Sucrose-6-phosphate hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sucrose hydrolase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WXQ4_LEIDO

TriTrypDb:

LdBPK_272290.1 , LdCL_230017800 , LDHU3_23.1430

Length:

513

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A0A3S7WXQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXQ4

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	20
GO:0008152	metabolic process	1	20
GO:0044238	primary metabolic process	2	20
GO:0071704	organic substance metabolic process	2	20

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	20
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	20
GO:0004564	beta-fructofuranosidase activity	5	18
GO:0016787	hydrolase activity	2	20
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.260
CLV_NRD_NRD_1	314	316	PF00675	0.315
CLV_PCSK_KEX2_1	314	316	PF00082	0.315
CLV_PCSK_KEX2_1	426	428	PF00082	0.319
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.319
CLV_PCSK_SKI1_1	100	104	PF00082	0.244
CLV_PCSK_SKI1_1	197	201	PF00082	0.348
CLV_PCSK_SKI1_1	231	235	PF00082	0.349
CLV_PCSK_SKI1_1	251	255	PF00082	0.191
CLV_PCSK_SKI1_1	314	318	PF00082	0.279
CLV_PCSK_SKI1_1	427	431	PF00082	0.338
DEG_COP1_1	367	376	PF00400	0.335
DOC_CDC14_PxL_1	370	378	PF14671	0.228
DOC_CKS1_1	279	284	PF01111	0.202
DOC_CKS1_1	365	370	PF01111	0.386
DOC_MAPK_MEF2A_6	247	254	PF00069	0.299
DOC_MAPK_MEF2A_6	461	468	PF00069	0.284
DOC_MAPK_NFAT4_5	247	255	PF00069	0.239
DOC_PP1_RVXF_1	249	256	PF00149	0.254
DOC_PP2B_LxvP_1	339	342	PF13499	0.332
DOC_PP4_FxxP_1	178	181	PF00568	0.322
DOC_USP7_MATH_1	139	143	PF00917	0.262
DOC_USP7_MATH_1	154	158	PF00917	0.384
DOC_WW_Pin1_4	137	142	PF00397	0.228
DOC_WW_Pin1_4	278	283	PF00397	0.234
DOC_WW_Pin1_4	323	328	PF00397	0.381
DOC_WW_Pin1_4	364	369	PF00397	0.380
LIG_14-3-3_CanoR_1	489	494	PF00244	0.398
LIG_APCC_ABBA_1	455	460	PF00400	0.284
LIG_BIR_II_1	1	5	PF00653	0.674
LIG_BRCT_BRCA1_1	476	480	PF00533	0.338
LIG_deltaCOP1_diTrp_1	79	85	PF00928	0.289
LIG_DLG_GKlike_1	343	351	PF00625	0.239
LIG_FHA_1	116	122	PF00498	0.228
LIG_FHA_1	198	204	PF00498	0.374
LIG_FHA_1	209	215	PF00498	0.285
LIG_FHA_1	349	355	PF00498	0.302
LIG_FHA_1	373	379	PF00498	0.269
LIG_FHA_1	447	453	PF00498	0.249
LIG_FHA_1	56	62	PF00498	0.234
LIG_FHA_2	15	21	PF00498	0.369
LIG_FHA_2	389	395	PF00498	0.302
LIG_FHA_2	87	93	PF00498	0.307
LIG_KLC1_Yacidic_2	418	422	PF13176	0.427
LIG_LIR_Gen_1	219	227	PF02991	0.322
LIG_LIR_Gen_1	65	75	PF02991	0.243
LIG_LIR_Nem_3	124	130	PF02991	0.282
LIG_LIR_Nem_3	187	193	PF02991	0.349
LIG_LIR_Nem_3	219	225	PF02991	0.322
LIG_LIR_Nem_3	240	244	PF02991	0.265
LIG_LIR_Nem_3	291	295	PF02991	0.330
LIG_LIR_Nem_3	40	45	PF02991	0.337
LIG_LIR_Nem_3	65	70	PF02991	0.259
LIG_NRBOX	202	208	PF00104	0.348
LIG_Pex14_1	41	45	PF04695	0.367
LIG_PTB_Apo_2	428	435	PF02174	0.319
LIG_PTB_Phospho_1	428	434	PF10480	0.319
LIG_SH2_NCK_1	347	351	PF00017	0.254
LIG_SH2_SRC	420	423	PF00017	0.438
LIG_SH2_SRC	71	74	PF00017	0.231
LIG_SH2_STAP1	393	397	PF00017	0.328
LIG_SH2_STAP1	76	80	PF00017	0.244
LIG_SH2_STAT3	302	305	PF00017	0.330
LIG_SH2_STAT5	127	130	PF00017	0.322
LIG_SH2_STAT5	175	178	PF00017	0.346
LIG_SH2_STAT5	241	244	PF00017	0.262
LIG_SH2_STAT5	275	278	PF00017	0.348
LIG_SH2_STAT5	420	423	PF00017	0.466
LIG_SH3_2	282	287	PF14604	0.202
LIG_SH3_3	138	144	PF00018	0.244
LIG_SH3_3	165	171	PF00018	0.322
LIG_SH3_3	279	285	PF00018	0.327
LIG_SUMO_SIM_par_1	374	379	PF11976	0.274
