Leucine Rich repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WXH1_LEIDO

TriTrypDb:

LdBPK_230170.1 , LdCL_230006600 , LDHU3_23.0210

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10

Expansion

Sequence features

A0A3S7WXH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXH1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	259	261	PF00675	0.452
CLV_NRD_NRD_1	320	322	PF00675	0.523
CLV_PCSK_KEX2_1	259	261	PF00082	0.420
CLV_PCSK_KEX2_1	320	322	PF00082	0.523
CLV_PCSK_PC7_1	255	261	PF00082	0.484
CLV_PCSK_SKI1_1	182	186	PF00082	0.490
CLV_PCSK_SKI1_1	320	324	PF00082	0.468
DEG_APCC_DBOX_1	181	189	PF00400	0.544
DEG_Kelch_Keap1_1	24	29	PF01344	0.369
DEG_Nend_Nbox_1	1	3	PF02207	0.415
DOC_CYCLIN_RxL_1	179	189	PF00134	0.509
DOC_CYCLIN_RxL_1	314	328	PF00134	0.474
DOC_MAPK_MEF2A_6	142	149	PF00069	0.514
DOC_MAPK_NFAT4_5	142	150	PF00069	0.510
DOC_PP2B_LxvP_1	65	68	PF13499	0.488
DOC_USP7_MATH_1	11	15	PF00917	0.516
DOC_USP7_MATH_1	332	336	PF00917	0.469
DOC_USP7_MATH_1	60	64	PF00917	0.483
DOC_USP7_MATH_1	68	72	PF00917	0.457
DOC_WW_Pin1_4	327	332	PF00397	0.487
LIG_14-3-3_CanoR_1	204	209	PF00244	0.484
LIG_14-3-3_CanoR_1	320	325	PF00244	0.455
LIG_14-3-3_CanoR_1	33	38	PF00244	0.485
LIG_14-3-3_CanoR_1	43	49	PF00244	0.356
LIG_FHA_1	223	229	PF00498	0.485
LIG_FHA_1	235	241	PF00498	0.439
LIG_FHA_1	25	31	PF00498	0.457
LIG_FHA_1	328	334	PF00498	0.478
LIG_FHA_1	91	97	PF00498	0.408
LIG_FHA_2	205	211	PF00498	0.436
LIG_FHA_2	298	304	PF00498	0.471
LIG_FHA_2	338	344	PF00498	0.453
LIG_FHA_2	43	49	PF00498	0.364
LIG_GBD_Chelix_1	194	202	PF00786	0.421
LIG_LIR_Gen_1	338	347	PF02991	0.557
LIG_LIR_Gen_1	36	44	PF02991	0.496
LIG_LIR_Gen_1	95	105	PF02991	0.426
LIG_LIR_LC3C_4	303	308	PF02991	0.505
LIG_LIR_Nem_3	262	266	PF02991	0.391
LIG_LIR_Nem_3	338	344	PF02991	0.447
LIG_LIR_Nem_3	36	40	PF02991	0.513
LIG_LIR_Nem_3	63	69	PF02991	0.431
LIG_LIR_Nem_3	95	101	PF02991	0.403
LIG_NRBOX	252	258	PF00104	0.392
LIG_PCNA_yPIPBox_3	142	153	PF02747	0.505
LIG_PDZ_Class_2	361	366	PF00595	0.561
LIG_Pex14_1	2	6	PF04695	0.368
LIG_SH2_CRK	69	73	PF00017	0.413
LIG_SH2_CRK	98	102	PF00017	0.409
LIG_SH2_NCK_1	69	73	PF00017	0.355
LIG_SH2_STAT5	215	218	PF00017	0.455
LIG_SH2_STAT5	66	69	PF00017	0.486
LIG_SUMO_SIM_par_1	305	312	PF11976	0.411
LIG_SUMO_SIM_par_1	89	95	PF11976	0.471
LIG_TRAF2_1	207	210	PF00917	0.470
LIG_TYR_ITIM	67	72	PF00017	0.369
LIG_TYR_ITIM	96	101	PF00017	0.417
MOD_CK1_1	23	29	PF00069	0.521
MOD_CK1_1	233	239	PF00069	0.379
MOD_CK1_1	312	318	PF00069	0.471
MOD_CK1_1	335	341	PF00069	0.522
MOD_CK1_1	71	77	PF00069	0.518
MOD_CK1_1	90	96	PF00069	0.436
MOD_CK2_1	203	209	PF00069	0.454
MOD_CK2_1	23	29	PF00069	0.540
MOD_CK2_1	297	303	PF00069	0.468
MOD_GlcNHglycan	12	16	PF01048	0.432
