Putative_methyltransferase/Methyltransferase_smal l_domain/Methyltransferase_domain_containing_protein_putati ve/Pfam:PF10294/Pfam:PF05175/Pfam:PF13847/Pfam:PF08241/Pfam:PF08242

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative methyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WXK7_LEIDO

TriTrypDb:

LdBPK_230110.1 , LdCL_230006000 , LDHU3_23.0130

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WXK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXK7

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	4
GO:0032259	methylation	2	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0008168	methyltransferase activity	4	4
GO:0016740	transferase activity	2	4
GO:0016741	transferase activity, transferring one-carbon groups	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	26	28	PF00675	0.406
CLV_PCSK_SKI1_1	105	109	PF00082	0.270
CLV_PCSK_SKI1_1	201	205	PF00082	0.483
CLV_PCSK_SKI1_1	57	61	PF00082	0.479
CLV_PCSK_SKI1_1	8	12	PF00082	0.540
DEG_Nend_UBRbox_1	1	4	PF02207	0.571
DOC_CKS1_1	43	48	PF01111	0.444
DOC_CKS1_1	63	68	PF01111	0.377
DOC_MAPK_gen_1	221	229	PF00069	0.423
DOC_MAPK_MEF2A_6	221	229	PF00069	0.429
DOC_MAPK_MEF2A_6	35	43	PF00069	0.459
DOC_PP4_FxxP_1	43	46	PF00568	0.431
DOC_WW_Pin1_4	131	136	PF00397	0.364
DOC_WW_Pin1_4	42	47	PF00397	0.486
DOC_WW_Pin1_4	62	67	PF00397	0.467
LIG_14-3-3_CanoR_1	57	66	PF00244	0.374
LIG_Actin_WH2_2	179	196	PF00022	0.305
LIG_AP2alpha_2	247	249	PF02296	0.427
LIG_BRCT_BRCA1_1	183	187	PF00533	0.270
LIG_BRCT_BRCA1_1	98	102	PF00533	0.364
LIG_Clathr_ClatBox_1	29	33	PF01394	0.408
LIG_CtBP_PxDLS_1	135	139	PF00389	0.351
LIG_HCF-1_HBM_1	17	20	PF13415	0.424
LIG_LIR_Apic_2	40	46	PF02991	0.398
LIG_LIR_Gen_1	17	26	PF02991	0.430
LIG_LIR_Gen_1	176	186	PF02991	0.305
LIG_LIR_Gen_1	33	43	PF02991	0.242
LIG_LIR_Nem_3	17	23	PF02991	0.445
LIG_LIR_Nem_3	176	181	PF02991	0.305
LIG_LIR_Nem_3	247	252	PF02991	0.380
LIG_LIR_Nem_3	33	39	PF02991	0.294
LIG_NRBOX	70	76	PF00104	0.413
LIG_Pex14_1	85	89	PF04695	0.301
LIG_SH2_GRB2like	20	23	PF00017	0.429
LIG_SH2_NCK_1	20	24	PF00017	0.431
LIG_SH2_PTP2	83	86	PF00017	0.364
LIG_SH2_SRC	20	23	PF00017	0.429
LIG_SH2_STAT5	188	191	PF00017	0.305
LIG_SH2_STAT5	252	255	PF00017	0.390
LIG_SH2_STAT5	83	86	PF00017	0.305
LIG_SH3_3	242	248	PF00018	0.485
LIG_SH3_3	36	42	PF00018	0.409
LIG_SH3_3	60	66	PF00018	0.459
LIG_SUMO_SIM_anti_2	137	144	PF11976	0.351
LIG_SUMO_SIM_anti_2	67	73	PF11976	0.435
LIG_TRAF2_1	233	236	PF00917	0.417
LIG_WRC_WIRS_1	175	180	PF05994	0.364
MOD_CDK_SPxxK_3	42	49	PF00069	0.433
MOD_CK1_1	134	140	PF00069	0.316
MOD_CK1_1	44	50	PF00069	0.572
MOD_CK2_1	61	67	PF00069	0.504
MOD_GlcNHglycan	201	204	PF01048	0.520
MOD_GlcNHglycan	46	49	PF01048	0.473
MOD_GSK3_1	215	222	PF00069	0.364
MOD_GSK3_1	57	64	PF00069	0.511
MOD_NEK2_1	117	122	PF00069	0.446
MOD_NEK2_1	187	192	PF00069	0.314
MOD_NEK2_1	215	220	PF00069	0.315
MOD_NEK2_1	240	245	PF00069	0.376
MOD_PKB_1	55	63	PF00069	0.455
MOD_Plk_4	240	246	PF00069	0.378
MOD_ProDKin_1	131	137	PF00069	0.364
MOD_ProDKin_1	42	48	PF00069	0.487
MOD_ProDKin_1	62	68	PF00069	0.457
MOD_SUMO_for_1	169	172	PF00179	0.351
TRG_DiLeu_BaEn_1	67	72	PF01217	0.434
TRG_ENDOCYTIC_2	20	23	PF00928	0.455
TRG_ENDOCYTIC_2	36	39	PF00928	0.413
TRG_ER_diArg_1	54	57	PF00400	0.436
TRG_NES_CRM1_1	223	236	PF08389	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I266	Leptomonas seymouri	55%	100%
A0A0S4J1S6	Bodo saltans	36%	84%
A0A1X0NX63	Trypanosomatidae	43%	100%
A4HCM3	Leishmania braziliensis	79%	100%
A4I047	Leishmania infantum	100%	100%
A4IGU3	Xenopus tropicalis	25%	100%
E9AW10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QBG6	Leishmania major	94%	100%
Q86JB0	Dictyostelium discoideum	24%	72%