Trypanothione synthetase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

trypanothione synthetase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WXK4_LEIDO

TriTrypDb:

LdBPK_230500.1 , LdCL_230010400 , LDHU3_23.0710

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WXK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXK4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016874	ligase activity	2	7
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	7
GO:0016880	acid-ammonia (or amide) ligase activity	4	7
GO:0047479	trypanothione synthase activity	5	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.242
CLV_NRD_NRD_1	123	125	PF00675	0.464
CLV_NRD_NRD_1	313	315	PF00675	0.572
CLV_NRD_NRD_1	37	39	PF00675	0.758
CLV_PCSK_KEX2_1	123	125	PF00082	0.464
CLV_PCSK_KEX2_1	318	320	PF00082	0.480
CLV_PCSK_KEX2_1	37	39	PF00082	0.758
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.569
CLV_PCSK_PC7_1	314	320	PF00082	0.453
CLV_PCSK_SKI1_1	131	135	PF00082	0.487
CLV_PCSK_SKI1_1	209	213	PF00082	0.507
DEG_MDM2_SWIB_1	121	128	PF02201	0.339
DEG_SPOP_SBC_1	14	18	PF00917	0.588
DEG_SPOP_SBC_1	67	71	PF00917	0.685
DOC_CYCLIN_RxL_1	128	138	PF00134	0.277
DOC_CYCLIN_yCln2_LP_2	216	219	PF00134	0.281
DOC_PP2B_LxvP_1	132	135	PF13499	0.264
DOC_PP2B_LxvP_1	216	219	PF13499	0.281
DOC_SPAK_OSR1_1	280	284	PF12202	0.402
DOC_USP7_MATH_1	135	139	PF00917	0.281
DOC_USP7_MATH_1	14	18	PF00917	0.657
DOC_USP7_MATH_1	67	71	PF00917	0.629
DOC_USP7_UBL2_3	205	209	PF12436	0.360
DOC_WW_Pin1_4	154	159	PF00397	0.396
DOC_WW_Pin1_4	175	180	PF00397	0.333
DOC_WW_Pin1_4	230	235	PF00397	0.348
LIG_14-3-3_CanoR_1	68	76	PF00244	0.625
LIG_BRCT_BRCA1_1	268	272	PF00533	0.335
LIG_deltaCOP1_diTrp_1	201	210	PF00928	0.339
LIG_FHA_1	127	133	PF00498	0.356
LIG_FHA_2	168	174	PF00498	0.215
LIG_FHA_2	196	202	PF00498	0.281
LIG_FHA_2	240	246	PF00498	0.352
LIG_FHA_2	296	302	PF00498	0.481
LIG_LIR_Apic_2	230	234	PF02991	0.352
LIG_LIR_Gen_1	201	211	PF02991	0.339
LIG_LIR_Gen_1	267	274	PF02991	0.284
LIG_LIR_Nem_3	108	114	PF02991	0.382
LIG_LIR_Nem_3	180	185	PF02991	0.215
LIG_LIR_Nem_3	201	206	PF02991	0.339
LIG_LIR_Nem_3	233	238	PF02991	0.320
LIG_LIR_Nem_3	267	271	PF02991	0.401
LIG_Pex14_2	121	125	PF04695	0.264
LIG_SH2_CRK	268	272	PF00017	0.434
LIG_SH2_GRB2like	197	200	PF00017	0.215
LIG_SH2_GRB2like	92	95	PF00017	0.409
LIG_SH2_NCK_1	268	272	PF00017	0.434
LIG_SH2_STAP1	148	152	PF00017	0.335
LIG_SH2_STAP1	268	272	PF00017	0.343
LIG_SH2_STAT3	114	117	PF00017	0.264
LIG_SH2_STAT5	141	144	PF00017	0.352
LIG_SH2_STAT5	197	200	PF00017	0.305
LIG_SH2_STAT5	252	255	PF00017	0.316
LIG_SH2_STAT5	259	262	PF00017	0.472
LIG_SH2_STAT5	282	285	PF00017	0.319
LIG_SH2_STAT5	84	87	PF00017	0.541
LIG_SH3_3	23	29	PF00018	0.655
LIG_TRAF2_1	43	46	PF00917	0.633
MOD_CK1_1	144	150	PF00069	0.341
MOD_CK1_1	157	163	PF00069	0.393
MOD_CK1_1	178	184	PF00069	0.281
MOD_CK1_1	230	236	PF00069	0.348
MOD_CK1_1	93	99	PF00069	0.454
MOD_CK2_1	167	173	PF00069	0.215
MOD_CK2_1	178	184	PF00069	0.352
MOD_CK2_1	2	8	PF00069	0.708
MOD_CK2_1	295	301	PF00069	0.537
MOD_GlcNHglycan	17	20	PF01048	0.606
MOD_GlcNHglycan	268	271	PF01048	0.340
MOD_GSK3_1	15	22	PF00069	0.665
MOD_GSK3_1	167	174	PF00069	0.334
MOD_GSK3_1	63	70	PF00069	0.683
MOD_GSK3_1	90	97	PF00069	0.526
MOD_N-GLC_1	93	98	PF02516	0.469
MOD_NEK2_1	1	6	PF00069	0.674
MOD_NEK2_1	126	131	PF00069	0.352
MOD_NEK2_1	167	172	PF00069	0.215
MOD_NEK2_1	63	68	PF00069	0.607
MOD_NEK2_2	74	79	PF00069	0.556
MOD_NMyristoyl	1	7	PF02799	0.670
MOD_OFUCOSY	139	146	PF10250	0.552
MOD_PIKK_1	157	163	PF00454	0.307
MOD_PIKK_1	82	88	PF00454	0.335
MOD_PKA_2	24	30	PF00069	0.696
MOD_PKA_2	67	73	PF00069	0.630
MOD_Plk_4	212	218	PF00069	0.299
MOD_Plk_4	220	226	PF00069	0.260
MOD_ProDKin_1	154	160	PF00069	0.396
MOD_ProDKin_1	175	181	PF00069	0.333
MOD_ProDKin_1	230	236	PF00069	0.348
MOD_SUMO_rev_2	184	194	PF00179	0.355
MOD_SUMO_rev_2	5	11	PF00179	0.676
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.352
TRG_ENDOCYTIC_2	268	271	PF00928	0.445
TRG_ER_diArg_1	123	125	PF00400	0.264
TRG_ER_diArg_1	23	26	PF00400	0.559
TRG_ER_diArg_1	37	40	PF00400	0.476
TRG_ER_diArg_1	59	62	PF00400	0.649
TRG_Pf-PMV_PEXEL_1	131	136	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II02	Leptomonas seymouri	61%	100%
A0A0S4IVA9	Bodo saltans	37%	100%
A0A422N6B5	Trypanosoma rangeli	39%	100%
A4HCR0	Leishmania braziliensis	73%	100%
A4I085	Leishmania infantum	98%	100%
C9ZV01	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AW49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	95%
Q4QBC8	Leishmania major	84%	100%
V5BCE6	Trypanosoma cruzi	41%	100%