Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WX91_LEIDO

TriTrypDb:

LdBPK_221200.1 , LdCL_220019100 , LDHU3_22.1730

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A0A3S7WX91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WX91

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	2
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006897	endocytosis	5	2
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016192	vesicle-mediated transport	4	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018198	peptidyl-cysteine modification	6	2
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	2
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	2
GO:0018345	protein palmitoylation	6	2
GO:0019538	protein metabolic process	3	2
GO:0033036	macromolecule localization	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071705	nitrogen compound transport	4	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	15
GO:0016409	palmitoyltransferase activity	5	15
GO:0016417	S-acyltransferase activity	5	15
GO:0016740	transferase activity	2	15
GO:0016746	acyltransferase activity	3	15
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	15
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	15
GO:0019707	protein-cysteine S-acyltransferase activity	3	15
GO:0140096	catalytic activity, acting on a protein	2	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.726
CLV_C14_Caspase3-7	324	328	PF00656	0.756
CLV_NRD_NRD_1	125	127	PF00675	0.245
CLV_NRD_NRD_1	257	259	PF00675	0.371
CLV_NRD_NRD_1	26	28	PF00675	0.289
CLV_NRD_NRD_1	285	287	PF00675	0.417
CLV_NRD_NRD_1	288	290	PF00675	0.415
CLV_NRD_NRD_1	352	354	PF00675	0.559
CLV_PCSK_FUR_1	24	28	PF00082	0.305
CLV_PCSK_FUR_1	286	290	PF00082	0.427
CLV_PCSK_KEX2_1	125	127	PF00082	0.246
CLV_PCSK_KEX2_1	197	199	PF00082	0.474
CLV_PCSK_KEX2_1	256	258	PF00082	0.356
CLV_PCSK_KEX2_1	26	28	PF00082	0.289
CLV_PCSK_KEX2_1	261	263	PF00082	0.362
CLV_PCSK_KEX2_1	287	289	PF00082	0.423
CLV_PCSK_KEX2_1	292	294	PF00082	0.446
CLV_PCSK_KEX2_1	351	353	PF00082	0.567
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.524
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.352
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.355
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.422
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.446
CLV_PCSK_PC7_1	257	263	PF00082	0.425
CLV_PCSK_PC7_1	288	294	PF00082	0.457
CLV_PCSK_SKI1_1	261	265	PF00082	0.410
CLV_PCSK_SKI1_1	289	293	PF00082	0.503
CLV_PCSK_SKI1_1	83	87	PF00082	0.305
DEG_APCC_DBOX_1	97	105	PF00400	0.530
DEG_Nend_Nbox_1	1	3	PF02207	0.637
DOC_MAPK_MEF2A_6	210	217	PF00069	0.263
