00069	0.335
MOD_GSK3_1	503	510	PF00069	0.316
MOD_N-GLC_1	33	38	PF02516	0.345
MOD_N-GLC_1	393	398	PF02516	0.272
MOD_N-GLC_1	402	407	PF02516	0.235
MOD_N-GLC_1	507	512	PF02516	0.422
MOD_NEK2_1	122	127	PF00069	0.339
MOD_NEK2_1	415	420	PF00069	0.358
MOD_NEK2_1	521	526	PF00069	0.509
MOD_PK_1	39	45	PF00069	0.302
MOD_PK_1	503	509	PF00069	0.307
MOD_PKA_1	274	280	PF00069	0.272
MOD_PKA_2	474	480	PF00069	0.299
MOD_Plk_1	277	283	PF00069	0.422
MOD_Plk_1	33	39	PF00069	0.382
MOD_Plk_1	357	363	PF00069	0.253
MOD_Plk_1	402	408	PF00069	0.361
MOD_Plk_1	473	479	PF00069	0.335
MOD_Plk_1	485	491	PF00069	0.335
MOD_Plk_2-3	474	480	PF00069	0.335
MOD_Plk_4	157	163	PF00069	0.297
MOD_Plk_4	317	323	PF00069	0.422
MOD_Plk_4	386	392	PF00069	0.277
MOD_Plk_4	514	520	PF00069	0.409
MOD_ProDKin_1	292	298	PF00069	0.231
MOD_ProDKin_1	337	343	PF00069	0.384
MOD_ProDKin_1	378	384	PF00069	0.390
MOD_SUMO_for_1	20	23	PF00179	0.497
MOD_SUMO_rev_2	260	267	PF00179	0.251
TRG_DiLeu_BaEn_1	262	267	PF01217	0.253
TRG_ENDOCYTIC_2	189	192	PF00928	0.365
TRG_ENDOCYTIC_2	255	258	PF00928	0.451
TRG_ENDOCYTIC_2	74	77	PF00928	0.339
TRG_ENDOCYTIC_2	80	83	PF00928	0.339
TRG_ER_diArg_1	281	284	PF00400	0.338
TRG_ER_diArg_1	328	330	PF00400	0.332
TRG_NES_CRM1_1	460	474	PF08389	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8F7	Leptomonas seymouri	52%	100%
A0A0N1PBT6	Leptomonas seymouri	27%	82%
A0A1X0NFY9	Trypanosomatidae	26%	100%
A0A1X0NTL0	Trypanosomatidae	24%	83%
A0A1X0NTM3	Trypanosomatidae	25%	83%
A0A1X0NY19	Trypanosomatidae	28%	83%
A0A1X0P322	Trypanosomatidae	25%	84%
A0A1X0P5Y7	Trypanosomatidae	26%	82%
A0A3Q8IB13	Leishmania donovani	80%	95%
A0A3Q8IFU7	Leishmania donovani	100%	100%
A0A3S5H595	Leishmania donovani	27%	82%
A0A3S5H7I4	Leishmania donovani	52%	98%
A0A3S7WXQ4	Leishmania donovani	86%	100%
A1STJ9	Psychromonas ingrahamii (strain 37)	33%	97%
A2R0E0	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	25%	98%
A2X5P7	Oryza sativa subsp. indica	27%	91%
A2YZ01	Oryza sativa subsp. indica	30%	88%
A4H3V1	Leishmania braziliensis	28%	82%
A4HCV9	Leishmania braziliensis	69%	99%
A4HCW0	Leishmania braziliensis	78%	99%
A4HG14	Leishmania braziliensis	50%	98%
A4HS26	Leishmania infantum	27%	82%
A4I0D9	Leishmania infantum	80%	99%
A4I0E0	Leishmania infantum	86%	100%
A4I336	Leishmania infantum	51%	98%
A4IAW1	Leishmania infantum	27%	75%
A5ABL2	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	26%	100%
A5DHM6	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	26%	100%
A5EZZ8	Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)	32%	97%
A8W7I5	Meyerozyma guilliermondii	26%	100%
B6DXP5	Leymus chinensis	26%	88%
B6DZC8	Triticum aestivum	25%	88%
B6DZD0	Triticum urartu	25%	88%
B6DZD1	Aegilops speltoides	25%	89%
B6DZD2	Aegilops tauschii	25%	88%
D2IGW7	Bromus pictus	25%	88%
E1ABX2	Aspergillus ficuum	26%	98%
E8NHF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
E8NHF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
E9ACV4	Leishmania major	52%	98%
E9AK13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AWA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
