Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WXI7_LEIDO

TriTrypDb:

LdBPK_221460.1 , LdCL_220021900 , LDHU3_22.2100

Length:

730

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WXI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXI7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	503	507	PF00656	0.585
CLV_C14_Caspase3-7	97	101	PF00656	0.584
CLV_NRD_NRD_1	27	29	PF00675	0.546
CLV_NRD_NRD_1	400	402	PF00675	0.799
CLV_NRD_NRD_1	406	408	PF00675	0.672
CLV_NRD_NRD_1	538	540	PF00675	0.552
CLV_NRD_NRD_1	641	643	PF00675	0.722
CLV_NRD_NRD_1	75	77	PF00675	0.519
CLV_PCSK_FUR_1	536	540	PF00082	0.626
CLV_PCSK_KEX2_1	131	133	PF00082	0.546
CLV_PCSK_KEX2_1	363	365	PF00082	0.601
CLV_PCSK_KEX2_1	400	402	PF00082	0.670
CLV_PCSK_KEX2_1	538	540	PF00082	0.650
CLV_PCSK_KEX2_1	599	601	PF00082	0.475
CLV_PCSK_KEX2_1	641	643	PF00082	0.723
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.546
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.601
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.475
CLV_PCSK_SKI1_1	128	132	PF00082	0.586
CLV_PCSK_SKI1_1	321	325	PF00082	0.621
CLV_PCSK_SKI1_1	548	552	PF00082	0.404
CLV_PCSK_SKI1_1	610	614	PF00082	0.568
CLV_PCSK_SKI1_1	622	626	PF00082	0.360
CLV_Separin_Metazoa	533	537	PF03568	0.571
DEG_SPOP_SBC_1	708	712	PF00917	0.683
DOC_CKS1_1	433	438	PF01111	0.800
DOC_CYCLIN_RxL_1	128	139	PF00134	0.532
DOC_CYCLIN_RxL_1	545	556	PF00134	0.406
DOC_CYCLIN_yCln2_LP_2	433	439	PF00134	0.717
DOC_MAPK_gen_1	238	247	PF00069	0.577
DOC_MAPK_MEF2A_6	158	167	PF00069	0.668
DOC_MAPK_MEF2A_6	241	249	PF00069	0.565
DOC_PP1_RVXF_1	129	136	PF00149	0.570
DOC_PP1_RVXF_1	620	626	PF00149	0.467
DOC_PP4_FxxP_1	262	265	PF00568	0.618
DOC_USP7_MATH_1	140	144	PF00917	0.522
DOC_USP7_MATH_1	420	424	PF00917	0.801
DOC_USP7_MATH_1	446	450	PF00917	0.593
DOC_USP7_MATH_1	553	557	PF00917	0.588
DOC_USP7_MATH_1	576	580	PF00917	0.479
DOC_USP7_MATH_1	591	595	PF00917	0.576
DOC_USP7_MATH_1	612	616	PF00917	0.551
DOC_USP7_MATH_1	678	682	PF00917	0.599
DOC_USP7_MATH_1	726	730	PF00917	0.797
DOC_WW_Pin1_4	138	143	PF00397	0.634
DOC_WW_Pin1_4	168	173	PF00397	0.660
DOC_WW_Pin1_4	219	224	PF00397	0.507
DOC_WW_Pin1_4	252	257	PF00397	0.558
DOC_WW_Pin1_4	273	278	PF00397	0.599
DOC_WW_Pin1_4	285	290	PF00397	0.442
DOC_WW_Pin1_4	383	388	PF00397	0.727
DOC_WW_Pin1_4	432	437	PF00397	0.772
DOC_WW_Pin1_4	46	51	PF00397	0.578
DOC_WW_Pin1_4	636	641	PF00397	0.509
DOC_WW_Pin1_4	95	100	PF00397	0.775
LIG_14-3-3_CanoR_1	28	34	PF00244	0.484
LIG_14-3-3_CanoR_1	425	433	PF00244	0.808
LIG_14-3-3_CanoR_1	630	635	PF00244	0.487
LIG_Actin_WH2_2	117	133	PF00022	0.563
LIG_BRCT_BRCA1_1	348	352	PF00533	0.601
LIG_BRCT_BRCA1_1	578	582	PF00533	0.471
LIG_BRCT_BRCA1_1	588	592	PF00533	0.571
LIG_CSL_BTD_1	58	61	PF09270	0.459
LIG_EH1_1	528	536	PF00400	0.455
LIG_eIF4E_1	529	535	PF01652	0.454
LIG_FHA_1	109	115	PF00498	0.422
LIG_FHA_1	11	17	PF00498	0.518
LIG_FHA_1	180	186	PF00498	0.451
LIG_FHA_1	253	259	PF00498	0.483
LIG_FHA_1	28	34	PF00498	0.405
LIG_FHA_1	476	482	PF00498	0.581
