ATP-grasp domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WXM2_LEIDO

TriTrypDb:

LdBPK_230830.1 , LdCL_230014900 , LDHU3_23.1130

Length:

886

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WXM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXM2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	441	445	PF00656	0.702
CLV_C14_Caspase3-7	75	79	PF00656	0.655
CLV_C14_Caspase3-7	853	857	PF00656	0.790
CLV_NRD_NRD_1	140	142	PF00675	0.674
CLV_NRD_NRD_1	374	376	PF00675	0.691
CLV_NRD_NRD_1	385	387	PF00675	0.562
CLV_NRD_NRD_1	392	394	PF00675	0.538
CLV_NRD_NRD_1	578	580	PF00675	0.621
CLV_NRD_NRD_1	754	756	PF00675	0.683
CLV_NRD_NRD_1	830	832	PF00675	0.755
CLV_PCSK_FUR_1	752	756	PF00082	0.639
CLV_PCSK_FUR_1	828	832	PF00082	0.752
CLV_PCSK_KEX2_1	363	365	PF00082	0.726
CLV_PCSK_KEX2_1	374	376	PF00082	0.558
CLV_PCSK_KEX2_1	392	394	PF00082	0.492
CLV_PCSK_KEX2_1	578	580	PF00082	0.621
CLV_PCSK_KEX2_1	754	756	PF00082	0.683
CLV_PCSK_KEX2_1	830	832	PF00082	0.755
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.726
CLV_PCSK_SKI1_1	321	325	PF00082	0.563
CLV_PCSK_SKI1_1	363	367	PF00082	0.616
CLV_PCSK_SKI1_1	392	396	PF00082	0.712
CLV_PCSK_SKI1_1	410	414	PF00082	0.499
CLV_PCSK_SKI1_1	416	420	PF00082	0.738
CLV_PCSK_SKI1_1	647	651	PF00082	0.721
CLV_PCSK_SKI1_1	660	664	PF00082	0.647
CLV_PCSK_SKI1_1	739	743	PF00082	0.753
DEG_APCC_DBOX_1	320	328	PF00400	0.551
DEG_SCF_FBW7_1	285	292	PF00400	0.685
DEG_SCF_FBW7_1	475	482	PF00400	0.811
DEG_SCF_FBW7_2	490	497	PF00400	0.717
DEG_SPOP_SBC_1	209	213	PF00917	0.762
DEG_SPOP_SBC_1	263	267	PF00917	0.667
DEG_SPOP_SBC_1	694	698	PF00917	0.643
DOC_AGCK_PIF_2	437	442	PF00069	0.661
DOC_ANK_TNKS_1	179	186	PF00023	0.696
DOC_CYCLIN_yCln2_LP_2	669	675	PF00134	0.666
DOC_MAPK_DCC_7	579	589	PF00069	0.647
DOC_MAPK_gen_1	752	761	PF00069	0.698
DOC_MAPK_JIP1_4	619	625	PF00069	0.573
DOC_MAPK_MEF2A_6	174	181	PF00069	0.764
DOC_MAPK_MEF2A_6	619	627	PF00069	0.566
DOC_PP1_RVXF_1	152	159	PF00149	0.700
DOC_PP2B_LxvP_1	487	490	PF13499	0.748
DOC_USP7_MATH_1	120	124	PF00917	0.737
DOC_USP7_MATH_1	134	138	PF00917	0.560
DOC_USP7_MATH_1	164	168	PF00917	0.666
DOC_USP7_MATH_1	216	220	PF00917	0.624
DOC_USP7_MATH_1	263	267	PF00917	0.781
DOC_USP7_MATH_1	277	281	PF00917	0.569
