Myosin_tail_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WXH9_LEIDO

TriTrypDb:

LdBPK_230090.1 , LdCL_230005800 , LDHU3_23.0110

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WXH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXH9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	30	36	PF00089	0.518
CLV_NRD_NRD_1	23	25	PF00675	0.486
CLV_NRD_NRD_1	35	37	PF00675	0.451
CLV_NRD_NRD_1	356	358	PF00675	0.486
CLV_NRD_NRD_1	394	396	PF00675	0.574
CLV_NRD_NRD_1	62	64	PF00675	0.541
CLV_NRD_NRD_1	98	100	PF00675	0.489
CLV_PCSK_KEX2_1	133	135	PF00082	0.638
CLV_PCSK_KEX2_1	159	161	PF00082	0.586
CLV_PCSK_KEX2_1	22	24	PF00082	0.505
CLV_PCSK_KEX2_1	254	256	PF00082	0.592
CLV_PCSK_KEX2_1	393	395	PF00082	0.589
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.665
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.594
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.592
CLV_PCSK_SKI1_1	127	131	PF00082	0.483
CLV_PCSK_SKI1_1	233	237	PF00082	0.554
CLV_PCSK_SKI1_1	254	258	PF00082	0.504
CLV_PCSK_SKI1_1	273	277	PF00082	0.460
CLV_PCSK_SKI1_1	297	301	PF00082	0.636
DOC_CYCLIN_RxL_1	124	131	PF00134	0.524
DOC_MAPK_gen_1	229	237	PF00069	0.626
DOC_MAPK_gen_1	399	407	PF00069	0.538
DOC_MAPK_gen_1	52	62	PF00069	0.549
DOC_MAPK_MEF2A_6	273	282	PF00069	0.461
DOC_MAPK_NFAT4_5	273	281	PF00069	0.472
DOC_MAPK_RevD_3	85	100	PF00069	0.545
DOC_USP7_MATH_1	132	136	PF00917	0.622
DOC_USP7_MATH_1	150	154	PF00917	0.433
DOC_USP7_MATH_1	365	369	PF00917	0.470
DOC_USP7_MATH_1	389	393	PF00917	0.559
DOC_WW_Pin1_4	77	82	PF00397	0.651
DOC_WW_Pin1_4	9	14	PF00397	0.671
LIG_14-3-3_CanoR_1	160	166	PF00244	0.583
LIG_14-3-3_CanoR_1	170	179	PF00244	0.551
LIG_14-3-3_CanoR_1	22	30	PF00244	0.491
LIG_14-3-3_CanoR_1	233	238	PF00244	0.641
LIG_14-3-3_CanoR_1	273	279	PF00244	0.566
LIG_14-3-3_CanoR_1	382	388	PF00244	0.555
LIG_14-3-3_CanoR_1	99	103	PF00244	0.512
LIG_Actin_WH2_2	282	299	PF00022	0.588
LIG_BIR_II_1	1	5	PF00653	0.645
LIG_CtBP_PxDLS_1	81	85	PF00389	0.614
LIG_FHA_1	229	235	PF00498	0.586
LIG_FHA_1	99	105	PF00498	0.501
LIG_FHA_2	134	140	PF00498	0.576
LIG_FHA_2	147	153	PF00498	0.579
LIG_FHA_2	169	175	PF00498	0.606
LIG_FHA_2	285	291	PF00498	0.458
LIG_FHA_2	398	404	PF00498	0.538
LIG_FHA_2	54	60	PF00498	0.612
LIG_LIR_Gen_1	298	308	PF02991	0.656
LIG_LIR_Nem_3	290	295	PF02991	0.529
LIG_LIR_Nem_3	298	303	PF02991	0.625
LIG_PDZ_Class_3	414	419	PF00595	0.456
LIG_SH2_CRK	244	248	PF00017	0.518
LIG_SH3_3	314	320	PF00018	0.656
LIG_SUMO_SIM_par_1	100	107	PF11976	0.544
LIG_SUMO_SIM_par_1	274	279	PF11976	0.471
LIG_TRAF2_1	203	206	PF00917	0.548
LIG_TRAF2_1	44	47	PF00917	0.492
MOD_CK1_1	12	18	PF00069	0.653
MOD_CK1_1	144	150	PF00069	0.605
MOD_CK1_1	164	170	PF00069	0.287
MOD_CK1_1	173	179	PF00069	0.579
MOD_CK1_1	274	280	PF00069	0.462