DOC_MAPK_MEF2A_6	64	71	PF00069	0.251
DOC_PP1_RVXF_1	233	240	PF00149	0.350
DOC_PP2B_LxvP_1	365	368	PF13499	0.655
DOC_SPAK_OSR1_1	64	68	PF12202	0.223
DOC_USP7_MATH_1	114	118	PF00917	0.600
DOC_USP7_MATH_1	25	29	PF00917	0.515
DOC_USP7_MATH_1	314	318	PF00917	0.763
DOC_USP7_MATH_1	355	359	PF00917	0.769
DOC_USP7_UBL2_3	256	260	PF12436	0.524
DOC_WW_Pin1_4	204	209	PF00397	0.269
DOC_WW_Pin1_4	316	321	PF00397	0.770
LIG_14-3-3_CanoR_1	162	168	PF00244	0.562
LIG_14-3-3_CanoR_1	198	208	PF00244	0.261
LIG_14-3-3_CanoR_1	7	15	PF00244	0.634
LIG_APCC_ABBA_1	239	244	PF00400	0.469
LIG_BIR_III_4	327	331	PF00653	0.656
LIG_BRCT_BRCA1_1	383	387	PF00533	0.671
LIG_BRCT_BRCA1_1	77	81	PF00533	0.391
LIG_BRCT_BRCA1_2	77	83	PF00533	0.217
LIG_CaM_IQ_9	183	199	PF13499	0.400
LIG_EH1_1	183	191	PF00400	0.323
LIG_FHA_1	183	189	PF00498	0.430
LIG_FHA_1	75	81	PF00498	0.266
LIG_FHA_2	322	328	PF00498	0.707
LIG_GBD_Chelix_1	67	75	PF00786	0.280
LIG_IRF3_LxIS_1	33	40	PF10401	0.485
LIG_IRF3_LxIS_1	65	72	PF10401	0.453
LIG_LIR_Apic_2	17	22	PF02991	0.538
LIG_LIR_Apic_2	202	208	PF02991	0.269
LIG_LIR_Apic_2	28	33	PF02991	0.487
LIG_LIR_Gen_1	249	255	PF02991	0.440
LIG_LIR_Gen_1	40	50	PF02991	0.400
LIG_LIR_Gen_1	78	89	PF02991	0.411
LIG_LIR_Nem_3	12	18	PF02991	0.581
LIG_LIR_Nem_3	166	170	PF02991	0.368
LIG_LIR_Nem_3	249	254	PF02991	0.483
LIG_LIR_Nem_3	384	390	PF02991	0.694
LIG_LIR_Nem_3	40	45	PF02991	0.400
LIG_LIR_Nem_3	78	84	PF02991	0.325
LIG_Pex14_1	15	19	PF04695	0.548
LIG_Pex14_2	123	127	PF04695	0.431
LIG_SH2_CRK	205	209	PF00017	0.269
LIG_SH2_NCK_1	356	360	PF00017	0.586
LIG_SH2_SRC	242	245	PF00017	0.515
LIG_SH2_SRC	251	254	PF00017	0.463
LIG_SH2_SRC	30	33	PF00017	0.538
LIG_SH2_SRC	364	367	PF00017	0.726
LIG_SH2_STAP1	184	188	PF00017	0.320
LIG_SH2_STAP1	251	255	PF00017	0.445
LIG_SH2_STAT3	184	187	PF00017	0.406
LIG_SH2_STAT3	267	270	PF00017	0.596
LIG_SH2_STAT3	89	92	PF00017	0.511
LIG_SH2_STAT5	184	187	PF00017	0.300
LIG_SH2_STAT5	242	245	PF00017	0.464
LIG_SH2_STAT5	364	367	PF00017	0.685
LIG_SH2_STAT5	385	388	PF00017	0.675
LIG_SH3_1	19	25	PF00018	0.529
LIG_SH3_2	22	27	PF14604	0.505
LIG_SH3_3	19	25	PF00018	0.529
LIG_SH3_3	317	323	PF00018	0.749
LIG_SH3_3	52	58	PF00018	0.340
LIG_SUMO_SIM_par_1	66	73	PF11976	0.309
LIG_WRC_WIRS_1	164	169	PF05994	0.380
MOD_CDC14_SPxK_1	207	210	PF00782	0.223
MOD_CDK_SPxK_1	204	210	PF00069	0.223
MOD_CK1_1	182	188	PF00069	0.397
MOD_CK1_1	276	282	PF00069	0.715
MOD_CK1_1	316	322	PF00069	0.695
MOD_CK1_1	329	335	PF00069	0.723
MOD_CK1_1	339	345	PF00069	0.633
MOD_CK2_1	246	252	PF00069	0.463
MOD_CK2_1	25	31	PF00069	0.483
MOD_CK2_1	342	348	PF00069	0.755
MOD_GlcNHglycan	112	115	PF01048	0.427
MOD_GlcNHglycan	27	30	PF01048	0.314
