MORN repeat, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WXA1_LEIDO

TriTrypDb:

LdBPK_221250.1 , LdCL_220019600 , LDHU3_22.1800

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WXA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WXA1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	455	459	PF00656	0.447
CLV_C14_Caspase3-7	501	505	PF00656	0.449
CLV_NRD_NRD_1	161	163	PF00675	0.478
CLV_NRD_NRD_1	227	229	PF00675	0.493
CLV_NRD_NRD_1	490	492	PF00675	0.640
CLV_NRD_NRD_1	87	89	PF00675	0.585
CLV_PCSK_KEX2_1	160	162	PF00082	0.476
CLV_PCSK_KEX2_1	227	229	PF00082	0.445
CLV_PCSK_KEX2_1	434	436	PF00082	0.301
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.596
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.320
CLV_PCSK_SKI1_1	118	122	PF00082	0.713
CLV_PCSK_SKI1_1	43	47	PF00082	0.558
CLV_PCSK_SKI1_1	62	66	PF00082	0.623
DEG_APCC_DBOX_1	117	125	PF00400	0.698
DEG_APCC_DBOX_1	187	195	PF00400	0.621
DEG_Nend_UBRbox_2	1	3	PF02207	0.570
DOC_CYCLIN_RxL_1	115	125	PF00134	0.677
DOC_CYCLIN_yCln2_LP_2	120	126	PF00134	0.693
DOC_MAPK_FxFP_2	202	205	PF00069	0.557
DOC_PP2B_LxvP_1	65	68	PF13499	0.495
DOC_PP4_FxxP_1	202	205	PF00568	0.512
DOC_PP4_MxPP_1	39	42	PF00568	0.646
DOC_USP7_MATH_1	166	170	PF00917	0.601
DOC_USP7_MATH_1	171	175	PF00917	0.568
DOC_USP7_MATH_1	394	398	PF00917	0.325
DOC_USP7_MATH_1	45	49	PF00917	0.720
DOC_USP7_MATH_1	511	515	PF00917	0.510
DOC_USP7_UBL2_3	268	272	PF12436	0.430
DOC_USP7_UBL2_3	36	40	PF12436	0.565
DOC_WW_Pin1_4	49	54	PF00397	0.775
DOC_WW_Pin1_4	7	12	PF00397	0.653
LIG_14-3-3_CanoR_1	128	133	PF00244	0.645
LIG_14-3-3_CanoR_1	190	195	PF00244	0.627
LIG_14-3-3_CanoR_1	227	231	PF00244	0.431
LIG_14-3-3_CanoR_1	71	79	PF00244	0.686
LIG_deltaCOP1_diTrp_1	402	408	PF00928	0.389
LIG_FHA_1	107	113	PF00498	0.683
LIG_FHA_1	411	417	PF00498	0.337
LIG_FHA_1	504	510	PF00498	0.655
LIG_FHA_2	2	8	PF00498	0.569
LIG_Integrin_RGDW_4	306	309	PF00362	0.385
LIG_LIR_Apic_2	201	205	PF02991	0.529
LIG_LIR_Apic_2	319	323	PF02991	0.389
LIG_LIR_Apic_2	413	417	PF02991	0.524
LIG_LIR_Gen_1	197	205	PF02991	0.456
LIG_LIR_Gen_1	253	260	PF02991	0.433
LIG_LIR_Nem_3	197	202	PF02991	0.438
LIG_LIR_Nem_3	253	259	PF02991	0.368
LIG_SH2_CRK	256	260	PF00017	0.418
LIG_SH2_CRK	382	386	PF00017	0.434
LIG_SH2_GRB2like	430	433	PF00017	0.383
LIG_SH2_SRC	320	323	PF00017	0.398
LIG_SH2_SRC	430	433	PF00017	0.383
LIG_SH2_STAT3	236	239	PF00017	0.417
LIG_SH2_STAT5	282	285	PF00017	0.362
LIG_SH2_STAT5	297	300	PF00017	0.310
LIG_SH2_STAT5	320	323	PF00017	0.304
LIG_SH2_STAT5	351	354	PF00017	0.319
LIG_SH2_STAT5	399	402	PF00017	0.405
LIG_SH2_STAT5	426	429	PF00017	0.454
LIG_SH2_STAT5	441	444	PF00017	0.334
LIG_SH2_STAT5	448	451	PF00017	0.370
LIG_SH2_STAT5	486	489	PF00017	0.482
LIG_SH2_STAT6	198	202	PF00017	0.553
LIG_SH3_3	100	106	PF00018	0.596
LIG_SH3_3	72	78	PF00018	0.615
LIG_SUMO_SIM_par_1	174	182	PF11976	0.570
LIG_WRC_WIRS_1	199	204	PF05994	0.549