MOD_GlcNHglycan	23	26	PF01048	0.457
MOD_GlcNHglycan	232	235	PF01048	0.374
MOD_GlcNHglycan	334	337	PF01048	0.431
MOD_GlcNHglycan	62	65	PF01048	0.473
MOD_GSK3_1	19	26	PF00069	0.508
MOD_GSK3_1	230	237	PF00069	0.503
MOD_N-GLC_1	115	120	PF02516	0.461
MOD_N-GLC_1	204	209	PF02516	0.404
MOD_NEK2_1	230	235	PF00069	0.411
MOD_NEK2_1	266	271	PF00069	0.341
MOD_NEK2_1	309	314	PF00069	0.509
MOD_NEK2_1	337	342	PF00069	0.424
MOD_PIKK_1	243	249	PF00454	0.427
MOD_PKA_1	320	326	PF00069	0.518
MOD_PKA_2	203	209	PF00069	0.527
MOD_PKA_2	320	326	PF00069	0.495
MOD_PKA_2	42	48	PF00069	0.391
MOD_Plk_1	115	121	PF00069	0.489
MOD_Plk_1	204	210	PF00069	0.405
MOD_Plk_2-3	297	303	PF00069	0.468
MOD_Plk_4	190	196	PF00069	0.459
MOD_Plk_4	222	228	PF00069	0.433
MOD_Plk_4	320	326	PF00069	0.476
MOD_Plk_4	87	93	PF00069	0.481
MOD_ProDKin_1	327	333	PF00069	0.480
TRG_DiLeu_BaEn_1	75	80	PF01217	0.508
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.434
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.460
TRG_ENDOCYTIC_2	215	218	PF00928	0.455
TRG_ENDOCYTIC_2	69	72	PF00928	0.338
TRG_ENDOCYTIC_2	98	101	PF00928	0.421
TRG_ER_diArg_1	319	321	PF00400	0.499
TRG_NES_CRM1_1	189	203	PF08389	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N0	Leptomonas seymouri	62%	100%
A0A0N1HUH0	Leptomonas seymouri	26%	78%
A0A0N1I317	Leptomonas seymouri	25%	92%
A0A0S4JGH2	Bodo saltans	34%	100%
A0A0S4JPV3	Bodo saltans	26%	76%
A0A0S4JV86	Bodo saltans	21%	97%
A0A1X0NG92	Trypanosomatidae	39%	100%
A0A1X0NTY3	Trypanosomatidae	26%	82%
A0A1X0P2M5	Trypanosomatidae	27%	100%
A0A1X0P4Z4	Trypanosomatidae	26%	93%
A0A3Q8IDE6	Leishmania donovani	25%	100%
A0A3R7L7Y9	Trypanosoma rangeli	27%	82%
A0A3R7NL91	Trypanosoma rangeli	25%	92%
A0A3R7NVI2	Trypanosoma rangeli	24%	88%
A0A3S7WZL6	Leishmania donovani	26%	85%
A0A422NW39	Trypanosoma rangeli	40%	99%
A0JPI9	Rattus norvegicus	25%	76%
A4HCM9	Leishmania braziliensis	88%	100%
A4HEQ6	Leishmania braziliensis	26%	88%
A4HFQ6	Leishmania braziliensis	24%	100%
A4I053	Leishmania infantum	99%	100%
A4I1Y5	Leishmania infantum	26%	85%
A4I2T1	Leishmania infantum	25%	100%
C9ZS33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	82%
D0A5Z5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	88%
E9ADA9	Leishmania major	24%	100%
E9AW16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AY32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AZ34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q0VAA2	Homo sapiens	25%	75%
Q4Q9E1	Leishmania major	25%	100%
Q4QBG0	Leishmania major	95%	100%
Q4V8D9	Rattus norvegicus	31%	88%
Q8IZ02	Homo sapiens	31%	79%
Q9DAM1	Mus musculus	32%	88%
Q9LE82	Arabidopsis thaliana	24%	68%
Q9M651	Arabidopsis thaliana	23%	67%
V5BJF0	Trypanosoma cruzi	24%	74%
V5DHF2	Trypanosoma cruzi	24%	93%