Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WXE8_LEIDO

TriTrypDb:

LdBPK_221050.1 , LdCL_220017900 , LDHU3_22.1560

Length:

970

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WXE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXE8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.646
CLV_C14_Caspase3-7	306	310	PF00656	0.690
CLV_C14_Caspase3-7	411	415	PF00656	0.531
CLV_NRD_NRD_1	191	193	PF00675	0.564
CLV_NRD_NRD_1	2	4	PF00675	0.538
CLV_NRD_NRD_1	34	36	PF00675	0.576
CLV_NRD_NRD_1	341	343	PF00675	0.604
CLV_NRD_NRD_1	540	542	PF00675	0.396
CLV_NRD_NRD_1	558	560	PF00675	0.394
CLV_NRD_NRD_1	63	65	PF00675	0.639
CLV_NRD_NRD_1	649	651	PF00675	0.416
CLV_NRD_NRD_1	670	672	PF00675	0.406
CLV_NRD_NRD_1	847	849	PF00675	0.429
CLV_NRD_NRD_1	855	857	PF00675	0.591
CLV_NRD_NRD_1	968	970	PF00675	0.451
CLV_PCSK_KEX2_1	191	193	PF00082	0.565
CLV_PCSK_KEX2_1	2	4	PF00082	0.538
CLV_PCSK_KEX2_1	271	273	PF00082	0.666
CLV_PCSK_KEX2_1	34	36	PF00082	0.613
CLV_PCSK_KEX2_1	341	343	PF00082	0.617
CLV_PCSK_KEX2_1	402	404	PF00082	0.596
CLV_PCSK_KEX2_1	527	529	PF00082	0.437
CLV_PCSK_KEX2_1	540	542	PF00082	0.426
CLV_PCSK_KEX2_1	558	560	PF00082	0.394
CLV_PCSK_KEX2_1	63	65	PF00082	0.668
CLV_PCSK_KEX2_1	649	651	PF00082	0.416
CLV_PCSK_KEX2_1	669	671	PF00082	0.259
CLV_PCSK_KEX2_1	855	857	PF00082	0.627
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.666
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.596
CLV_PCSK_PC1ET2_1	527	529	PF00082	0.431
CLV_PCSK_PC7_1	398	404	PF00082	0.580
CLV_PCSK_SKI1_1	129	133	PF00082	0.497
CLV_PCSK_SKI1_1	324	328	PF00082	0.636
CLV_PCSK_SKI1_1	398	402	PF00082	0.579
CLV_PCSK_SKI1_1	610	614	PF00082	0.442
CLV_PCSK_SKI1_1	633	637	PF00082	0.670
CLV_PCSK_SKI1_1	695	699	PF00082	0.462
CLV_PCSK_SKI1_1	817	821	PF00082	0.423
CLV_PCSK_SKI1_1	823	827	PF00082	0.404
CLV_PCSK_SKI1_1	848	852	PF00082	0.470
CLV_PCSK_SKI1_1	92	96	PF00082	0.594
CLV_PCSK_SKI1_1	957	961	PF00082	0.442
DEG_APCC_DBOX_1	190	198	PF00400	0.482
DEG_APCC_DBOX_1	397	405	PF00400	0.579
DEG_Nend_UBRbox_1	1	4	PF02207	0.546
DEG_SPOP_SBC_1	164	168	PF00917	0.550
DEG_SPOP_SBC_1	374	378	PF00917	0.577
DEG_SPOP_SBC_1	66	70	PF00917	0.636
DOC_CKS1_1	298	303	PF01111	0.715
DOC_CKS1_1	392	397	PF01111	0.590
DOC_CKS1_1	71	76	PF01111	0.630
DOC_CYCLIN_RxL_1	201	211	PF00134	0.361
DOC_CYCLIN_yCln2_LP_2	639	645	PF00134	0.473
DOC_MAPK_DCC_7	67	77	PF00069	0.640
DOC_MAPK_FxFP_2	132	135	PF00069	0.431
DOC_MAPK_gen_1	2	9	PF00069	0.570
DOC_MAPK_MEF2A_6	710	718	PF00069	0.363
DOC_PP1_RVXF_1	127	133	PF00149	0.486
