Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S7WXS1_LEIDO

TriTrypDb:

LdCL_230015800 , LDHU3_23.1250

Length:

888

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WXS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXS1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	498	502	PF00656	0.716
CLV_C14_Caspase3-7	599	603	PF00656	0.654
CLV_C14_Caspase3-7	745	749	PF00656	0.777
CLV_NRD_NRD_1	157	159	PF00675	0.629
CLV_NRD_NRD_1	163	165	PF00675	0.650
CLV_NRD_NRD_1	167	169	PF00675	0.633
CLV_NRD_NRD_1	239	241	PF00675	0.812
CLV_NRD_NRD_1	327	329	PF00675	0.690
CLV_NRD_NRD_1	35	37	PF00675	0.516
CLV_NRD_NRD_1	394	396	PF00675	0.488
CLV_NRD_NRD_1	403	405	PF00675	0.379
CLV_NRD_NRD_1	55	57	PF00675	0.450
CLV_NRD_NRD_1	68	70	PF00675	0.489
CLV_NRD_NRD_1	7	9	PF00675	0.494
CLV_NRD_NRD_1	718	720	PF00675	0.712
CLV_NRD_NRD_1	737	739	PF00675	0.485
CLV_NRD_NRD_1	743	745	PF00675	0.638
CLV_PCSK_KEX2_1	157	159	PF00082	0.598
CLV_PCSK_KEX2_1	167	169	PF00082	0.752
CLV_PCSK_KEX2_1	239	241	PF00082	0.730
CLV_PCSK_KEX2_1	34	36	PF00082	0.520
CLV_PCSK_KEX2_1	394	396	PF00082	0.488
CLV_PCSK_KEX2_1	403	405	PF00082	0.283
CLV_PCSK_KEX2_1	479	481	PF00082	0.521
CLV_PCSK_KEX2_1	68	70	PF00082	0.534
CLV_PCSK_KEX2_1	7	9	PF00082	0.494
CLV_PCSK_KEX2_1	718	720	PF00082	0.712
CLV_PCSK_KEX2_1	743	745	PF00082	0.601
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.520
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.521
CLV_PCSK_PC7_1	3	9	PF00082	0.487
CLV_PCSK_SKI1_1	168	172	PF00082	0.759
CLV_PCSK_SKI1_1	320	324	PF00082	0.542
CLV_PCSK_SKI1_1	532	536	PF00082	0.558
CLV_PCSK_SKI1_1	558	562	PF00082	0.481
CLV_PCSK_SKI1_1	607	611	PF00082	0.558
DEG_APCC_DBOX_1	479	487	PF00400	0.454
DEG_COP1_1	668	675	PF00400	0.596
DEG_Nend_Nbox_1	1	3	PF02207	0.453
DEG_SPOP_SBC_1	108	112	PF00917	0.706
DEG_SPOP_SBC_1	382	386	PF00917	0.426
DOC_ANK_TNKS_1	241	248	PF00023	0.754
DOC_CYCLIN_RxL_1	276	287	PF00134	0.480
DOC_CYCLIN_yCln2_LP_2	277	283	PF00134	0.501
DOC_MAPK_gen_1	542	552	PF00069	0.549
DOC_MAPK_gen_1	555	564	PF00069	0.503
DOC_MAPK_gen_1	7	13	PF00069	0.489
DOC_MAPK_MEF2A_6	544	552	PF00069	0.541
DOC_MAPK_MEF2A_6	555	564	PF00069	0.506
DOC_MAPK_MEF2A_6	79	88	PF00069	0.741
DOC_PP4_FxxP_1	681	684	PF00568	0.627
DOC_USP7_MATH_1	108	112	PF00917	0.606
DOC_USP7_MATH_1	297	301	PF00917	0.599
DOC_USP7_MATH_1	614	618	PF00917	0.671
DOC_USP7_MATH_1	648	652	PF00917	0.768
DOC_USP7_MATH_1	796	800	PF00917	0.620
DOC_USP7_MATH_1	846	850	PF00917	0.664
DOC_USP7_UBL2_3	165	169	PF12436	0.646
