Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WXA7_LEIDO

TriTrypDb:

LdBPK_220860.1 , LdCL_220016000 , LDHU3_22.1370

Length:

678

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WXA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXA7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.374
CLV_C14_Caspase3-7	135	139	PF00656	0.516
CLV_MEL_PAP_1	203	209	PF00089	0.505
CLV_NRD_NRD_1	153	155	PF00675	0.453
CLV_NRD_NRD_1	251	253	PF00675	0.434
CLV_NRD_NRD_1	293	295	PF00675	0.484
CLV_NRD_NRD_1	313	315	PF00675	0.357
CLV_NRD_NRD_1	336	338	PF00675	0.505
CLV_NRD_NRD_1	383	385	PF00675	0.793
CLV_NRD_NRD_1	455	457	PF00675	0.545
CLV_NRD_NRD_1	48	50	PF00675	0.445
CLV_NRD_NRD_1	613	615	PF00675	0.698
CLV_NRD_NRD_1	648	650	PF00675	0.784
CLV_NRD_NRD_1	658	660	PF00675	0.776
CLV_NRD_NRD_1	80	82	PF00675	0.443
CLV_PCSK_KEX2_1	155	157	PF00082	0.381
CLV_PCSK_KEX2_1	251	253	PF00082	0.413
CLV_PCSK_KEX2_1	3	5	PF00082	0.609
CLV_PCSK_KEX2_1	313	315	PF00082	0.523
CLV_PCSK_KEX2_1	336	338	PF00082	0.492
CLV_PCSK_KEX2_1	383	385	PF00082	0.720
CLV_PCSK_KEX2_1	47	49	PF00082	0.416
CLV_PCSK_KEX2_1	594	596	PF00082	0.643
CLV_PCSK_KEX2_1	613	615	PF00082	0.709
CLV_PCSK_KEX2_1	648	650	PF00082	0.785
CLV_PCSK_KEX2_1	658	660	PF00082	0.779
CLV_PCSK_KEX2_1	80	82	PF00082	0.385
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.381
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.609
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.412
CLV_PCSK_PC1ET2_1	594	596	PF00082	0.640
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.385
CLV_PCSK_PC7_1	590	596	PF00082	0.474
CLV_PCSK_SKI1_1	128	132	PF00082	0.508
CLV_PCSK_SKI1_1	252	256	PF00082	0.472
CLV_PCSK_SKI1_1	346	350	PF00082	0.541
CLV_PCSK_SKI1_1	457	461	PF00082	0.594
CLV_PCSK_SKI1_1	521	525	PF00082	0.528
CLV_PCSK_SKI1_1	628	632	PF00082	0.673
CLV_PCSK_SKI1_1	81	85	PF00082	0.402
DEG_Nend_Nbox_1	1	3	PF02207	0.637
DEG_SPOP_SBC_1	619	623	PF00917	0.733
DOC_MAPK_gen_1	166	175	PF00069	0.559
DOC_MAPK_gen_1	352	359	PF00069	0.456
DOC_MAPK_gen_1	362	369	PF00069	0.389
DOC_MAPK_MEF2A_6	188	196	PF00069	0.427
DOC_MAPK_MEF2A_6	90	99	PF00069	0.513
DOC_PP1_RVXF_1	104	110	PF00149	0.353
DOC_PP4_FxxP_1	160	163	PF00568	0.427
DOC_PP4_FxxP_1	583	586	PF00568	0.533
DOC_SPAK_OSR1_1	206	210	PF12202	0.514
DOC_USP7_MATH_1	130	134	PF00917	0.429
DOC_USP7_MATH_1	414	418	PF00917	0.663
DOC_USP7_MATH_1	440	444	PF00917	0.677
DOC_USP7_MATH_1	452	456	PF00917	0.624
DOC_USP7_MATH_1	647	651	PF00917	0.646
DOC_USP7_MATH_1	652	656	PF00917	0.645
DOC_USP7_MATH_1	668	672	PF00917	0.646
DOC_USP7_UBL2_3	235	239	PF12436	0.469
DOC_USP7_UBL2_3	295	299	PF12436	0.548
DOC_USP7_UBL2_3	503	507	PF12436	0.750
DOC_USP7_UBL2_3	80	84	PF12436	0.383
DOC_WW_Pin1_4	613	618	PF00397	0.630
DOC_WW_Pin1_4	630	635	PF00397	0.732
