Oxidoreductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxidoreductase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WXP2_LEIDO

TriTrypDb:

LdBPK_230620.1 , LdCL_230011700 , LDHU3_23.0860

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WXP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXP2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	21
GO:0005488	binding	1	21
GO:0036094	small molecule binding	2	21
GO:0097159	organic cyclic compound binding	2	21
GO:1901265	nucleoside phosphate binding	3	21
GO:1901363	heterocyclic compound binding	2	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	368	372	PF00656	0.504
CLV_C14_Caspase3-7	409	413	PF00656	0.547
CLV_NRD_NRD_1	1	3	PF00675	0.597
CLV_NRD_NRD_1	265	267	PF00675	0.547
CLV_PCSK_KEX2_1	265	267	PF00082	0.547
CLV_PCSK_KEX2_1	269	271	PF00082	0.527
CLV_PCSK_KEX2_1	99	101	PF00082	0.401
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.480
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.401
CLV_PCSK_PC7_1	265	271	PF00082	0.477
CLV_PCSK_SKI1_1	138	142	PF00082	0.371
CLV_PCSK_SKI1_1	207	211	PF00082	0.325
CLV_PCSK_SKI1_1	347	351	PF00082	0.407
CLV_Separin_Metazoa	4	8	PF03568	0.365
DEG_APCC_DBOX_1	206	214	PF00400	0.337
DEG_Nend_UBRbox_1	1	4	PF02207	0.598
DEG_SPOP_SBC_1	289	293	PF00917	0.644
DEG_SPOP_SBC_1	389	393	PF00917	0.424
DEG_SPOP_SBC_1	457	461	PF00917	0.706
DOC_CYCLIN_yClb1_LxF_4	136	141	PF00134	0.301
DOC_CYCLIN_yCln2_LP_2	163	169	PF00134	0.465
DOC_CYCLIN_yCln2_LP_2	191	197	PF00134	0.259
DOC_MAPK_gen_1	2	10	PF00069	0.311
DOC_MAPK_gen_1	99	106	PF00069	0.401
DOC_MAPK_MEF2A_6	2	10	PF00069	0.311
DOC_MAPK_MEF2A_6	250	259	PF00069	0.482
DOC_PP1_RVXF_1	136	142	PF00149	0.404
DOC_PP1_RVXF_1	5	11	PF00149	0.369
DOC_PP4_FxxP_1	215	218	PF00568	0.372
DOC_PP4_FxxP_1	285	288	PF00568	0.512
DOC_PP4_FxxP_1	71	74	PF00568	0.401
DOC_USP7_MATH_1	120	124	PF00917	0.285
DOC_USP7_MATH_1	171	175	PF00917	0.409
DOC_USP7_MATH_1	290	294	PF00917	0.646
DOC_USP7_MATH_1	364	368	PF00917	0.540
DOC_USP7_MATH_1	72	76	PF00917	0.300
DOC_WW_Pin1_4	175	180	PF00397	0.553
DOC_WW_Pin1_4	390	395	PF00397	0.473
LIG_14-3-3_CanoR_1	224	232	PF00244	0.558
LIG_14-3-3_CanoR_1	347	355	PF00244	0.444
LIG_BRCT_BRCA1_1	177	181	PF00533	0.411
LIG_Clathr_ClatBox_1	139	143	PF01394	0.345
LIG_deltaCOP1_diTrp_1	200	208	PF00928	0.328
LIG_FHA_1	178	184	PF00498	0.537
LIG_FHA_1	320	326	PF00498	0.434
LIG_FHA_1	329	335	PF00498	0.398
LIG_FHA_1	438	444	PF00498	0.356
LIG_FHA_2	224	230	PF00498	0.475
LIG_FHA_2	275	281	PF00498	0.468
LIG_FHA_2	289	295	PF00498	0.625
LIG_FHA_2	339	345	PF00498	0.531
LIG_FHA_2	391	397	PF00498	0.506
LIG_LIR_Apic_2	214	218	PF02991	0.415
LIG_LIR_Apic_2	282	288	PF02991	0.500
LIG_LIR_Gen_1	434	444	PF02991	0.365
LIG_LIR_Gen_1	78	85	PF02991	0.323
LIG_LIR_Gen_1	89	96	PF02991	0.303
LIG_LIR_Nem_3	193	198	PF02991	0.356
LIG_LIR_Nem_3	200	206	PF02991	0.339
LIG_LIR_Nem_3	373	379	PF02991	0.522
LIG_LIR_Nem_3	404	410	PF02991	0.417
