50S ribosome-binding GTPase/Dynamin family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosome-binding GTPase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WXN4_LEIDO

TriTrypDb:

LdBPK_230910.1 , LdCL_230015700 , LDHU3_23.1240

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WXN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXN4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0005488	binding	1	10
GO:0005525	GTP binding	5	10
GO:0017076	purine nucleotide binding	4	10
GO:0019001	guanyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032561	guanyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	326	330	PF00656	0.584
CLV_C14_Caspase3-7	540	544	PF00656	0.791
CLV_C14_Caspase3-7	601	605	PF00656	0.405
CLV_C14_Caspase3-7	73	77	PF00656	0.505
CLV_MEL_PAP_1	126	132	PF00089	0.435
CLV_NRD_NRD_1	212	214	PF00675	0.645
CLV_NRD_NRD_1	258	260	PF00675	0.532
CLV_NRD_NRD_1	309	311	PF00675	0.557
CLV_NRD_NRD_1	312	314	PF00675	0.580
CLV_NRD_NRD_1	511	513	PF00675	0.651
CLV_NRD_NRD_1	79	81	PF00675	0.653
CLV_PCSK_KEX2_1	212	214	PF00082	0.563
CLV_PCSK_KEX2_1	309	311	PF00082	0.546
CLV_PCSK_KEX2_1	316	318	PF00082	0.573
CLV_PCSK_KEX2_1	384	386	PF00082	0.765
CLV_PCSK_KEX2_1	511	513	PF00082	0.649
CLV_PCSK_KEX2_1	567	569	PF00082	0.394
CLV_PCSK_KEX2_1	78	80	PF00082	0.619
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.608
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.791
CLV_PCSK_PC1ET2_1	567	569	PF00082	0.389
CLV_PCSK_SKI1_1	14	18	PF00082	0.493
CLV_PCSK_SKI1_1	167	171	PF00082	0.642
CLV_PCSK_SKI1_1	25	29	PF00082	0.405
CLV_PCSK_SKI1_1	296	300	PF00082	0.519
CLV_PCSK_SKI1_1	313	317	PF00082	0.567
CLV_PCSK_SKI1_1	355	359	PF00082	0.520
CLV_PCSK_SKI1_1	37	41	PF00082	0.346
CLV_PCSK_SKI1_1	387	391	PF00082	0.695
CLV_PCSK_SKI1_1	462	466	PF00082	0.253
CLV_PCSK_SKI1_1	564	568	PF00082	0.404
DEG_APCC_DBOX_1	295	303	PF00400	0.512
DEG_SCF_FBW7_1	372	379	PF00400	0.664
DEG_SPOP_SBC_1	191	195	PF00917	0.739
DEG_SPOP_SBC_1	198	202	PF00917	0.586
DEG_SPOP_SBC_1	280	284	PF00917	0.683
DOC_CKS1_1	148	153	PF01111	0.694
DOC_CKS1_1	440	445	PF01111	0.566
DOC_CKS1_1	477	482	PF01111	0.469
DOC_CKS1_1	7	12	PF01111	0.503
DOC_CKS1_1	88	93	PF01111	0.455
DOC_CYCLIN_RxL_1	229	237	PF00134	0.478
DOC_CYCLIN_yClb1_LxF_4	451	457	PF00134	0.499
DOC_MAPK_DCC_7	412	421	PF00069	0.559
DOC_MAPK_DCC_7	47	57	PF00069	0.404
DOC_MAPK_gen_1	109	119	PF00069	0.581
DOC_MAPK_gen_1	511	519	PF00069	0.519
