Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WXR6_LEIDO

TriTrypDb:

LdBPK_231150.1 , LdCL_230018800 , LDHU3_23.1520

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WXR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXR6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	156	158	PF00675	0.613
CLV_NRD_NRD_1	175	177	PF00675	0.504
CLV_NRD_NRD_1	199	201	PF00675	0.478
CLV_PCSK_KEX2_1	175	177	PF00082	0.581
CLV_PCSK_KEX2_1	198	200	PF00082	0.528
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.528
CLV_PCSK_PC7_1	171	177	PF00082	0.530
CLV_PCSK_SKI1_1	144	148	PF00082	0.560
CLV_PCSK_SKI1_1	151	155	PF00082	0.555
CLV_PCSK_SKI1_1	195	199	PF00082	0.554
CLV_PCSK_SKI1_1	200	204	PF00082	0.568
CLV_PCSK_SKI1_1	30	34	PF00082	0.529
DEG_SCF_FBW7_1	253	260	PF00400	0.613
DOC_CYCLIN_RxL_1	25	35	PF00134	0.501
DOC_MAPK_gen_1	267	275	PF00069	0.634
DOC_MAPK_gen_1	30	39	PF00069	0.530
DOC_USP7_MATH_1	105	109	PF00917	0.498
DOC_USP7_MATH_1	202	206	PF00917	0.450
DOC_USP7_MATH_1	257	261	PF00917	0.629
DOC_USP7_MATH_1	8	12	PF00917	0.683
DOC_USP7_UBL2_3	154	158	PF12436	0.539
DOC_USP7_UBL2_3	191	195	PF12436	0.610
DOC_USP7_UBL2_3	291	295	PF12436	0.687
DOC_WW_Pin1_4	253	258	PF00397	0.613
DOC_WW_Pin1_4	294	299	PF00397	0.689
DOC_WW_Pin1_4	50	55	PF00397	0.509
LIG_14-3-3_CanoR_1	137	141	PF00244	0.507
LIG_14-3-3_CanoR_1	144	153	PF00244	0.538
LIG_14-3-3_CanoR_1	157	161	PF00244	0.586
LIG_14-3-3_CanoR_1	16	26	PF00244	0.588
LIG_14-3-3_CanoR_1	178	187	PF00244	0.497
LIG_Actin_WH2_2	138	156	PF00022	0.505
LIG_Actin_WH2_2	43	60	PF00022	0.494
LIG_BRCT_BRCA1_1	224	228	PF00533	0.543
LIG_FHA_1	137	143	PF00498	0.504
LIG_FHA_1	230	236	PF00498	0.547
LIG_FHA_1	248	254	PF00498	0.440
LIG_FHA_1	27	33	PF00498	0.473
LIG_FHA_1	298	304	PF00498	0.730
LIG_FHA_1	47	53	PF00498	0.519
LIG_FHA_2	112	118	PF00498	0.529
LIG_FHA_2	207	213	PF00498	0.507
LIG_FHA_2	247	253	PF00498	0.517
LIG_LIR_Gen_1	212	222	PF02991	0.488
LIG_LIR_Gen_1	280	288	PF02991	0.680
LIG_LIR_Gen_1	35	44	PF02991	0.561
LIG_LIR_Gen_1	62	71	PF02991	0.578
LIG_LIR_Nem_3	106	112	PF02991	0.685
LIG_LIR_Nem_3	212	217	PF02991	0.544
LIG_LIR_Nem_3	35	39	PF02991	0.502
LIG_LIR_Nem_3	62	67	PF02991	0.577
LIG_SH2_CRK	36	40	PF00017	0.534
LIG_SH2_CRK	64	68	PF00017	0.486
LIG_SH2_GRB2like	218	221	PF00017	0.436
LIG_SH2_GRB2like	64	67	PF00017	0.582
LIG_SH2_SRC	218	221	PF00017	0.537
LIG_SH2_STAP1	193	197	PF00017	0.551
LIG_SH2_STAP1	218	222	PF00017	0.461
LIG_SUMO_SIM_par_1	138	143	PF11976	0.498
LIG_SUMO_SIM_par_1	249	256	PF11976	0.603
LIG_TYR_ITIM	34	39	PF00017	0.564
LIG_TYR_ITSM	60	67	PF00017	0.573
LIG_WRC_WIRS_1	112	117	PF05994	0.569
MOD_CK1_1	179	185	PF00069	0.512
MOD_CK1_1	189	195	PF00069	0.474
MOD_CK1_1	230	236	PF00069	0.524
MOD_CK1_1	294	300	PF00069	0.751
MOD_CK2_1	111	117	PF00069	0.525
MOD_CK2_1	171	177	PF00069	0.632
MOD_CK2_1	206	212	PF00069	0.508
MOD_Cter_Amidation	155	158	PF01082	0.561
MOD_GlcNHglycan	177	181	PF01048	0.519
MOD_GlcNHglycan	6	9	PF01048	0.783
MOD_GlcNHglycan	75	78	PF01048	0.739
MOD_GSK3_1	185	192	PF00069	0.514
MOD_GSK3_1	202	209	PF00069	0.581
MOD_GSK3_1	247	254	PF00069	0.527
MOD_GSK3_1	257	264	PF00069	0.636
MOD_GSK3_1	293	300	PF00069	0.707
MOD_GSK3_1	4	11	PF00069	0.696
MOD_GSK3_1	42	49	PF00069	0.532
MOD_N-GLC_2	66	68	PF02516	0.534
MOD_NEK2_1	187	192	PF00069	0.614
MOD_NEK2_1	228	233	PF00069	0.508
MOD_NEK2_1	32	37	PF00069	0.526
MOD_NEK2_2	156	161	PF00069	0.523
MOD_NEK2_2	202	207	PF00069	0.442
MOD_NMyristoyl	1	7	PF02799	0.747
MOD_PIKK_1	179	185	PF00454	0.499
MOD_PIKK_1	222	228	PF00454	0.480
MOD_PKA_2	136	142	PF00069	0.484
MOD_PKA_2	156	162	PF00069	0.577
MOD_PKA_2	164	170	PF00069	0.513
MOD_PKB_1	263	271	PF00069	0.578
MOD_Plk_1	105	111	PF00069	0.581
MOD_Plk_1	176	182	PF00069	0.469
MOD_Plk_2-3	136	142	PF00069	0.506
MOD_Plk_4	202	208	PF00069	0.539
MOD_Plk_4	32	38	PF00069	0.550
MOD_ProDKin_1	253	259	PF00069	0.610
MOD_ProDKin_1	294	300	PF00069	0.687
MOD_ProDKin_1	50	56	PF00069	0.514
MOD_SUMO_rev_2	117	124	PF00179	0.551
TRG_ENDOCYTIC_2	109	112	PF00928	0.556
TRG_ENDOCYTIC_2	218	221	PF00928	0.469
TRG_ENDOCYTIC_2	244	247	PF00928	0.490
TRG_ENDOCYTIC_2	36	39	PF00928	0.524
TRG_ENDOCYTIC_2	64	67	PF00928	0.514
TRG_ER_diArg_1	262	265	PF00400	0.611
TRG_ER_diArg_1	266	269	PF00400	0.621
TRG_ER_diArg_1	97	100	PF00400	0.718
TRG_NES_CRM1_1	136	150	PF08389	0.507
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6C0	Leptomonas seymouri	36%	96%
A4HCW7	Leishmania braziliensis	57%	99%
A4I0E7	Leishmania infantum	100%	100%
E9AWB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QB65	Leishmania major	89%	100%