LIG_TRFH_1	45	49	PF08558	0.223
LIG_WW_1	172	175	PF00397	0.348
MOD_CK1_1	263	269	PF00069	0.201
MOD_CK2_1	14	20	PF00069	0.464
MOD_CK2_1	343	349	PF00069	0.239
MOD_CK2_1	388	394	PF00069	0.316
MOD_CK2_1	401	407	PF00069	0.319
MOD_CK2_1	412	418	PF00069	0.319
MOD_CK2_1	459	465	PF00069	0.319
MOD_Cter_Amidation	258	261	PF01082	0.254
MOD_GlcNHglycan	115	118	PF01048	0.311
MOD_GlcNHglycan	335	338	PF01048	0.368
MOD_GlcNHglycan	414	417	PF01048	0.359
MOD_GlcNHglycan	439	442	PF01048	0.324
MOD_GlcNHglycan	76	79	PF01048	0.466
MOD_GSK3_1	323	330	PF00069	0.326
MOD_GSK3_1	33	40	PF00069	0.356
MOD_GSK3_1	333	340	PF00069	0.330
MOD_GSK3_1	437	444	PF00069	0.319
MOD_GSK3_1	489	496	PF00069	0.300
MOD_N-GLC_1	37	42	PF02516	0.334
MOD_N-GLC_1	379	384	PF02516	0.254
MOD_N-GLC_1	388	393	PF02516	0.224
MOD_N-GLC_1	493	498	PF02516	0.380
MOD_NEK2_1	115	120	PF00069	0.322
MOD_NEK2_1	401	406	PF00069	0.349
MOD_NEK2_1	507	512	PF00069	0.478
MOD_PK_1	489	495	PF00069	0.292
MOD_PKA_1	260	266	PF00069	0.254
MOD_PKA_2	14	20	PF00069	0.548
MOD_PKA_2	460	466	PF00069	0.297
MOD_Plk_1	263	269	PF00069	0.408
MOD_Plk_1	343	349	PF00069	0.239
MOD_Plk_1	37	43	PF00069	0.334
MOD_Plk_1	388	394	PF00069	0.345
MOD_Plk_1	459	465	PF00069	0.319
MOD_Plk_1	471	477	PF00069	0.319
MOD_Plk_2-3	460	466	PF00069	0.319
MOD_Plk_4	303	309	PF00069	0.406
MOD_Plk_4	37	43	PF00069	0.268
MOD_Plk_4	372	378	PF00069	0.289
MOD_Plk_4	500	506	PF00069	0.393
MOD_ProDKin_1	137	143	PF00069	0.228
MOD_ProDKin_1	278	284	PF00069	0.234
MOD_ProDKin_1	323	329	PF00069	0.381
MOD_ProDKin_1	364	370	PF00069	0.385
MOD_SUMO_rev_2	246	253	PF00179	0.237
TRG_DiLeu_BaEn_1	248	253	PF01217	0.239
TRG_ENDOCYTIC_2	175	178	PF00928	0.349
TRG_ENDOCYTIC_2	241	244	PF00928	0.439
TRG_ENDOCYTIC_2	67	70	PF00928	0.322
TRG_ER_diArg_1	267	270	PF00400	0.321
TRG_ER_diArg_1	314	316	PF00400	0.315
TRG_NES_CRM1_1	446	460	PF08389	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8F7	Leptomonas seymouri	52%	100%
A0A0N1PBT6	Leptomonas seymouri	27%	80%
A0A1X0NFY9	Trypanosomatidae	27%	100%
A0A1X0NTL0	Trypanosomatidae	25%	81%
A0A1X0NTM3	Trypanosomatidae	26%	81%
A0A1X0NY19	Trypanosomatidae	29%	81%
A0A1X0P322	Trypanosomatidae	25%	81%
A0A1X0P5Y7	Trypanosomatidae	27%	80%
A0A3Q8IB13	Leishmania donovani	66%	93%
A0A3Q8IFU7	Leishmania donovani	86%	100%
A0A3S5H595	Leishmania donovani	27%	80%
A0A3S5H7I4	Leishmania donovani	51%	100%
A0A3S7WXS2	Leishmania donovani	86%	97%
A1STJ9	Psychromonas ingrahamii (strain 37)	33%	94%
A2R0E0	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	25%	96%
A2X5P7	Oryza sativa subsp. indica	28%	89%
A2YZ01	Oryza sativa subsp. indica	24%	86%
A4H3V1	Leishmania braziliensis	28%	80%
A4HCV9	Leishmania braziliensis	64%	100%
A4HCW0	Leishmania braziliensis	83%	100%
A4HG14	Leishmania braziliensis	51%	100%
A4HS26	Leishmania infantum	27%	80%
A4I0D9	Leishmania infantum	66%	100%
A4I0E0	Leishmania infantum	99%	100%
A4I336	Leishmania infantum	51%	100%
A4IAW1	Leishmania infantum	28%	73%
A5ABL2	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	26%	99%
A5DHM6	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	26%	100%
A5EZZ8	Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)	32%	94%
A8W7I5	Meyerozyma guilliermondii	26%	100%
B6DXP5	Leymus chinensis	26%	86%
B6DZC8	Triticum aestivum	25%	86%
B6DZD0	Triticum urartu	26%	86%
B6DZD1	Aegilops speltoides	25%	86%
B6DZD2	Aegilops tauschii	26%	86%
D2IGW7	Bromus pictus	26%	85%
E1ABX2	Aspergillus ficuum	25%	96%
