DUF1767 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF1767), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WXE9_LEIDO

TriTrypDb:

LdBPK_230100.1 , LdCL_230005900 , LDHU3_23.0120

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WXE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXE9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	181	183	PF00675	0.533
CLV_NRD_NRD_1	274	276	PF00675	0.581
CLV_NRD_NRD_1	303	305	PF00675	0.622
CLV_PCSK_KEX2_1	107	109	PF00082	0.323
CLV_PCSK_KEX2_1	180	182	PF00082	0.476
CLV_PCSK_KEX2_1	274	276	PF00082	0.581
CLV_PCSK_KEX2_1	303	305	PF00082	0.622
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.302
CLV_PCSK_PC7_1	103	109	PF00082	0.302
CLV_PCSK_PC7_1	270	276	PF00082	0.571
CLV_PCSK_SKI1_1	107	111	PF00082	0.285
CLV_PCSK_SKI1_1	78	82	PF00082	0.259
DOC_CKS1_1	135	140	PF01111	0.508
DOC_MAPK_gen_1	107	114	PF00069	0.506
DOC_MAPK_gen_1	9	16	PF00069	0.354
DOC_MAPK_MEF2A_6	107	114	PF00069	0.502
DOC_MAPK_NFAT4_5	107	115	PF00069	0.502
DOC_USP7_MATH_1	27	31	PF00917	0.476
DOC_USP7_MATH_1	60	64	PF00917	0.491
DOC_USP7_MATH_1	88	92	PF00917	0.502
DOC_WW_Pin1_4	134	139	PF00397	0.508
DOC_WW_Pin1_4	225	230	PF00397	0.596
LIG_14-3-3_CanoR_1	103	110	PF00244	0.472
LIG_14-3-3_CanoR_1	111	121	PF00244	0.444
LIG_14-3-3_CanoR_1	209	213	PF00244	0.742
LIG_APCC_ABBA_1	142	147	PF00400	0.468
LIG_APCC_ABBAyCdc20_2	141	147	PF00400	0.468
LIG_FHA_1	126	132	PF00498	0.498
LIG_FHA_1	49	55	PF00498	0.482
LIG_FHA_1	79	85	PF00498	0.459
LIG_FHA_2	135	141	PF00498	0.508
LIG_FHA_2	30	36	PF00498	0.510
LIG_LIR_Gen_1	40	48	PF02991	0.476
LIG_LIR_Nem_3	325	331	PF02991	0.737
LIG_LIR_Nem_3	339	345	PF02991	0.548
LIG_LIR_Nem_3	40	45	PF02991	0.476
LIG_PTB_Apo_2	95	102	PF02174	0.476
LIG_SH2_STAP1	12	16	PF00017	0.508
LIG_SH2_STAT5	20	23	PF00017	0.508
LIG_SH3_3	116	122	PF00018	0.432
LIG_SH3_3	80	86	PF00018	0.475
LIG_SUMO_SIM_anti_2	158	166	PF11976	0.499
MOD_CDK_SPxxK_3	134	141	PF00069	0.508
MOD_CK1_1	15	21	PF00069	0.542
MOD_CK1_1	160	166	PF00069	0.504
MOD_CK1_1	30	36	PF00069	0.439
MOD_CK2_1	134	140	PF00069	0.478
MOD_CK2_1	261	267	PF00069	0.562
MOD_CK2_1	29	35	PF00069	0.502
MOD_CK2_1	37	43	PF00069	0.502
MOD_CK2_1	88	94	PF00069	0.475
MOD_Cter_Amidation	272	275	PF01082	0.588
MOD_Cter_Amidation	301	304	PF01082	0.610
MOD_GlcNHglycan	214	217	PF01048	0.712
MOD_GlcNHglycan	234	238	PF01048	0.563
MOD_GlcNHglycan	263	266	PF01048	0.802
MOD_GlcNHglycan	62	65	PF01048	0.259
MOD_GSK3_1	10	17	PF00069	0.502
MOD_GSK3_1	208	215	PF00069	0.737
MOD_GSK3_1	26	33	PF00069	0.502
MOD_GSK3_1	74	81	PF00069	0.494
MOD_N-GLC_1	103	108	PF02516	0.308
MOD_N-GLC_1	160	165	PF02516	0.268
MOD_N-GLC_1	240	245	PF02516	0.643
MOD_N-GLC_1	74	79	PF02516	0.259
MOD_N-GLC_2	152	154	PF02516	0.302
MOD_N-GLC_2	245	247	PF02516	0.556
MOD_NEK2_1	124	129	PF00069	0.494
MOD_NEK2_1	157	162	PF00069	0.468
MOD_PIKK_1	78	84	PF00454	0.479
MOD_PKA_2	102	108	PF00069	0.512
MOD_PKA_2	208	214	PF00069	0.655
MOD_PKA_2	261	267	PF00069	0.639
MOD_Plk_1	124	130	PF00069	0.455
MOD_Plk_1	160	166	PF00069	0.507
MOD_Plk_4	160	166	PF00069	0.502
MOD_Plk_4	37	43	PF00069	0.483
MOD_Plk_4	49	55	PF00069	0.456
MOD_ProDKin_1	134	140	PF00069	0.508
MOD_ProDKin_1	225	231	PF00069	0.595
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.459
TRG_ER_diArg_1	180	182	PF00400	0.462
TRG_ER_diArg_1	274	277	PF00400	0.584
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.259

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCI0	Leptomonas seymouri	72%	100%
A0A1X0NX66	Trypanosomatidae	48%	100%
A4HCM2	Leishmania braziliensis	74%	99%
A4I046	Leishmania infantum	99%	100%
E9AW09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QBG7	Leishmania major	86%	100%