Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WXM6_LEIDO

TriTrypDb:

LdBPK_230260.1 , LdCL_230008000 , LDHU3_23.0330

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3S7WXM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXM6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	84	88	PF00656	0.720
CLV_NRD_NRD_1	71	73	PF00675	0.486
CLV_PCSK_KEX2_1	71	73	PF00082	0.486
CLV_PCSK_SKI1_1	160	164	PF00082	0.426
CLV_PCSK_SKI1_1	90	94	PF00082	0.457
DEG_Nend_UBRbox_1	1	4	PF02207	0.712
DEG_SCF_FBW7_1	39	46	PF00400	0.675
DEG_SPOP_SBC_1	26	30	PF00917	0.635
DOC_CKS1_1	40	45	PF01111	0.669
DOC_PP2B_LxvP_1	92	95	PF13499	0.698
DOC_PP4_FxxP_1	119	122	PF00568	0.747
DOC_PP4_MxPP_1	129	132	PF00568	0.731
DOC_USP7_MATH_1	13	17	PF00917	0.621
DOC_WW_Pin1_4	39	44	PF00397	0.662
DOC_WW_Pin1_4	50	55	PF00397	0.597
LIG_14-3-3_CanoR_1	160	165	PF00244	0.633
LIG_deltaCOP1_diTrp_1	199	209	PF00928	0.543
LIG_FHA_1	27	33	PF00498	0.692
LIG_FHA_1	34	40	PF00498	0.690
LIG_FHA_2	123	129	PF00498	0.714
LIG_FHA_2	44	50	PF00498	0.612
LIG_FHA_2	82	88	PF00498	0.713
LIG_LIR_Apic_2	75	81	PF02991	0.637
LIG_LIR_Gen_1	200	211	PF02991	0.543
LIG_LIR_Nem_3	199	205	PF02991	0.543
LIG_LIR_Nem_3	208	212	PF02991	0.417
LIG_MYND_1	181	185	PF01753	0.713
LIG_Pex14_2	209	213	PF04695	0.417
LIG_SH2_CRK	191	195	PF00017	0.720
LIG_SH2_STAT3	115	118	PF00017	0.714
LIG_SH2_STAT3	41	44	PF00017	0.713
LIG_SH2_STAT5	35	38	PF00017	0.716
LIG_SH2_STAT5	41	44	PF00017	0.664
LIG_SH2_STAT5	50	53	PF00017	0.628
LIG_SH3_1	37	43	PF00018	0.635
LIG_SH3_3	128	134	PF00018	0.794
LIG_SH3_3	174	180	PF00018	0.639
LIG_SH3_3	182	188	PF00018	0.647
LIG_SH3_3	37	43	PF00018	0.645
LIG_SH3_3	88	94	PF00018	0.663
LIG_UBA3_1	212	221	PF00899	0.419
LIG_WRC_WIRS_1	206	211	PF05994	0.404
LIG_WW_1	112	115	PF00397	0.714
MOD_CDK_SPK_2	50	55	PF00069	0.677
MOD_CK2_1	165	171	PF00069	0.663
MOD_GSK3_1	39	46	PF00069	0.663
MOD_N-GLC_1	26	31	PF02516	0.458
MOD_NEK2_1	198	203	PF00069	0.643
MOD_NEK2_1	205	210	PF00069	0.419
MOD_PKB_1	158	166	PF00069	0.626
MOD_Plk_1	198	204	PF00069	0.524
MOD_Plk_4	198	204	PF00069	0.492
MOD_ProDKin_1	39	45	PF00069	0.660
MOD_ProDKin_1	50	56	PF00069	0.597
TRG_ER_diArg_1	158	161	PF00400	0.643
TRG_Pf-PMV_PEXEL_1	139	144	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHG6	Leptomonas seymouri	61%	100%
A0A0S4JGN0	Bodo saltans	34%	88%
A0A1X0NGS3	Trypanosomatidae	43%	100%
A0A3Q8ICE4	Leishmania donovani	100%	100%
A4HCN7	Leishmania braziliensis	81%	100%
A4I062	Leishmania infantum	100%	100%
E9AW25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QBF2	Leishmania major	97%	100%
V5B7Q1	Trypanosoma cruzi	43%	91%