EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:

Gene product:

phosphoinositide-specific phospholipase C, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WXD5_LEIDO

TriTrypDb:

LdBPK_221530.1 , LdCL_220022600 , LDHU3_22.2180

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WXD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXD5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005509	calcium ion binding	5	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	221	223	PF00675	0.440
CLV_PCSK_KEX2_1	122	124	PF00082	0.199
CLV_PCSK_KEX2_1	13	15	PF00082	0.362
CLV_PCSK_KEX2_1	221	223	PF00082	0.440
CLV_PCSK_KEX2_1	71	73	PF00082	0.308
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.199
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.362
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.308
CLV_PCSK_SKI1_1	132	136	PF00082	0.199
CLV_PCSK_SKI1_1	137	141	PF00082	0.199
CLV_PCSK_SKI1_1	14	18	PF00082	0.343
CLV_PCSK_SKI1_1	221	225	PF00082	0.439
CLV_PCSK_SKI1_1	23	27	PF00082	0.269
CLV_PCSK_SKI1_1	48	52	PF00082	0.258
DEG_APCC_DBOX_1	47	55	PF00400	0.260
DOC_CKS1_1	184	189	PF01111	0.456
DOC_MAPK_gen_1	122	130	PF00069	0.199
DOC_USP7_MATH_1	217	221	PF00917	0.435
DOC_USP7_MATH_1	50	54	PF00917	0.266
DOC_USP7_MATH_2	35	41	PF00917	0.286
DOC_USP7_UBL2_3	87	91	PF12436	0.367
DOC_WW_Pin1_4	183	188	PF00397	0.457
LIG_14-3-3_CanoR_1	14	19	PF00244	0.335
LIG_14-3-3_CanoR_1	207	211	PF00244	0.443
LIG_14-3-3_CanoR_1	221	229	PF00244	0.440
LIG_14-3-3_CanoR_1	23	30	PF00244	0.275
LIG_14-3-3_CanoR_1	72	80	PF00244	0.286
LIG_APCC_ABBA_1	139	144	PF00400	0.199
LIG_BRCT_BRCA1_1	39	43	PF00533	0.269
LIG_FHA_1	133	139	PF00498	0.199
LIG_FHA_1	87	93	PF00498	0.358
LIG_FHA_2	222	228	PF00498	0.438
LIG_LIR_Gen_1	115	125	PF02991	0.199
LIG_LIR_Gen_1	149	159	PF02991	0.199
LIG_LIR_Nem_3	149	155	PF02991	0.199
LIG_LIR_Nem_3	164	168	PF02991	0.370
LIG_PDZ_Class_3	224	229	PF00595	0.440
LIG_Rb_pABgroove_1	102	110	PF01858	0.199
LIG_SH2_GRB2like	159	162	PF00017	0.296
LIG_SH2_SRC	18	21	PF00017	0.299
LIG_SH2_STAP1	159	163	PF00017	0.299
LIG_SH2_STAT3	170	173	PF00017	0.402
LIG_SH2_STAT5	170	173	PF00017	0.402
LIG_SH2_STAT5	18	21	PF00017	0.299
LIG_SH2_STAT5	29	32	PF00017	0.307
LIG_SxIP_EBH_1	13	25	PF03271	0.310
LIG_TRAF2_1	58	61	PF00917	0.306
LIG_WRC_WIRS_1	201	206	PF05994	0.442
MOD_CK1_1	180	186	PF00069	0.452
MOD_CK1_1	203	209	PF00069	0.443
MOD_CK1_1	215	221	PF00069	0.436
MOD_CK1_1	73	79	PF00069	0.284
MOD_CK2_1	114	120	PF00069	0.199
MOD_CK2_1	161	167	PF00069	0.345
MOD_CK2_1	55	61	PF00069	0.301
MOD_CK2_1	6	12	PF00069	0.420
MOD_GlcNHglycan	111	115	PF01048	0.199
MOD_GlcNHglycan	214	217	PF01048	0.436
MOD_GlcNHglycan	39	42	PF01048	0.275
MOD_GlcNHglycan	76	79	PF01048	0.273
MOD_GSK3_1	110	117	PF00069	0.199
MOD_GSK3_1	128	135	PF00069	0.199
MOD_GSK3_1	146	153	PF00069	0.199
MOD_GSK3_1	157	164	PF00069	0.304
MOD_GSK3_1	192	199	PF00069	0.467
MOD_GSK3_1	202	209	PF00069	0.441
MOD_GSK3_1	217	224	PF00069	0.436
MOD_GSK3_1	66	73	PF00069	0.282
MOD_GSK3_1	82	89	PF00069	0.328
MOD_N-GLC_1	37	42	PF02516	0.288
MOD_N-GLC_1	87	92	PF02516	0.358
MOD_NEK2_1	191	196	PF00069	0.470
MOD_NEK2_1	4	9	PF00069	0.450
MOD_NEK2_1	43	48	PF00069	0.238
MOD_NEK2_1	66	71	PF00069	0.276
MOD_NMyristoyl	1	7	PF02799	0.458
MOD_PKA_1	221	227	PF00069	0.439
MOD_PKA_2	146	152	PF00069	0.199
MOD_PKA_2	180	186	PF00069	0.452
MOD_PKA_2	206	212	PF00069	0.444
MOD_PKA_2	221	227	PF00069	0.439
MOD_Plk_1	114	120	PF00069	0.199
MOD_Plk_1	37	43	PF00069	0.281
MOD_Plk_4	14	20	PF00069	0.334
MOD_Plk_4	206	212	PF00069	0.444
MOD_ProDKin_1	183	189	PF00069	0.456
MOD_SUMO_rev_2	115	124	PF00179	0.199
TRG_DiLeu_BaEn_1	120	125	PF01217	0.199
TRG_DiLeu_BaEn_3	60	66	PF01217	0.281
TRG_ENDOCYTIC_2	118	121	PF00928	0.199
TRG_ER_diArg_1	221	223	PF00400	0.440
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.199
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.199
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.269