E9AZE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	97%
F8DVG5	Zymomonas mobilis subsp. mobilis (strain ATCC 10988 / DSM 424 / LMG 404 / NCIMB 8938 / NRRL B-806 / ZM1)	39%	100%
H2DF87	Rosa hybrid cultivar	28%	90%
H2DF88	Rosa hybrid cultivar	26%	82%
K0E681	Aspergillus rugulosus	26%	100%
O07003	Bacillus subtilis (strain 168)	26%	100%
O33833	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	32%	100%
O42878	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
O59852	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	91%
O74641	Aspergillus niger	26%	100%
O74642	Aspergillus niger	26%	100%
O94220	Aspergillus ficuum	26%	100%
P00724	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	99%
P05656	Bacillus subtilis (strain 168)	28%	78%
P07819	Bacillus subtilis (strain 168)	35%	100%
P0DJA7	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	39%	100%
P10594	Saccharomyces cerevisiae	24%	99%
P10596	Saccharomyces cerevisiae	23%	99%
P13394	Vibrio alginolyticus	30%	100%
P13522	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	29%	100%
P16553	Escherichia coli	46%	100%
P24133	Schwanniomyces occidentalis	24%	99%
P27217	Klebsiella pneumoniae	35%	100%
P28999	Kluyveromyces marxianus	25%	95%
P29000	Solanum lycopersicum	26%	83%
P29001	Vigna radiata var. radiata	26%	81%
P37075	Salmonella typhimurium	36%	100%
P40714	Escherichia coli	47%	100%
P40912	Wickerhamomyces anomalus	24%	96%
P43471	Pediococcus pentosaceus	26%	100%
P49174	Zea mays	26%	89%
P49175	Zea mays	26%	79%
P80065	Daucus carota	26%	80%
P92916	Allium cepa	24%	86%
P93761	Capsicum annuum	25%	82%
P94469	Geobacillus stearothermophilus	27%	100%
Q01IS7	Oryza sativa subsp. indica	25%	88%
Q01IS8	Oryza sativa subsp. indica	25%	90%
Q04937	Lactococcus lactis subsp. lactis	28%	100%
Q05936	Staphylococcus xylosus	30%	100%
Q0E0P0	Oryza sativa subsp. japonica	27%	91%
Q0J360	Oryza sativa subsp. japonica	25%	88%
Q0JDC5	Oryza sativa subsp. japonica	25%	88%
Q0JDC6	Oryza sativa subsp. japonica	25%	90%
Q1PEF8	Arabidopsis thaliana	26%	89%
Q2UXF7	Triticum aestivum	29%	88%
Q39692	Daucus carota	30%	89%
Q39693	Daucus carota	30%	90%
Q43089	Pisum sativum	25%	95%
Q43348	Arabidopsis thaliana	24%	81%
Q43857	Vicia faba	25%	82%
Q43866	Arabidopsis thaliana	26%	90%
Q4QB75	Leishmania major	84%	100%
Q4QB76	Leishmania major	78%	99%
Q56660	Vibrio cholerae	31%	97%
Q56UD0	Oryza sativa subsp. japonica	28%	88%
Q56UD1	Oryza sativa subsp. japonica	24%	97%
Q5FC15	Asparagus officinalis	25%	86%
Q5JJV0	Oryza sativa subsp. japonica	27%	89%
Q67XZ3	Arabidopsis thaliana	28%	89%
Q70AT7	Hordeum vulgare	26%	88%
Q70XE6	Beta vulgaris	27%	87%
Q76HP6	Aspergillus niger	26%	98%
Q84LA1	Triticum aestivum	25%	88%
Q84PN8	Triticum aestivum	25%	88%
Q8W413	Arabidopsis thaliana	28%	89%
Q8W4S6	Arabidopsis thaliana	24%	96%
Q96TU3	Aspergillus awamori	25%	98%
Q9FSV7	Festuca arundinacea	24%	81%
Q9KLT6	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	30%	96%
Q9LIB9	Arabidopsis thaliana	23%	92%
Q9XTP3	Leishmania major	26%	82%