Intraflagellar_transport_protein-like_protein/Gen eDB:LmjF.22.1370

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

intraflagellar transport protein-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WX98_LEIDO

TriTrypDb:

LdBPK_221220.1 , LdCL_220019300 , LDHU3_22.1760

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0030992	intraciliary transport particle B	2	11
GO:0031514	motile cilium	5	9
GO:0032991	protein-containing complex	1	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005737	cytoplasm	2	1
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0030990	intraciliary transport particle	2	1
GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	4	1
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain	3	1
GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1

Expansion

Sequence features

A0A3S7WX98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WX98

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006996	organelle organization	4	10
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0010970	transport along microtubule	4	11
GO:0016043	cellular component organization	3	10
GO:0022607	cellular component assembly	4	10
GO:0030030	cell projection organization	4	10
GO:0030031	cell projection assembly	5	10
GO:0030705	cytoskeleton-dependent intracellular transport	4	11
GO:0031503	protein-containing complex localization	2	11
GO:0042073	intraciliary transport	3	11
GO:0044782	cilium organization	5	10
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0060271	cilium assembly	6	10
GO:0070925	organelle assembly	5	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0099111	microtubule-based transport	4	11
GO:0120031	plasma membrane bounded cell projection assembly	6	10
GO:0120036	plasma membrane bounded cell projection organization	5	10
GO:0035735	intraciliary transport involved in cilium assembly	4	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006164	purine nucleotide biosynthetic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006754	ATP biosynthetic process	8	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009141	nucleoside triphosphate metabolic process	5	1
GO:0009142	nucleoside triphosphate biosynthetic process	6	1
GO:0009144	purine nucleoside triphosphate metabolic process	6	1
GO:0009145	purine nucleoside triphosphate biosynthetic process	7	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009152	purine ribonucleotide biosynthetic process	7	1
GO:0009165	nucleotide biosynthetic process	6	1
GO:0009199	ribonucleoside triphosphate metabolic process	6	1
GO:0009201	ribonucleoside triphosphate biosynthetic process	7	1
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	1
GO:0009206	purine ribonucleoside triphosphate biosynthetic process	8	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009260	ribonucleotide biosynthetic process	6	1
GO:0015986	proton motive force-driven ATP synthesis	9	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046034	ATP metabolic process	7	1
GO:0046390	ribose phosphate biosynthetic process	5	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072522	purine-containing compound biosynthetic process	5	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901293	nucleoside phosphate biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0015631	tubulin binding	4	11
GO:0048487	beta-tubulin binding	5	11
GO:0005215	transporter activity	1	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015078	proton transmembrane transporter activity	5	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022890	inorganic cation transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	408	412	PF00656	0.535