DOC_USP7_MATH_1	289	293	PF00917	0.634
DOC_USP7_MATH_1	403	407	PF00917	0.592
DOC_USP7_MATH_1	430	434	PF00917	0.690
DOC_USP7_MATH_1	470	474	PF00917	0.706
DOC_USP7_MATH_1	514	518	PF00917	0.699
DOC_USP7_MATH_1	542	546	PF00917	0.740
DOC_USP7_MATH_1	618	622	PF00917	0.632
DOC_USP7_MATH_1	673	677	PF00917	0.758
DOC_USP7_MATH_1	680	684	PF00917	0.707
DOC_USP7_MATH_1	693	697	PF00917	0.563
DOC_USP7_MATH_1	708	712	PF00917	0.715
DOC_USP7_MATH_1	732	736	PF00917	0.711
DOC_USP7_MATH_1	843	847	PF00917	0.695
DOC_USP7_MATH_1	882	886	PF00917	0.655
DOC_USP7_UBL2_3	359	363	PF12436	0.738
DOC_USP7_UBL2_3	397	401	PF12436	0.726
DOC_USP7_UBL2_3	495	499	PF12436	0.747
DOC_WW_Pin1_4	285	290	PF00397	0.745
DOC_WW_Pin1_4	404	409	PF00397	0.785
DOC_WW_Pin1_4	475	480	PF00397	0.810
DOC_WW_Pin1_4	490	495	PF00397	0.581
DOC_WW_Pin1_4	531	536	PF00397	0.692
DOC_WW_Pin1_4	671	676	PF00397	0.802
DOC_WW_Pin1_4	678	683	PF00397	0.742
DOC_WW_Pin1_4	706	711	PF00397	0.761
DOC_WW_Pin1_4	743	748	PF00397	0.672
DOC_WW_Pin1_4	785	790	PF00397	0.730
DOC_WW_Pin1_4	80	85	PF00397	0.716
LIG_14-3-3_CanoR_1	108	112	PF00244	0.608
LIG_14-3-3_CanoR_1	16	24	PF00244	0.662
LIG_14-3-3_CanoR_1	261	270	PF00244	0.683
LIG_14-3-3_CanoR_1	31	40	PF00244	0.631
LIG_14-3-3_CanoR_1	374	382	PF00244	0.625
LIG_14-3-3_CanoR_1	386	390	PF00244	0.642
LIG_14-3-3_CanoR_1	466	475	PF00244	0.657
LIG_14-3-3_CanoR_1	739	747	PF00244	0.730
LIG_14-3-3_CanoR_1	808	813	PF00244	0.579
LIG_14-3-3_CanoR_1	828	838	PF00244	0.752
LIG_Actin_WH2_2	436	454	PF00022	0.797
LIG_BIR_II_1	1	5	PF00653	0.642
LIG_BIR_III_4	453	457	PF00653	0.829
LIG_BRCT_BRCA1_1	18	22	PF00533	0.693
LIG_BRCT_BRCA1_1	237	241	PF00533	0.592
LIG_FHA_1	204	210	PF00498	0.766
LIG_FHA_1	484	490	PF00498	0.644
LIG_FHA_1	657	663	PF00498	0.783
LIG_FHA_1	795	801	PF00498	0.769
LIG_FHA_1	81	87	PF00498	0.630
LIG_FHA_2	486	492	PF00498	0.745
LIG_FHA_2	565	571	PF00498	0.626
LIG_FHA_2	598	604	PF00498	0.686
LIG_FHA_2	638	644	PF00498	0.717
LIG_LIR_Apic_2	565	569	PF02991	0.619
LIG_LIR_Gen_1	235	245	PF02991	0.568
LIG_LIR_Gen_1	417	427	PF02991	0.802
LIG_LIR_Gen_1	438	447	PF02991	0.697
LIG_LIR_Gen_1	551	561	PF02991	0.594
LIG_LIR_Gen_1	621	630	PF02991	0.599
LIG_LIR_Gen_1	772	780	PF02991	0.730
LIG_LIR_Nem_3	2	6	PF02991	0.644
