Beta propeller protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Beta propeller protein 1

Species:

Leishmania donovani

UniProt:

A0A3S7WXD4_LEIDO

TriTrypDb:

LdBPK_230040.1 , LdCL_230005300 , LDHU3_23.0060

Length:

477

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0016020	membrane	2	1
GO:0020016	ciliary pocket	2	1

Expansion

Sequence features

A0A3S7WXD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXD4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006356	regulation of transcription by RNA polymerase I	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0045943	positive regulation of transcription by RNA polymerase I	8	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	230	232	PF00675	0.424
CLV_NRD_NRD_1	317	319	PF00675	0.318
CLV_NRD_NRD_1	385	387	PF00675	0.275
CLV_NRD_NRD_1	77	79	PF00675	0.491
CLV_NRD_NRD_1	9	11	PF00675	0.571
CLV_PCSK_KEX2_1	285	287	PF00082	0.509
CLV_PCSK_KEX2_1	385	387	PF00082	0.275
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.509
CLV_PCSK_SKI1_1	258	262	PF00082	0.495
CLV_PCSK_SKI1_1	362	366	PF00082	0.294
CLV_PCSK_SKI1_1	406	410	PF00082	0.335
CLV_PCSK_SKI1_1	438	442	PF00082	0.348
CLV_PCSK_SKI1_1	444	448	PF00082	0.315
CLV_PCSK_SKI1_1	99	103	PF00082	0.368
CLV_Separin_Metazoa	382	386	PF03568	0.335
DEG_Nend_UBRbox_3	1	3	PF02207	0.584
DEG_SPOP_SBC_1	305	309	PF00917	0.469
DOC_CKS1_1	234	239	PF01111	0.493
DOC_CYCLIN_RxL_1	255	264	PF00134	0.458
DOC_CYCLIN_RxL_1	399	409	PF00134	0.335
DOC_MAPK_gen_1	118	126	PF00069	0.443
DOC_MAPK_gen_1	385	393	PF00069	0.275
DOC_MAPK_gen_1	451	459	PF00069	0.410
DOC_MAPK_gen_1	78	85	PF00069	0.364
DOC_MAPK_MEF2A_6	385	393	PF00069	0.281
DOC_PP1_RVXF_1	222	229	PF00149	0.467
DOC_PP1_RVXF_1	347	354	PF00149	0.393
DOC_PP1_RVXF_1	401	408	PF00149	0.309
DOC_PP2B_LxvP_1	62	65	PF13499	0.406
DOC_USP7_MATH_1	132	136	PF00917	0.528
DOC_USP7_MATH_1	168	172	PF00917	0.517
DOC_USP7_MATH_1	304	308	PF00917	0.416
DOC_USP7_UBL2_3	336	340	PF12436	0.562
DOC_WW_Pin1_4	233	238	PF00397	0.529
LIG_14-3-3_CanoR_1	103	109	PF00244	0.402
LIG_14-3-3_CanoR_1	231	237	PF00244	0.423
LIG_14-3-3_CanoR_1	406	415	PF00244	0.335
LIG_14-3-3_CanoR_1	63	72	PF00244	0.400
LIG_14-3-3_CanoR_1	78	84	PF00244	0.338
LIG_Actin_WH2_2	267	282	PF00022	0.501
LIG_Actin_WH2_2	89	105	PF00022	0.388
LIG_APCC_ABBA_1	472	477	PF00400	0.532
LIG_BRCT_BRCA1_1	121	125	PF00533	0.516
LIG_BRCT_BRCA1_1	438	442	PF00533	0.367
LIG_BRCT_BRCA1_1	81	85	PF00533	0.341
LIG_Clathr_ClatBox_1	422	426	PF01394	0.329
LIG_FHA_1	137	143	PF00498	0.441
LIG_FHA_1	151	157	PF00498	0.371
LIG_FHA_1	200	206	PF00498	0.467
LIG_FHA_1	24	30	PF00498	0.264
LIG_FHA_1	243	249	PF00498	0.365
LIG_FHA_1	260	266	PF00498	0.313
LIG_FHA_1	307	313	PF00498	0.467
LIG_FHA_1	4	10	PF00498	0.544
LIG_FHA_1	407	413	PF00498	0.367
LIG_FHA_1	418	424	PF00498	0.367
LIG_FHA_1	65	71	PF00498	0.451
LIG_FHA_2	105	111	PF00498	0.403
LIG_FHA_2	194	200	PF00498	0.531
LIG_FHA_2	306	312	PF00498	0.518
LIG_FHA_2	377	383	PF00498	0.275
LIG_FHA_2	425	431	PF00498	0.336
LIG_LIR_Apic_2	4	8	PF02991	0.455
LIG_LIR_Gen_1	21	31	PF02991	0.516
LIG_LIR_Gen_1	378	388	PF02991	0.398
LIG_LIR_Gen_1	56	65	PF02991	0.464
LIG_LIR_LC3C_4	419	424	PF02991	0.329
LIG_LIR_Nem_3	21	27	PF02991	0.513
LIG_LIR_Nem_3	34	39	PF02991	0.334
LIG_LIR_Nem_3	378	383	PF02991	0.398
LIG_LIR_Nem_3	426	432	PF02991	0.278
LIG_LIR_Nem_3	56	62	PF02991	0.444
LIG_MLH1_MIPbox_1	438	442	PF16413	0.367
LIG_NRBOX	256	262	PF00104	0.462
