Metallo-beta-lactamase superfamily/Beta-lactamase superfamily domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Beta-lactamase superfamily domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WXD8_LEIDO

TriTrypDb:

LdBPK_220940.1 , LdCL_220016900 , LDHU3_22.1460

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WXD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXD8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.479
CLV_NRD_NRD_1	348	350	PF00675	0.407
CLV_NRD_NRD_1	44	46	PF00675	0.319
CLV_NRD_NRD_1	5	7	PF00675	0.549
CLV_PCSK_KEX2_1	145	147	PF00082	0.496
CLV_PCSK_KEX2_1	348	350	PF00082	0.426
CLV_PCSK_KEX2_1	44	46	PF00082	0.320
CLV_PCSK_KEX2_1	5	7	PF00082	0.534
CLV_PCSK_SKI1_1	403	407	PF00082	0.459
DEG_APCC_DBOX_1	379	387	PF00400	0.478
DEG_APCC_DBOX_1	5	13	PF00400	0.291
DEG_ODPH_VHL_1	84	97	PF01847	0.403
DEG_SPOP_SBC_1	123	127	PF00917	0.192
DEG_SPOP_SBC_1	195	199	PF00917	0.515
DOC_CDC14_PxL_1	150	158	PF14671	0.311
DOC_MAPK_gen_1	216	225	PF00069	0.478
DOC_MAPK_gen_1	376	385	PF00069	0.536
DOC_MAPK_gen_1	44	52	PF00069	0.318
DOC_MAPK_gen_1	5	11	PF00069	0.463
DOC_MAPK_gen_1	74	83	PF00069	0.292
DOC_MAPK_HePTP_8	375	387	PF00069	0.350
DOC_MAPK_MEF2A_6	216	225	PF00069	0.542
DOC_MAPK_MEF2A_6	313	321	PF00069	0.303
DOC_MAPK_MEF2A_6	378	387	PF00069	0.531
DOC_MAPK_MEF2A_6	44	52	PF00069	0.361
DOC_PP1_RVXF_1	400	407	PF00149	0.313
DOC_PP1_RVXF_1	6	12	PF00149	0.281
DOC_PP2B_LxvP_1	151	154	PF13499	0.296
DOC_USP7_MATH_1	123	127	PF00917	0.204
DOC_USP7_MATH_1	182	186	PF00917	0.575
DOC_USP7_MATH_1	195	199	PF00917	0.587
DOC_USP7_MATH_1	230	234	PF00917	0.575
DOC_USP7_MATH_1	272	276	PF00917	0.442
DOC_USP7_MATH_1	301	305	PF00917	0.500
DOC_USP7_MATH_1	328	332	PF00917	0.336
DOC_USP7_MATH_1	37	41	PF00917	0.491
DOC_USP7_MATH_1	388	392	PF00917	0.474
DOC_WW_Pin1_4	124	129	PF00397	0.424
DOC_WW_Pin1_4	160	165	PF00397	0.549
DOC_WW_Pin1_4	226	231	PF00397	0.512
LIG_14-3-3_CanoR_1	348	352	PF00244	0.399
LIG_14-3-3_CanoR_1	409	414	PF00244	0.444
LIG_14-3-3_CanoR_1	45	51	PF00244	0.396
LIG_14-3-3_CanoR_1	6	12	PF00244	0.399
LIG_BRCT_BRCA1_1	303	307	PF00533	0.464
LIG_BRCT_BRCA1_1	52	56	PF00533	0.301
LIG_Clathr_ClatBox_1	311	315	PF01394	0.351
LIG_eIF4E_1	91	97	PF01652	0.348
LIG_FHA_1	348	354	PF00498	0.287
LIG_FHA_1	367	373	PF00498	0.429
LIG_FHA_2	204	210	PF00498	0.450
LIG_IRF3_LxIS_1	48	53	PF10401	0.395
LIG_LIR_Gen_1	64	70	PF02991	0.319
LIG_LIR_Gen_1	78	87	PF02991	0.298
LIG_LIR_Nem_3	246	252	PF02991	0.365
LIG_LIR_Nem_3	64	68	PF02991	0.311
LIG_LIR_Nem_3	78	83	PF02991	0.295
LIG_Pex14_2	352	356	PF04695	0.456
LIG_RPA_C_Fungi	404	416	PF08784	0.281
LIG_SH2_CRK	250	254	PF00017	0.340
LIG_SH2_CRK	80	84	PF00017	0.403
LIG_SH2_SRC	91	94	PF00017	0.348
LIG_SH2_STAT3	417	420	PF00017	0.466
LIG_SH2_STAT5	260	263	PF00017	0.410
LIG_SH2_STAT5	293	296	PF00017	0.315
LIG_SH2_STAT5	333	336	PF00017	0.375
LIG_SH2_STAT5	351	354	PF00017	0.310
LIG_SH2_STAT5	91	94	PF00017	0.384
LIG_SH3_2	39	44	PF14604	0.434
LIG_SH3_3	221	227	PF00018	0.449
LIG_SH3_3	36	42	PF00018	0.471