DOC_USP7_UBL2_3	735	739	PF12436	0.782
DOC_WW_Pin1_4	27	32	PF00397	0.518
DOC_WW_Pin1_4	350	355	PF00397	0.622
DOC_WW_Pin1_4	643	648	PF00397	0.710
DOC_WW_Pin1_4	797	802	PF00397	0.510
LIG_14-3-3_CanoR_1	127	131	PF00244	0.515
LIG_14-3-3_CanoR_1	35	44	PF00244	0.518
LIG_14-3-3_CanoR_1	380	389	PF00244	0.637
LIG_14-3-3_CanoR_1	403	409	PF00244	0.426
LIG_14-3-3_CanoR_1	410	415	PF00244	0.457
LIG_14-3-3_CanoR_1	508	514	PF00244	0.641
LIG_14-3-3_CanoR_1	532	541	PF00244	0.531
LIG_14-3-3_CanoR_1	626	632	PF00244	0.595
LIG_14-3-3_CanoR_1	68	73	PF00244	0.554
LIG_14-3-3_CanoR_1	695	703	PF00244	0.621
LIG_14-3-3_CanoR_1	718	725	PF00244	0.719
LIG_14-3-3_CanoR_1	767	777	PF00244	0.564
LIG_14-3-3_CanoR_1	793	801	PF00244	0.578
LIG_14-3-3_CanoR_1	83	87	PF00244	0.501
LIG_14-3-3_CanoR_1	879	884	PF00244	0.637
LIG_Actin_WH2_2	864	881	PF00022	0.603
LIG_BIR_III_4	501	505	PF00653	0.725
LIG_BIR_III_4	567	571	PF00653	0.622
LIG_BIR_III_4	748	752	PF00653	0.747
LIG_BRCT_BRCA1_1	360	364	PF00533	0.433
LIG_BRCT_BRCA1_1	84	88	PF00533	0.539
LIG_BRCT_BRCA1_1	881	885	PF00533	0.760
LIG_Clathr_ClatBox_1	283	287	PF01394	0.451
LIG_CSL_BTD_1	324	327	PF09270	0.682
LIG_eIF4E_1	142	148	PF01652	0.515
LIG_FHA_1	272	278	PF00498	0.482
LIG_FHA_1	411	417	PF00498	0.380
LIG_FHA_1	444	450	PF00498	0.358
LIG_FHA_1	509	515	PF00498	0.692
LIG_FHA_1	533	539	PF00498	0.533
LIG_FHA_1	611	617	PF00498	0.765
LIG_FHA_1	697	703	PF00498	0.541
LIG_FHA_1	79	85	PF00498	0.741
LIG_FHA_2	200	206	PF00498	0.713
LIG_LIR_Apic_2	129	134	PF02991	0.573
LIG_LIR_Apic_2	668	673	PF02991	0.587
LIG_LIR_Apic_2	678	684	PF02991	0.446
LIG_LIR_Gen_1	118	128	PF02991	0.543
LIG_LIR_Gen_1	71	82	PF02991	0.636
LIG_LIR_Nem_3	118	124	PF02991	0.551
LIG_LIR_Nem_3	129	133	PF02991	0.560
LIG_LIR_Nem_3	425	431	PF02991	0.478
LIG_LIR_Nem_3	656	661	PF02991	0.368
LIG_LIR_Nem_3	89	95	PF02991	0.597
LIG_Pex14_2	88	92	PF04695	0.591
LIG_REV1ctd_RIR_1	362	370	PF16727	0.418
LIG_SH2_CRK	131	135	PF00017	0.612
LIG_SH2_CRK	268	272	PF00017	0.609
LIG_SH2_CRK	406	410	PF00017	0.446
LIG_SH2_CRK	698	702	PF00017	0.450
LIG_SH2_NCK_1	131	135	PF00017	0.612
LIG_SH2_SRC	142	145	PF00017	0.612
LIG_SH2_STAP1	42	46	PF00017	0.487
LIG_SH2_STAP1	698	702	PF00017	0.541
LIG_SH2_STAP1	703	707	PF00017	0.510
LIG_SH2_STAT3	314	317	PF00017	0.470
LIG_SH2_STAT3	423	426	PF00017	0.507
LIG_SH2_STAT3	811	814	PF00017	0.596
LIG_SH2_STAT5	282	285	PF00017	0.455
LIG_SH2_STAT5	290	293	PF00017	0.560
LIG_SH2_STAT5	551	554	PF00017	0.475
LIG_SH2_STAT5	583	586	PF00017	0.577
LIG_SH2_STAT5	665	668	PF00017	0.504