E8NHF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
E8NHF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	99%
E9ACV4	Leishmania major	52%	100%
E9AK13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AWA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AZE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
F8DVG5	Zymomonas mobilis subsp. mobilis (strain ATCC 10988 / DSM 424 / LMG 404 / NCIMB 8938 / NRRL B-806 / ZM1)	43%	100%
H2DF87	Rosa hybrid cultivar	27%	87%
H2DF88	Rosa hybrid cultivar	26%	80%
K0E681	Aspergillus rugulosus	28%	100%
O07003	Bacillus subtilis (strain 168)	27%	99%
O24509	Phaseolus vulgaris	27%	79%
O33833	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	33%	100%
O42878	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
O59852	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	88%
O74641	Aspergillus niger	26%	99%
O74642	Aspergillus niger	26%	99%
O94220	Aspergillus ficuum	26%	99%
P00724	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	96%
P05656	Bacillus subtilis (strain 168)	29%	76%
P07819	Bacillus subtilis (strain 168)	36%	100%
P0DJA7	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	42%	100%
P10594	Saccharomyces cerevisiae	24%	96%
P10596	Saccharomyces cerevisiae	23%	96%
P13394	Vibrio alginolyticus	31%	100%
P13522	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	30%	100%
P16553	Escherichia coli	49%	100%
P24133	Schwanniomyces occidentalis	24%	96%
P26792	Daucus carota	24%	87%
P27217	Klebsiella pneumoniae	36%	100%
P28999	Kluyveromyces marxianus	24%	92%
P29000	Solanum lycopersicum	26%	81%
P29001	Vigna radiata var. radiata	26%	79%
P37075	Salmonella typhimurium	36%	100%
P40714	Escherichia coli	49%	100%
P40912	Wickerhamomyces anomalus	25%	93%
P43471	Pediococcus pentosaceus	28%	100%
P49174	Zea mays	27%	87%
P49175	Zea mays	26%	77%
P80065	Daucus carota	26%	78%
P92916	Allium cepa	25%	84%
P93761	Capsicum annuum	26%	80%
P94469	Geobacillus stearothermophilus	27%	100%
Q01IS7	Oryza sativa subsp. indica	26%	86%
Q01IS8	Oryza sativa subsp. indica	24%	88%
Q04937	Lactococcus lactis subsp. lactis	29%	100%
Q05936	Staphylococcus xylosus	31%	100%
Q0E0P0	Oryza sativa subsp. japonica	28%	89%
Q0J360	Oryza sativa subsp. japonica	24%	86%
Q0JDC5	Oryza sativa subsp. japonica	26%	86%
Q0JDC6	Oryza sativa subsp. japonica	24%	88%
Q1PEF8	Arabidopsis thaliana	26%	87%
Q2UXF7	Triticum aestivum	29%	86%
Q39041	Arabidopsis thaliana	24%	77%
Q39692	Daucus carota	28%	87%
Q39693	Daucus carota	29%	88%
Q43089	Pisum sativum	26%	92%
Q43348	Arabidopsis thaliana	24%	79%
Q43857	Vicia faba	24%	80%
Q43866	Arabidopsis thaliana	26%	88%
Q4QB75	Leishmania major	96%	100%
Q4QB76	Leishmania major	66%	100%
Q56660	Vibrio cholerae	32%	94%
Q56UD0	Oryza sativa subsp. japonica	26%	86%
Q56UD1	Oryza sativa subsp. japonica	23%	95%
Q5FC15	Asparagus officinalis	25%	84%
Q5JJV0	Oryza sativa subsp. japonica	27%	87%
Q67XZ3	Arabidopsis thaliana	27%	86%
Q6BJW6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	24%	96%
Q70AT7	Hordeum vulgare	26%	86%
Q70XE6	Beta vulgaris	27%	85%
Q76HP6	Aspergillus niger	25%	96%
Q84LA1	Triticum aestivum	26%	86%
Q84PN8	Triticum aestivum	26%	86%
Q8W413	Arabidopsis thaliana	28%	87%
Q8W4S6	Arabidopsis thaliana	24%	93%
Q96TU3	Aspergillus awamori	24%	96%
Q9FSV7	Festuca arundinacea	25%	78%
Q9KLT6	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	32%	94%
Q9LIB9	Arabidopsis thaliana	23%	90%
Q9XTP3	Leishmania major	27%	80%