DOC_PP2B_LxvP_1	170	173	PF13499	0.430
DOC_PP2B_LxvP_1	519	522	PF13499	0.431
DOC_PP4_FxxP_1	132	135	PF00568	0.431
DOC_USP7_MATH_1	117	121	PF00917	0.579
DOC_USP7_MATH_1	160	164	PF00917	0.532
DOC_USP7_MATH_1	17	21	PF00917	0.508
DOC_USP7_MATH_1	375	379	PF00917	0.483
DOC_USP7_MATH_1	426	430	PF00917	0.609
DOC_USP7_MATH_1	437	441	PF00917	0.558
DOC_USP7_MATH_1	753	757	PF00917	0.382
DOC_USP7_MATH_1	8	12	PF00917	0.569
DOC_USP7_MATH_1	930	934	PF00917	0.457
DOC_USP7_UBL2_3	175	179	PF12436	0.506
DOC_USP7_UBL2_3	966	970	PF12436	0.438
DOC_WW_Pin1_4	108	113	PF00397	0.557
DOC_WW_Pin1_4	179	184	PF00397	0.535
DOC_WW_Pin1_4	278	283	PF00397	0.642
DOC_WW_Pin1_4	297	302	PF00397	0.562
DOC_WW_Pin1_4	391	396	PF00397	0.598
DOC_WW_Pin1_4	464	469	PF00397	0.581
DOC_WW_Pin1_4	70	75	PF00397	0.633
DOC_WW_Pin1_4	716	721	PF00397	0.433
DOC_WW_Pin1_4	772	777	PF00397	0.686
DOC_WW_Pin1_4	782	787	PF00397	0.512
DOC_WW_Pin1_4	810	815	PF00397	0.390
DOC_WW_Pin1_4	838	843	PF00397	0.476
LIG_14-3-3_CanoR_1	103	112	PF00244	0.541
LIG_14-3-3_CanoR_1	230	239	PF00244	0.635
LIG_14-3-3_CanoR_1	249	253	PF00244	0.404
LIG_14-3-3_CanoR_1	344	352	PF00244	0.615
LIG_14-3-3_CanoR_1	358	366	PF00244	0.565
LIG_14-3-3_CanoR_1	403	413	PF00244	0.526
LIG_14-3-3_CanoR_1	452	458	PF00244	0.562
LIG_14-3-3_CanoR_1	461	469	PF00244	0.466
LIG_14-3-3_CanoR_1	477	481	PF00244	0.463
LIG_14-3-3_CanoR_1	528	538	PF00244	0.430
LIG_14-3-3_CanoR_1	64	74	PF00244	0.649
LIG_14-3-3_CanoR_1	661	668	PF00244	0.406
LIG_14-3-3_CanoR_1	678	687	PF00244	0.390
LIG_14-3-3_CanoR_1	882	890	PF00244	0.506
LIG_Actin_WH2_2	544	560	PF00022	0.407
LIG_Actin_WH2_2	589	604	PF00022	0.559
LIG_APCC_ABBA_1	561	566	PF00400	0.421
LIG_BIR_III_2	465	469	PF00653	0.486
LIG_CtBP_PxDLS_1	626	630	PF00389	0.419
LIG_eIF4E_1	662	668	PF01652	0.473
LIG_FHA_1	165	171	PF00498	0.516
LIG_FHA_1	552	558	PF00498	0.407
LIG_FHA_1	611	617	PF00498	0.446
LIG_FHA_1	67	73	PF00498	0.643
LIG_FHA_1	962	968	PF00498	0.442
LIG_FHA_2	108	114	PF00498	0.627
LIG_FHA_2	120	126	PF00498	0.441
LIG_FHA_2	183	189	PF00498	0.535
LIG_FHA_2	291	297	PF00498	0.664
LIG_FHA_2	298	304	PF00498	0.674
LIG_FHA_2	382	388	PF00498	0.599
LIG_FHA_2	496	502	PF00498	0.409
LIG_FHA_2	569	575	PF00498	0.465
LIG_FHA_2	719	725	PF00498	0.485
LIG_FHA_2	869	875	PF00498	0.731
LIG_FHA_2	902	908	PF00498	0.469
LIG_IBAR_NPY_1	781	783	PF08397	0.425
LIG_LIR_Apic_2	622	626	PF02991	0.350
LIG_LIR_Apic_2	780	786	PF02991	0.505
LIG_LIR_Gen_1	125	135	PF02991	0.488
LIG_LIR_Gen_1	166	177	PF02991	0.461
LIG_LIR_Gen_1	363	374	PF02991	0.549
LIG_LIR_Gen_1	4	10	PF02991	0.530
