Cytochrome_c_oxidase_subunit_10_putative/GeneDB:L mjF.23.0370

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome c oxidase subunit 10, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WXI5_LEIDO

TriTrypDb:

LdBPK_230420.1 , LdCL_230009700 , LDHU3_23.0610

Length:

118

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), cytochrome c oxidase subunit 10

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7WXI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXI5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016491	oxidoreductase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.398
CLV_NRD_NRD_1	2	4	PF00675	0.447
CLV_NRD_NRD_1	51	53	PF00675	0.350
CLV_NRD_NRD_1	86	88	PF00675	0.322
CLV_PCSK_KEX2_1	2	4	PF00082	0.487
CLV_PCSK_KEX2_1	51	53	PF00082	0.380
CLV_PCSK_KEX2_1	86	88	PF00082	0.319
CLV_PCSK_PC7_1	47	53	PF00082	0.322
CLV_PCSK_SKI1_1	100	104	PF00082	0.295
CLV_PCSK_SKI1_1	2	6	PF00082	0.571
CLV_PCSK_SKI1_1	79	83	PF00082	0.365
CLV_PCSK_SKI1_1	87	91	PF00082	0.313
DEG_Nend_UBRbox_1	1	4	PF02207	0.567
DOC_CYCLIN_RxL_1	18	28	PF00134	0.442
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.433
DOC_PP1_RVXF_1	19	26	PF00149	0.425
DOC_PP1_RVXF_1	60	67	PF00149	0.317
DOC_PP1_RVXF_1	85	92	PF00149	0.344
DOC_WW_Pin1_4	25	30	PF00397	0.487
DOC_WW_Pin1_4	79	84	PF00397	0.358
LIG_14-3-3_CanoR_1	100	105	PF00244	0.342
LIG_14-3-3_CanoR_1	2	11	PF00244	0.574
LIG_deltaCOP1_diTrp_1	88	98	PF00928	0.446
LIG_FHA_1	101	107	PF00498	0.291
LIG_FHA_1	18	24	PF00498	0.586
LIG_FHA_1	3	9	PF00498	0.578
LIG_FHA_2	80	86	PF00498	0.348
LIG_HCF-1_HBM_1	111	114	PF13415	0.315
LIG_LIR_Gen_1	63	73	PF02991	0.343
LIG_LIR_Nem_3	63	69	PF02991	0.328
LIG_LIR_Nem_3	97	102	PF02991	0.287
LIG_REV1ctd_RIR_1	96	104	PF16727	0.311
LIG_SH2_PTP2	101	104	PF00017	0.291
LIG_SH2_SRC	36	39	PF00017	0.408
LIG_SH2_STAT5	101	104	PF00017	0.444
LIG_SH2_STAT5	36	39	PF00017	0.332
LIG_SH3_3	23	29	PF00018	0.475
LIG_SUMO_SIM_par_1	30	35	PF11976	0.384
LIG_TRAF2_1	82	85	PF00917	0.429
MOD_CDK_SPxxK_3	79	86	PF00069	0.352
MOD_CK2_1	79	85	PF00069	0.341
MOD_GSK3_1	100	107	PF00069	0.293
MOD_N-GLC_1	79	84	PF02516	0.340
MOD_NEK2_1	104	109	PF00069	0.330
MOD_PKA_1	2	8	PF00069	0.571
MOD_PKA_2	2	8	PF00069	0.571
MOD_ProDKin_1	25	31	PF00069	0.488
MOD_ProDKin_1	79	85	PF00069	0.359
TRG_ENDOCYTIC_2	101	104	PF00928	0.393
TRG_ER_diArg_1	1	3	PF00400	0.458
TRG_ER_diArg_1	51	53	PF00400	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKB5	Leptomonas seymouri	86%	99%
A0A0S4JCT0	Bodo saltans	71%	100%
A0A1X0NX91	Trypanosomatidae	74%	100%
A4HCQ2	Leishmania braziliensis	86%	100%
A4I077	Leishmania infantum	100%	100%
D0A9J4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
D0A9J6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
E9AW41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QBD7	Leishmania major	98%	100%