CLV_C14_Caspase3-7	470	474	PF00656	0.437
CLV_NRD_NRD_1	170	172	PF00675	0.380
CLV_NRD_NRD_1	204	206	PF00675	0.394
CLV_NRD_NRD_1	268	270	PF00675	0.438
CLV_NRD_NRD_1	271	273	PF00675	0.432
CLV_NRD_NRD_1	433	435	PF00675	0.455
CLV_NRD_NRD_1	482	484	PF00675	0.401
CLV_NRD_NRD_1	513	515	PF00675	0.407
CLV_PCSK_FUR_1	269	273	PF00082	0.526
CLV_PCSK_KEX2_1	170	172	PF00082	0.396
CLV_PCSK_KEX2_1	204	206	PF00082	0.394
CLV_PCSK_KEX2_1	258	260	PF00082	0.409
CLV_PCSK_KEX2_1	270	272	PF00082	0.377
CLV_PCSK_KEX2_1	413	415	PF00082	0.489
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.409
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.377
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.522
CLV_PCSK_SKI1_1	204	208	PF00082	0.514
CLV_PCSK_SKI1_1	265	269	PF00082	0.409
CLV_PCSK_SKI1_1	429	433	PF00082	0.441
CLV_PCSK_SKI1_1	446	450	PF00082	0.430
CLV_PCSK_SKI1_1	483	487	PF00082	0.410
CLV_Separin_Metazoa	262	266	PF03568	0.418
DEG_APCC_DBOX_1	363	371	PF00400	0.521
DEG_Nend_UBRbox_3	1	3	PF02207	0.481
DOC_CYCLIN_RxL_1	424	433	PF00134	0.450
DOC_CYCLIN_yCln2_LP_2	44	50	PF00134	0.484
DOC_MAPK_gen_1	170	179	PF00069	0.374
DOC_MAPK_gen_1	297	305	PF00069	0.378
DOC_MAPK_gen_1	495	504	PF00069	0.487
DOC_MAPK_MEF2A_6	172	181	PF00069	0.390
DOC_MAPK_MEF2A_6	566	575	PF00069	0.421
DOC_PP1_SILK_1	265	270	PF00149	0.476
DOC_USP7_MATH_1	298	302	PF00917	0.458
DOC_USP7_MATH_1	322	326	PF00917	0.533
DOC_USP7_MATH_1	453	457	PF00917	0.419
DOC_USP7_MATH_1	54	58	PF00917	0.583
DOC_USP7_MATH_1	64	68	PF00917	0.554
LIG_14-3-3_CanoR_1	112	117	PF00244	0.564
LIG_14-3-3_CanoR_1	17	23	PF00244	0.519
LIG_14-3-3_CanoR_1	321	331	PF00244	0.456
LIG_14-3-3_CanoR_1	383	390	PF00244	0.469
LIG_14-3-3_CanoR_1	483	493	PF00244	0.562
LIG_EH1_1	223	231	PF00400	0.448
LIG_FHA_1	398	404	PF00498	0.568
LIG_FHA_1	405	411	PF00498	0.482
LIG_FHA_1	480	486	PF00498	0.466
LIG_FHA_1	539	545	PF00498	0.494
LIG_FHA_1	553	559	PF00498	0.368
LIG_FHA_1	584	590	PF00498	0.653
LIG_FHA_2	124	130	PF00498	0.448
LIG_FHA_2	135	141	PF00498	0.315
LIG_FHA_2	159	165	PF00498	0.380
LIG_FHA_2	297	303	PF00498	0.442
LIG_FHA_2	314	320	PF00498	0.551
LIG_FHA_2	352	358	PF00498	0.517
LIG_FHA_2	400	406	PF00498	0.682
LIG_FHA_2	558	564	PF00498	0.469
LIG_LIR_Gen_1	175	186	PF02991	0.425
LIG_LIR_Gen_1	467	477	PF02991	0.554
LIG_LIR_Gen_1	522	531	PF02991	0.523
LIG_LIR_Gen_1	545	554	PF02991	0.387
LIG_LIR_Nem_3	12	16	PF02991	0.504
LIG_LIR_Nem_3	175	181	PF02991	0.427
LIG_LIR_Nem_3	212	216	PF02991	0.372
LIG_LIR_Nem_3	467	472	PF02991	0.568
LIG_LIR_Nem_3	522	527	PF02991	0.485
LIG_LIR_Nem_3	545	550	PF02991	0.374
LIG_LIR_Nem_3	83	88	PF02991	0.408
LIG_Pex14_1	538	542	PF04695	0.499
LIG_SH2_CRK	216	220	PF00017	0.493
LIG_SH2_CRK	493	497	PF00017	0.454
LIG_SH2_PTP2	547	550	PF00017	0.461
LIG_SH2_PTP2	85	88	PF00017	0.397
LIG_SH2_STAT5	493	496	PF00017	0.473
LIG_SH2_STAT5	547	550	PF00017	0.438
LIG_SH2_STAT5	557	560	PF00017	0.364
LIG_SH2_STAT5	85	88	PF00017	0.397
LIG_SUMO_SIM_anti_2	301	307	PF11976	0.381
LIG_SUMO_SIM_par_1	46	51	PF11976	0.497
LIG_TRAF2_1	194	197	PF00917	0.404
LIG_TRAF2_1	242	245	PF00917	0.384
LIG_TRAF2_1	316	319	PF00917	0.532
LIG_TRAF2_1	326	329	PF00917	0.451
LIG_TRAF2_1	341	344	PF00917	0.334
LIG_TRAF2_1	528	531	PF00917	0.449
LIG_UBA3_1	263	270	PF00899	0.478
LIG_UBA3_1	292	297	PF00899	0.519
LIG_Vh1_VBS_1	177	195	PF01044	0.457
LIG_WRC_WIRS_1	10	15	PF05994	0.500
LIG_WRC_WIRS_1	352	357	PF05994	0.402
MOD_CK1_1	115	121	PF00069	0.472
MOD_CK1_1	279	285	PF00069	0.429
MOD_CK1_1	382	388	PF00069	0.518
MOD_CK1_1	540	546	PF00069	0.411
MOD_CK1_1	9	15	PF00069	0.586
MOD_CK2_1	158	164	PF00069	0.493
MOD_CK2_1	191	197	PF00069	0.444