LIG_LIR_Gen_1	456	462	PF02991	0.512
LIG_LIR_Gen_1	501	511	PF02991	0.378
LIG_LIR_Gen_1	573	584	PF02991	0.543
LIG_LIR_Gen_1	654	662	PF02991	0.388
LIG_LIR_Gen_1	712	720	PF02991	0.377
LIG_LIR_Gen_1	93	100	PF02991	0.493
LIG_LIR_Nem_3	125	130	PF02991	0.489
LIG_LIR_Nem_3	363	369	PF02991	0.530
LIG_LIR_Nem_3	4	9	PF02991	0.535
LIG_LIR_Nem_3	456	460	PF02991	0.550
LIG_LIR_Nem_3	501	506	PF02991	0.370
LIG_LIR_Nem_3	573	579	PF02991	0.534
LIG_LIR_Nem_3	622	627	PF02991	0.351
LIG_LIR_Nem_3	654	658	PF02991	0.368
LIG_LIR_Nem_3	659	665	PF02991	0.423
LIG_LIR_Nem_3	712	718	PF02991	0.388
LIG_LIR_Nem_3	93	98	PF02991	0.493
LIG_LIR_Nem_3	940	945	PF02991	0.418
LIG_LYPXL_yS_3	436	439	PF13949	0.571
LIG_MYND_1	50	54	PF01753	0.614
LIG_Pex14_1	679	683	PF04695	0.391
LIG_Pex14_2	127	131	PF04695	0.427
LIG_Pex14_2	647	651	PF04695	0.462
LIG_Pex14_2	831	835	PF04695	0.419
LIG_SH2_CRK	242	246	PF00017	0.494
LIG_SH2_CRK	366	370	PF00017	0.546
LIG_SH2_CRK	783	787	PF00017	0.539
LIG_SH2_NCK_1	662	666	PF00017	0.490
LIG_SH2_PTP2	473	476	PF00017	0.584
LIG_SH2_PTP2	508	511	PF00017	0.381
LIG_SH2_PTP2	713	716	PF00017	0.371
LIG_SH2_PTP2	795	798	PF00017	0.385
LIG_SH2_SRC	508	511	PF00017	0.381
LIG_SH2_SRC	713	716	PF00017	0.435
LIG_SH2_STAP1	462	466	PF00017	0.522
LIG_SH2_STAT5	359	362	PF00017	0.493
LIG_SH2_STAT5	399	402	PF00017	0.578
LIG_SH2_STAT5	473	476	PF00017	0.584
LIG_SH2_STAT5	508	511	PF00017	0.381
LIG_SH2_STAT5	545	548	PF00017	0.363
LIG_SH2_STAT5	623	626	PF00017	0.346
LIG_SH2_STAT5	634	637	PF00017	0.485
LIG_SH2_STAT5	713	716	PF00017	0.371
LIG_SH2_STAT5	795	798	PF00017	0.385
LIG_SH2_STAT5	807	810	PF00017	0.415
LIG_SH2_STAT5	941	944	PF00017	0.418
LIG_SH3_1	752	758	PF00018	0.403
LIG_SH3_3	291	297	PF00018	0.688
LIG_SH3_3	298	304	PF00018	0.651
LIG_SH3_3	351	357	PF00018	0.657
LIG_SH3_3	559	565	PF00018	0.407
LIG_SH3_3	597	603	PF00018	0.590
LIG_SH3_3	68	74	PF00018	0.640
LIG_SH3_3	752	758	PF00018	0.403
LIG_SH3_3	816	822	PF00018	0.496
LIG_SH3_3	847	853	PF00018	0.547
LIG_SH3_3	918	924	PF00018	0.496
LIG_SUMO_SIM_anti_2	788	793	PF11976	0.380
LIG_SUMO_SIM_par_1	625	630	PF11976	0.415
LIG_SxIP_EBH_1	658	671	PF03271	0.470
LIG_TRAF2_1	123	126	PF00917	0.507
LIG_TRAF2_1	571	574	PF00917	0.548
LIG_TRAF2_1	721	724	PF00917	0.482
LIG_TRAF2_1	904	907	PF00917	0.502
LIG_TYR_ITIM	506	511	PF00017	0.383
LIG_TYR_ITSM	362	369	PF00017	0.516
LIG_ULM_U2AF65_1	34	39	PF00076	0.602
LIG_WW_3	467	471	PF00397	0.515
LIG_WW_3	64	68	PF00397	0.664
LIG_WW_3	820	824	PF00397	0.509
MOD_CDC14_SPxK_1	467	470	PF00782	0.586
MOD_CDK_SPK_2	782	787	PF00069	0.500