MOD_CK1_1	334	340	PF00069	0.476
MOD_CK1_1	80	86	PF00069	0.510
MOD_CK2_1	12	18	PF00069	0.615
MOD_CK2_1	146	152	PF00069	0.658
MOD_CK2_1	168	174	PF00069	0.620
MOD_CK2_1	284	290	PF00069	0.459
MOD_CK2_1	32	38	PF00069	0.303
MOD_CK2_1	53	59	PF00069	0.563
MOD_CK2_1	80	86	PF00069	0.538
MOD_GlcNHglycan	143	146	PF01048	0.627
MOD_GlcNHglycan	325	330	PF01048	0.554
MOD_GlcNHglycan	370	374	PF01048	0.487
MOD_GlcNHglycan	74	77	PF01048	0.633
MOD_GSK3_1	118	125	PF00069	0.625
MOD_GSK3_1	146	153	PF00069	0.622
MOD_GSK3_1	160	167	PF00069	0.581
MOD_GSK3_1	233	240	PF00069	0.622
MOD_GSK3_1	267	274	PF00069	0.535
MOD_GSK3_1	365	372	PF00069	0.461
MOD_GSK3_1	383	390	PF00069	0.480
MOD_GSK3_1	393	400	PF00069	0.399
MOD_LATS_1	391	397	PF00433	0.552
MOD_N-GLC_1	259	264	PF02516	0.511
MOD_N-GLC_1	267	272	PF02516	0.473
MOD_NEK2_1	264	269	PF00069	0.506
MOD_NEK2_1	32	37	PF00069	0.599
MOD_NEK2_1	387	392	PF00069	0.594
MOD_PIKK_1	237	243	PF00454	0.674
MOD_PIKK_1	393	399	PF00454	0.601
MOD_PKA_1	133	139	PF00069	0.650
MOD_PKA_1	22	28	PF00069	0.603
MOD_PKA_1	393	399	PF00069	0.563
MOD_PKA_2	133	139	PF00069	0.652
MOD_PKA_2	141	147	PF00069	0.696
MOD_PKA_2	22	28	PF00069	0.490
MOD_PKA_2	264	270	PF00069	0.495
MOD_PKA_2	32	38	PF00069	0.477
MOD_PKA_2	334	340	PF00069	0.460
MOD_PKA_2	393	399	PF00069	0.601
MOD_PKA_2	98	104	PF00069	0.511
MOD_Plk_1	118	124	PF00069	0.629
MOD_Plk_1	407	413	PF00069	0.592
MOD_Plk_2-3	103	109	PF00069	0.442
MOD_Plk_2-3	168	174	PF00069	0.620
MOD_Plk_2-3	53	59	PF00069	0.563
MOD_Plk_4	407	413	PF00069	0.518
MOD_ProDKin_1	77	83	PF00069	0.643
MOD_ProDKin_1	9	15	PF00069	0.662
MOD_SUMO_for_1	44	47	PF00179	0.492
MOD_SUMO_rev_2	126	135	PF00179	0.622
MOD_SUMO_rev_2	216	223	PF00179	0.437
MOD_SUMO_rev_2	343	352	PF00179	0.490
MOD_SUMO_rev_2	353	360	PF00179	0.453
TRG_DiLeu_BaEn_1	46	51	PF01217	0.495
TRG_DiLeu_BaEn_4	46	52	PF01217	0.493
TRG_ENDOCYTIC_2	214	217	PF00928	0.486
TRG_ENDOCYTIC_2	244	247	PF00928	0.516
TRG_ER_diArg_1	22	24	PF00400	0.615
TRG_ER_diArg_1	280	283	PF00400	0.450
TRG_ER_diArg_1	393	395	PF00400	0.649
TRG_ER_diArg_1	412	415	PF00400	0.353
TRG_NES_CRM1_1	53	66	PF08389	0.498
TRG_NES_CRM1_1	68	82	PF08389	0.561
TRG_NES_CRM1_1	86	97	PF08389	0.536
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.624
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	248	253	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV61	Leptomonas seymouri	73%	100%
A0A0S4J5N8	Bodo saltans	37%	96%
A0A1X0NXM5	Trypanosomatidae	45%	100%
A0A422N5Q1	Trypanosoma rangeli	47%	99%
A4HCM1	Leishmania braziliensis	80%	100%
A4I045	Leishmania infantum	100%	100%
C9ZUY1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AW08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QBG8	Leishmania major	94%	100%
V5B6S0	Trypanosoma cruzi	47%	84%