DOC_MAPK_HePTP_8	28	40	PF00069	0.401
DOC_MAPK_MEF2A_6	31	40	PF00069	0.395
DOC_MAPK_MEF2A_6	412	421	PF00069	0.479
DOC_MAPK_RevD_3	63	79	PF00069	0.470
DOC_PP1_RVXF_1	315	322	PF00149	0.560
DOC_PP1_RVXF_1	35	41	PF00149	0.388
DOC_PP2B_LxvP_1	102	105	PF13499	0.676
DOC_PP4_FxxP_1	101	104	PF00568	0.464
DOC_USP7_MATH_1	187	191	PF00917	0.684
DOC_USP7_MATH_1	198	202	PF00917	0.657
DOC_USP7_MATH_1	223	227	PF00917	0.596
DOC_USP7_MATH_1	411	415	PF00917	0.594
DOC_USP7_UBL2_3	390	394	PF12436	0.697
DOC_WW_Pin1_4	1	6	PF00397	0.515
DOC_WW_Pin1_4	100	105	PF00397	0.644
DOC_WW_Pin1_4	147	152	PF00397	0.722
DOC_WW_Pin1_4	194	199	PF00397	0.639
DOC_WW_Pin1_4	372	377	PF00397	0.731
DOC_WW_Pin1_4	439	444	PF00397	0.550
DOC_WW_Pin1_4	476	481	PF00397	0.469
DOC_WW_Pin1_4	520	525	PF00397	0.663
DOC_WW_Pin1_4	64	69	PF00397	0.657
DOC_WW_Pin1_4	660	665	PF00397	0.596
DOC_WW_Pin1_4	87	92	PF00397	0.610
LIG_14-3-3_CanoR_1	112	119	PF00244	0.449
LIG_14-3-3_CanoR_1	164	170	PF00244	0.632
LIG_14-3-3_CanoR_1	212	222	PF00244	0.631
LIG_14-3-3_CanoR_1	31	36	PF00244	0.401
LIG_14-3-3_CanoR_1	317	322	PF00244	0.618
LIG_14-3-3_CanoR_1	355	360	PF00244	0.557
LIG_14-3-3_CanoR_1	412	416	PF00244	0.575
LIG_14-3-3_CanoR_1	424	432	PF00244	0.424
LIG_14-3-3_CanoR_1	512	518	PF00244	0.732
LIG_14-3-3_CanoR_1	624	632	PF00244	0.464
LIG_14-3-3_CanoR_1	66	72	PF00244	0.459
LIG_14-3-3_CanoR_1	78	84	PF00244	0.477
LIG_Actin_WH2_2	151	166	PF00022	0.591
LIG_Actin_WH2_2	433	450	PF00022	0.566
LIG_BIR_II_1	1	5	PF00653	0.513
LIG_BRCT_BRCA1_1	452	456	PF00533	0.488
LIG_BRCT_BRCA1_1	606	610	PF00533	0.356
LIG_Clathr_ClatBox_1	463	467	PF01394	0.539
LIG_eIF4E_1	583	589	PF01652	0.464
LIG_eIF4E_1	617	623	PF01652	0.538
LIG_FHA_1	329	335	PF00498	0.586
LIG_FHA_1	449	455	PF00498	0.473
LIG_FHA_1	477	483	PF00498	0.460
LIG_FHA_1	553	559	PF00498	0.670
LIG_FHA_1	632	638	PF00498	0.407
LIG_FHA_2	324	330	PF00498	0.578
LIG_FHA_2	544	550	PF00498	0.769
LIG_FHA_2	599	605	PF00498	0.375
LIG_FHA_2	71	77	PF00498	0.496
LIG_GBD_Chelix_1	432	440	PF00786	0.350
LIG_GSK3_LRP6_1	87	92	PF00069	0.462
LIG_LIR_Apic_2	590	595	PF02991	0.492
LIG_LIR_Gen_1	582	592	PF02991	0.417
LIG_LIR_Gen_1	663	670	PF02991	0.553
LIG_LIR_Nem_3	301	306	PF02991	0.500
LIG_LIR_Nem_3	33	38	PF02991	0.388
LIG_LIR_Nem_3	442	447	PF02991	0.500
LIG_LIR_Nem_3	453	459	PF02991	0.420
LIG_LIR_Nem_3	582	588	PF02991	0.347
LIG_LIR_Nem_3	663	669	PF02991	0.549
LIG_PCNA_yPIPBox_3	429	441	PF02747	0.474