LIG_SH2_STAT5	670	673	PF00017	0.447
LIG_SH2_STAT5	698	701	PF00017	0.531
LIG_SH3_1	102	108	PF00018	0.616
LIG_SH3_3	102	108	PF00018	0.604
LIG_SH3_3	130	136	PF00018	0.653
LIG_SH3_3	211	217	PF00018	0.644
LIG_SH3_3	23	29	PF00018	0.529
LIG_SH3_3	342	348	PF00018	0.791
LIG_SH3_3	490	496	PF00018	0.605
LIG_SH3_3	661	667	PF00018	0.453
LIG_SH3_3	681	687	PF00018	0.535
LIG_SH3_3	881	887	PF00018	0.759
LIG_SUMO_SIM_par_1	273	278	PF11976	0.502
LIG_SUMO_SIM_par_1	450	456	PF11976	0.511
LIG_SUMO_SIM_par_1	490	498	PF11976	0.506
LIG_SUMO_SIM_par_1	613	619	PF11976	0.667
LIG_SUMO_SIM_par_1	821	827	PF11976	0.516
LIG_TRAF2_1	231	234	PF00917	0.764
LIG_TRAF2_2	345	350	PF00917	0.535
LIG_TYR_ITIM	696	701	PF00017	0.516
LIG_UBA3_1	449	457	PF00899	0.380
LIG_UBA3_1	559	563	PF00899	0.464
LIG_WW_3	325	329	PF00397	0.693
MOD_CDK_SPK_2	797	802	PF00069	0.610
MOD_CDK_SPxxK_3	27	34	PF00069	0.508
MOD_CK1_1	15	21	PF00069	0.509
MOD_CK1_1	299	305	PF00069	0.491
MOD_CK1_1	399	405	PF00069	0.411
MOD_CK1_1	453	459	PF00069	0.423
MOD_CK1_1	512	518	PF00069	0.582
MOD_CK1_1	643	649	PF00069	0.765
MOD_CK1_1	737	743	PF00069	0.711
MOD_CK1_1	768	774	PF00069	0.458
MOD_CK2_1	199	205	PF00069	0.626
MOD_CK2_1	228	234	PF00069	0.762
MOD_CK2_1	459	465	PF00069	0.411
MOD_CK2_1	491	497	PF00069	0.502
MOD_CK2_1	533	539	PF00069	0.577
MOD_CK2_1	777	783	PF00069	0.709
MOD_Cter_Amidation	165	168	PF01082	0.495
MOD_Cter_Amidation	392	395	PF01082	0.439
MOD_GlcNHglycan	214	217	PF01048	0.759
MOD_GlcNHglycan	247	250	PF01048	0.763
MOD_GlcNHglycan	497	500	PF01048	0.761
MOD_GlcNHglycan	535	538	PF01048	0.574
MOD_GlcNHglycan	597	601	PF01048	0.705
MOD_GlcNHglycan	650	653	PF01048	0.717
MOD_GlcNHglycan	691	694	PF01048	0.457
MOD_GlcNHglycan	720	723	PF01048	0.599
MOD_GlcNHglycan	739	742	PF01048	0.519
MOD_GlcNHglycan	770	773	PF01048	0.775
MOD_GlcNHglycan	826	829	PF01048	0.576
MOD_GlcNHglycan	835	838	PF01048	0.571
MOD_GlcNHglycan	848	851	PF01048	0.670
MOD_GlcNHglycan	881	884	PF01048	0.559
MOD_GSK3_1	103	110	PF00069	0.599
MOD_GSK3_1	271	278	PF00069	0.529
MOD_GSK3_1	293	300	PF00069	0.552
MOD_GSK3_1	36	43	PF00069	0.502
MOD_GSK3_1	491	498	PF00069	0.508
MOD_GSK3_1	508	515	PF00069	0.653
MOD_GSK3_1	528	535	PF00069	0.475
MOD_GSK3_1	610	617	PF00069	0.605
MOD_GSK3_1	634	641	PF00069	0.735
MOD_GSK3_1	671	678	PF00069	0.510
MOD_GSK3_1	773	780	PF00069	0.738
MOD_GSK3_1	78	85	PF00069	0.545
MOD_GSK3_1	797	804	PF00069	0.532
MOD_LATS_1	506	512	PF00433	0.534
MOD_N-GLC_1	382	387	PF02516	0.424
MOD_N-GLC_1	40	45	PF02516	0.494
MOD_NEK2_1	109	114	PF00069	0.697