LIG_LIR_Nem_3	235	240	PF02991	0.553
LIG_LIR_Nem_3	417	422	PF02991	0.802
LIG_LIR_Nem_3	48	53	PF02991	0.712
LIG_LIR_Nem_3	551	557	PF02991	0.597
LIG_LIR_Nem_3	592	597	PF02991	0.724
LIG_LIR_Nem_3	621	625	PF02991	0.610
LIG_LIR_Nem_3	772	776	PF02991	0.767
LIG_LIR_Nem_3	797	801	PF02991	0.811
LIG_MLH1_MIPbox_1	237	241	PF16413	0.592
LIG_NRBOX	323	329	PF00104	0.650
LIG_PALB2_WD40_1	235	243	PF16756	0.636
LIG_Pex14_1	237	241	PF04695	0.631
LIG_Pex14_2	96	100	PF04695	0.579
LIG_PTAP_UEV_1	501	506	PF05743	0.657
LIG_PTAP_UEV_1	728	733	PF05743	0.687
LIG_PTB_Apo_2	799	806	PF02174	0.721
LIG_PTB_Phospho_1	799	805	PF10480	0.723
LIG_SH2_CRK	159	163	PF00017	0.653
LIG_SH2_CRK	53	57	PF00017	0.580
LIG_SH2_GRB2like	805	808	PF00017	0.800
LIG_SH2_STAT5	307	310	PF00017	0.655
LIG_SH2_STAT5	622	625	PF00017	0.597
LIG_SH3_1	499	505	PF00018	0.775
LIG_SH3_1	614	620	PF00018	0.504
LIG_SH3_3	178	184	PF00018	0.737
LIG_SH3_3	402	408	PF00018	0.586
LIG_SH3_3	499	505	PF00018	0.766
LIG_SH3_3	614	620	PF00018	0.534
LIG_SH3_3	662	668	PF00018	0.693
LIG_SH3_3	704	710	PF00018	0.705
LIG_SH3_3	726	732	PF00018	0.670
LIG_SH3_4	359	366	PF00018	0.724
LIG_SUMO_SIM_anti_2	292	302	PF11976	0.642
LIG_SUMO_SIM_anti_2	555	561	PF11976	0.685
LIG_SUMO_SIM_par_1	485	491	PF11976	0.610
LIG_SUMO_SIM_par_1	526	531	PF11976	0.593
LIG_SUMO_SIM_par_1	661	666	PF11976	0.674
LIG_TRAF2_1	224	227	PF00917	0.671
LIG_TRFH_1	241	245	PF08558	0.611
LIG_UBA3_1	324	332	PF00899	0.656
MOD_CDC14_SPxK_1	407	410	PF00782	0.722
MOD_CDK_SPK_2	490	495	PF00069	0.713
MOD_CDK_SPK_2	785	790	PF00069	0.746
MOD_CDK_SPK_2	80	85	PF00069	0.716
MOD_CDK_SPxK_1	404	410	PF00069	0.725
MOD_CK1_1	200	206	PF00069	0.731
MOD_CK1_1	219	225	PF00069	0.729
MOD_CK1_1	246	252	PF00069	0.773
MOD_CK1_1	284	290	PF00069	0.724
MOD_CK1_1	292	298	PF00069	0.751
MOD_CK1_1	34	40	PF00069	0.727
MOD_CK1_1	341	347	PF00069	0.537
MOD_CK1_1	404	410	PF00069	0.720
MOD_CK1_1	417	423	PF00069	0.794
MOD_CK1_1	473	479	PF00069	0.750
MOD_CK1_1	534	540	PF00069	0.673
MOD_CK1_1	674	680	PF00069	0.774
MOD_CK1_1	698	704	PF00069	0.748
MOD_CK1_1	706	712	PF00069	0.698
MOD_CK1_1	715	721	PF00069	0.594
MOD_CK1_1	746	752	PF00069	0.804
MOD_CK1_1	788	794	PF00069	0.745
MOD_CK1_1	846	852	PF00069	0.746
MOD_CK2_1	134	140	PF00069	0.550
