SET domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WXM7_LEIDO

TriTrypDb:

LdBPK_230960.1 , LdCL_230016200 , LDHU3_23.1310

Length:

857

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WXM7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXM7

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	2
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	2
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	493	497	PF00656	0.545
CLV_C14_Caspase3-7	551	555	PF00656	0.539
CLV_C14_Caspase3-7	621	625	PF00656	0.473
CLV_NRD_NRD_1	206	208	PF00675	0.600
CLV_NRD_NRD_1	218	220	PF00675	0.580
CLV_NRD_NRD_1	22	24	PF00675	0.486
CLV_NRD_NRD_1	245	247	PF00675	0.560
CLV_NRD_NRD_1	251	253	PF00675	0.585
CLV_NRD_NRD_1	261	263	PF00675	0.704
CLV_NRD_NRD_1	502	504	PF00675	0.586
CLV_NRD_NRD_1	736	738	PF00675	0.375
CLV_NRD_NRD_1	76	78	PF00675	0.571
CLV_PCSK_FUR_1	249	253	PF00082	0.559
CLV_PCSK_KEX2_1	22	24	PF00082	0.486
CLV_PCSK_KEX2_1	244	246	PF00082	0.561
CLV_PCSK_KEX2_1	249	251	PF00082	0.577
CLV_PCSK_KEX2_1	261	263	PF00082	0.685
CLV_PCSK_KEX2_1	502	504	PF00082	0.586
CLV_PCSK_KEX2_1	601	603	PF00082	0.266
CLV_PCSK_KEX2_1	735	737	PF00082	0.359
CLV_PCSK_PC1ET2_1	601	603	PF00082	0.328
CLV_PCSK_PC7_1	245	251	PF00082	0.560
CLV_PCSK_PC7_1	597	603	PF00082	0.247
CLV_PCSK_SKI1_1	207	211	PF00082	0.543
CLV_PCSK_SKI1_1	601	605	PF00082	0.257
CLV_PCSK_SKI1_1	616	620	PF00082	0.328
CLV_PCSK_SKI1_1	737	741	PF00082	0.364
DEG_APCC_DBOX_1	152	160	PF00400	0.571
DEG_Nend_UBRbox_2	1	3	PF02207	0.512
DEG_SCF_FBW7_1	822	829	PF00400	0.554
DEG_SPOP_SBC_1	268	272	PF00917	0.519
DEG_SPOP_SBC_1	334	338	PF00917	0.641
DEG_SPOP_SBC_1	359	363	PF00917	0.566
DEG_SPOP_SBC_1	459	463	PF00917	0.613
DOC_ANK_TNKS_1	513	520	PF00023	0.573
DOC_CKS1_1	265	270	PF01111	0.507
DOC_CYCLIN_RxL_1	227	240	PF00134	0.549
DOC_CYCLIN_RxL_1	734	742	PF00134	0.362
DOC_CYCLIN_yCln2_LP_2	437	440	PF00134	0.546
DOC_MAPK_gen_1	219	226	PF00069	0.534
DOC_MAPK_gen_1	249	259	PF00069	0.581
DOC_MAPK_MEF2A_6	755	763	PF00069	0.352
DOC_PP1_RVXF_1	364	371	PF00149	0.518
DOC_PP2B_LxvP_1	437	440	PF13499	0.546
DOC_PP2B_LxvP_1	806	809	PF13499	0.520
DOC_PP2B_PxIxI_1	758	764	PF00149	0.364
DOC_PP4_FxxP_1	787	790	PF00568	0.492
DOC_USP7_MATH_1	212	216	PF00917	0.567
