Phosphoinositide phospholipase C

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoinositide-specific phospholipase C, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WXG5_LEIDO

TriTrypDb:

LdBPK_221530.1 , LdCL_220022700 , LDHU3_22.2180

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WXG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXG5

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	5
GO:0007165	signal transduction	2	5
GO:0008152	metabolic process	1	5
GO:0009056	catabolic process	2	5
GO:0009987	cellular process	1	5
GO:0016042	lipid catabolic process	4	5
GO:0035556	intracellular signal transduction	3	5
GO:0044238	primary metabolic process	2	5
GO:0050789	regulation of biological process	2	5
GO:0050794	regulation of cellular process	3	5
GO:0065007	biological regulation	1	5
GO:0071704	organic substance metabolic process	2	5
GO:1901575	organic substance catabolic process	3	5
GO:0048015	phosphatidylinositol-mediated signaling	5	1
GO:0048017	inositol lipid-mediated signaling	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004435	phosphatidylinositol phospholipase C activity	7	5
GO:0004620	phospholipase activity	5	5
GO:0004629	phospholipase C activity	6	5
GO:0008081	phosphoric diester hydrolase activity	5	5
GO:0016298	lipase activity	4	5
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0042578	phosphoric ester hydrolase activity	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.416
CLV_C14_Caspase3-7	260	264	PF00656	0.165
CLV_C14_Caspase3-7	436	440	PF00656	0.217
CLV_C14_Caspase3-7	455	459	PF00656	0.205
CLV_NRD_NRD_1	183	185	PF00675	0.350
CLV_NRD_NRD_1	230	232	PF00675	0.165
CLV_NRD_NRD_1	432	434	PF00675	0.254
CLV_PCSK_KEX2_1	145	147	PF00082	0.279
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.279
CLV_PCSK_SKI1_1	296	300	PF00082	0.341
CLV_PCSK_SKI1_1	315	319	PF00082	0.447
CLV_PCSK_SKI1_1	329	333	PF00082	0.234
CLV_PCSK_SKI1_1	33	37	PF00082	0.145
CLV_PCSK_SKI1_1	66	70	PF00082	0.146
DEG_APCC_DBOX_1	395	403	PF00400	0.146
DEG_Nend_UBRbox_2	1	3	PF02207	0.146
DEG_SCF_FBW7_1	363	370	PF00400	0.146
DOC_CYCLIN_RxL_1	31	38	PF00134	0.161
DOC_MAPK_gen_1	184	193	PF00069	0.354
DOC_MAPK_MEF2A_6	315	324	PF00069	0.289
DOC_MAPK_MEF2A_6	396	403	PF00069	0.146
DOC_PP1_RVXF_1	64	70	PF00149	0.145
DOC_PP4_FxxP_1	117	120	PF00568	0.190
DOC_PP4_FxxP_1	339	342	PF00568	0.185
DOC_USP7_MATH_1	120	124	PF00917	0.227
DOC_USP7_MATH_1	199	203	PF00917	0.221
DOC_USP7_MATH_1	257	261	PF00917	0.165
DOC_USP7_MATH_1	342	346	PF00917	0.193
DOC_USP7_UBL2_3	139	143	PF12436	0.161
DOC_USP7_UBL2_3	430	434	PF12436	0.228
DOC_WW_Pin1_4	129	134	PF00397	0.177
DOC_WW_Pin1_4	265	270	PF00397	0.146
DOC_WW_Pin1_4	363	368	PF00397	0.146
LIG_14-3-3_CanoR_1	192	200	PF00244	0.277