LIG_LIR_Nem_3	434	439	PF02991	0.446
LIG_LIR_Nem_3	78	82	PF02991	0.323
LIG_LIR_Nem_3	89	95	PF02991	0.303
LIG_MYND_1	190	194	PF01753	0.407
LIG_Pex14_2	311	315	PF04695	0.422
LIG_SH2_CRK	195	199	PF00017	0.231
LIG_SH2_PTP2	92	95	PF00017	0.313
LIG_SH2_STAT3	438	441	PF00017	0.310
LIG_SH2_STAT5	204	207	PF00017	0.304
LIG_SH2_STAT5	438	441	PF00017	0.458
LIG_SH2_STAT5	92	95	PF00017	0.313
LIG_SH3_1	265	271	PF00018	0.489
LIG_SH3_3	173	179	PF00018	0.340
LIG_SH3_3	265	271	PF00018	0.489
LIG_SUMO_SIM_anti_2	331	336	PF11976	0.285
LIG_SUMO_SIM_anti_2	86	92	PF11976	0.373
LIG_TYR_ITIM	90	95	PF00017	0.315
LIG_UBA3_1	414	419	PF00899	0.328
MOD_CK1_1	75	81	PF00069	0.502
MOD_CK1_1	94	100	PF00069	0.320
MOD_CK2_1	120	126	PF00069	0.365
MOD_CK2_1	274	280	PF00069	0.482
MOD_CK2_1	390	396	PF00069	0.424
MOD_GlcNHglycan	122	125	PF01048	0.363
MOD_GlcNHglycan	247	250	PF01048	0.766
MOD_GlcNHglycan	367	370	PF01048	0.667
MOD_GlcNHglycan	461	464	PF01048	0.659
MOD_GSK3_1	171	178	PF00069	0.449
MOD_GSK3_1	240	247	PF00069	0.674
MOD_GSK3_1	303	310	PF00069	0.459
MOD_GSK3_1	390	397	PF00069	0.513
MOD_GSK3_1	458	465	PF00069	0.645
MOD_GSK3_1	91	98	PF00069	0.420
MOD_N-GLC_1	56	61	PF02516	0.393
MOD_NEK2_1	11	16	PF00069	0.349
MOD_NEK2_1	142	147	PF00069	0.382
MOD_NEK2_1	283	288	PF00069	0.449
MOD_PIKK_1	147	153	PF00454	0.536
MOD_PIKK_1	347	353	PF00454	0.345
MOD_PIKK_1	437	443	PF00454	0.336
MOD_PKA_1	431	437	PF00069	0.460
MOD_PKA_2	223	229	PF00069	0.510
MOD_PKA_2	29	35	PF00069	0.352
MOD_PKB_1	345	353	PF00069	0.355
MOD_Plk_1	283	289	PF00069	0.459
MOD_Plk_1	319	325	PF00069	0.454
MOD_Plk_4	177	183	PF00069	0.489
MOD_Plk_4	255	261	PF00069	0.424
MOD_Plk_4	330	336	PF00069	0.450
MOD_Plk_4	410	416	PF00069	0.426
MOD_Plk_4	75	81	PF00069	0.350
MOD_ProDKin_1	175	181	PF00069	0.546
MOD_ProDKin_1	390	396	PF00069	0.465
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.308
TRG_DiLeu_BaLyEn_6	187	192	PF01217	0.347
TRG_DiLeu_BaLyEn_6	419	424	PF01217	0.534
TRG_ENDOCYTIC_2	195	198	PF00928	0.232
TRG_ENDOCYTIC_2	379	382	PF00928	0.632
TRG_ENDOCYTIC_2	79	82	PF00928	0.323
TRG_ENDOCYTIC_2	92	95	PF00928	0.295
TRG_ER_diArg_1	345	348	PF00400	0.559
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P740	Leptomonas seymouri	63%	100%
A0A0N1I5Z7	Leptomonas seymouri	31%	100%
A0A0N1I7E8	Leptomonas seymouri	33%	100%
A0A1X0NX10	Trypanosomatidae	31%	100%
A0A1X0NX22	Trypanosomatidae	39%	100%
A0A1X0NXP4	Trypanosomatidae	30%	100%
A0A3Q8IM07	Leishmania donovani	30%	80%
A0A3S7WXT7	Leishmania donovani	32%	100%
A4HCS3	Leishmania braziliensis	78%	100%
A4I097	Leishmania infantum	100%	100%
A4I0B8	Leishmania infantum	32%	83%
E9AH12	Leishmania infantum	31%	100%
E9AW61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AW62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AW82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	83%
Q4QBB6	Leishmania major	30%	82%
Q4QBB7	Leishmania major	93%	100%
Q9U0V7	Leishmania major	32%	83%
V5BH08	Trypanosoma cruzi	36%	100%