Autophagy-related protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATG12/APG12, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WX93_LEIDO

TriTrypDb:

LdBPK_221120.1 , LdCL_220018600 , LDHU3_22.1650

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7WX93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WX93

Function

Biological processes
Term	Name	Level	Count
GO:0006914	autophagy	3	6
GO:0008152	metabolic process	1	6
GO:0009056	catabolic process	2	6
GO:0009987	cellular process	1	6
GO:0044237	cellular metabolic process	2	6
GO:0044248	cellular catabolic process	3	6
GO:0061919	process utilizing autophagic mechanism	2	6
GO:0006950	response to stress	2	1
GO:0006995	cellular response to nitrogen starvation	5	1
GO:0007154	cell communication	2	1
GO:0009267	cellular response to starvation	4	1
GO:0009605	response to external stimulus	2	1
GO:0009991	response to extracellular stimulus	3	1
GO:0031667	response to nutrient levels	4	1
GO:0031668	cellular response to extracellular stimulus	3	1
GO:0031669	cellular response to nutrient levels	4	1
GO:0033554	cellular response to stress	3	1
GO:0042594	response to starvation	3	1
GO:0043562	cellular response to nitrogen levels	5	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071496	cellular response to external stimulus	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	112	116	PF00082	0.375
CLV_PCSK_SKI1_1	131	135	PF00082	0.208
CLV_PCSK_SKI1_1	24	28	PF00082	0.609
CLV_PCSK_SKI1_1	29	33	PF00082	0.561
DOC_MAPK_gen_1	117	126	PF00069	0.334
DOC_MAPK_MEF2A_6	119	128	PF00069	0.388
DOC_PP4_FxxP_1	102	105	PF00568	0.628
DOC_USP7_MATH_1	133	137	PF00917	0.375
DOC_USP7_MATH_1	152	156	PF00917	0.375
DOC_USP7_MATH_1	46	50	PF00917	0.663
DOC_USP7_UBL2_3	108	112	PF12436	0.646
DOC_WW_Pin1_4	101	106	PF00397	0.774
DOC_WW_Pin1_4	51	56	PF00397	0.683
LIG_14-3-3_CanoR_1	117	122	PF00244	0.334
LIG_Actin_WH2_2	37	54	PF00022	0.660
LIG_FHA_1	37	43	PF00498	0.643
LIG_LIR_Apic_2	100	105	PF02991	0.775
LIG_LIR_Apic_2	162	167	PF02991	0.348
LIG_LIR_Gen_1	13	21	PF02991	0.608
LIG_LIR_Gen_1	139	149	PF02991	0.456
LIG_LIR_Gen_1	168	177	PF02991	0.375
LIG_LIR_Nem_3	139	144	PF02991	0.456
LIG_LIR_Nem_3	159	164	PF02991	0.397
LIG_LIR_Nem_3	168	173	PF02991	0.295
LIG_LIR_Nem_3	73	77	PF02991	0.567
LIG_NRBOX	172	178	PF00104	0.375
LIG_PCNA_yPIPBox_3	154	165	PF02747	0.375
LIG_SH2_STAT5	172	175	PF00017	0.375
LIG_SH3_1	52	58	PF00018	0.638
LIG_SH3_2	7	12	PF14604	0.599
LIG_SH3_3	1	7	PF00018	0.663
LIG_SH3_3	146	152	PF00018	0.375
LIG_SH3_3	52	58	PF00018	0.675
LIG_SH3_CIN85_PxpxPR_1	7	12	PF14604	0.599
LIG_SUMO_SIM_par_1	39	45	PF11976	0.649
LIG_WRC_WIRS_1	18	23	PF05994	0.597
LIG_WW_3	9	13	PF00397	0.639
MOD_CDK_SPxxK_3	101	108	PF00069	0.634
MOD_CK1_1	106	112	PF00069	0.563
MOD_CK1_1	136	142	PF00069	0.375
MOD_CK1_1	56	62	PF00069	0.647
MOD_CK1_1	64	70	PF00069	0.667
MOD_CK1_1	86	92	PF00069	0.578
MOD_CK1_1	97	103	PF00069	0.664
MOD_CK2_1	117	123	PF00069	0.375
MOD_CK2_1	140	146	PF00069	0.485
MOD_GlcNHglycan	105	108	PF01048	0.611
MOD_GlcNHglycan	186	189	PF01048	0.594
MOD_GlcNHglycan	66	69	PF01048	0.632
MOD_GlcNHglycan	85	88	PF01048	0.503
MOD_GlcNHglycan	96	99	PF01048	0.559
MOD_GSK3_1	103	110	PF00069	0.621
MOD_GSK3_1	136	143	PF00069	0.478
MOD_GSK3_1	63	70	PF00069	0.726
MOD_GSK3_1	82	89	PF00069	0.597
MOD_GSK3_1	93	100	PF00069	0.604
MOD_NEK2_1	140	145	PF00069	0.508
MOD_NEK2_1	177	182	PF00069	0.375
MOD_NEK2_1	83	88	PF00069	0.658
MOD_NEK2_2	107	112	PF00069	0.603
MOD_PK_1	117	123	PF00069	0.334
MOD_Plk_1	177	183	PF00069	0.348
MOD_Plk_1	190	196	PF00069	0.491
MOD_Plk_4	136	142	PF00069	0.375
MOD_Plk_4	152	158	PF00069	0.208
MOD_ProDKin_1	101	107	PF00069	0.773
MOD_ProDKin_1	51	57	PF00069	0.680
MOD_SUMO_rev_2	59	67	PF00179	0.649
TRG_DiLeu_BaEn_1	146	151	PF01217	0.375
TRG_DiLeu_BaEn_1	22	27	PF01217	0.602
TRG_ENDOCYTIC_2	15	18	PF00928	0.608
TRG_ER_diArg_1	128	131	PF00400	0.375
TRG_NES_CRM1_1	123	135	PF08389	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HCG9	Leishmania braziliensis	80%	100%
E9AH00	Leishmania infantum	99%	100%
E9AVW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QBL7	Leishmania major	93%	100%