Peptidyl-prolyl cis-trans isomerase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WXF4_LEIDO

TriTrypDb:

LdBPK_230060.1 , LdCL_230005500 , LDHU3_23.0080

Length:

296

Annotations

LeishMANIAdb annotations

A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 20
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	3
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7WXF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXF4

PDB structure(s): 2hqj_A

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	22
GO:0006457	protein folding	2	22
GO:0006807	nitrogen compound metabolic process	2	22
GO:0008152	metabolic process	1	22
GO:0009987	cellular process	1	22
GO:0018193	peptidyl-amino acid modification	5	22
GO:0018208	peptidyl-proline modification	6	22
GO:0019538	protein metabolic process	3	22
GO:0036211	protein modification process	4	22
GO:0043170	macromolecule metabolic process	3	22
GO:0043412	macromolecule modification	4	22
GO:0044238	primary metabolic process	2	22
GO:0071704	organic substance metabolic process	2	22
GO:1901564	organonitrogen compound metabolic process	3	22

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	22
GO:0003824	catalytic activity	1	22
GO:0016853	isomerase activity	2	22
GO:0016859	cis-trans isomerase activity	3	22
GO:0140096	catalytic activity, acting on a protein	2	22
GO:0005488	binding	1	3
GO:0016018	cyclosporin A binding	4	3
GO:0033218	amide binding	2	3
GO:0042277	peptide binding	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	263	265	PF00082	0.456
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.456
CLV_PCSK_SKI1_1	25	29	PF00082	0.336
CLV_PCSK_SKI1_1	281	285	PF00082	0.423
DOC_MAPK_gen_1	181	188	PF00069	0.224
DOC_MAPK_MEF2A_6	20	28	PF00069	0.481
DOC_MAPK_MEF2A_6	9	18	PF00069	0.614
DOC_PP1_RVXF_1	153	160	PF00149	0.299
DOC_PP1_RVXF_1	23	29	PF00149	0.329
DOC_PP2B_PxIxI_1	13	19	PF00149	0.607
DOC_USP7_MATH_1	196	200	PF00917	0.450
DOC_USP7_MATH_1	212	216	PF00917	0.487
DOC_USP7_MATH_1	256	260	PF00917	0.703
DOC_USP7_MATH_1	287	291	PF00917	0.601
DOC_WW_Pin1_4	146	151	PF00397	0.224
DOC_WW_Pin1_4	233	238	PF00397	0.638
LIG_14-3-3_CanoR_1	174	182	PF00244	0.441
LIG_14-3-3_CanoR_1	185	194	PF00244	0.341
LIG_14-3-3_CanoR_1	243	252	PF00244	0.499
LIG_14-3-3_CanoR_1	3	7	PF00244	0.596
LIG_APCC_ABBA_1	42	47	PF00400	0.299
LIG_BIR_II_1	1	5	PF00653	0.553
LIG_BRCT_BRCA1_1	139	143	PF00533	0.299
LIG_FHA_1	147	153	PF00498	0.277
LIG_FHA_2	107	113	PF00498	0.277
LIG_FHA_2	98	104	PF00498	0.277
LIG_LIR_Gen_1	78	88	PF02991	0.408
LIG_LIR_Nem_3	54	59	PF02991	0.298
LIG_LIR_Nem_3	78	83	PF02991	0.422
LIG_MLH1_MIPbox_1	139	143	PF16413	0.299
LIG_PTB_Apo_2	74	81	PF02174	0.260
LIG_SH2_STAP1	45	49	PF00017	0.224
LIG_SH3_3	231	237	PF00018	0.607
LIG_SH3_3	252	258	PF00018	0.715
LIG_SUMO_SIM_anti_2	164	170	PF11976	0.214
MOD_CK1_1	2	8	PF00069	0.532
MOD_CK2_1	97	103	PF00069	0.283
MOD_GlcNHglycan	115	118	PF01048	0.239
MOD_GlcNHglycan	178	181	PF01048	0.277
MOD_GlcNHglycan	214	217	PF01048	0.532
MOD_GlcNHglycan	245	248	PF01048	0.726
MOD_GlcNHglycan	290	293	PF01048	0.472
MOD_GlcNHglycan	68	71	PF01048	0.282
MOD_GlcNHglycan	77	80	PF01048	0.286
MOD_GSK3_1	45	52	PF00069	0.273
MOD_GSK3_1	97	104	PF00069	0.299
MOD_N-GLC_1	137	142	PF02516	0.311
MOD_N-GLC_1	97	102	PF02516	0.304
