Aldose_1-epimerase-like_protein/GeneDB:LmjF.23.04 30

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aldose 1-epimerase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WXI1_LEIDO

TriTrypDb:

LdBPK_230470.1 , LdCL_230010100 , LDHU3_23.0680

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WXI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXI1

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	10
GO:0008152	metabolic process	1	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:0005996	monosaccharide metabolic process	3	4
GO:0006006	glucose metabolic process	5	1
GO:0006012	galactose metabolic process	5	1
GO:0009056	catabolic process	2	1
GO:0016052	carbohydrate catabolic process	4	1
GO:0019318	hexose metabolic process	4	4
GO:0019320	hexose catabolic process	5	1
GO:0019388	galactose catabolic process	6	1
GO:0033499	galactose catabolic process via UDP-galactose	7	1
GO:0044281	small molecule metabolic process	2	4
GO:0044282	small molecule catabolic process	3	1
GO:0046365	monosaccharide catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004034	aldose 1-epimerase activity	5	9
GO:0005488	binding	1	10
GO:0016853	isomerase activity	2	10
GO:0016854	racemase and epimerase activity	3	9
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	4	9
GO:0030246	carbohydrate binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.571
CLV_NRD_NRD_1	406	408	PF00675	0.620
CLV_NRD_NRD_1	51	53	PF00675	0.380
CLV_PCSK_KEX2_1	406	408	PF00082	0.620
CLV_PCSK_SKI1_1	141	145	PF00082	0.337
CLV_PCSK_SKI1_1	188	192	PF00082	0.376
DOC_ANK_TNKS_1	273	280	PF00023	0.563
DOC_CYCLIN_yClb5_NLxxxL_5	30	39	PF00134	0.521
DOC_MAPK_gen_1	349	358	PF00069	0.482
DOC_PP2B_LxvP_1	253	256	PF13499	0.538
DOC_PP2B_PxIxI_1	327	333	PF00149	0.603
DOC_USP7_MATH_1	340	344	PF00917	0.571
DOC_USP7_MATH_1	371	375	PF00917	0.571
DOC_USP7_MATH_1	45	49	PF00917	0.606
DOC_USP7_MATH_1	56	60	PF00917	0.617
DOC_USP7_MATH_2	84	90	PF00917	0.571
DOC_WW_Pin1_4	156	161	PF00397	0.520
DOC_WW_Pin1_4	196	201	PF00397	0.505
DOC_WW_Pin1_4	263	268	PF00397	0.521
DOC_WW_Pin1_4	311	316	PF00397	0.520
DOC_WW_Pin1_4	363	368	PF00397	0.537
DOC_WW_Pin1_4	396	401	PF00397	0.596
LIG_14-3-3_CanoR_1	221	231	PF00244	0.488
LIG_14-3-3_CanoR_1	352	358	PF00244	0.463
LIG_Actin_WH2_2	292	309	PF00022	0.480
LIG_APCC_ABBA_1	158	163	PF00400	0.537
LIG_BIR_II_1	1	5	PF00653	0.794
LIG_BRCT_BRCA1_1	243	247	PF00533	0.603
LIG_Clathr_ClatBox_1	296	300	PF01394	0.480
LIG_CtBP_PxDLS_1	200	204	PF00389	0.578
LIG_FHA_1	114	120	PF00498	0.588
LIG_FHA_1	173	179	PF00498	0.520
LIG_FHA_1	2	8	PF00498	0.674
LIG_FHA_1	223	229	PF00498	0.665