LIG_FHA_1	492	498	PF00498	0.376
LIG_FHA_1	591	597	PF00498	0.571
LIG_FHA_2	38	44	PF00498	0.550
LIG_FHA_2	528	534	PF00498	0.555
LIG_FHA_2	555	561	PF00498	0.591
LIG_FHA_2	658	664	PF00498	0.500
LIG_FHA_2	95	101	PF00498	0.766
LIG_Integrin_RGD_1	37	39	PF01839	0.670
LIG_LIR_Apic_2	259	265	PF02991	0.596
LIG_LIR_Apic_2	272	277	PF02991	0.335
LIG_LIR_Gen_1	468	479	PF02991	0.564
LIG_LIR_Nem_3	468	474	PF02991	0.579
LIG_MAD2	132	140	PF02301	0.437
LIG_MYND_1	58	62	PF01753	0.450
LIG_SH2_CRK	12	16	PF00017	0.373
LIG_SH2_CRK	121	125	PF00017	0.457
LIG_SH2_CRK	519	523	PF00017	0.482
LIG_SH2_SRC	463	466	PF00017	0.358
LIG_SH2_STAP1	12	16	PF00017	0.509
LIG_SH2_STAP1	81	85	PF00017	0.491
LIG_SH2_STAT5	12	15	PF00017	0.504
LIG_SH2_STAT5	17	20	PF00017	0.478
LIG_SH2_STAT5	480	483	PF00017	0.610
LIG_SH2_STAT5	529	532	PF00017	0.451
LIG_SH2_STAT5	601	604	PF00017	0.467
LIG_SH2_STAT5	671	674	PF00017	0.663
LIG_SH3_3	195	201	PF00018	0.577
LIG_SH3_3	433	439	PF00018	0.783
LIG_SH3_3	55	61	PF00018	0.412
LIG_SH3_3	686	692	PF00018	0.668
LIG_SH3_4	561	568	PF00018	0.513
LIG_SUMO_SIM_anti_2	530	536	PF11976	0.455
LIG_SUMO_SIM_anti_2	663	670	PF11976	0.546
LIG_SUMO_SIM_par_1	123	129	PF11976	0.543
LIG_SUMO_SIM_par_1	165	171	PF11976	0.660
LIG_SUMO_SIM_par_1	550	557	PF11976	0.483
LIG_TRAF2_1	276	279	PF00917	0.637
LIG_TRFH_1	136	140	PF08558	0.454
LIG_TRFH_1	261	265	PF08558	0.607
LIG_TYR_ITIM	119	124	PF00017	0.463
LIG_TYR_ITIM	517	522	PF00017	0.495
MOD_CDK_SPK_2	252	257	PF00069	0.500
MOD_CDK_SPK_2	636	641	PF00069	0.509
MOD_CDK_SPxK_1	636	642	PF00069	0.518
MOD_CDK_SPxxK_3	168	175	PF00069	0.551
MOD_CK1_1	108	114	PF00069	0.443
MOD_CK1_1	143	149	PF00069	0.533
MOD_CK1_1	202	208	PF00069	0.515
MOD_CK1_1	222	228	PF00069	0.321
MOD_CK1_1	285	291	PF00069	0.531
MOD_CK1_1	337	343	PF00069	0.616
MOD_CK1_1	355	361	PF00069	0.435
MOD_CK1_1	382	388	PF00069	0.812
MOD_CK1_1	423	429	PF00069	0.746
MOD_CK1_1	486	492	PF00069	0.593
MOD_CK1_1	499	505	PF00069	0.401
MOD_CK2_1	273	279	PF00069	0.599
MOD_CK2_1	408	414	PF00069	0.737
MOD_CK2_1	527	533	PF00069	0.503
MOD_CK2_1	591	597	PF00069	0.529
MOD_CK2_1	657	663	PF00069	0.512
MOD_CK2_1	667	673	PF00069	0.571
MOD_GlcNHglycan	142	145	PF01048	0.550
MOD_GlcNHglycan	175	178	PF01048	0.579
MOD_GlcNHglycan	202	205	PF01048	0.537
MOD_GlcNHglycan	214	217	PF01048	0.473
MOD_GlcNHglycan	284	287	PF01048	0.522
MOD_GlcNHglycan	348	351	PF01048	0.529
MOD_GlcNHglycan	354	357	PF01048	0.395
MOD_GlcNHglycan	372	375	PF01048	0.605
MOD_GlcNHglycan	388	391	PF01048	0.508
MOD_GlcNHglycan	409	413	PF01048	0.739
MOD_GlcNHglycan	428	431	PF01048	0.569
MOD_GlcNHglycan	452	455	PF01048	0.572
MOD_GlcNHglycan	483	486	PF01048	0.669
MOD_GlcNHglycan	488	491	PF01048	0.639
MOD_GlcNHglycan	498	501	PF01048	0.371
MOD_GlcNHglycan	541	544	PF01048	0.617
MOD_GlcNHglycan	578	581	PF01048	0.451
MOD_GlcNHglycan	588	591	PF01048	0.569
MOD_GlcNHglycan	614	617	PF01048	0.565
MOD_GlcNHglycan	685	688	PF01048	0.669
MOD_GSK3_1	134	141	PF00069	0.499
MOD_GSK3_1	142	149	PF00069	0.517
MOD_GSK3_1	218	225	PF00069	0.549