MOD_CDK_SPxK_1	464	470	PF00069	0.586
MOD_CDK_SPxK_1	70	76	PF00069	0.608
MOD_CDK_SPxxK_3	179	186	PF00069	0.531
MOD_CDK_SPxxK_3	391	398	PF00069	0.595
MOD_CDK_SPxxK_3	810	817	PF00069	0.383
MOD_CK1_1	120	126	PF00069	0.535
MOD_CK1_1	163	169	PF00069	0.557
MOD_CK1_1	182	188	PF00069	0.404
MOD_CK1_1	275	281	PF00069	0.666
MOD_CK1_1	283	289	PF00069	0.599
MOD_CK1_1	292	298	PF00069	0.534
MOD_CK1_1	347	353	PF00069	0.626
MOD_CK1_1	44	50	PF00069	0.740
MOD_CK1_1	55	61	PF00069	0.559
MOD_CK1_1	660	666	PF00069	0.487
MOD_CK1_1	881	887	PF00069	0.588
MOD_CK2_1	119	125	PF00069	0.524
MOD_CK2_1	229	235	PF00069	0.609
MOD_CK2_1	263	269	PF00069	0.644
MOD_CK2_1	290	296	PF00069	0.782
MOD_CK2_1	297	303	PF00069	0.674
MOD_CK2_1	381	387	PF00069	0.635
MOD_CK2_1	404	410	PF00069	0.557
MOD_CK2_1	568	574	PF00069	0.468
MOD_CK2_1	716	722	PF00069	0.397
MOD_CK2_1	782	788	PF00069	0.494
MOD_CK2_1	8	14	PF00069	0.569
MOD_CK2_1	901	907	PF00069	0.493
MOD_CK2_1	916	922	PF00069	0.419
MOD_GlcNHglycan	115	118	PF01048	0.602
MOD_GlcNHglycan	119	122	PF01048	0.531
MOD_GlcNHglycan	162	165	PF01048	0.590
MOD_GlcNHglycan	282	285	PF01048	0.642
MOD_GlcNHglycan	346	349	PF01048	0.771
MOD_GlcNHglycan	377	380	PF01048	0.618
MOD_GlcNHglycan	426	429	PF01048	0.644
MOD_GlcNHglycan	675	678	PF01048	0.524
MOD_GlcNHglycan	883	886	PF01048	0.747
MOD_GlcNHglycan	918	921	PF01048	0.425
MOD_GSK3_1	104	111	PF00069	0.630
MOD_GSK3_1	113	120	PF00069	0.555
MOD_GSK3_1	159	166	PF00069	0.585
MOD_GSK3_1	357	364	PF00069	0.551
MOD_GSK3_1	373	380	PF00069	0.457
MOD_GSK3_1	404	411	PF00069	0.545
MOD_GSK3_1	418	425	PF00069	0.488
MOD_GSK3_1	460	467	PF00069	0.649
MOD_GSK3_1	491	498	PF00069	0.563
MOD_GSK3_1	52	59	PF00069	0.596
MOD_GSK3_1	656	663	PF00069	0.396
MOD_GSK3_1	66	73	PF00069	0.607
MOD_GSK3_1	957	964	PF00069	0.466
MOD_LATS_1	529	535	PF00433	0.424
MOD_N-GLC_1	551	556	PF02516	0.502
MOD_N-GLC_1	637	642	PF02516	0.438
MOD_NEK2_1	277	282	PF00069	0.678
MOD_NEK2_1	404	409	PF00069	0.579
MOD_NEK2_1	557	562	PF00069	0.427
MOD_NEK2_1	608	613	PF00069	0.430
MOD_NEK2_1	627	632	PF00069	0.400
MOD_NEK2_1	700	705	PF00069	0.402
MOD_NEK2_1	878	883	PF00069	0.610
MOD_NEK2_1	928	933	PF00069	0.441
MOD_NEK2_2	843	848	PF00069	0.514
MOD_PIKK_1	198	204	PF00454	0.384
MOD_PIKK_1	229	235	PF00454	0.672
MOD_PIKK_1	272	278	PF00454	0.668
MOD_PKA_2	229	235	PF00069	0.640
MOD_PKA_2	248	254	PF00069	0.400
MOD_PKA_2	357	363	PF00069	0.555
MOD_PKA_2	36	42	PF00069	0.564
MOD_PKA_2	404	410	PF00069	0.527
MOD_PKA_2	447	453	PF00069	0.531
MOD_PKA_2	460	466	PF00069	0.504
MOD_PKA_2	476	482	PF00069	0.476