LIG_WW_3	40	44	PF00397	0.520
MOD_CDK_SPK_2	49	54	PF00069	0.545
MOD_CK1_1	10	16	PF00069	0.694
MOD_CK1_1	365	371	PF00069	0.567
MOD_CK1_1	444	450	PF00069	0.434
MOD_CK1_1	52	58	PF00069	0.525
MOD_CK2_1	1	7	PF00069	0.573
MOD_CK2_1	134	140	PF00069	0.528
MOD_Cter_Amidation	432	435	PF01082	0.325
MOD_GlcNHglycan	168	171	PF01048	0.669
MOD_GlcNHglycan	252	255	PF01048	0.391
MOD_GlcNHglycan	310	313	PF01048	0.434
MOD_GlcNHglycan	323	326	PF01048	0.373
MOD_GlcNHglycan	43	46	PF01048	0.746
MOD_GlcNHglycan	47	50	PF01048	0.699
MOD_GlcNHglycan	72	75	PF01048	0.635
MOD_GlcNHglycan	84	87	PF01048	0.535
MOD_GSK3_1	31	38	PF00069	0.693
MOD_GSK3_1	339	346	PF00069	0.374
MOD_GSK3_1	362	369	PF00069	0.388
MOD_GSK3_1	41	48	PF00069	0.700
MOD_GSK3_1	440	447	PF00069	0.428
MOD_GSK3_1	77	84	PF00069	0.695
MOD_N-GLC_1	316	321	PF02516	0.440
MOD_N-GLC_1	366	371	PF02516	0.552
MOD_NEK2_1	1	6	PF00069	0.597
MOD_NEK2_1	134	139	PF00069	0.489
MOD_NEK2_1	226	231	PF00069	0.474
MOD_NEK2_1	366	371	PF00069	0.542
MOD_PIKK_1	226	232	PF00454	0.424
MOD_PKA_2	189	195	PF00069	0.583
MOD_PKA_2	226	232	PF00069	0.563
MOD_PKA_2	339	345	PF00069	0.325
MOD_PKA_2	374	380	PF00069	0.504
MOD_PKA_2	410	416	PF00069	0.454
MOD_PKA_2	424	430	PF00069	0.286
MOD_PKA_2	58	64	PF00069	0.773
MOD_PKA_2	70	76	PF00069	0.503
MOD_PKB_1	188	196	PF00069	0.642
MOD_Plk_1	1	7	PF00069	0.563
MOD_Plk_1	114	120	PF00069	0.695
MOD_Plk_1	287	293	PF00069	0.481
MOD_Plk_1	511	517	PF00069	0.459
MOD_Plk_4	1	7	PF00069	0.730
MOD_Plk_4	260	266	PF00069	0.343
MOD_Plk_4	316	322	PF00069	0.342
MOD_Plk_4	381	387	PF00069	0.426
MOD_Plk_4	467	473	PF00069	0.528
MOD_Plk_4	52	58	PF00069	0.538
MOD_ProDKin_1	49	55	PF00069	0.773
MOD_ProDKin_1	7	13	PF00069	0.653
MOD_SUMO_for_1	326	329	PF00179	0.426
MOD_SUMO_rev_2	263	269	PF00179	0.462
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.694
TRG_DiLeu_BaLyEn_6	519	524	PF01217	0.580
TRG_ENDOCYTIC_2	199	202	PF00928	0.471
TRG_ENDOCYTIC_2	256	259	PF00928	0.431
TRG_ENDOCYTIC_2	382	385	PF00928	0.434
TRG_ER_diArg_1	226	228	PF00400	0.385
TRG_ER_diArg_1	333	336	PF00400	0.337
TRG_ER_diArg_1	405	408	PF00400	0.434
TRG_LysEnd_GGAAcLL_1	520	526	PF00790	0.584
TRG_NES_CRM1_1	175	189	PF08389	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIF6	Leptomonas seymouri	68%	92%
A0A1X0NTG8	Trypanosomatidae	44%	100%
A0A1X0P961	Trypanosomatidae	29%	76%
A0A3R7NAK8	Trypanosoma rangeli	45%	100%
A0A3S7X3U7	Leishmania donovani	36%	100%
A4HCH7	Leishmania braziliensis	87%	100%
A4HIR9	Leishmania braziliensis	36%	100%
A4HZZ9	Leishmania infantum	100%	100%
A4I615	Leishmania infantum	36%	100%
C9ZSQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A328	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	76%
E9AVX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B1A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
Q4Q6V8	Leishmania major	36%	100%
Q4QBK7	Leishmania major	96%	100%