DOC_USP7_MATH_1	268	272	PF00917	0.540
DOC_USP7_MATH_1	283	287	PF00917	0.379
DOC_USP7_MATH_1	335	339	PF00917	0.537
DOC_USP7_MATH_1	400	404	PF00917	0.500
DOC_USP7_MATH_1	466	470	PF00917	0.591
DOC_USP7_MATH_1	521	525	PF00917	0.719
DOC_USP7_MATH_1	62	66	PF00917	0.586
DOC_USP7_MATH_1	682	686	PF00917	0.434
DOC_USP7_MATH_1	795	799	PF00917	0.538
DOC_USP7_MATH_1	815	819	PF00917	0.643
DOC_USP7_MATH_1	93	97	PF00917	0.739
DOC_USP7_MATH_1	98	102	PF00917	0.752
DOC_USP7_MATH_2	473	479	PF00917	0.486
DOC_USP7_UBL2_3	210	214	PF12436	0.552
DOC_USP7_UBL2_3	485	489	PF12436	0.487
DOC_WW_Pin1_4	119	124	PF00397	0.604
DOC_WW_Pin1_4	130	135	PF00397	0.431
DOC_WW_Pin1_4	23	28	PF00397	0.380
DOC_WW_Pin1_4	264	269	PF00397	0.525
DOC_WW_Pin1_4	412	417	PF00397	0.591
DOC_WW_Pin1_4	439	444	PF00397	0.764
DOC_WW_Pin1_4	451	456	PF00397	0.647
DOC_WW_Pin1_4	524	529	PF00397	0.827
DOC_WW_Pin1_4	565	570	PF00397	0.538
DOC_WW_Pin1_4	780	785	PF00397	0.459
DOC_WW_Pin1_4	811	816	PF00397	0.598
DOC_WW_Pin1_4	822	827	PF00397	0.449
LIG_14-3-3_CanoR_1	128	134	PF00244	0.541
LIG_14-3-3_CanoR_1	360	365	PF00244	0.522
LIG_14-3-3_CanoR_1	391	401	PF00244	0.488
LIG_14-3-3_CanoR_1	514	521	PF00244	0.790
LIG_14-3-3_CanoR_1	536	543	PF00244	0.649
LIG_14-3-3_CanoR_1	589	593	PF00244	0.481
LIG_14-3-3_CanoR_1	616	621	PF00244	0.581
LIG_14-3-3_CanoR_1	836	841	PF00244	0.406
LIG_14-3-3_CanoR_1	88	95	PF00244	0.533
LIG_Actin_WH2_2	475	491	PF00022	0.465
LIG_APCC_ABBA_1	678	683	PF00400	0.447
LIG_BIR_III_2	496	500	PF00653	0.581
LIG_BRCT_BRCA1_1	137	141	PF00533	0.420
LIG_BRCT_BRCA1_1	270	274	PF00533	0.597
LIG_BRCT_BRCA1_1	371	375	PF00533	0.406
LIG_EVH1_2	807	811	PF00568	0.404
LIG_FHA_1	106	112	PF00498	0.579
LIG_FHA_1	329	335	PF00498	0.606
LIG_FHA_1	428	434	PF00498	0.663
LIG_FHA_1	489	495	PF00498	0.657
LIG_FHA_1	641	647	PF00498	0.475
LIG_FHA_2	393	399	PF00498	0.701
LIG_FHA_2	430	436	PF00498	0.712
LIG_FHA_2	549	555	PF00498	0.679
LIG_FHA_2	723	729	PF00498	0.639
LIG_FHA_2	827	833	PF00498	0.470
LIG_GSK3_LRP6_1	439	444	PF00069	0.544
LIG_Integrin_RGD_1	449	451	PF01839	0.565
LIG_LIR_Apic_2	263	268	PF02991	0.500
LIG_LIR_Gen_1	133	144	PF02991	0.551
LIG_LIR_Gen_1	369	378	PF02991	0.370
LIG_LIR_Gen_1	568	577	PF02991	0.563
LIG_LIR_Gen_1	651	661	PF02991	0.435