MOD_PKA_2	530	536	PF00069	0.497
MOD_PKA_2	557	563	PF00069	0.398
MOD_PKA_2	601	607	PF00069	0.587
MOD_PKA_2	66	72	PF00069	0.596
MOD_PKA_2	660	666	PF00069	0.415
MOD_PKA_2	868	874	PF00069	0.684
MOD_PKA_2	881	887	PF00069	0.517
MOD_PKB_1	342	350	PF00069	0.601
MOD_PKB_1	403	411	PF00069	0.570
MOD_Plk_1	608	614	PF00069	0.430
MOD_Plk_1	769	775	PF00069	0.583
MOD_Plk_4	165	171	PF00069	0.516
MOD_Plk_4	361	367	PF00069	0.473
MOD_Plk_4	408	414	PF00069	0.553
MOD_Plk_4	453	459	PF00069	0.567
MOD_Plk_4	491	497	PF00069	0.538
MOD_Plk_4	532	538	PF00069	0.487
MOD_Plk_4	587	593	PF00069	0.443
MOD_Plk_4	619	625	PF00069	0.488
MOD_Plk_4	67	73	PF00069	0.713
MOD_Plk_4	823	829	PF00069	0.424
MOD_ProDKin_1	108	114	PF00069	0.557
MOD_ProDKin_1	179	185	PF00069	0.529
MOD_ProDKin_1	278	284	PF00069	0.641
MOD_ProDKin_1	297	303	PF00069	0.559
MOD_ProDKin_1	391	397	PF00069	0.591
MOD_ProDKin_1	464	470	PF00069	0.586
MOD_ProDKin_1	70	76	PF00069	0.634
MOD_ProDKin_1	716	722	PF00069	0.432
MOD_ProDKin_1	772	778	PF00069	0.677
MOD_ProDKin_1	782	788	PF00069	0.507
MOD_ProDKin_1	810	816	PF00069	0.388
MOD_ProDKin_1	838	844	PF00069	0.476
MOD_SUMO_rev_2	266	273	PF00179	0.649
MOD_SUMO_rev_2	302	310	PF00179	0.633
TRG_DiLeu_BaEn_1	587	592	PF01217	0.529
TRG_DiLeu_BaEn_1	922	927	PF01217	0.411
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.616
TRG_ENDOCYTIC_2	171	174	PF00928	0.381
TRG_ENDOCYTIC_2	242	245	PF00928	0.517
TRG_ENDOCYTIC_2	359	362	PF00928	0.493
TRG_ENDOCYTIC_2	366	369	PF00928	0.475
TRG_ENDOCYTIC_2	436	439	PF00928	0.571
TRG_ENDOCYTIC_2	503	506	PF00928	0.374
TRG_ENDOCYTIC_2	508	511	PF00928	0.381
TRG_ENDOCYTIC_2	545	548	PF00928	0.363
TRG_ENDOCYTIC_2	662	665	PF00928	0.512
TRG_ENDOCYTIC_2	713	716	PF00928	0.371
TRG_ENDOCYTIC_2	729	732	PF00928	0.363
TRG_ER_diArg_1	1	3	PF00400	0.548
TRG_ER_diArg_1	190	192	PF00400	0.564
TRG_ER_diArg_1	34	37	PF00400	0.601
TRG_ER_diArg_1	403	406	PF00400	0.587
TRG_ER_diArg_1	539	541	PF00400	0.395
TRG_ER_diArg_1	557	559	PF00400	0.385
TRG_ER_diArg_1	63	65	PF00400	0.668
TRG_ER_diArg_1	648	650	PF00400	0.406
TRG_ER_diArg_1	668	671	PF00400	0.252
TRG_ER_diArg_1	854	856	PF00400	0.620
TRG_NLS_MonoExtN_4	523	530	PF00514	0.516
TRG_Pf-PMV_PEXEL_1	637	641	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	678	682	PF00026	0.382
TRG_Pf-PMV_PEXEL_1	913	918	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMB4	Leptomonas seymouri	48%	100%
A4HCG3	Leishmania braziliensis	81%	98%
A4HZZ4	Leishmania infantum	100%	100%
E9AVV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
Q4QBM4	Leishmania major	93%	100%