Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WXI2_LEIDO

TriTrypDb:

LdBPK_230270.1 , LdCL_230007600 , LdCL_230008100 , LDHU3_23.0370

Length:

185

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S7WXI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXI2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.633
CLV_NRD_NRD_1	154	156	PF00675	0.517
CLV_NRD_NRD_1	24	26	PF00675	0.679
CLV_NRD_NRD_1	39	41	PF00675	0.560
CLV_PCSK_FUR_1	22	26	PF00082	0.623
CLV_PCSK_KEX2_1	10	12	PF00082	0.607
CLV_PCSK_KEX2_1	125	127	PF00082	0.360
CLV_PCSK_KEX2_1	154	156	PF00082	0.495
CLV_PCSK_KEX2_1	24	26	PF00082	0.702
CLV_PCSK_KEX2_1	39	41	PF00082	0.567
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.360
CLV_PCSK_PC7_1	6	12	PF00082	0.592
CLV_PCSK_SKI1_1	144	148	PF00082	0.463
DEG_APCC_DBOX_1	11	19	PF00400	0.304
DOC_MAPK_gen_1	10	17	PF00069	0.420
DOC_MAPK_MEF2A_6	10	17	PF00069	0.420
DOC_MAPK_NFAT4_5	10	18	PF00069	0.421
DOC_PP1_RVXF_1	73	80	PF00149	0.284
LIG_14-3-3_CanoR_1	6	10	PF00244	0.408
LIG_BIR_II_1	1	5	PF00653	0.401
LIG_EH1_1	45	53	PF00400	0.327
LIG_FHA_1	26	32	PF00498	0.502
LIG_FHA_1	89	95	PF00498	0.315
LIG_LIR_Apic_2	55	61	PF02991	0.414
LIG_LIR_Gen_1	80	89	PF02991	0.348
LIG_LIR_Nem_3	80	84	PF02991	0.348
LIG_Pex14_2	88	92	PF04695	0.388
LIG_SH2_STAP1	139	143	PF00017	0.509
LIG_SH2_STAT5	14	17	PF00017	0.474
LIG_SH3_3	79	85	PF00018	0.294
LIG_TRAF2_1	111	114	PF00917	0.592
LIG_UBA3_1	69	75	PF00899	0.356
LIG_WRC_WIRS_1	89	94	PF05994	0.315
MOD_CK2_1	177	183	PF00069	0.768
MOD_GlcNHglycan	54	57	PF01048	0.629
MOD_N-GLC_1	25	30	PF02516	0.681
MOD_NEK2_1	17	22	PF00069	0.469
MOD_NEK2_1	52	57	PF00069	0.451
MOD_NEK2_1	77	82	PF00069	0.459
MOD_NEK2_1	88	93	PF00069	0.327
MOD_PKA_2	5	11	PF00069	0.397
MOD_Plk_4	142	148	PF00069	0.624
MOD_Plk_4	88	94	PF00069	0.315
TRG_DiLeu_BaEn_1	142	147	PF01217	0.529
TRG_ENDOCYTIC_2	14	17	PF00928	0.421
TRG_ER_diArg_1	154	156	PF00400	0.717
TRG_ER_diArg_1	24	27	PF00400	0.458
TRG_ER_diArg_1	9	12	PF00400	0.405
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.301
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.360
TRG_PTS2	1	35	PF00400	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Y2	Leptomonas seymouri	46%	100%
A0A0S4JFQ3	Bodo saltans	33%	100%
A4HCN8	Leishmania braziliensis	65%	100%
A4I063	Leishmania infantum	98%	100%
E9AW26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QBF1	Leishmania major	89%	100%