LIG_LIR_Gen_1	721	730	PF02991	0.504
LIG_LIR_Nem_3	133	139	PF02991	0.480
LIG_LIR_Nem_3	320	325	PF02991	0.472
LIG_LIR_Nem_3	369	373	PF02991	0.381
LIG_LIR_Nem_3	568	574	PF02991	0.570
LIG_LIR_Nem_3	590	595	PF02991	0.451
LIG_LIR_Nem_3	651	657	PF02991	0.435
LIG_LIR_Nem_3	665	669	PF02991	0.430
LIG_LIR_Nem_3	721	727	PF02991	0.434
LIG_LIR_Nem_3	742	746	PF02991	0.364
LIG_LYPXL_S_1	321	325	PF13949	0.356
LIG_LYPXL_yS_3	322	325	PF13949	0.363
LIG_NRBOX	606	612	PF00104	0.485
LIG_SH2_GRB2like	686	689	PF00017	0.434
LIG_SH2_NCK_1	280	284	PF00017	0.445
LIG_SH2_NCK_1	724	728	PF00017	0.448
LIG_SH2_SRC	280	283	PF00017	0.466
LIG_SH2_STAP1	107	111	PF00017	0.580
LIG_SH2_STAP1	571	575	PF00017	0.536
LIG_SH2_STAP1	709	713	PF00017	0.485
LIG_SH2_STAT3	669	672	PF00017	0.485
LIG_SH2_STAT5	107	110	PF00017	0.718
LIG_SH2_STAT5	130	133	PF00017	0.446
LIG_SH2_STAT5	330	333	PF00017	0.617
LIG_SH2_STAT5	653	656	PF00017	0.528
LIG_SH2_STAT5	686	689	PF00017	0.434
LIG_SH2_STAT5	724	727	PF00017	0.374
LIG_SH2_STAT5	802	805	PF00017	0.309
LIG_SH3_1	802	808	PF00018	0.351
LIG_SH3_3	345	351	PF00018	0.710
LIG_SH3_3	37	43	PF00018	0.441
LIG_SH3_3	408	414	PF00018	0.696
LIG_SH3_3	437	443	PF00018	0.625
LIG_SH3_3	467	473	PF00018	0.710
LIG_SH3_3	505	511	PF00018	0.712
LIG_SH3_3	713	719	PF00018	0.502
LIG_SH3_3	769	775	PF00018	0.695
LIG_SH3_3	802	808	PF00018	0.413
LIG_SH3_CIN85_PxpxPR_1	528	533	PF14604	0.565
LIG_SUMO_SIM_anti_2	491	496	PF11976	0.550
LIG_SUMO_SIM_anti_2	578	585	PF11976	0.436
LIG_SUMO_SIM_par_1	490	496	PF11976	0.574
LIG_TRAF2_1	11	14	PF00917	0.604
LIG_TRAF2_1	279	282	PF00917	0.489
LIG_TRAF2_1	715	718	PF00917	0.485
LIG_TRAF2_1	829	832	PF00917	0.546
LIG_TYR_ITIM	722	727	PF00017	0.359
MOD_CDC14_SPxK_1	814	817	PF00782	0.594
MOD_CDK_SPK_2	565	570	PF00069	0.535
MOD_CDK_SPxK_1	811	817	PF00069	0.586
MOD_CK1_1	105	111	PF00069	0.744
MOD_CK1_1	122	128	PF00069	0.607
MOD_CK1_1	213	219	PF00069	0.648
MOD_CK1_1	270	276	PF00069	0.714
MOD_CK1_1	286	292	PF00069	0.352
MOD_CK1_1	3	9	PF00069	0.465
MOD_CK1_1	337	343	PF00069	0.600
MOD_CK1_1	454	460	PF00069	0.746
MOD_CK1_1	461	467	PF00069	0.636
MOD_CK1_1	524	530	PF00069	0.712
MOD_CK1_1	54	60	PF00069	0.570
MOD_CK1_1	545	551	PF00069	0.682
MOD_CK1_1	65	71	PF00069	0.650