LIG_FHA_1	248	254	PF00498	0.588
LIG_FHA_2	197	203	PF00498	0.603
LIG_FHA_2	264	270	PF00498	0.537
LIG_FHA_2	281	287	PF00498	0.539
LIG_FHA_2	303	309	PF00498	0.642
LIG_FHA_2	397	403	PF00498	0.714
LIG_FHA_2	80	86	PF00498	0.585
LIG_LIR_Gen_1	173	184	PF02991	0.560
LIG_LIR_Gen_1	236	247	PF02991	0.559
LIG_LIR_Gen_1	269	277	PF02991	0.603
LIG_LIR_Gen_1	388	398	PF02991	0.547
LIG_LIR_Gen_1	71	81	PF02991	0.522
LIG_LIR_Nem_3	139	143	PF02991	0.544
LIG_LIR_Nem_3	173	179	PF02991	0.564
LIG_LIR_Nem_3	236	242	PF02991	0.568
LIG_LIR_Nem_3	244	249	PF02991	0.665
LIG_LIR_Nem_3	269	273	PF02991	0.563
LIG_LIR_Nem_3	71	77	PF02991	0.522
LIG_MLH1_MIPbox_1	243	247	PF16413	0.603
LIG_Pex14_2	22	26	PF04695	0.666
LIG_PTB_Apo_2	104	111	PF02174	0.549
LIG_PTB_Apo_2	207	214	PF02174	0.520
LIG_PTB_Phospho_1	111	117	PF10480	0.555
LIG_PTB_Phospho_1	207	213	PF10480	0.520
LIG_SH2_CRK	176	180	PF00017	0.563
LIG_SH2_CRK	270	274	PF00017	0.588
LIG_SH2_GRB2like	213	216	PF00017	0.520
LIG_SH2_GRB2like	81	84	PF00017	0.603
LIG_SH2_NCK_1	313	317	PF00017	0.571
LIG_SH2_NCK_1	81	85	PF00017	0.563
LIG_SH2_STAP1	293	297	PF00017	0.480
LIG_SH2_STAT5	117	120	PF00017	0.600
LIG_SH2_STAT5	142	145	PF00017	0.520
LIG_SH2_STAT5	239	242	PF00017	0.582
LIG_SH2_STAT5	246	249	PF00017	0.454
LIG_SH2_STAT5	333	336	PF00017	0.520
LIG_SH2_STAT5	362	365	PF00017	0.520
LIG_SH2_STAT5	81	84	PF00017	0.584
LIG_SH3_3	216	222	PF00018	0.535
LIG_SH3_3	309	315	PF00018	0.588
LIG_SH3_3	361	367	PF00018	0.522
LIG_SH3_3	48	54	PF00018	0.615
LIG_SUMO_SIM_par_1	24	33	PF11976	0.556
LIG_SUMO_SIM_par_1	294	301	PF11976	0.520
LIG_TRAF2_1	283	286	PF00917	0.571
LIG_TRAF2_1	399	402	PF00917	0.646
MOD_CDK_SPxxK_3	311	318	PF00069	0.603
MOD_CDK_SPxxK_3	363	370	PF00069	0.538
MOD_CDK_SPxxK_3	396	403	PF00069	0.586
MOD_CK1_1	196	202	PF00069	0.598
MOD_CK1_1	314	320	PF00069	0.520
MOD_CK1_1	59	65	PF00069	0.480
MOD_CK2_1	280	286	PF00069	0.539
MOD_CK2_1	302	308	PF00069	0.674
MOD_CK2_1	396	402	PF00069	0.712
MOD_CK2_1	79	85	PF00069	0.589
MOD_GlcNHglycan	12	15	PF01048	0.722
MOD_GlcNHglycan	180	183	PF01048	0.403
MOD_GlcNHglycan	269	273	PF01048	0.416
MOD_GlcNHglycan	342	345	PF01048	0.336
MOD_GlcNHglycan	353	356	PF01048	0.335
MOD_GlcNHglycan	58	61	PF01048	0.366
MOD_GlcNHglycan	64	67	PF01048	0.357
MOD_GlcNHglycan	88	91	PF01048	0.439
MOD_GSK3_1	170	177	PF00069	0.601
MOD_GSK3_1	22	29	PF00069	0.583
MOD_GSK3_1	247	254	PF00069	0.642
MOD_GSK3_1	298	305	PF00069	0.661
MOD_GSK3_1	58	65	PF00069	0.594
MOD_N-GLC_1	113	118	PF02516	0.321
MOD_N-GLC_1	206	211	PF02516	0.342
MOD_N-GLC_1	340	345	PF02516	0.301
MOD_N-GLC_1	383	388	PF02516	0.338
MOD_NEK2_1	1	6	PF00069	0.724