MOD_GlcNHglycan	327	331	PF01048	0.554
MOD_GlcNHglycan	341	345	PF01048	0.591
MOD_GlcNHglycan	357	360	PF01048	0.527
MOD_GlcNHglycan	39	42	PF01048	0.338
MOD_GSK3_1	110	117	PF00069	0.673
MOD_GSK3_1	243	250	PF00069	0.443
MOD_GSK3_1	336	343	PF00069	0.743
MOD_GSK3_1	377	384	PF00069	0.751
MOD_GSK3_1	70	77	PF00069	0.287
MOD_N-GLC_2	153	155	PF02516	0.236
MOD_NEK2_1	163	168	PF00069	0.309
MOD_NEK2_1	243	248	PF00069	0.444
MOD_NEK2_1	37	42	PF00069	0.536
MOD_NEK2_1	69	74	PF00069	0.331
MOD_NEK2_1	75	80	PF00069	0.284
MOD_OFUCOSY	149	155	PF10250	0.245
MOD_PIKK_1	199	205	PF00454	0.239
MOD_PIKK_1	266	272	PF00454	0.683
MOD_PIKK_1	336	342	PF00454	0.724
MOD_PK_1	133	139	PF00069	0.488
MOD_PKA_2	25	31	PF00069	0.493
MOD_Plk_1	314	320	PF00069	0.689
MOD_Plk_4	163	169	PF00069	0.392
MOD_Plk_4	179	185	PF00069	0.371
MOD_Plk_4	70	76	PF00069	0.356
MOD_ProDKin_1	204	210	PF00069	0.269
MOD_ProDKin_1	316	322	PF00069	0.772
MOD_SUMO_rev_2	10	18	PF00179	0.638
MOD_SUMO_rev_2	269	279	PF00179	0.614
TRG_ENDOCYTIC_2	161	164	PF00928	0.445
TRG_ENDOCYTIC_2	242	245	PF00928	0.478
TRG_ENDOCYTIC_2	251	254	PF00928	0.410
TRG_ENDOCYTIC_2	364	367	PF00928	0.753
TRG_ER_diArg_1	125	127	PF00400	0.446
TRG_ER_diArg_1	23	26	PF00400	0.504
TRG_ER_diArg_1	285	288	PF00400	0.622
TRG_ER_diArg_1	350	353	PF00400	0.768
TRG_NLS_MonoCore_2	285	290	PF00514	0.726
TRG_NLS_MonoExtN_4	286	291	PF00514	0.676
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3T7	Leptomonas seymouri	66%	97%
A0A0S4IT15	Bodo saltans	24%	100%
A0A0S4J1K8	Bodo saltans	24%	86%
A0A0S4JRL4	Bodo saltans	23%	100%
A0A1X0NUX2	Trypanosomatidae	49%	100%
A0A3R7RC91	Trypanosoma rangeli	43%	100%
A0A3S5H6J6	Leishmania donovani	31%	100%
A4H6N2	Leishmania braziliensis	33%	75%
A4HCH5	Leishmania braziliensis	74%	99%
A4HD15	Leishmania braziliensis	24%	100%
B3DN87	Arabidopsis thaliana	24%	100%
C9ZSP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
D0A148	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
D0A7D2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	75%
E7EZI4	Danio rerio	27%	92%
E7F4Z4	Danio rerio	27%	68%
E9AH03	Leishmania infantum	100%	100%
E9AVW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
F1R013	Danio rerio	24%	100%
P0C7U3	Homo sapiens	26%	100%
P59268	Mus musculus	26%	100%
Q14AK4	Mus musculus	27%	100%
Q4QBL2	Leishmania major	93%	100%
Q4QGX1	Leishmania major	29%	100%
Q6DR03	Arabidopsis thaliana	26%	70%
Q8R0N9	Mus musculus	28%	81%
Q8VYP5	Arabidopsis thaliana	26%	100%
Q8WTX9	Homo sapiens	27%	81%
Q9H8X9	Homo sapiens	26%	96%
Q9M306	Arabidopsis thaliana	26%	83%
Q9SB58	Arabidopsis thaliana	24%	97%
V5B8P9	Trypanosoma cruzi	47%	100%
V5BWI0	Trypanosoma cruzi	27%	100%