MOD_CK1_1	824	830	PF00069	0.584
MOD_CK2_1	152	158	PF00069	0.567
MOD_CK2_1	23	29	PF00069	0.255
MOD_CK2_1	358	364	PF00069	0.535
MOD_CK2_1	429	435	PF00069	0.726
MOD_CK2_1	475	481	PF00069	0.577
MOD_CK2_1	512	518	PF00069	0.748
MOD_CK2_1	7	13	PF00069	0.546
MOD_CK2_1	722	728	PF00069	0.398
MOD_CK2_1	826	832	PF00069	0.491
MOD_DYRK1A_RPxSP_1	565	569	PF00069	0.434
MOD_GlcNHglycan	100	103	PF01048	0.714
MOD_GlcNHglycan	198	201	PF01048	0.627
MOD_GlcNHglycan	215	218	PF01048	0.456
MOD_GlcNHglycan	285	288	PF01048	0.432
MOD_GlcNHglycan	310	314	PF01048	0.461
MOD_GlcNHglycan	337	340	PF01048	0.619
MOD_GlcNHglycan	375	378	PF01048	0.481
MOD_GlcNHglycan	420	423	PF01048	0.687
MOD_GlcNHglycan	443	446	PF01048	0.621
MOD_GlcNHglycan	47	50	PF01048	0.379
MOD_GlcNHglycan	507	511	PF01048	0.635
MOD_GlcNHglycan	515	518	PF01048	0.663
MOD_GlcNHglycan	64	67	PF01048	0.578
MOD_GlcNHglycan	731	734	PF01048	0.516
MOD_GlcNHglycan	752	755	PF01048	0.440
MOD_GlcNHglycan	772	775	PF01048	0.684
MOD_GlcNHglycan	776	779	PF01048	0.574
MOD_GlcNHglycan	819	822	PF01048	0.635
MOD_GlcNHglycan	90	93	PF01048	0.664
MOD_GlcNHglycan	95	98	PF01048	0.693
MOD_GSK3_1	124	131	PF00069	0.510
MOD_GSK3_1	264	271	PF00069	0.683
MOD_GSK3_1	3	10	PF00069	0.504
MOD_GSK3_1	333	340	PF00069	0.671
MOD_GSK3_1	369	376	PF00069	0.436
MOD_GSK3_1	425	432	PF00069	0.735
MOD_GSK3_1	454	461	PF00069	0.678
MOD_GSK3_1	50	57	PF00069	0.577
MOD_GSK3_1	544	551	PF00069	0.715
MOD_GSK3_1	61	68	PF00069	0.594
MOD_GSK3_1	616	623	PF00069	0.417
MOD_GSK3_1	624	631	PF00069	0.360
MOD_GSK3_1	718	725	PF00069	0.446
MOD_GSK3_1	770	777	PF00069	0.656
MOD_GSK3_1	811	818	PF00069	0.683
MOD_GSK3_1	822	829	PF00069	0.475
MOD_GSK3_1	836	843	PF00069	0.394
MOD_GSK3_1	98	105	PF00069	0.782
MOD_N-GLC_1	187	192	PF02516	0.698
MOD_N-GLC_1	549	554	PF02516	0.615
MOD_N-GLC_1	579	584	PF02516	0.270
MOD_N-GLC_1	687	692	PF02516	0.270
MOD_N-GLC_2	44	46	PF02516	0.459
MOD_N-GLC_2	694	696	PF02516	0.270
MOD_NEK2_1	170	175	PF00069	0.523
MOD_NEK2_1	317	322	PF00069	0.462
MOD_NEK2_1	373	378	PF00069	0.450
MOD_NEK2_1	458	463	PF00069	0.688
MOD_NEK2_1	50	55	PF00069	0.538
MOD_NEK2_1	687	692	PF00069	0.270
MOD_NEK2_1	7	12	PF00069	0.601
MOD_NEK2_1	739	744	PF00069	0.372
MOD_NEK2_1	810	815	PF00069	0.740
MOD_NEK2_2	795	800	PF00069	0.363