LIG_PDZ_Class_1	665	670	PF00595	0.612
LIG_RPA_C_Fungi	74	86	PF08784	0.516
LIG_SH2_CRK	592	596	PF00017	0.507
LIG_SH2_NCK_1	457	461	PF00017	0.315
LIG_SH2_PTP2	54	57	PF00017	0.414
LIG_SH2_PTP2	62	65	PF00017	0.380
LIG_SH2_SRC	54	57	PF00017	0.414
LIG_SH2_SRC	62	65	PF00017	0.380
LIG_SH2_STAT5	118	121	PF00017	0.438
LIG_SH2_STAT5	29	32	PF00017	0.419
LIG_SH2_STAT5	303	306	PF00017	0.623
LIG_SH2_STAT5	48	51	PF00017	0.327
LIG_SH2_STAT5	494	497	PF00017	0.412
LIG_SH2_STAT5	54	57	PF00017	0.393
LIG_SH2_STAT5	585	588	PF00017	0.358
LIG_SH2_STAT5	617	620	PF00017	0.541
LIG_SH2_STAT5	62	65	PF00017	0.359
LIG_SH2_STAT5	625	628	PF00017	0.480
LIG_SH3_3	176	182	PF00018	0.638
LIG_SH3_3	2	8	PF00018	0.509
LIG_SH3_3	217	223	PF00018	0.575
LIG_SH3_3	463	469	PF00018	0.315
LIG_SH3_3	50	56	PF00018	0.410
LIG_SH3_3	514	520	PF00018	0.726
LIG_SH3_3	85	91	PF00018	0.481
LIG_TRFH_1	100	104	PF08558	0.468
LIG_TYR_ITIM	46	51	PF00017	0.391
LIG_TYR_ITIM	52	57	PF00017	0.391
LIG_WRC_WIRS_1	649	654	PF05994	0.530
LIG_WW_2	5	8	PF00397	0.479
MOD_CDC14_SPxK_1	202	205	PF00782	0.702
MOD_CDK_SPK_2	6	11	PF00069	0.506
MOD_CDK_SPK_2	64	69	PF00069	0.439
MOD_CDK_SPxK_1	199	205	PF00069	0.704
MOD_CDK_SPxxK_3	147	154	PF00069	0.606
MOD_CDK_SPxxK_3	520	527	PF00069	0.592
MOD_CK1_1	103	109	PF00069	0.603
MOD_CK1_1	120	126	PF00069	0.383
MOD_CK1_1	165	171	PF00069	0.596
MOD_CK1_1	190	196	PF00069	0.662
MOD_CK1_1	197	203	PF00069	0.456
MOD_CK1_1	281	287	PF00069	0.676
MOD_CK1_1	427	433	PF00069	0.315
MOD_CK1_1	67	73	PF00069	0.464
MOD_CK2_1	223	229	PF00069	0.616
MOD_CK2_1	281	287	PF00069	0.676
MOD_CMANNOS	321	324	PF00535	0.565
MOD_Cter_Amidation	307	310	PF01082	0.532
MOD_Cter_Amidation	382	385	PF01082	0.768
MOD_GlcNHglycan	105	108	PF01048	0.666
MOD_GlcNHglycan	183	186	PF01048	0.729
MOD_GlcNHglycan	189	192	PF01048	0.695
MOD_GlcNHglycan	215	218	PF01048	0.577
MOD_GlcNHglycan	225	228	PF01048	0.441
MOD_GlcNHglycan	381	384	PF01048	0.746
MOD_GlcNHglycan	426	429	PF01048	0.348
MOD_GlcNHglycan	527	530	PF01048	0.723
MOD_GlcNHglycan	573	576	PF01048	0.460
MOD_GSK3_1	187	194	PF00069	0.614
MOD_GSK3_1	274	281	PF00069	0.622
MOD_GSK3_1	372	379	PF00069	0.717
MOD_GSK3_1	423	430	PF00069	0.316
MOD_GSK3_1	600	607	PF00069	0.319
MOD_GSK3_1	660	667	PF00069	0.558
MOD_GSK3_1	67	74	PF00069	0.467
MOD_LATS_1	211	217	PF00433	0.622
MOD_LATS_1	446	452	PF00433	0.459
MOD_LATS_1	550	556	PF00433	0.755
MOD_N-GLC_1	335	340	PF02516	0.605
MOD_N-GLC_1	543	548	PF02516	0.797