DOC_WW_Pin1_4	640	645	PF00397	0.603
LIG_14-3-3_CanoR_1	188	193	PF00244	0.433
LIG_14-3-3_CanoR_1	269	275	PF00244	0.562
LIG_14-3-3_CanoR_1	314	322	PF00244	0.591
LIG_14-3-3_CanoR_1	384	392	PF00244	0.722
LIG_14-3-3_CanoR_1	4	8	PF00244	0.505
LIG_14-3-3_CterR_2	676	678	PF00244	0.612
LIG_Actin_WH2_2	299	315	PF00022	0.581
LIG_Actin_WH2_2	8	23	PF00022	0.431
LIG_Actin_WH2_2	96	113	PF00022	0.345
LIG_AP2alpha_2	471	473	PF02296	0.493
LIG_BRCT_BRCA1_1	243	247	PF00533	0.464
LIG_FHA_1	251	257	PF00498	0.503
LIG_FHA_1	565	571	PF00498	0.504
LIG_FHA_1	607	613	PF00498	0.640
LIG_FHA_1	662	668	PF00498	0.713
LIG_FHA_1	90	96	PF00498	0.516
LIG_FHA_2	180	186	PF00498	0.459
LIG_FHA_2	316	322	PF00498	0.474
LIG_FHA_2	428	434	PF00498	0.634
LIG_LIR_Apic_2	157	163	PF02991	0.416
LIG_LIR_Apic_2	467	472	PF02991	0.501
LIG_LIR_Gen_1	112	121	PF02991	0.350
LIG_LIR_Gen_1	24	30	PF02991	0.421
LIG_LIR_Gen_1	470	481	PF02991	0.513
LIG_LIR_Nem_3	112	117	PF02991	0.349
LIG_LIR_Nem_3	30	35	PF02991	0.432
LIG_LIR_Nem_3	37	43	PF02991	0.357
LIG_LIR_Nem_3	470	476	PF02991	0.542
LIG_LIR_Nem_3	486	490	PF02991	0.487
LIG_LIR_Nem_3	553	558	PF02991	0.562
LIG_RPA_C_Fungi	129	141	PF08784	0.461
LIG_SH2_CRK	189	193	PF00017	0.454
LIG_SH2_CRK	487	491	PF00017	0.557
LIG_SH2_NCK_1	469	473	PF00017	0.501
LIG_SH2_SRC	469	472	PF00017	0.499
LIG_SH2_STAP1	237	241	PF00017	0.496
LIG_SH2_STAP1	491	495	PF00017	0.526
LIG_SH2_STAP1	574	578	PF00017	0.574
LIG_SH2_STAT3	341	344	PF00017	0.576
LIG_SH2_STAT3	505	508	PF00017	0.559
LIG_SH2_STAT5	356	359	PF00017	0.543
LIG_SH2_STAT5	43	46	PF00017	0.405
LIG_SH2_STAT5	505	508	PF00017	0.673
LIG_SH2_STAT5	554	557	PF00017	0.480
LIG_SH3_3	559	565	PF00018	0.538
LIG_SUMO_SIM_anti_2	301	308	PF11976	0.457
LIG_SUMO_SIM_par_1	95	101	PF11976	0.474
LIG_TRAF2_1	318	321	PF00917	0.598
LIG_TRAF2_1	430	433	PF00917	0.537
LIG_UBA3_1	587	594	PF00899	0.625
MOD_CDC14_SPxK_1	633	636	PF00782	0.647
MOD_CDK_SPxK_1	630	636	PF00069	0.636
MOD_CK1_1	13	19	PF00069	0.564
MOD_CK1_1	250	256	PF00069	0.411
MOD_CK1_1	315	321	PF00069	0.580
MOD_CK1_1	385	391	PF00069	0.722
MOD_CK1_1	422	428	PF00069	0.678
MOD_CK1_1	445	451	PF00069	0.700
MOD_CK1_1	608	614	PF00069	0.681
MOD_CK1_1	622	628	PF00069	0.762
MOD_CK2_1	121	127	PF00069	0.425
MOD_CK2_1	171	177	PF00069	0.502
MOD_CK2_1	179	185	PF00069	0.401
MOD_CK2_1	24	30	PF00069	0.456
MOD_CK2_1	255	261	PF00069	0.447
MOD_CK2_1	315	321	PF00069	0.483
MOD_CK2_1	427	433	PF00069	0.700
MOD_CK2_1	98	104	PF00069	0.403
MOD_Cter_Amidation	381	384	PF01082	0.557
MOD_Cter_Amidation	501	504	PF01082	0.535
MOD_GlcNHglycan	100	103	PF01048	0.537
MOD_GlcNHglycan	12	15	PF01048	0.426
MOD_GlcNHglycan	242	246	PF01048	0.474
MOD_GlcNHglycan	314	317	PF01048	0.576
MOD_GlcNHglycan	380	383	PF01048	0.572
MOD_GlcNHglycan	393	397	PF01048	0.570
MOD_GlcNHglycan	421	424	PF01048	0.679