MOD_NEK2_1	143	148	PF00069	0.299
MOD_NEK2_1	175	180	PF00069	0.354
MOD_NEK2_1	232	237	PF00069	0.549
MOD_NEK2_1	288	293	PF00069	0.420
MOD_NEK2_2	101	106	PF00069	0.299
MOD_PIKK_1	137	143	PF00454	0.299
MOD_PKA_2	120	126	PF00069	0.266
MOD_PKA_2	2	8	PF00069	0.665
MOD_PKA_2	273	279	PF00069	0.413
MOD_PKA_2	288	294	PF00069	0.447
MOD_Plk_1	111	117	PF00069	0.305
MOD_Plk_1	28	34	PF00069	0.269
MOD_Plk_4	101	107	PF00069	0.299
MOD_ProDKin_1	146	152	PF00069	0.224
MOD_ProDKin_1	233	239	PF00069	0.639
MOD_SUMO_for_1	247	250	PF00179	0.712
MOD_SUMO_rev_2	215	221	PF00179	0.775
MOD_SUMO_rev_2	223	233	PF00179	0.494
MOD_SUMO_rev_2	29	37	PF00179	0.239
TRG_ER_diArg_1	182	185	PF00400	0.234
TRG_NLS_Bipartite_1	248	266	PF00514	0.630
TRG_NLS_MonoExtC_3	261	266	PF00514	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P364	Leptomonas seymouri	44%	100%
A0A0N0P523	Leptomonas seymouri	74%	100%
A0A0N1I8P9	Leptomonas seymouri	57%	100%
A0A0S4J465	Bodo saltans	27%	100%
A0A1X0NXG7	Trypanosomatidae	60%	100%
A0A3Q8ICB3	Leishmania donovani	48%	100%
A0A3Q8IDR1	Leishmania donovani	36%	100%
A0A3R7RE54	Trypanosoma rangeli	61%	100%
A0A3S5H7U6	Leishmania donovani	66%	100%
A0A3S7WYD9	Leishmania donovani	31%	100%
A0A3S7X325	Leishmania donovani	35%	100%
A0A3S7X410	Leishmania donovani	59%	100%
A0A3S7XB52	Leishmania donovani	40%	100%
A4H8P7	Leishmania braziliensis	33%	100%
A4HCI8	Leishmania braziliensis	48%	100%
A4HCL8	Leishmania braziliensis	83%	99%
A4HHU7	Leishmania braziliensis	36%	100%
A4HIW9	Leishmania braziliensis	56%	100%
A4HLM4	Leishmania braziliensis	73%	100%
A4HPH9	Leishmania braziliensis	41%	100%
A4I004	Leishmania infantum	48%	100%
A4I042	Leishmania infantum	100%	100%
A4I0X0	Leishmania infantum	31%	100%
A4I4Z7	Leishmania infantum	35%	100%
A4I698	Leishmania infantum	59%	100%
A4I935	Leishmania infantum	66%	100%
A4IDA1	Leishmania infantum	40%	100%
C9ZUX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	98%
D4AY02	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	53%	100%
E9AQT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AT91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AVX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AW05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	98%
E9AWX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B0C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B1F3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
E9B400	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
O65220	Arabidopsis thaliana	27%	100%
O93826	Arthroderma benhamiae	53%	100%
P35176	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	49%	100%
Q11004	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	83%
Q4G338	Haemonchus contortus	50%	91%
Q4P0V4	Ustilago maydis (strain 521 / FGSC 9021)	48%	74%
Q4Q1A6	Leishmania major	40%	100%
Q4Q424	Leishmania major	66%	100%
Q4Q6Q9	Leishmania major	59%	100%
Q4Q7V7	Leishmania major	35%	100%
Q4QAK0	Leishmania major	31%	100%
Q4QBH1	Leishmania major	91%	100%
Q4QBK2	Leishmania major	48%	100%
Q4QEP7	Leishmania major	34%	100%
Q5UP71	Acanthamoeba polyphaga mimivirus	29%	100%
Q7S7Z6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	54%	100%
Q9P3X9	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	51%	79%
V5B2A0	Trypanosoma cruzi	60%	100%
V5DJ29	Trypanosoma cruzi	38%	92%