LIG_14-3-3_CanoR_1	315	320	PF00244	0.363
LIG_14-3-3_CanoR_1	329	334	PF00244	0.148
LIG_14-3-3_CanoR_1	396	402	PF00244	0.146
LIG_14-3-3_CanoR_1	411	418	PF00244	0.131
LIG_14-3-3_CanoR_1	433	438	PF00244	0.210
LIG_Actin_RPEL_3	404	423	PF02755	0.146
LIG_AP2alpha_2	351	353	PF02296	0.161
LIG_APCC_ABBA_1	354	359	PF00400	0.169
LIG_BRCT_BRCA1_1	113	117	PF00533	0.242
LIG_BRCT_BRCA1_1	252	256	PF00533	0.206
LIG_BRCT_BRCA1_1	286	290	PF00533	0.165
LIG_Clathr_ClatBox_1	200	204	PF01394	0.146
LIG_deltaCOP1_diTrp_1	389	397	PF00928	0.161
LIG_FHA_1	163	169	PF00498	0.418
LIG_FHA_1	330	336	PF00498	0.185
LIG_FHA_1	353	359	PF00498	0.311
LIG_FHA_1	368	374	PF00498	0.130
LIG_FHA_1	386	392	PF00498	0.392
LIG_FHA_1	62	68	PF00498	0.161
LIG_FHA_2	161	167	PF00498	0.426
LIG_FHA_2	316	322	PF00498	0.286
LIG_FHA_2	94	100	PF00498	0.291
LIG_Integrin_RGD_1	146	148	PF01839	0.297
LIG_LIR_Apic_2	114	120	PF02991	0.190
LIG_LIR_Apic_2	337	342	PF02991	0.157
LIG_LIR_Apic_2	440	446	PF02991	0.228
LIG_LIR_Apic_2	46	51	PF02991	0.161
LIG_LIR_Gen_1	175	181	PF02991	0.343
LIG_LIR_Gen_1	275	282	PF02991	0.296
LIG_LIR_Gen_1	351	361	PF02991	0.161
LIG_LIR_Nem_3	264	270	PF02991	0.302
LIG_LIR_Nem_3	275	280	PF02991	0.278
LIG_LIR_Nem_3	326	331	PF02991	0.220
LIG_LIR_Nem_3	351	356	PF02991	0.161
LIG_LIR_Nem_3	84	89	PF02991	0.190
LIG_LYPXL_yS_3	86	89	PF13949	0.145
LIG_NRBOX	111	117	PF00104	0.165
LIG_PDZ_Class_3	458	463	PF00595	0.319
LIG_Pex14_1	273	277	PF04695	0.146
LIG_Pex14_2	117	121	PF04695	0.173
LIG_Pex14_2	353	357	PF04695	0.147
LIG_Pex14_2	378	382	PF04695	0.281
LIG_PTB_Apo_2	372	379	PF02174	0.145
LIG_SH2_CRK	267	271	PF00017	0.165
LIG_SH2_CRK	443	447	PF00017	0.283
LIG_SH2_NCK_1	443	447	PF00017	0.233
LIG_SH2_NCK_1	456	460	PF00017	0.228
LIG_SH2_STAP1	79	83	PF00017	0.170
LIG_SH2_STAT5	17	20	PF00017	0.162
LIG_SH2_STAT5	176	179	PF00017	0.339
LIG_SH2_STAT5	216	219	PF00017	0.177
LIG_SH2_STAT5	307	310	PF00017	0.330
LIG_SH2_STAT5	456	459	PF00017	0.388
LIG_SH2_STAT5	61	64	PF00017	0.165
LIG_SH2_STAT5	8	11	PF00017	0.161
LIG_SH3_3	314	320	PF00018	0.244
LIG_SH3_3	346	352	PF00018	0.178
LIG_SUMO_SIM_anti_2	332	337	PF11976	0.190
LIG_SUMO_SIM_anti_2	398	403	PF11976	0.146
LIG_SUMO_SIM_par_1	198	206	PF11976	0.190
LIG_SUMO_SIM_par_1	330	337	PF11976	0.163
LIG_SUMO_SIM_par_1	86	91	PF11976	0.163
LIG_TRAF2_1	68	71	PF00917	0.165
LIG_TRFH_1	307	311	PF08558	0.351
LIG_UBA3_1	422	430	PF00899	0.146
MOD_CDK_SPK_2	363	368	PF00069	0.146
MOD_CK1_1	13	19	PF00069	0.161
MOD_CK1_1	167	173	PF00069	0.482
MOD_CK1_1	202	208	PF00069	0.190
MOD_CK1_1	226	232	PF00069	0.165
MOD_CK1_1	25	31	PF00069	0.161
MOD_CK1_1	265	271	PF00069	0.323
MOD_CK1_1	286	292	PF00069	0.190
MOD_CK1_1	337	343	PF00069	0.146
MOD_CK1_1	369	375	PF00069	0.146
MOD_CK2_1	224	230	PF00069	0.174
MOD_CK2_1	342	348	PF00069	0.146
