Na/H antiporter-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Na/H antiporter-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WXR0_LEIDO

TriTrypDb:

LdBPK_231000.1 , LdCL_230016600 , LDHU3_23.1350

Length:

1500

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

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Expansion

Sequence features

A0A3S7WXR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006811	monoatomic ion transport	4	7
GO:0006812	monoatomic cation transport	5	7
GO:0006813	potassium ion transport	7	1
GO:0006814	sodium ion transport	7	7
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006885	regulation of pH	8	1
GO:0009987	cellular process	1	1
GO:0019725	cellular homeostasis	2	1
GO:0030001	metal ion transport	6	7

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	7
GO:0005451	obsolete monoatomic cation:proton antiporter activity	5	7
GO:0008324	monoatomic cation transmembrane transporter activity	4	7
GO:0015075	monoatomic ion transmembrane transporter activity	3	7
GO:0015078	proton transmembrane transporter activity	5	7
GO:0015079	potassium ion transmembrane transporter activity	6	1
GO:0015081	sodium ion transmembrane transporter activity	6	1
GO:0015291	secondary active transmembrane transporter activity	4	7
GO:0015297	antiporter activity	5	7
GO:0015298	obsolete solute:monoatomic cation antiporter activity	5	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1271	1275	PF00656	0.644
CLV_C14_Caspase3-7	890	894	PF00656	0.606
CLV_C14_Caspase3-7	996	1000	PF00656	0.632
CLV_MEL_PAP_1	1078	1084	PF00089	0.348
CLV_MEL_PAP_1	572	578	PF00089	0.456
CLV_NRD_NRD_1	1125	1127	PF00675	0.454
CLV_NRD_NRD_1	116	118	PF00675	0.395
CLV_NRD_NRD_1	1424	1426	PF00675	0.375
CLV_NRD_NRD_1	1447	1449	PF00675	0.352
CLV_NRD_NRD_1	1457	1459	PF00675	0.349

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYG3	Leptomonas seymouri	61%	94%
A4HCV3	Leishmania braziliensis	75%	97%
A4I0D4	Leishmania infantum	99%	100%
E9AW98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QB80	Leishmania major	94%	100%

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