LIG_Pex14_2	239	243	PF04695	0.505
LIG_Pex14_2	425	429	PF04695	0.401
LIG_PTB_Apo_2	281	288	PF02174	0.500
LIG_REV1ctd_RIR_1	439	448	PF16727	0.367
LIG_SH2_NCK_1	44	48	PF00017	0.423
LIG_SH2_SRC	358	361	PF00017	0.367
LIG_SH2_STAP1	177	181	PF00017	0.431
LIG_SH2_STAP1	253	257	PF00017	0.457
LIG_SH2_STAP1	31	35	PF00017	0.357
LIG_SH2_STAP1	432	436	PF00017	0.304
LIG_SH2_STAP1	81	85	PF00017	0.476
LIG_SH2_STAT5	113	116	PF00017	0.516
LIG_SH2_STAT5	160	163	PF00017	0.438
LIG_SH2_STAT5	411	414	PF00017	0.410
LIG_SH2_STAT5	435	438	PF00017	0.410
LIG_SH2_STAT5	92	95	PF00017	0.444
LIG_SH3_3	224	230	PF00018	0.418
LIG_SH3_3	409	415	PF00018	0.367
LIG_SUMO_SIM_anti_2	456	461	PF11976	0.322
LIG_SUMO_SIM_par_1	418	427	PF11976	0.315
LIG_TRAF2_1	212	215	PF00917	0.493
LIG_TRAF2_1	327	330	PF00917	0.725
LIG_TRAF2_1	379	382	PF00917	0.275
LIG_WRC_WIRS_1	377	382	PF05994	0.410
MOD_CK1_1	104	110	PF00069	0.408
MOD_CK1_1	135	141	PF00069	0.446
MOD_CK1_1	171	177	PF00069	0.529
MOD_CK1_1	242	248	PF00069	0.375
MOD_CK1_1	259	265	PF00069	0.347
MOD_CK2_1	104	110	PF00069	0.399
MOD_CK2_1	305	311	PF00069	0.435
MOD_CK2_1	375	381	PF00069	0.275
MOD_GlcNHglycan	121	124	PF01048	0.277
MOD_GlcNHglycan	132	135	PF01048	0.196
MOD_GlcNHglycan	173	176	PF01048	0.232
MOD_GlcNHglycan	196	199	PF01048	0.438
MOD_GlcNHglycan	432	435	PF01048	0.389
MOD_GlcNHglycan	438	441	PF01048	0.368
MOD_GSK3_1	132	139	PF00069	0.443
MOD_GSK3_1	14	21	PF00069	0.634
MOD_GSK3_1	270	277	PF00069	0.473
MOD_GSK3_1	363	370	PF00069	0.292
MOD_N-GLC_1	79	84	PF02516	0.487
MOD_NEK2_1	239	244	PF00069	0.402
MOD_NEK2_1	417	422	PF00069	0.310
MOD_NEK2_1	463	468	PF00069	0.283
MOD_NEK2_1	51	56	PF00069	0.421
MOD_NEK2_2	168	173	PF00069	0.448
MOD_NEK2_2	23	28	PF00069	0.556
MOD_NEK2_2	31	36	PF00069	0.413
MOD_PIKK_1	199	205	PF00454	0.469
MOD_PIKK_1	251	257	PF00454	0.461
MOD_PK_1	18	24	PF00069	0.610
MOD_PK_1	79	85	PF00069	0.442
MOD_PKA_2	102	108	PF00069	0.390
MOD_Plk_1	135	141	PF00069	0.432
MOD_Plk_1	3	9	PF00069	0.515
MOD_Plk_1	31	37	PF00069	0.430
MOD_Plk_1	397	403	PF00069	0.288
MOD_Plk_1	463	469	PF00069	0.291
MOD_Plk_1	79	85	PF00069	0.486
MOD_Plk_2-3	144	150	PF00069	0.529
MOD_Plk_2-3	325	331	PF00069	0.484
MOD_Plk_4	168	174	PF00069	0.504
MOD_Plk_4	244	250	PF00069	0.403
MOD_Plk_4	31	37	PF00069	0.440
MOD_Plk_4	417	423	PF00069	0.291
MOD_Plk_4	424	430	PF00069	0.291
MOD_Plk_4	46	52	PF00069	0.284
MOD_ProDKin_1	233	239	PF00069	0.528
MOD_SUMO_rev_2	328	337	PF00179	0.539
MOD_SUMO_rev_2	82	91	PF00179	0.382
TRG_DiLeu_BaEn_2	205	211	PF01217	0.451
TRG_ER_diArg_1	384	386	PF00400	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N2	Leptomonas seymouri	79%	99%
A0A0S4J5C8	Bodo saltans	48%	95%
A0A1X0NXU5	Trypanosomatidae	55%	100%
A0A422N5S6	Trypanosoma rangeli	52%	99%
A2RRU3	Rattus norvegicus	29%	90%
A4HCL6	Leishmania braziliensis	88%	100%
A4I040	Leishmania infantum	99%	100%
A7MB12	Bos taurus	28%	92%
C9ZUX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AW03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O82266	Arabidopsis thaliana	22%	90%
O94365	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	97%
Q04305	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	93%
Q4QBH3	Leishmania major	96%	100%
Q5F3D7	Gallus gallus	29%	92%
Q5REE0	Pongo abelii	28%	92%
Q5XGE2	Xenopus tropicalis	28%	93%
Q7ZW33	Danio rerio	28%	92%
Q7ZXZ2	Xenopus laevis	28%	93%
Q8C7V3	Mus musculus	28%	90%
Q8TED0	Homo sapiens	28%	92%
V5D2J8	Trypanosoma cruzi	52%	99%