Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WXL7_LEIDO

TriTrypDb:

LdBPK_230210.1 , LdCL_230007000 , LDHU3_23.0260

Length:

125

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WXL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXL7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.583
CLV_NRD_NRD_1	43	45	PF00675	0.473
CLV_NRD_NRD_1	67	69	PF00675	0.473
CLV_NRD_NRD_1	87	89	PF00675	0.325
CLV_NRD_NRD_1	90	92	PF00675	0.514
CLV_PCSK_FUR_1	68	72	PF00082	0.565
CLV_PCSK_FUR_1	85	89	PF00082	0.607
CLV_PCSK_KEX2_1	42	44	PF00082	0.489
CLV_PCSK_KEX2_1	67	69	PF00082	0.473
CLV_PCSK_KEX2_1	70	72	PF00082	0.496
CLV_PCSK_KEX2_1	87	89	PF00082	0.325
CLV_PCSK_KEX2_1	90	92	PF00082	0.325
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.561
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.394
CLV_PCSK_PC7_1	83	89	PF00082	0.532
CLV_PCSK_SKI1_1	24	28	PF00082	0.454
CLV_PCSK_SKI1_1	46	50	PF00082	0.507
DEG_Nend_UBRbox_3	1	3	PF02207	0.658
DEG_ODPH_VHL_1	14	27	PF01847	0.525
DOC_USP7_MATH_1	96	100	PF00917	0.612
LIG_14-3-3_CanoR_1	68	76	PF00244	0.538
LIG_Actin_WH2_2	38	53	PF00022	0.482
LIG_Clathr_ClatBox_1	101	105	PF01394	0.665
LIG_FHA_2	116	122	PF00498	0.720
LIG_SUMO_SIM_anti_2	19	24	PF11976	0.529
LIG_SUMO_SIM_par_1	25	31	PF11976	0.435
LIG_SUMO_SIM_par_1	99	105	PF11976	0.656
LIG_TRAF2_1	117	120	PF00917	0.741
LIG_TRAF2_1	16	19	PF00917	0.493
LIG_TRAF2_1	79	82	PF00917	0.594
MOD_CK1_1	112	118	PF00069	0.739
MOD_CK1_1	53	59	PF00069	0.534
MOD_CK2_1	114	120	PF00069	0.694
MOD_CK2_1	76	82	PF00069	0.641
MOD_Cter_Amidation	68	71	PF01082	0.564
MOD_GlcNHglycan	107	110	PF01048	0.624
MOD_GlcNHglycan	113	117	PF01048	0.659
MOD_GlcNHglycan	2	5	PF01048	0.636
MOD_GSK3_1	105	112	PF00069	0.644
MOD_GSK3_1	49	56	PF00069	0.525
MOD_PIKK_1	69	75	PF00454	0.533
MOD_Plk_2-3	28	34	PF00069	0.531
TRG_DiLeu_BaEn_4	81	87	PF01217	0.496
TRG_ER_diArg_1	41	44	PF00400	0.469
TRG_ER_diArg_1	66	68	PF00400	0.475
TRG_ER_diArg_1	83	86	PF00400	0.536
TRG_ER_diArg_1	88	91	PF00400	0.505
TRG_NLS_Bipartite_1	70	91	PF00514	0.566
TRG_NLS_MonoCore_2	86	91	PF00514	0.555
TRG_NLS_MonoExtC_3	38	43	PF00514	0.515
TRG_NLS_MonoExtC_3	86	91	PF00514	0.555
TRG_NLS_MonoExtN_4	85	91	PF00514	0.560
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV53	Leptomonas seymouri	79%	98%
A0A1X0NGK1	Trypanosomatidae	50%	100%
A0A3R7MXM6	Trypanosoma rangeli	47%	100%
A4HCN3	Leishmania braziliensis	85%	100%
A4I057	Leishmania infantum	100%	100%
E9AW20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QBF6	Leishmania major	96%	100%