MOD_NEK2_1	162	167	PF00069	0.598
MOD_NEK2_1	335	340	PF00069	0.596
MOD_NEK2_1	447	452	PF00069	0.341
MOD_NEK2_1	571	576	PF00069	0.509
MOD_NEK2_1	632	637	PF00069	0.400
MOD_NEK2_1	648	653	PF00069	0.414
MOD_PIKK_1	118	124	PF00454	0.439
MOD_PIKK_1	617	623	PF00454	0.515
MOD_PK_1	79	85	PF00069	0.518
MOD_PKA_1	212	218	PF00069	0.537
MOD_PKA_1	79	85	PF00069	0.518
MOD_PKA_2	111	117	PF00069	0.449
MOD_PKA_2	163	169	PF00069	0.638
MOD_PKA_2	212	218	PF00069	0.599
MOD_PKA_2	251	257	PF00069	0.577
MOD_PKA_2	274	280	PF00069	0.584
MOD_PKA_2	30	36	PF00069	0.400
MOD_PKA_2	411	417	PF00069	0.564
MOD_PKA_2	423	429	PF00069	0.279
MOD_PKA_2	447	453	PF00069	0.467
MOD_PKA_2	612	618	PF00069	0.511
MOD_PKA_2	623	629	PF00069	0.444
MOD_PKA_2	79	85	PF00069	0.518
MOD_Plk_1	243	249	PF00069	0.588
MOD_Plk_1	664	670	PF00069	0.559
MOD_Plk_2-3	543	549	PF00069	0.578
MOD_Plk_4	411	417	PF00069	0.551
MOD_Plk_4	428	434	PF00069	0.218
MOD_ProDKin_1	1	7	PF00069	0.515
MOD_ProDKin_1	100	106	PF00069	0.642
MOD_ProDKin_1	147	153	PF00069	0.720
MOD_ProDKin_1	194	200	PF00069	0.638
MOD_ProDKin_1	372	378	PF00069	0.734
MOD_ProDKin_1	439	445	PF00069	0.436
MOD_ProDKin_1	476	482	PF00069	0.471
MOD_ProDKin_1	520	526	PF00069	0.664
MOD_ProDKin_1	64	70	PF00069	0.660
MOD_ProDKin_1	660	666	PF00069	0.598
MOD_ProDKin_1	87	93	PF00069	0.607
MOD_SUMO_for_1	135	138	PF00179	0.482
MOD_SUMO_rev_2	248	256	PF00179	0.656
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.449
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.345
TRG_DiLeu_BaLyEn_6	554	559	PF01217	0.759
TRG_ENDOCYTIC_2	303	306	PF00928	0.502
TRG_ENDOCYTIC_2	444	447	PF00928	0.302
TRG_ENDOCYTIC_2	474	477	PF00928	0.443
TRG_ENDOCYTIC_2	48	51	PF00928	0.394
TRG_ENDOCYTIC_2	54	57	PF00928	0.393
TRG_ENDOCYTIC_2	585	588	PF00928	0.443
TRG_ENDOCYTIC_2	62	65	PF00928	0.359
TRG_ER_diArg_1	212	214	PF00400	0.675
TRG_ER_diArg_1	289	292	PF00400	0.568
TRG_ER_diArg_1	309	311	PF00400	0.364
TRG_ER_diArg_1	511	513	PF00400	0.591
TRG_ER_diArg_1	78	80	PF00400	0.520
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.694
TRG_Pf-PMV_PEXEL_1	232	237	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I045	Leptomonas seymouri	61%	100%
A0A0S4IVC3	Bodo saltans	45%	100%
A0A1X0NWZ9	Trypanosomatidae	51%	100%
A0A422MX57	Trypanosoma rangeli	52%	100%
A4HCU4	Leishmania braziliensis	83%	100%
A4I0C5	Leishmania infantum	100%	100%
C9ZV46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
V5ARP5	Trypanosoma cruzi	53%	100%