MOD_CK2_1	485	491	PF00069	0.610
MOD_CK2_1	597	603	PF00069	0.680
MOD_Cter_Amidation	828	831	PF01082	0.752
MOD_GlcNHglycan	13	16	PF01048	0.640
MOD_GlcNHglycan	143	146	PF01048	0.591
MOD_GlcNHglycan	166	169	PF01048	0.690
MOD_GlcNHglycan	203	206	PF01048	0.727
MOD_GlcNHglycan	216	219	PF01048	0.604
MOD_GlcNHglycan	245	248	PF01048	0.725
MOD_GlcNHglycan	257	260	PF01048	0.606
MOD_GlcNHglycan	266	269	PF01048	0.641
MOD_GlcNHglycan	279	282	PF01048	0.701
MOD_GlcNHglycan	293	297	PF01048	0.555
MOD_GlcNHglycan	340	343	PF01048	0.645
MOD_GlcNHglycan	36	39	PF01048	0.747
MOD_GlcNHglycan	416	419	PF01048	0.687
MOD_GlcNHglycan	457	460	PF01048	0.842
MOD_GlcNHglycan	502	505	PF01048	0.779
MOD_GlcNHglycan	56	59	PF01048	0.689
MOD_GlcNHglycan	6	9	PF01048	0.707
MOD_GlcNHglycan	609	612	PF01048	0.746
MOD_GlcNHglycan	682	685	PF01048	0.720
MOD_GlcNHglycan	722	725	PF01048	0.734
MOD_GlcNHglycan	74	77	PF01048	0.786
MOD_GlcNHglycan	748	751	PF01048	0.803
MOD_GlcNHglycan	762	765	PF01048	0.573
MOD_GlcNHglycan	785	788	PF01048	0.739
MOD_GlcNHglycan	790	793	PF01048	0.685
MOD_GlcNHglycan	817	820	PF01048	0.643
MOD_GlcNHglycan	845	848	PF01048	0.721
MOD_GlcNHglycan	858	861	PF01048	0.585
MOD_GlcNHglycan	879	882	PF01048	0.641
MOD_GSK3_1	16	23	PF00069	0.732
MOD_GSK3_1	197	204	PF00069	0.829
MOD_GSK3_1	210	217	PF00069	0.775
MOD_GSK3_1	235	242	PF00069	0.685
MOD_GSK3_1	26	33	PF00069	0.805
MOD_GSK3_1	264	271	PF00069	0.735
MOD_GSK3_1	277	284	PF00069	0.663
MOD_GSK3_1	285	292	PF00069	0.747
MOD_GSK3_1	404	411	PF00069	0.746
MOD_GSK3_1	414	421	PF00069	0.682
MOD_GSK3_1	466	473	PF00069	0.767
MOD_GSK3_1	475	482	PF00069	0.646
MOD_GSK3_1	628	635	PF00069	0.594
MOD_GSK3_1	674	681	PF00069	0.745
MOD_GSK3_1	694	701	PF00069	0.650
MOD_GSK3_1	702	709	PF00069	0.800
MOD_GSK3_1	711	718	PF00069	0.649
MOD_GSK3_1	739	746	PF00069	0.678
MOD_GSK3_1	873	880	PF00069	0.619
MOD_N-GLC_1	164	169	PF02516	0.711
MOD_N-GLC_1	780	785	PF02516	0.812
MOD_NEK2_1	107	112	PF00069	0.543
MOD_NEK2_1	11	16	PF00069	0.582
MOD_NEK2_1	127	132	PF00069	0.443
MOD_NEK2_1	264	269	PF00069	0.759
MOD_NEK2_1	385	390	PF00069	0.736
MOD_NEK2_1	442	447	PF00069	0.691
MOD_NEK2_1	564	569	PF00069	0.602
MOD_NEK2_1	623	628	PF00069	0.686
MOD_NEK2_1	650	655	PF00069	0.776
MOD_NEK2_1	700	705	PF00069	0.713