MOD_CK2_1	93	99	PF00069	0.291
MOD_GlcNHglycan	193	196	PF01048	0.431
MOD_GlcNHglycan	197	200	PF01048	0.306
MOD_GlcNHglycan	274	277	PF01048	0.315
MOD_GlcNHglycan	336	339	PF01048	0.182
MOD_GlcNHglycan	342	345	PF01048	0.197
MOD_GlcNHglycan	439	442	PF01048	0.238
MOD_GlcNHglycan	83	86	PF01048	0.165
MOD_GSK3_1	125	132	PF00069	0.190
MOD_GSK3_1	160	167	PF00069	0.509
MOD_GSK3_1	191	198	PF00069	0.291
MOD_GSK3_1	199	206	PF00069	0.190
MOD_GSK3_1	21	28	PF00069	0.161
MOD_GSK3_1	257	264	PF00069	0.424
MOD_GSK3_1	340	347	PF00069	0.146
MOD_GSK3_1	362	369	PF00069	0.169
MOD_GSK3_1	433	440	PF00069	0.217
MOD_GSK3_1	441	448	PF00069	0.399
MOD_GSK3_1	9	16	PF00069	0.161
MOD_LATS_1	313	319	PF00433	0.212
MOD_LATS_1	409	415	PF00433	0.146
MOD_N-GLC_1	247	252	PF02516	0.233
MOD_N-GLC_1	265	270	PF02516	0.362
MOD_N-GLC_1	437	442	PF02516	0.210
MOD_N-GLC_2	295	297	PF02516	0.165
MOD_N-GLC_2	302	304	PF02516	0.152
MOD_N-GLC_2	410	412	PF02516	0.146
MOD_NEK2_1	179	184	PF00069	0.330
MOD_NEK2_1	437	442	PF00069	0.316
MOD_NEK2_1	81	86	PF00069	0.165
MOD_NEK2_1	9	14	PF00069	0.172
MOD_NEK2_2	352	357	PF00069	0.146
MOD_NEK2_2	390	395	PF00069	0.146
MOD_NEK2_2	72	77	PF00069	0.146
MOD_PIKK_1	26	32	PF00454	0.146
MOD_PIKK_1	412	418	PF00454	0.146
MOD_PKA_1	433	439	PF00069	0.212
MOD_PKA_2	191	197	PF00069	0.299
MOD_PKA_2	395	401	PF00069	0.146
MOD_PKA_2	410	416	PF00069	0.131
MOD_PKA_2	62	68	PF00069	0.165
MOD_Plk_1	212	218	PF00069	0.177
MOD_Plk_1	247	253	PF00069	0.165
MOD_Plk_2-3	160	166	PF00069	0.491
MOD_Plk_4	111	117	PF00069	0.215
MOD_Plk_4	13	19	PF00069	0.161
MOD_Plk_4	212	218	PF00069	0.177
MOD_Plk_4	352	358	PF00069	0.146
MOD_Plk_4	397	403	PF00069	0.163
MOD_Plk_4	445	451	PF00069	0.224
MOD_ProDKin_1	129	135	PF00069	0.177
MOD_ProDKin_1	265	271	PF00069	0.146
MOD_ProDKin_1	363	369	PF00069	0.146
MOD_SUMO_for_1	309	312	PF00179	0.146
MOD_SUMO_rev_2	204	214	PF00179	0.146
TRG_DiLeu_BaLyEn_6	266	271	PF01217	0.165
TRG_ENDOCYTIC_2	176	179	PF00928	0.339
TRG_ENDOCYTIC_2	267	270	PF00928	0.165
TRG_ENDOCYTIC_2	86	89	PF00928	0.181
TRG_Pf-PMV_PEXEL_1	329	334	PF00026	0.190

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J9Y4	Bodo saltans	38%	78%
A0A422N571	Trypanosoma rangeli	50%	76%
Q1RML2	Bos taurus	32%	73%
Q2VRL0	Gallus gallus	36%	73%
Q39032	Arabidopsis thaliana	31%	83%
Q39033	Arabidopsis thaliana	28%	80%
Q4QBH9	Leishmania major	84%	83%
Q56W08	Arabidopsis thaliana	30%	82%
Q5FX52	Rattus norvegicus	33%	72%
Q6NMA7	Arabidopsis thaliana	23%	87%
Q7YRU3	Sus scrofa	32%	73%
Q86YW0	Homo sapiens	33%	76%
Q8GV43	Arabidopsis thaliana	29%	76%
Q8K4D7	Mus musculus	32%	72%
Q944C1	Arabidopsis thaliana	29%	78%
Q944C2	Arabidopsis thaliana	29%	80%
Q95JS1	Macaca fascicularis	32%	72%
Q9LY51	Arabidopsis thaliana	29%	79%
Q9STZ3	Arabidopsis thaliana	24%	87%