Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WXC4_LEIDO

TriTrypDb:

LdBPK_221490.1 , LdCL_220022200 , LDHU3_22.2140

Length:

103

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WXC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	93	95	PF00675	0.529
CLV_NRD_NRD_1	98	100	PF00675	0.549
CLV_PCSK_FUR_1	91	95	PF00082	0.586
CLV_PCSK_KEX2_1	93	95	PF00082	0.529
CLV_PCSK_SKI1_1	51	55	PF00082	0.389
DEG_APCC_DBOX_1	25	33	PF00400	0.470
DOC_CKS1_1	60	65	PF01111	0.458
DOC_CYCLIN_RxL_1	73	82	PF00134	0.409
DOC_MAPK_gen_1	74	81	PF00069	0.546
DOC_USP7_MATH_1	12	16	PF00917	0.549
DOC_WW_Pin1_4	59	64	PF00397	0.363
LIG_APCC_ABBA_1	32	37	PF00400	0.412
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_Clathr_ClatBox_1	78	82	PF01394	0.455
LIG_CSL_BTD_1	60	63	PF09270	0.372
LIG_deltaCOP1_diTrp_1	16	25	PF00928	0.481
LIG_deltaCOP1_diTrp_1	43	52	PF00928	0.389
LIG_HCF-1_HBM_1	37	40	PF13415	0.449
LIG_IBAR_NPY_1	101	103	PF08397	0.567
LIG_LIR_Apic_2	15	21	PF02991	0.462
LIG_LIR_Apic_2	50	55	PF02991	0.384
LIG_LIR_Gen_1	43	53	PF02991	0.401
LIG_LIR_Gen_1	62	71	PF02991	0.356
LIG_LIR_Nem_3	43	48	PF02991	0.395
LIG_PCNA_yPIPBox_3	39	51	PF02747	0.399
LIG_Pex14_1	61	65	PF04695	0.358
LIG_SH2_SRC	35	38	PF00017	0.469
LIG_SH2_STAT5	35	38	PF00017	0.563
LIG_SH2_STAT5	40	43	PF00017	0.470
LIG_SH2_STAT5	57	60	PF00017	0.307
LIG_SUMO_SIM_par_1	6	16	PF11976	0.510
LIG_WRPW_2	87	90	PF00400	0.474
MOD_GSK3_1	12	19	PF00069	0.565
MOD_PIKK_1	69	75	PF00454	0.373
MOD_PK_1	30	36	PF00069	0.490
MOD_Plk_4	30	36	PF00069	0.425
MOD_Plk_4	66	72	PF00069	0.394
MOD_ProDKin_1	59	65	PF00069	0.360
MOD_SUMO_rev_2	96	102	PF00179	0.609
TRG_ENDOCYTIC_2	65	68	PF00928	0.449
TRG_ER_diArg_1	92	94	PF00400	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV98	Leptomonas seymouri	79%	100%
A0A0S4J8T6	Bodo saltans	60%	100%
A4HCK5	Leishmania braziliensis	90%	100%
A4I023	Leishmania infantum	100%	100%
C9ZQ65	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9AVZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QBI3	Leishmania major	98%	100%