MOD_NEK2_1	12	17	PF00069	0.470
MOD_NEK2_1	275	280	PF00069	0.488
MOD_NEK2_1	629	634	PF00069	0.790
MOD_NEK2_1	702	707	PF00069	0.630
MOD_NEK2_1	734	739	PF00069	0.716
MOD_NEK2_1	78	83	PF00069	0.746
MOD_NEK2_1	794	799	PF00069	0.521
MOD_NEK2_1	833	838	PF00069	0.452
MOD_NEK2_1	841	846	PF00069	0.493
MOD_NEK2_2	360	365	PF00069	0.431
MOD_NEK2_2	427	432	PF00069	0.380
MOD_OFUCOSY	10	16	PF10250	0.508
MOD_PIKK_1	225	231	PF00454	0.607
MOD_PIKK_1	313	319	PF00454	0.434
MOD_PIKK_1	422	428	PF00454	0.511
MOD_PIKK_1	638	644	PF00454	0.649
MOD_PIKK_1	659	665	PF00454	0.449
MOD_PIKK_1	801	807	PF00454	0.620
MOD_PIKK_1	841	847	PF00454	0.509
MOD_PIKK_1	86	92	PF00454	0.591
MOD_PK_1	68	74	PF00069	0.494
MOD_PKA_1	544	550	PF00069	0.418
MOD_PKA_1	68	74	PF00069	0.538
MOD_PKA_1	718	724	PF00069	0.628
MOD_PKA_2	126	132	PF00069	0.627
MOD_PKA_2	68	74	PF00069	0.558
MOD_PKA_2	718	724	PF00069	0.626
MOD_PKA_2	726	732	PF00069	0.635
MOD_PKA_2	737	743	PF00069	0.676
MOD_PKA_2	82	88	PF00069	0.508
MOD_Plk_1	233	239	PF00069	0.727
MOD_Plk_1	40	46	PF00069	0.492
MOD_Plk_1	634	640	PF00069	0.666
MOD_Plk_2-3	726	732	PF00069	0.691
MOD_Plk_2-3	853	859	PF00069	0.734
MOD_Plk_4	126	132	PF00069	0.589
MOD_Plk_4	360	366	PF00069	0.514
MOD_Plk_4	466	472	PF00069	0.604
MOD_Plk_4	509	515	PF00069	0.692
MOD_Plk_4	666	672	PF00069	0.479
MOD_Plk_4	702	708	PF00069	0.532
MOD_Plk_4	73	79	PF00069	0.570
MOD_Plk_4	82	88	PF00069	0.535
MOD_ProDKin_1	27	33	PF00069	0.514
MOD_ProDKin_1	350	356	PF00069	0.619
MOD_ProDKin_1	643	649	PF00069	0.708
MOD_ProDKin_1	797	803	PF00069	0.514
MOD_SUMO_rev_2	730	737	PF00179	0.545
TRG_DiLeu_BaEn_1	876	881	PF01217	0.721
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.513
TRG_DiLeu_LyEn_5	876	881	PF01217	0.678
TRG_ENDOCYTIC_2	551	554	PF00928	0.575
TRG_ENDOCYTIC_2	698	701	PF00928	0.459
TRG_ENDOCYTIC_2	703	706	PF00928	0.468
TRG_ENDOCYTIC_2	74	77	PF00928	0.578
TRG_ER_diArg_1	238	240	PF00400	0.738
TRG_ER_diArg_1	242	245	PF00400	0.688
TRG_ER_diArg_1	35	37	PF00400	0.516
TRG_ER_diArg_1	403	405	PF00400	0.318
TRG_ER_diArg_1	6	8	PF00400	0.490
TRG_ER_diArg_1	67	69	PF00400	0.540
TRG_ER_diArg_1	717	719	PF00400	0.692
TRG_NLS_MonoExtC_3	163	168	PF00514	0.536
TRG_NLS_MonoExtN_4	31	38	PF00514	0.507
TRG_NLS_MonoExtN_4	326	332	PF00514	0.538
TRG_Pf-PMV_PEXEL_1	807	812	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6S9	Leptomonas seymouri	35%	100%
A4HCU0	Leishmania braziliensis	61%	99%
A4I0C6	Leishmania infantum	98%	100%
E9AW90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QB88	Leishmania major	82%	100%