Exosome_complex_exonuclease_RRP45_homolog_putativ e/GeneDB:LmjF.22.1580

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exosome complex exonuclease RRP45 homolog, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WXC3_LEIDO

TriTrypDb:

LdBPK_221430.1 , LdCL_220021600 , LDHU3_22.2060

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000178	exosome (RNase complex)	4	11
GO:0005634	nucleus	5	9
GO:0005737	cytoplasm	2	9
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:1902494	catalytic complex	2	11
GO:1905354	exoribonuclease complex	3	11
GO:0000176	nuclear exosome (RNase complex)	3	1
GO:0000177	cytoplasmic exosome (RNase complex)	5	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3S7WXC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXC3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0000291	nuclear-transcribed mRNA catabolic process, exonucleolytic	8	1
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	1
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006364	rRNA processing	8	1
GO:0006399	tRNA metabolic process	7	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006417	regulation of translation	6	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009896	positive regulation of catabolic process	5	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016071	mRNA metabolic process	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0016073	snRNA metabolic process	7	1
GO:0016075	rRNA catabolic process	7	1
GO:0016078	tRNA catabolic process	7	1
GO:0016180	snRNA processing	8	1
GO:0017148	negative regulation of translation	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031125	rRNA 3'-end processing	9	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031331	positive regulation of cellular catabolic process	6	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034249	negative regulation of amide metabolic process	6	1
GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'	9	1
GO:0034470	ncRNA processing	7	1
GO:0034472	snRNA 3'-end processing	8	1
GO:0034473	U1 snRNA 3'-end processing	9	1
GO:0034475	U4 snRNA 3'-end processing	9	1
GO:0034476	U5 snRNA 3'-end processing	9	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0034660	ncRNA metabolic process	6	1
GO:0034661	ncRNA catabolic process	6	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043628	regulatory ncRNA 3'-end processing	8	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0043633	polyadenylation-dependent RNA catabolic process	6	1
GO:0043634	polyadenylation-dependent ncRNA catabolic process	7	1
GO:0043928	exonucleolytic catabolism of deadenylated mRNA	9	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050779	RNA destabilization	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051248	negative regulation of protein metabolic process	6	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0061014	positive regulation of mRNA catabolic process	7	1
GO:0061157	mRNA destabilization	5	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071025	RNA surveillance	6	1
GO:0071027	nuclear RNA surveillance	7	1
GO:0071028	nuclear mRNA surveillance	8	1
GO:0071029	nuclear ncRNA surveillance	7	1
GO:0071035	nuclear polyadenylation-dependent rRNA catabolic process	8	1
GO:0071038	nuclear polyadenylation-dependent tRNA catabolic process	8	1
GO:0071042	nuclear polyadenylation-dependent mRNA catabolic process	7	1
GO:0071046	nuclear polyadenylation-dependent ncRNA catabolic process	8	1
GO:0071047	polyadenylation-dependent mRNA catabolic process	6	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	7	1
GO:0106354	tRNA surveillance	7	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903313	positive regulation of mRNA metabolic process	7	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1
GO:2000113	obsolete negative regulation of cellular macromolecule biosynthetic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004518	nuclease activity	4	7
GO:0004527	exonuclease activity	5	7
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	236	240	PF00656	0.632
CLV_C14_Caspase3-7	284	288	PF00656	0.567
CLV_NRD_NRD_1	132	134	PF00675	0.251
CLV_NRD_NRD_1	166	168	PF00675	0.251
CLV_NRD_NRD_1	220	222	PF00675	0.585
CLV_NRD_NRD_1	324	326	PF00675	0.415
CLV_PCSK_KEX2_1	106	108	PF00082	0.323
CLV_PCSK_KEX2_1	132	134	PF00082	0.251
CLV_PCSK_KEX2_1	166	168	PF00082	0.242
CLV_PCSK_KEX2_1	220	222	PF00082	0.585
CLV_PCSK_KEX2_1	324	326	PF00082	0.434
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.322
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.463
CLV_PCSK_SKI1_1	103	107	PF00082	0.206
CLV_PCSK_SKI1_1	215	219	PF00082	0.499
CLV_PCSK_SKI1_1	301	305	PF00082	0.197
CLV_PCSK_SKI1_1	357	361	PF00082	0.651
CLV_PCSK_SKI1_1	90	94	PF00082	0.310
DEG_Nend_Nbox_1	1	3	PF02207	0.629
DEG_SCF_FBW7_2	345	351	PF00400	0.621
DOC_CKS1_1	345	350	PF01111	0.617
DOC_CYCLIN_RxL_1	14	24	PF00134	0.444
DOC_CYCLIN_RxL_1	87	97	PF00134	0.527
DOC_MAPK_gen_1	103	112	PF00069	0.527
DOC_MAPK_gen_1	166	172	PF00069	0.521
DOC_MAPK_MEF2A_6	185	192	PF00069	0.421
DOC_PP1_RVXF_1	15	22	PF00149	0.386
DOC_PP1_RVXF_1	241	248	PF00149	0.548
DOC_USP7_MATH_1	227	231	PF00917	0.674
DOC_USP7_MATH_1	328	332	PF00917	0.513
DOC_USP7_MATH_1	66	70	PF00917	0.494
DOC_USP7_UBL2_3	301	305	PF12436	0.397
DOC_WW_Pin1_4	192	197	PF00397	0.364
DOC_WW_Pin1_4	344	349	PF00397	0.610
DOC_WW_Pin1_4	73	78	PF00397	0.498
LIG_14-3-3_CanoR_1	107	111	PF00244	0.572
LIG_14-3-3_CanoR_1	114	121	PF00244	0.574
LIG_14-3-3_CanoR_1	215	220	PF00244	0.564
LIG_Actin_WH2_2	207	222	PF00022	0.557
LIG_BRCT_BRCA1_1	197	201	PF00533	0.367
LIG_FHA_1	111	117	PF00498	0.469
LIG_FHA_1	121	127	PF00498	0.422
LIG_FHA_1	198	204	PF00498	0.406
LIG_FHA_1	267	273	PF00498	0.503
LIG_FHA_1	305	311	PF00498	0.504
LIG_FHA_1	63	69	PF00498	0.452
LIG_FHA_2	345	351	PF00498	0.692
LIG_LIR_Nem_3	100	105	PF02991	0.397
LIG_LIR_Nem_3	44	50	PF02991	0.408
LIG_NRBOX	111	117	PF00104	0.515
LIG_SH2_STAT3	295	298	PF00017	0.476
LIG_SH2_STAT5	111	114	PF00017	0.572
LIG_SH2_STAT5	295	298	PF00017	0.467
LIG_SH3_3	162	168	PF00018	0.527
LIG_SH3_3	176	182	PF00018	0.449
LIG_SH3_3	185	191	PF00018	0.444
LIG_SH3_3	252	258	PF00018	0.281
LIG_SH3_3	4	10	PF00018	0.569
LIG_SH3_3	74	80	PF00018	0.451
LIG_SUMO_SIM_anti_2	140	145	PF11976	0.439
LIG_TRAF2_1	259	262	PF00917	0.493
LIG_UBA3_1	310	315	PF00899	0.514
MOD_CDC14_SPxK_1	76	79	PF00782	0.527
MOD_CDK_SPxK_1	73	79	PF00069	0.498
MOD_CK2_1	116	122	PF00069	0.527
MOD_CK2_1	256	262	PF00069	0.421
MOD_Cter_Amidation	130	133	PF01082	0.251
MOD_GlcNHglycan	230	233	PF01048	0.664
MOD_GSK3_1	106	113	PF00069	0.523
MOD_GSK3_1	116	123	PF00069	0.505
MOD_GSK3_1	62	69	PF00069	0.531
MOD_NEK2_1	110	115	PF00069	0.488
MOD_NEK2_1	116	121	PF00069	0.449
MOD_NEK2_1	19	24	PF00069	0.391
MOD_NEK2_1	197	202	PF00069	0.352
MOD_NEK2_1	2	7	PF00069	0.612
MOD_NEK2_1	245	250	PF00069	0.422
MOD_NEK2_2	168	173	PF00069	0.395
MOD_PIKK_1	304	310	PF00454	0.612
MOD_PIKK_1	328	334	PF00454	0.553
MOD_PK_1	133	139	PF00069	0.451
MOD_PKA_1	106	112	PF00069	0.527
MOD_PKA_2	106	112	PF00069	0.536
MOD_Plk_1	168	174	PF00069	0.403
MOD_Plk_1	289	295	PF00069	0.511
MOD_Plk_4	116	122	PF00069	0.527
MOD_ProDKin_1	192	198	PF00069	0.358
MOD_ProDKin_1	344	350	PF00069	0.614
MOD_ProDKin_1	73	79	PF00069	0.498
MOD_SUMO_for_1	359	362	PF00179	0.642
MOD_SUMO_rev_2	100	108	PF00179	0.473
MOD_SUMO_rev_2	236	245	PF00179	0.595
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.453
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.392
TRG_ER_diArg_1	132	134	PF00400	0.451
TRG_ER_diArg_1	165	167	PF00400	0.451
TRG_ER_diArg_1	219	221	PF00400	0.545
TRG_ER_diLys_1	358	363	PF00400	0.593
TRG_NES_CRM1_1	39	53	PF08389	0.395
TRG_NLS_MonoExtC_3	356	362	PF00514	0.609
TRG_Pf-PMV_PEXEL_1	90	95	PF00026	0.293