MOD_NEK2_1	780	785	PF00069	0.711
MOD_NEK2_1	800	805	PF00069	0.721
MOD_NEK2_2	435	440	PF00069	0.713
MOD_NEK2_2	632	637	PF00069	0.513
MOD_PIKK_1	31	37	PF00454	0.730
MOD_PIKK_1	380	386	PF00454	0.639
MOD_PIKK_1	739	745	PF00454	0.659
MOD_PIKK_1	775	781	PF00454	0.772
MOD_PK_1	401	407	PF00069	0.591
MOD_PK_1	808	814	PF00069	0.581
MOD_PKA_1	141	147	PF00069	0.669
MOD_PKA_1	201	207	PF00069	0.717
MOD_PKA_1	392	398	PF00069	0.792
MOD_PKA_2	107	113	PF00069	0.648
MOD_PKA_2	127	133	PF00069	0.442
MOD_PKA_2	26	32	PF00069	0.738
MOD_PKA_2	385	391	PF00069	0.670
MOD_PKA_2	392	398	PF00069	0.655
MOD_PKA_2	618	624	PF00069	0.530
MOD_PKA_2	824	830	PF00069	0.794
MOD_Plk_1	292	298	PF00069	0.453
MOD_Plk_1	470	476	PF00069	0.750
MOD_Plk_1	757	763	PF00069	0.697
MOD_Plk_4	107	113	PF00069	0.476
MOD_Plk_4	210	216	PF00069	0.777
MOD_Plk_4	295	301	PF00069	0.726
MOD_Plk_4	514	520	PF00069	0.741
MOD_Plk_4	618	624	PF00069	0.627
MOD_Plk_4	695	701	PF00069	0.741
MOD_Plk_4	873	879	PF00069	0.644
MOD_Plk_4	91	97	PF00069	0.681
MOD_ProDKin_1	285	291	PF00069	0.745
MOD_ProDKin_1	404	410	PF00069	0.787
MOD_ProDKin_1	475	481	PF00069	0.809
MOD_ProDKin_1	490	496	PF00069	0.584
MOD_ProDKin_1	531	537	PF00069	0.693
MOD_ProDKin_1	671	677	PF00069	0.803
MOD_ProDKin_1	678	684	PF00069	0.744
MOD_ProDKin_1	706	712	PF00069	0.762
MOD_ProDKin_1	743	749	PF00069	0.672
MOD_ProDKin_1	785	791	PF00069	0.729
MOD_ProDKin_1	80	86	PF00069	0.705
MOD_SUMO_for_1	494	497	PF00179	0.761
MOD_SUMO_rev_2	116	121	PF00179	0.709
MOD_SUMO_rev_2	137	144	PF00179	0.619
MOD_SUMO_rev_2	197	203	PF00179	0.699
MOD_SUMO_rev_2	603	610	PF00179	0.700
TRG_DiLeu_BaEn_1	304	309	PF01217	0.655
TRG_DiLeu_BaLyEn_6	665	670	PF01217	0.711
TRG_ENDOCYTIC_2	53	56	PF00928	0.581
TRG_ENDOCYTIC_2	594	597	PF00928	0.638
TRG_ENDOCYTIC_2	622	625	PF00928	0.597
TRG_ER_diArg_1	24	27	PF00400	0.697
TRG_ER_diArg_1	391	393	PF00400	0.783
TRG_ER_diArg_1	577	579	PF00400	0.592
TRG_ER_diArg_1	828	831	PF00400	0.823
TRG_PTS1	883	886	PF00515	0.662

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I942	Leptomonas seymouri	38%	97%
A4HCT7	Leishmania braziliensis	71%	99%
A4I0B7	Leishmania infantum	99%	100%
E9AW81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q9U0V6	Leishmania major	91%	100%