MOD_GSK3_1	252	259	PF00069	0.522
MOD_GSK3_1	269	276	PF00069	0.591
MOD_GSK3_1	310	317	PF00069	0.627
MOD_GSK3_1	331	338	PF00069	0.565
MOD_GSK3_1	358	365	PF00069	0.588
MOD_GSK3_1	370	377	PF00069	0.795
MOD_GSK3_1	378	385	PF00069	0.560
MOD_GSK3_1	408	415	PF00069	0.783
MOD_GSK3_1	420	427	PF00069	0.726
MOD_GSK3_1	446	453	PF00069	0.604
MOD_GSK3_1	465	472	PF00069	0.489
MOD_GSK3_1	481	488	PF00069	0.633
MOD_GSK3_1	582	589	PF00069	0.630
MOD_GSK3_1	663	670	PF00069	0.563
MOD_GSK3_1	672	679	PF00069	0.633
MOD_GSK3_1	91	98	PF00069	0.770
MOD_N-GLC_1	10	15	PF02516	0.521
MOD_N-GLC_1	382	387	PF02516	0.681
MOD_NEK2_1	120	125	PF00069	0.458
MOD_NEK2_1	194	199	PF00069	0.551
MOD_NEK2_1	218	223	PF00069	0.588
MOD_NEK2_1	280	285	PF00069	0.591
MOD_NEK2_1	309	314	PF00069	0.510
MOD_NEK2_1	331	336	PF00069	0.573
MOD_NEK2_1	352	357	PF00069	0.565
MOD_NEK2_1	378	383	PF00069	0.704
MOD_NEK2_1	582	587	PF00069	0.634
MOD_NEK2_1	667	672	PF00069	0.523
MOD_NEK2_1	676	681	PF00069	0.607
MOD_NEK2_1	720	725	PF00069	0.668
MOD_NEK2_2	126	131	PF00069	0.566
MOD_PIKK_1	158	164	PF00454	0.637
MOD_PIKK_1	644	650	PF00454	0.643
MOD_PKA_1	407	413	PF00069	0.728
MOD_PKA_2	256	262	PF00069	0.477
MOD_PKA_2	27	33	PF00069	0.485
MOD_PKA_2	292	298	PF00069	0.476
MOD_PKA_2	424	430	PF00069	0.765
MOD_PKA_2	475	481	PF00069	0.534
MOD_PKB_1	405	413	PF00069	0.646
MOD_Plk_1	10	16	PF00069	0.519
MOD_Plk_1	179	185	PF00069	0.596
MOD_Plk_1	423	429	PF00069	0.688
MOD_Plk_1	43	49	PF00069	0.536
MOD_Plk_1	657	663	PF00069	0.508
MOD_Plk_1	672	678	PF00069	0.617
MOD_Plk_4	120	126	PF00069	0.454
MOD_Plk_4	194	200	PF00069	0.554
MOD_Plk_4	314	320	PF00069	0.531
MOD_Plk_4	355	361	PF00069	0.577
MOD_Plk_4	465	471	PF00069	0.520
MOD_Plk_4	475	481	PF00069	0.463
MOD_Plk_4	527	533	PF00069	0.557
MOD_Plk_4	630	636	PF00069	0.506
MOD_ProDKin_1	138	144	PF00069	0.634
MOD_ProDKin_1	168	174	PF00069	0.660
MOD_ProDKin_1	219	225	PF00069	0.509
MOD_ProDKin_1	252	258	PF00069	0.551
MOD_ProDKin_1	273	279	PF00069	0.599
MOD_ProDKin_1	285	291	PF00069	0.434
MOD_ProDKin_1	383	389	PF00069	0.729
MOD_ProDKin_1	432	438	PF00069	0.772
MOD_ProDKin_1	46	52	PF00069	0.581
MOD_ProDKin_1	636	642	PF00069	0.518
MOD_ProDKin_1	95	101	PF00069	0.766
MOD_SUMO_rev_2	21	31	PF00179	0.580
TRG_DiLeu_BaEn_1	663	668	PF01217	0.537
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.449
TRG_DiLeu_BaLyEn_6	619	624	PF01217	0.478
TRG_ENDOCYTIC_2	12	15	PF00928	0.510
TRG_ENDOCYTIC_2	121	124	PF00928	0.463
TRG_ENDOCYTIC_2	519	522	PF00928	0.487
TRG_ENDOCYTIC_2	529	532	PF00928	0.451
TRG_ENDOCYTIC_2	81	84	PF00928	0.489
TRG_ER_diArg_1	399	401	PF00400	0.660
TRG_ER_diArg_1	516	519	PF00400	0.515
TRG_ER_diArg_1	537	539	PF00400	0.637
TRG_ER_diArg_1	640	642	PF00400	0.688
TRG_ER_diLys_1	727	730	PF00400	0.623
TRG_NES_CRM1_1	109	122	PF08389	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJC5	Leptomonas seymouri	47%	100%
A4HCK2	Leishmania braziliensis	75%	100%
A4I020	Leishmania infantum	100%	100%
E9AVZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QBI6	Leishmania major	90%	99%