MOD_CK2_1	281	287	PF00069	0.409
MOD_CK2_1	298	304	PF00069	0.376
MOD_CK2_1	313	319	PF00069	0.363
MOD_CK2_1	322	328	PF00069	0.412
MOD_CK2_1	525	531	PF00069	0.421
MOD_CK2_1	557	563	PF00069	0.500
MOD_GlcNHglycan	324	327	PF01048	0.442
MOD_GlcNHglycan	334	337	PF01048	0.381
MOD_GlcNHglycan	455	458	PF01048	0.476
MOD_GlcNHglycan	486	489	PF01048	0.384
MOD_GlcNHglycan	50	53	PF01048	0.529
MOD_GlcNHglycan	590	593	PF01048	0.574
MOD_GlcNHglycan	66	69	PF01048	0.565
MOD_GlcNHglycan	71	74	PF01048	0.544
MOD_GlcNHglycan	95	99	PF01048	0.459
MOD_GSK3_1	111	118	PF00069	0.567
MOD_GSK3_1	181	188	PF00069	0.457
MOD_GSK3_1	313	320	PF00069	0.492
MOD_GSK3_1	393	400	PF00069	0.759
MOD_GSK3_1	588	595	PF00069	0.598
MOD_GSK3_1	64	71	PF00069	0.667
MOD_N-GLC_1	112	117	PF02516	0.415
MOD_N-GLC_1	146	151	PF02516	0.531
MOD_N-GLC_1	332	337	PF02516	0.503
MOD_N-GLC_1	397	402	PF02516	0.557
MOD_NEK2_1	134	139	PF00069	0.374
MOD_NEK2_1	296	301	PF00069	0.494
MOD_NEK2_1	317	322	PF00069	0.403
MOD_NEK2_1	537	542	PF00069	0.368
MOD_NEK2_1	590	595	PF00069	0.575
MOD_NEK2_2	18	23	PF00069	0.520
MOD_NEK2_2	281	286	PF00069	0.543
MOD_PIKK_1	115	121	PF00454	0.472
MOD_PIKK_1	23	29	PF00454	0.522
MOD_PIKK_1	276	282	PF00454	0.516
MOD_PIKK_1	370	376	PF00454	0.441
MOD_PIKK_1	382	388	PF00454	0.415
MOD_PIKK_1	4	10	PF00454	0.489
MOD_PIKK_1	405	411	PF00454	0.581
MOD_PIKK_1	526	532	PF00454	0.458
MOD_PIKK_1	552	558	PF00454	0.546
MOD_PK_1	112	118	PF00069	0.414
MOD_PKA_1	271	277	PF00069	0.418
MOD_PKA_2	111	117	PF00069	0.579
MOD_PKA_2	271	277	PF00069	0.418
MOD_PKA_2	313	319	PF00069	0.530
MOD_PKA_2	322	328	PF00069	0.534
MOD_PKA_2	382	388	PF00069	0.429
MOD_PKB_1	269	277	PF00069	0.422
MOD_PKB_1	495	503	PF00069	0.508
MOD_Plk_1	112	118	PF00069	0.414
MOD_Plk_1	146	152	PF00069	0.569
MOD_Plk_1	158	164	PF00069	0.424
MOD_Plk_1	80	86	PF00069	0.425
MOD_Plk_2-3	351	357	PF00069	0.402
MOD_Plk_2-3	467	473	PF00069	0.573
MOD_Plk_4	112	118	PF00069	0.408
MOD_Plk_4	351	357	PF00069	0.402
MOD_SUMO_for_1	156	159	PF00179	0.525
MOD_SUMO_for_1	242	245	PF00179	0.408
MOD_SUMO_for_1	285	288	PF00179	0.488
MOD_SUMO_for_1	448	451	PF00179	0.469
MOD_SUMO_rev_2	183	188	PF00179	0.501
MOD_SUMO_rev_2	254	260	PF00179	0.435
MOD_SUMO_rev_2	325	334	PF00179	0.436
MOD_SUMO_rev_2	415	423	PF00179	0.538
MOD_SUMO_rev_2	428	436	PF00179	0.358
MOD_SUMO_rev_2	439	448	PF00179	0.408
MOD_SUMO_rev_2	456	464	PF00179	0.407
TRG_AP2beta_CARGO_1	467	476	PF09066	0.557
TRG_DiLeu_BaEn_1	105	110	PF01217	0.397
TRG_DiLeu_BaEn_1	288	293	PF01217	0.399
TRG_DiLeu_BaEn_1	570	575	PF01217	0.385
TRG_DiLeu_BaEn_2	350	356	PF01217	0.406
TRG_DiLeu_BaEn_4	158	164	PF01217	0.488
TRG_DiLeu_BaEn_4	197	203	PF01217	0.369
TRG_ENDOCYTIC_2	216	219	PF00928	0.502
TRG_ENDOCYTIC_2	493	496	PF00928	0.455
TRG_ENDOCYTIC_2	547	550	PF00928	0.512
TRG_ENDOCYTIC_2	85	88	PF00928	0.397
TRG_ER_diArg_1	204	206	PF00400	0.394
TRG_ER_diArg_1	268	271	PF00400	0.416
TRG_ER_diArg_1	533	536	PF00400	0.499
TRG_ER_diArg_1	548	551	PF00400	0.515
TRG_NES_CRM1_1	379	393	PF08389	0.526
TRG_NES_CRM1_1	563	576	PF08389	0.465
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	375	379	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	535	539	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3E7	Leptomonas seymouri	79%	100%
A0A1X0NTR4	Trypanosomatidae	57%	99%
A0A3R7KQW5	Trypanosoma rangeli	58%	100%
A4HCH3	Leishmania braziliensis	92%	100%
C9ZSP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AH05	Leishmania infantum	100%	100%
E9AVW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QBL0	Leishmania major	98%	100%
Q6RCE1	Chlamydomonas reinhardtii	23%	93%
Q8BKE9	Mus musculus	26%	99%
Q96LB3	Homo sapiens	26%	99%
V5B464	Trypanosoma cruzi	59%	100%