LIG_SH3_3	382	388	PF00018	0.395
LIG_SH3_3	80	86	PF00018	0.355
LIG_SUMO_SIM_anti_2	315	320	PF11976	0.257
LIG_SUMO_SIM_anti_2	381	387	PF11976	0.429
LIG_SUMO_SIM_par_1	315	320	PF11976	0.265
LIG_UBA3_1	210	217	PF00899	0.475
LIG_WRC_WIRS_1	147	152	PF05994	0.460
MOD_CK1_1	126	132	PF00069	0.405
MOD_CK1_1	197	203	PF00069	0.516
MOD_CK1_1	275	281	PF00069	0.664
MOD_CK1_1	295	301	PF00069	0.317
MOD_CK2_1	196	202	PF00069	0.620
MOD_CK2_1	58	64	PF00069	0.462
MOD_GlcNHglycan	129	132	PF01048	0.450
MOD_GlcNHglycan	17	20	PF01048	0.377
MOD_GlcNHglycan	184	187	PF01048	0.562
MOD_GlcNHglycan	199	202	PF01048	0.663
MOD_GlcNHglycan	232	235	PF01048	0.659
MOD_GlcNHglycan	328	331	PF01048	0.505
MOD_GlcNHglycan	39	42	PF01048	0.577
MOD_GlcNHglycan	60	63	PF01048	0.519
MOD_GlcNHglycan	77	80	PF01048	0.329
MOD_GSK3_1	122	129	PF00069	0.374
MOD_GSK3_1	131	138	PF00069	0.362
MOD_GSK3_1	187	194	PF00069	0.616
MOD_GSK3_1	226	233	PF00069	0.624
MOD_GSK3_1	238	245	PF00069	0.572
MOD_GSK3_1	268	275	PF00069	0.407
MOD_GSK3_1	46	53	PF00069	0.362
MOD_GSK3_1	7	14	PF00069	0.341
MOD_N-GLC_1	238	243	PF02516	0.622
MOD_N-GLC_1	46	51	PF02516	0.373
MOD_NEK2_1	50	55	PF00069	0.375
MOD_NEK2_1	7	12	PF00069	0.392
MOD_NEK2_1	95	100	PF00069	0.407
MOD_NEK2_2	72	77	PF00069	0.283
MOD_PIKK_1	165	171	PF00454	0.334
MOD_PIKK_1	275	281	PF00454	0.684
MOD_PKA_2	268	274	PF00069	0.459
MOD_PKA_2	275	281	PF00069	0.592
MOD_PKA_2	347	353	PF00069	0.424
MOD_PKA_2	7	13	PF00069	0.397
MOD_Plk_1	295	301	PF00069	0.337
MOD_Plk_1	46	52	PF00069	0.367
MOD_Plk_4	135	141	PF00069	0.403
MOD_Plk_4	146	152	PF00069	0.428
MOD_Plk_4	203	209	PF00069	0.518
MOD_Plk_4	46	52	PF00069	0.287
MOD_Plk_4	7	13	PF00069	0.393
MOD_ProDKin_1	124	130	PF00069	0.424
MOD_ProDKin_1	160	166	PF00069	0.544
MOD_ProDKin_1	226	232	PF00069	0.512
MOD_SUMO_rev_2	209	218	PF00179	0.422
MOD_SUMO_rev_2	371	377	PF00179	0.466
MOD_SUMO_rev_2	399	405	PF00179	0.336
TRG_ENDOCYTIC_2	260	263	PF00928	0.351
TRG_ENDOCYTIC_2	80	83	PF00928	0.327
TRG_ER_diArg_1	144	146	PF00400	0.507
TRG_ER_diArg_1	347	349	PF00400	0.412
TRG_ER_diArg_1	4	6	PF00400	0.501
TRG_NES_CRM1_1	202	215	PF08389	0.360
TRG_NES_CRM1_1	309	320	PF08389	0.349
TRG_NES_CRM1_1	366	381	PF08389	0.272
TRG_Pf-PMV_PEXEL_1	370	374	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0M2	Leptomonas seymouri	39%	94%
A0A0N1PFX0	Leptomonas seymouri	58%	94%
A0A0S4J8Q0	Bodo saltans	35%	100%
A0A0S4JLW1	Bodo saltans	25%	96%
A0A1X0NTE2	Trypanosomatidae	41%	100%
A0A1X0NX03	Trypanosomatidae	24%	100%
A0A3Q8IFK3	Leishmania donovani	41%	100%
A0A422NHR8	Trypanosoma rangeli	41%	100%
A4HCF4	Leishmania braziliensis	46%	100%
A4HZY3	Leishmania infantum	44%	100%
A4HZY4	Leishmania infantum	100%	100%
C9ZSM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZVB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AVU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	91%
E9AVU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QBN4	Leishmania major	93%	99%
Q4QBN5	Leishmania major	42%	100%
V5BVW3	Trypanosoma cruzi	41%	100%