MOD_GlcNHglycan	427	430	PF01048	0.643
MOD_GlcNHglycan	442	445	PF01048	0.575
MOD_GlcNHglycan	449	452	PF01048	0.610
MOD_GlcNHglycan	601	604	PF01048	0.630
MOD_GlcNHglycan	624	627	PF01048	0.705
MOD_GSK3_1	130	137	PF00069	0.419
MOD_GSK3_1	378	385	PF00069	0.665
MOD_GSK3_1	427	434	PF00069	0.618
MOD_GSK3_1	601	608	PF00069	0.670
MOD_GSK3_1	613	620	PF00069	0.653
MOD_GSK3_1	658	665	PF00069	0.607
MOD_GSK3_1	89	96	PF00069	0.541
MOD_NEK2_1	241	246	PF00069	0.449
MOD_NEK2_1	247	252	PF00069	0.406
MOD_NEK2_1	255	260	PF00069	0.376
MOD_NEK2_1	312	317	PF00069	0.572
MOD_NEK2_1	419	424	PF00069	0.671
MOD_NEK2_1	431	436	PF00069	0.535
MOD_NEK2_1	538	543	PF00069	0.597
MOD_NEK2_1	618	623	PF00069	0.668
MOD_NEK2_2	472	477	PF00069	0.532
MOD_NEK2_2	527	532	PF00069	0.674
MOD_PIKK_1	112	118	PF00454	0.363
MOD_PIKK_1	382	388	PF00454	0.717
MOD_PIKK_1	414	420	PF00454	0.678
MOD_PK_1	3	9	PF00069	0.432
MOD_PKA_1	3	9	PF00069	0.432
MOD_PKA_1	503	509	PF00069	0.556
MOD_PKA_1	658	664	PF00069	0.607
MOD_PKA_2	121	127	PF00069	0.457
MOD_PKA_2	250	256	PF00069	0.435
MOD_PKA_2	3	9	PF00069	0.479
MOD_PKA_2	312	318	PF00069	0.573
MOD_PKA_2	382	388	PF00069	0.706
MOD_PKA_2	647	653	PF00069	0.789
MOD_PKA_2	658	664	PF00069	0.624
MOD_Plk_1	171	177	PF00069	0.642
MOD_Plk_1	652	658	PF00069	0.542
MOD_Plk_4	3	9	PF00069	0.432
MOD_Plk_4	538	544	PF00069	0.625
MOD_Plk_4	662	668	PF00069	0.575
MOD_ProDKin_1	613	619	PF00069	0.629
MOD_ProDKin_1	630	636	PF00069	0.735
MOD_ProDKin_1	640	646	PF00069	0.605
MOD_SUMO_for_1	221	224	PF00179	0.538
MOD_SUMO_for_1	298	301	PF00179	0.538
MOD_SUMO_for_1	363	366	PF00179	0.495
MOD_SUMO_for_1	593	596	PF00179	0.634
MOD_SUMO_rev_2	569	578	PF00179	0.646
MOD_SUMO_rev_2	86	92	PF00179	0.551
TRG_DiLeu_BaEn_1	279	284	PF01217	0.500
TRG_DiLeu_BaEn_4	320	326	PF01217	0.498
TRG_DiLeu_BaLyEn_6	583	588	PF01217	0.651
TRG_ENDOCYTIC_2	189	192	PF00928	0.404
TRG_ENDOCYTIC_2	237	240	PF00928	0.403
TRG_ENDOCYTIC_2	356	359	PF00928	0.543
TRG_ENDOCYTIC_2	487	490	PF00928	0.595
TRG_ER_diArg_1	106	109	PF00400	0.467
TRG_ER_diArg_1	19	22	PF00400	0.412
TRG_ER_diArg_1	312	314	PF00400	0.563
TRG_ER_diArg_1	612	614	PF00400	0.679
TRG_ER_diArg_1	648	651	PF00400	0.793
TRG_NES_CRM1_1	198	213	PF08389	0.519
TRG_NES_CRM1_1	358	371	PF08389	0.562
TRG_NLS_MonoExtC_3	79	84	PF00514	0.428
TRG_NLS_MonoExtN_4	454	460	PF00514	0.433
TRG_NLS_MonoExtN_4	80	85	PF00514	0.469
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8W6	Leptomonas seymouri	66%	100%
A0A0S4KMX4	Bodo saltans	45%	100%
A0A1X0NU00	Trypanosomatidae	54%	100%
A0A422MU25	Trypanosoma rangeli	54%	100%
A4HCC0	Leishmania braziliensis	83%	99%
A4HZX6	Leishmania infantum	99%	100%
C9ZSL5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AVT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QBP3	Leishmania major	95%	100%