Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WXJ0_LEIDO

TriTrypDb:

LdBPK_230190.1 , LdCL_230006800 , LDHU3_23.0230

Length:

227

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7WXJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXJ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.653
CLV_NRD_NRD_1	131	133	PF00675	0.599
CLV_NRD_NRD_1	143	145	PF00675	0.670
CLV_PCSK_KEX2_1	131	133	PF00082	0.599
CLV_PCSK_KEX2_1	142	144	PF00082	0.658
CLV_PCSK_KEX2_1	39	41	PF00082	0.352
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.323
CLV_PCSK_SKI1_1	153	157	PF00082	0.553
DOC_MAPK_gen_1	91	100	PF00069	0.344
DOC_MAPK_MEF2A_6	91	100	PF00069	0.379
DOC_WW_Pin1_4	10	15	PF00397	0.684
LIG_14-3-3_CanoR_1	104	110	PF00244	0.455
LIG_14-3-3_CanoR_1	143	149	PF00244	0.374
LIG_14-3-3_CanoR_1	150	156	PF00244	0.383
LIG_Actin_WH2_2	173	190	PF00022	0.319
LIG_FHA_1	182	188	PF00498	0.550
LIG_FHA_1	66	72	PF00498	0.455
LIG_FHA_2	90	96	PF00498	0.433
LIG_LIR_Nem_3	193	197	PF02991	0.597
LIG_LIR_Nem_3	58	63	PF02991	0.352
LIG_RPA_C_Fungi	139	151	PF08784	0.506
LIG_SH2_SRC	63	66	PF00017	0.465
LIG_SH2_STAT5	63	66	PF00017	0.396
MOD_CK1_1	105	111	PF00069	0.482
MOD_CK1_1	154	160	PF00069	0.472
MOD_CK2_1	197	203	PF00069	0.654
MOD_CK2_1	3	9	PF00069	0.576
MOD_CK2_1	35	41	PF00069	0.609
MOD_GlcNHglycan	159	162	PF01048	0.477
MOD_GlcNHglycan	209	212	PF01048	0.624
MOD_GlcNHglycan	57	60	PF01048	0.402
MOD_GSK3_1	151	158	PF00069	0.501
MOD_GSK3_1	3	10	PF00069	0.733
MOD_N-GLC_1	102	107	PF02516	0.509
MOD_N-GLC_1	144	149	PF02516	0.488
MOD_NEK2_1	134	139	PF00069	0.436
MOD_NEK2_1	155	160	PF00069	0.440
MOD_NEK2_1	34	39	PF00069	0.507
MOD_NEK2_1	89	94	PF00069	0.490
MOD_NMyristoyl	1	7	PF02799	0.560
MOD_PK_1	144	150	PF00069	0.512
MOD_PKA_2	66	72	PF00069	0.504
MOD_PKB_1	142	150	PF00069	0.444
MOD_Plk_1	102	108	PF00069	0.508
MOD_Plk_1	144	150	PF00069	0.490
MOD_ProDKin_1	10	16	PF00069	0.604
MOD_SUMO_for_1	98	101	PF00179	0.462
TRG_DiLeu_BaEn_1	102	107	PF01217	0.502
TRG_ENDOCYTIC_2	167	170	PF00928	0.385
TRG_ER_diArg_1	141	144	PF00400	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJU2	Leptomonas seymouri	51%	100%
A0A1X0NGY8	Trypanosomatidae	25%	100%
A4HCN1	Leishmania braziliensis	76%	100%
A4I055	Leishmania infantum	100%	100%
E9AW18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QBF8	Leishmania major	93%	100%
V5B4L7	Trypanosoma cruzi	33%	95%