MOD_PIKK_1	425	431	PF00454	0.819
MOD_PIKK_1	668	674	PF00454	0.342
MOD_PKA_1	210	216	PF00069	0.650
MOD_PKA_2	152	158	PF00069	0.567
MOD_PKA_2	359	365	PF00069	0.484
MOD_PKA_2	513	519	PF00069	0.574
MOD_PKA_2	535	541	PF00069	0.649
MOD_PKA_2	588	594	PF00069	0.305
MOD_PKA_2	750	756	PF00069	0.442
MOD_PKA_2	768	774	PF00069	0.610
MOD_PKB_1	542	550	PF00069	0.530
MOD_Plk_1	170	176	PF00069	0.522
MOD_Plk_1	579	585	PF00069	0.288
MOD_Plk_1	682	688	PF00069	0.270
MOD_Plk_1	795	801	PF00069	0.532
MOD_Plk_2-3	475	481	PF00069	0.481
MOD_Plk_4	344	350	PF00069	0.790
MOD_Plk_4	369	375	PF00069	0.371
MOD_Plk_4	454	460	PF00069	0.755
MOD_Plk_4	466	472	PF00069	0.603
MOD_Plk_4	579	585	PF00069	0.289
MOD_Plk_4	682	688	PF00069	0.275
MOD_ProDKin_1	119	125	PF00069	0.596
MOD_ProDKin_1	130	136	PF00069	0.424
MOD_ProDKin_1	23	29	PF00069	0.379
MOD_ProDKin_1	264	270	PF00069	0.526
MOD_ProDKin_1	412	418	PF00069	0.594
MOD_ProDKin_1	439	445	PF00069	0.767
MOD_ProDKin_1	451	457	PF00069	0.645
MOD_ProDKin_1	524	530	PF00069	0.827
MOD_ProDKin_1	565	571	PF00069	0.537
MOD_ProDKin_1	780	786	PF00069	0.453
MOD_ProDKin_1	811	817	PF00069	0.599
MOD_ProDKin_1	822	828	PF00069	0.430
TRG_DiLeu_BaEn_1	369	374	PF01217	0.331
TRG_DiLeu_BaEn_1	788	793	PF01217	0.452
TRG_DiLeu_BaLyEn_6	787	792	PF01217	0.454
TRG_ENDOCYTIC_2	322	325	PF00928	0.344
TRG_ENDOCYTIC_2	571	574	PF00928	0.560
TRG_ENDOCYTIC_2	596	599	PF00928	0.270
TRG_ENDOCYTIC_2	724	727	PF00928	0.374
TRG_ENDOCYTIC_2	743	746	PF00928	0.354
TRG_ER_diArg_1	243	246	PF00400	0.611
TRG_ER_diArg_1	249	252	PF00400	0.629
TRG_ER_diArg_1	260	262	PF00400	0.696
TRG_ER_diArg_1	501	503	PF00400	0.722
TRG_ER_diArg_1	564	567	PF00400	0.527
TRG_ER_diArg_1	735	737	PF00400	0.359
TRG_ER_diArg_1	842	845	PF00400	0.434
TRG_NLS_Bipartite_1	207	223	PF00514	0.485
TRG_NLS_MonoExtC_3	206	211	PF00514	0.593
TRG_Pf-PMV_PEXEL_1	366	371	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEZ6	Leptomonas seymouri	49%	100%
A0A1X0NYH3	Trypanosomatidae	30%	100%
A0A3R7KV16	Trypanosoma rangeli	30%	100%
A4I0D0	Leishmania infantum	100%	100%
C9ZV40	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AW94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QB84	Leishmania major	87%	100%
V5ARQ1	Trypanosoma cruzi	29%	100%