MOD_NEK2_1	112	117	PF00069	0.658
MOD_NEK2_1	170	175	PF00069	0.555
MOD_NEK2_1	191	196	PF00069	0.578
MOD_NEK2_1	22	27	PF00069	0.627
MOD_NEK2_1	79	84	PF00069	0.581
MOD_NEK2_2	302	307	PF00069	0.603
MOD_NEK2_2	45	50	PF00069	0.532
MOD_PIKK_1	1	7	PF00454	0.723
MOD_PKA_2	351	357	PF00069	0.517
MOD_Plk_1	113	119	PF00069	0.585
MOD_Plk_1	201	207	PF00069	0.534
MOD_Plk_1	251	257	PF00069	0.570
MOD_Plk_1	268	274	PF00069	0.538
MOD_Plk_1	302	308	PF00069	0.613
MOD_Plk_4	174	180	PF00069	0.523
MOD_Plk_4	201	207	PF00069	0.546
MOD_Plk_4	22	28	PF00069	0.589
MOD_Plk_4	372	378	PF00069	0.505
MOD_ProDKin_1	156	162	PF00069	0.520
MOD_ProDKin_1	196	202	PF00069	0.505
MOD_ProDKin_1	263	269	PF00069	0.521
MOD_ProDKin_1	311	317	PF00069	0.520
MOD_ProDKin_1	363	369	PF00069	0.537
MOD_ProDKin_1	396	402	PF00069	0.597
MOD_SUMO_rev_2	397	405	PF00179	0.609
TRG_DiLeu_BaEn_1	139	144	PF01217	0.603
TRG_ENDOCYTIC_2	176	179	PF00928	0.535
TRG_ENDOCYTIC_2	213	216	PF00928	0.550
TRG_ENDOCYTIC_2	239	242	PF00928	0.603
TRG_ENDOCYTIC_2	246	249	PF00928	0.603
TRG_ENDOCYTIC_2	270	273	PF00928	0.563
TRG_ENDOCYTIC_2	293	296	PF00928	0.480
TRG_ER_diArg_1	405	407	PF00400	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P441	Leptomonas seymouri	33%	100%
A0A0N0P558	Leptomonas seymouri	70%	100%
A0A0N1PBB3	Leptomonas seymouri	36%	100%
A0A1X0NJ33	Trypanosomatidae	36%	100%
A0A1X0NX70	Trypanosomatidae	57%	100%
A0A3R7MXQ5	Trypanosoma rangeli	54%	100%
A0A3S7X8W5	Leishmania donovani	33%	100%
A0A3S7X8Z3	Leishmania donovani	35%	100%
A0A422N115	Trypanosoma rangeli	35%	100%
A4HCQ7	Leishmania braziliensis	84%	100%
A4I082	Leishmania infantum	99%	100%
A4IAZ4	Leishmania infantum	33%	98%
D4AMB9	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	26%	93%
E9AES2	Leishmania major	33%	98%
E9AES3	Leishmania major	36%	100%
E9AW46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B5X7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	98%
E9B5X8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
P05149	Acinetobacter calcoaceticus	38%	100%
P0A9C3	Escherichia coli (strain K12)	32%	100%
P0A9C4	Shigella flexneri	32%	100%
P21955	Streptococcus thermophilus	28%	100%
P31765	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	28%	100%
P53757	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q03PA4	Levilactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947)	27%	100%
Q4QBD1	Leishmania major	96%	100%
Q5EA79	Bos taurus	33%	100%
Q5R8U1	Pongo abelii	31%	100%
Q66HG4	Rattus norvegicus	31%	100%
Q8K157	Mus musculus	32%	100%
Q96C23	Homo sapiens	32%	100%
Q9GKX6	Sus scrofa	34%	100%
V5B7Z0	Trypanosoma cruzi	54%	100%