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJW7	Leptomonas seymouri	75%	99%
A0A1X0NU08	Trypanosomatidae	46%	100%
A0A3R7LNR5	Trypanosoma rangeli	46%	100%
A4HCJ7	Leishmania braziliensis	90%	100%
A4I017	Leishmania infantum	100%	100%
B6YSE7	Thermococcus onnurineus (strain NA1)	22%	100%
C5A2B8	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	22%	100%
C9ZQ76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AVZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O26778	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	24%	100%
O59224	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	23%	100%
O74918	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q05636	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q0W2Y7	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	21%	100%
Q2KHU3	Bos taurus	24%	100%
Q3SWZ4	Bos taurus	25%	82%
Q4QBI9	Leishmania major	93%	100%
Q4QR75	Rattus norvegicus	26%	83%
Q5JIR7	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	21%	100%
Q5XJQ5	Danio rerio	26%	92%
Q8TYC2	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	23%	100%
Q8U0M0	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	21%	100%
Q96B26	Homo sapiens	25%	100%
Q975G9	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	22%	100%
Q9D753	Mus musculus	25%	100%
Q9HIP1	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	21%	100%
Q9JHI7	Mus musculus	26%	83%
Q9LDM2	Arabidopsis thaliana	28%	100%
Q9M209	Arabidopsis thaliana	28%	83%
Q9V118	Pyrococcus abyssi (strain GE5 / Orsay)	21%	100%
V5B7H1	Trypanosoma cruzi	47%	100%